-
1
-
-
84875432419
-
Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
-
Herold KC, Vignali DA, Cooke A, Bluestone JA (2013) Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 13(4):243-256.
-
(2013)
Nat Rev Immunol
, vol.13
, Issue.4
, pp. 243-256
-
-
Herold, K.C.1
Vignali, D.A.2
Cooke, A.3
Bluestone, J.A.4
-
2
-
-
39749147110
-
Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
-
DOI 10.1038/nrm2327, PII NRM2327
-
Muoio DM, Newgard CB (2008) Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 9(3):193-205. (Pubitemid 351301824)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.3
, pp. 193-205
-
-
Muoio, D.M.1
Newgard, C.B.2
-
3
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, et al. (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105(6):745-755.
-
(2001)
Cell
, vol.105
, Issue.6
, pp. 745-755
-
-
Zhang, C.Y.1
-
4
-
-
70449099192
-
Mitochondria mediated cell death in diabetes
-
Szabadkai G, Duchen MR (2009) Mitochondria mediated cell death in diabetes. Apoptosis 14(12):1405-1423.
-
(2009)
Apoptosis
, vol.14
, Issue.12
, pp. 1405-1423
-
-
Szabadkai, G.1
Duchen, M.R.2
-
6
-
-
77952227625
-
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
-
Suzuki S, et al. (2010) Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci USA 107(16):7461-7466.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.16
, pp. 7461-7466
-
-
Suzuki, S.1
-
7
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
DOI 10.1038/ncb1730, PII NCB1730
-
Tasdemir E, et al. (2008) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10(6):676-687. (Pubitemid 351772933)
-
(2008)
Nature Cell Biology
, vol.10
, Issue.6
, pp. 676-687
-
-
Tasdemir, E.1
Maiuri, M.C.2
Galluzzi, L.3
Vitale, I.4
Djavaheri-Mergny, M.5
D'Amelio, M.6
Criollo, A.7
Morselli, E.8
Zhu, C.9
Harper, F.10
Nannmark, U.11
Samara, C.12
Pinton, P.13
Vicencio, J.M.14
Carnuccio, R.15
Moll, U.M.16
Madeo, F.17
Paterlini-Brechot, P.18
Rizzuto, R.19
Szabadkai, G.20
Pierron, G.21
Blomgren, K.22
Tavernarakis, N.23
Codogno, P.24
Cecconi, F.25
Kroemer, G.26
more..
-
8
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
DOI 10.1126/science.1126863
-
Matoba S, et al. (2006) p53 regulates mitochondrial respiration. Science 312(5780): 1650-1653. (Pubitemid 43902663)
-
(2006)
Science
, vol.312
, Issue.5780
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.-G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
9
-
-
84882425828
-
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
-
Hoshino A, et al. (2013) Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nat Commun 4:2308.
-
(2013)
Nat Commun
, vol.4
, pp. 2308
-
-
Hoshino, A.1
-
10
-
-
77951243028
-
Autophagy regulation by p53
-
Maiuri MC, et al. (2010) Autophagy regulation by p53. Curr Opin Cell Biol 22(2): 181-185.
-
(2010)
Curr Opin Cell Biol
, vol.22
, Issue.2
, pp. 181-185
-
-
Maiuri, M.C.1
-
11
-
-
0017179001
-
Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
-
Like AA, Rossini AA (1976) Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus. Science 193(4251):415-417.
-
(1976)
Science
, vol.193
, Issue.4251
, pp. 415-417
-
-
Like, A.A.1
Rossini, A.A.2
-
12
-
-
38149028453
-
The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation
-
Nam SY, Lee MK, Sabapathy K (2008) The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation. J Physiol 586(2):407-417.
-
(2008)
J Physiol
, vol.586
, Issue.2
, pp. 407-417
-
-
Nam, S.Y.1
Lee, M.K.2
Sabapathy, K.3
-
13
-
-
80052145606
-
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery
-
Katayama H, Kogure T, Mizushima N, Yoshimori T, Miyawaki A (2011) A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol 18(8):1042-1052.
-
(2011)
Chem Biol
, vol.18
, Issue.8
, pp. 1042-1052
-
-
Katayama, H.1
Kogure, T.2
Mizushima, N.3
Yoshimori, T.4
Miyawaki, A.5
-
14
-
-
79957900616
-
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
-
Seino S, Shibasaki T, Minami K (2011) Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J Clin Invest 121(6):2118-2125.
-
(2011)
J Clin Invest
, vol.121
, Issue.6
, pp. 2118-2125
-
-
Seino, S.1
Shibasaki, T.2
Minami, K.3
-
15
-
-
80052389174
-
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
-
Kim KY, et al. (2011) Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest 121(9):3701-3712.
-
(2011)
J Clin Invest
, vol.121
, Issue.9
, pp. 3701-3712
-
-
Kim, K.Y.1
-
16
-
-
10744232627
-
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
-
DOI 10.1101/gad.1165804
-
Qu L, et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18(3):261-277. (Pubitemid 38199252)
-
(2004)
Genes and Development
, vol.18
, Issue.3
, pp. 261-277
-
-
Qu, L.1
Huang, S.2
Baltzis, D.3
Rivas-Estilla, A.-M.4
Pluquet, O.5
Hatzoglou, M.6
Koumenis, C.7
Taya, Y.8
Yoshimura, A.9
Koromilas, A.E.10
-
17
-
-
27144557493
-
Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta
-
DOI 10.1128/MCB.25.21.9392-9405.2005
-
Pluquet O, Qu LK, Baltzis D, Koromilas AE (2005) Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. Mol Cell Biol 25(21):9392-9405. (Pubitemid 41507840)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.21
, pp. 9392-9405
-
-
Pluquet, O.1
Qu, L.-K.2
Baltzis, D.3
Koromilas, A.E.4
-
18
-
-
70349200580
-
Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways
-
Lee MJ, Kee KH, Suh CH, Lim SC, Oh SH (2009) Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways. Toxicology 264(3):205-214.
-
(2009)
Toxicology
, vol.264
, Issue.3
, pp. 205-214
-
-
Lee, M.J.1
Kee, K.H.2
Suh, C.H.3
Lim, S.C.4
Oh, S.H.5
-
19
-
-
80755184724
-
Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: Role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet
-
Syed I, et al. (2011) Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: Role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes 60(11): 2843-2852.
-
(2011)
Diabetes
, vol.60
, Issue.11
, pp. 2843-2852
-
-
Syed, I.1
-
20
-
-
84884200949
-
NOX, NOX who is there? The contribution of NADPH oxidase one to beta cell dysfunction
-
Taylor-Fishwick DA (2013) NOX, NOX who is there? The contribution of NADPH oxidase one to beta cell dysfunction. Front Endocrinol (Lausanne) 4:40.
-
(2013)
Front Endocrinol (Lausanne)
, vol.4
, pp. 40
-
-
Taylor-Fishwick, D.A.1
-
21
-
-
80052266526
-
Cross talk between mitochondria and NADPH oxidases
-
Dikalov S (2011) Cross talk between mitochondria and NADPH oxidases. Free Radic Biol Med 51(7):1289-1301.
-
(2011)
Free Radic Biol Med
, vol.51
, Issue.7
, pp. 1289-1301
-
-
Dikalov, S.1
-
22
-
-
84860992488
-
A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets
-
Wikstrom JD, et al. (2012) A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS ONE 7(5):e33023.
-
(2012)
PLoS ONE
, vol.7
, Issue.5
-
-
Wikstrom, J.D.1
-
23
-
-
84869132706
-
Involvement of dynamin-related protein 1 in free fatty acid-induced INS-1-derived cell apoptosis
-
Peng L, et al. (2012) Involvement of dynamin-related protein 1 in free fatty acid-induced INS-1-derived cell apoptosis. PLoS ONE 7(11):e49258.
-
(2012)
PLoS ONE
, vol.7
, Issue.11
-
-
Peng, L.1
-
24
-
-
79959910616
-
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
-
Zhang Z, et al. (2011) The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell 22(13):2235-2245.
-
(2011)
Mol Biol Cell
, vol.22
, Issue.13
, pp. 2235-2245
-
-
Zhang, Z.1
-
25
-
-
52749094770
-
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
-
Jung HS, et al. (2008) Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 8(4):318-324.
-
(2008)
Cell Metab
, vol.8
, Issue.4
, pp. 318-324
-
-
Jung, H.S.1
-
26
-
-
84862833655
-
Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis
-
Armata HL, et al. (2010) Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol 30(24):5787-5794.
-
(2010)
Mol Cell Biol
, vol.30
, Issue.24
, pp. 5787-5794
-
-
Armata, H.L.1
-
27
-
-
69949150673
-
A crucial role for adipose tissue p53 in the regulation of insulin resistance
-
Minamino T, et al. (2009) A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15(9):1082-1087.
-
(2009)
Nat Med
, vol.15
, Issue.9
, pp. 1082-1087
-
-
Minamino, T.1
-
28
-
-
17844392396
-
Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function
-
DOI 10.2337/diabetes.54.5.1423
-
Zheng SJ, Lamhamedi-Cherradi SE, Wang P, Xu L, Chen YH (2005) Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 54(5): 1423-1428. (Pubitemid 40586673)
-
(2005)
Diabetes
, vol.54
, Issue.5
, pp. 1423-1428
-
-
Zheng, S.-J.1
Lamhamedi-Cherradi, S.-E.2
Wang, P.3
Xu, L.4
Chen, Y.H.5
-
29
-
-
33745918951
-
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
-
DOI 10.1016/j.cell.2006.05.036, PII S0092867406007628
-
Bensaad K, et al. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126(1):107-120. (Pubitemid 44040989)
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.C.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
30
-
-
79951812916
-
Telomere dysfunction induces metabolic and mitochondrial compromise
-
Sahin E, et al. (2011) Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470(7334):359-365.
-
(2011)
Nature
, vol.470
, Issue.7334
, pp. 359-365
-
-
Sahin, E.1
-
31
-
-
0025281303
-
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
-
Miyazaki J, et al. (1990) Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms. Endocrinology 127(1):126-132. (Pubitemid 20228111)
-
(1990)
Endocrinology
, vol.127
, Issue.1
, pp. 126-132
-
-
Miyazaki, J.-I.1
Araki, K.2
Yamato, E.3
Ikegami, H.4
Asano, T.5
Shibasaki, Y.6
Oka, Y.7
Yamamura, K.-I.8
|