Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype

Biotechnology Journal

Volumn 10, Issue 7, 2015, Pages 1029-1040

  Kelly, Paul S ^a   Breen, Laura ^a   Gallagher, Clair ^a   Kelly, Shane ^a   Henry, Michael ^a   Lao, Nga T ^a   Meleady, Paula ^a   O'Gorman, Donal ^a   Clynes, Martin ^a   Barron, Niall ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

microRNA sponge; miR 23; Mitochondria; Chinese hamster ovary (CHO); Productivity

Indexed keywords

BIOCHEMISTRY; CELLS; CLONE CELLS; CYTOLOGY; ELECTRON TRANSPORT PROPERTIES; MAMMALS; METABOLISM; MITOCHONDRIA; MOBILE SECURITY; PHYSIOLOGY; PRODUCTIVITY; RNA;

CHINESE HAMSTER OVARY; ELECTRON TRANSPORT SYSTEMS; INCREASED PRODUCTIVITY; MICRORNAS; MIR-23; MITOCHONDRIAL ACTIVITY; OXIDATIVE PHOSPHORYLATION; SPECIFIC PRODUCTIVITY;

CELL ENGINEERING;

ISOCITRATE DEHYDROGENASE 1; LETM1 PROTEIN; MEMBRANE PROTEIN; MICRORNA; MICRORNA 23; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; ALKALINE PHOSPHATASE; GLUTAMIC ACID; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE; MESSENGER RNA;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL METABOLISM; CHO CELL LINE; CONTROLLED STUDY; ELECTRON TRANSPORT; FEMALE; GENETIC ENGINEERING; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; PRIORITY JOURNAL; PRODUCTIVITY; PROTEOMICS; RESPIROMETER; TRANSIENT TRANSFECTION; ANIMAL; CELL ENGINEERING; CELL PROLIFERATION; CRICETULUS; GENETICS; HAMSTER; HUMAN; METABOLISM; MITOCHONDRION; RNA STABILITY; SECRETION (PROCESS);

CRICETULUS GRISEUS; MAMMALIA;

ALKALINE PHOSPHATASE; ANIMALS; CELL ENGINEERING; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; GLUTAMIC ACID; HUMANS; ISOCITRATE DEHYDROGENASE; MICRORNAS; MITOCHONDRIA; PHENOTYPE; PROTEOMICS; RNA STABILITY; RNA, MESSENGER;

EID: 84935756437     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201500101     Document Type: Article

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