Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T1-weighted MRI at 3 tesla

Magnetic Resonance in Medicine

Volumn 62, Issue 5, 2009, Pages 1270-1281

  Larsson, Henrik B W ^a,b   Courivaud, Frédéric ^c   Rostrup, Egill ^a   Hansen, Adam E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Blood brain barrier; Brain blood volume; Brain perfusion; Brain tumor; Dynamic contrast enhanced MRI; T1 weighted MRI

Indexed keywords

BRAIN; DECONVOLUTION; DIAGNOSIS; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING; PIXELS; TUMORS;

BLOOD VOLUMES; BLOOD-BRAIN BARRIER; BRAIN PERFUSION; BRAIN TUMORS; DYNAMIC CONTRAST ENHANCED MRI; T1-WEIGHTED;

BLOOD;

GADOLINIUM PENTETATE;

ADULT; ARTICLE; ASTROCYTOMA; BLOOD BRAIN BARRIER; BRAIN BLOOD VOLUME; BRAIN PERFUSION; BRAIN TUMOR; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; HUMAN; IMAGE QUALITY; MALE; MATHEMATICAL MODEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PERMEABILITY; SIGNAL NOISE RATIO;

EID: 70449411152     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22136     Document Type: Article

References (27)

1. Larsson HB, Stubgaard M, Frederiksen JL, Jensen M, Henriksen O, Paulson OB. Quantitative measurement of blood-brain barrier defect by use of magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumours. Magn Reson Med 1990;16: 117-131. (Pubitemid 20353802)
2. Tofts PS, Kermode AG. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging, 1: fundamental concepts. Magn Reson Med 1991;17:357-367.
3. 1-weighted MRI of a diffusible tracer: standardized quantities and symbols. J Magn Reson Imaging 1999;10:223-232.
4. Johnson G, Wetzel SG, Cha S, Babb J, Tofts PS. Measuring blood volume and vascular transfer constant from dynamic, T(2)*-weighted contrast-enhanced MRI. Magn Reson Med 2004;51:961-968.
5. Boxerman JL, Schmainda KM, Weisskoff RM. Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumour grade, whereas uncorrelated maps do not. Am J Neuroradiol 2006;27:859-867.
6. Marstrand JR, Rostrup E, Rosenbaum S, Garde E, Larsson HB. Cerebral hemodynamic changes measured by gradient-echo or spin-echo bolus tracking and its correlation to changes in ICA blood measured by phase-mapping MRI. J Magn Reson Imaging 2001;14:391-400. (Pubitemid 32906556)
7. 2* relaxivities of human whole blood to ProHance, Vasovist, and deoxyhemoglobin Magn Reson Med 2008;60:1313-1320.
8. 1-weighted MRI at 3T. J Magn Reson Imaging 2008;27:754-762.
9. Parker GJ, Padhani AR. T1-w DCE-MRI: T1-weighted dynamic contrast-enhanced MRI. In: Tofts P, editor. Quantitative MRI of the brain. John Wiley & Sons Ltd; 2004. 345-346.
10. Larsson HB, Fritz-Hansen T, Rostrup E, Sondergaard L, Ring P, Henriksen O. Myocardial perfusion modelling using MRI. Magn Reson Med 1996;35:716-726. (Pubitemid 26134567)
11. Patlak CS, Blasberg RG. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 1985;5:584-590.
12. Tikhonov AN, Arsenin VY, editors. Solutions of ill-posed problems [Fritz J, translator, editor]. Washington, DC: V. H. Winston; 1977. 258 p.
13. Tikhonov AN. Ill-posed problems in natural sciences. In: Leonov AS, editor. Proceedings of the International Conference Moscow 1991. Utrecht: VSP Science Press, TVP Science Publishers; 1992. 594 p.
14. Renkin EM. Exchangeability of tissue potassium in skeletal muscle. Am J Physiol 1959;197:1211-1215.
15. Crone C. The permeability of capillaries in various organs as determined by use of the indicator diffusion method. Acta Physiol Scand 1963;58:292-305.
16. Larsson HBW, Rosenbaum S, Fritz-Hansen T. Quantification of the effect of water exchange in dynamic contrast MRI perfusion measurements in the brain and heart. Magn Reson Med 2001;46:272-281. (Pubitemid 32703272)
17. Grubb RL, Raichle ME, Eichling JO, Ter Pogossian MM. The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 1974;5:630-639.
18. Rostrup E, Knudsen GM, Law I, Holm S, Larsson HB, Paulson OB. The relationship between cerebral blood flow and volume in humans. Neuroimage 2005;24:1-11. (Pubitemid 39611020)
19. Østergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages, part I: mathematical approach and statistical analysis. Magn Reson Med 1996;36:715-725.
20. 2-induced changes in the blood volume of the human brain. Acta Radiol 1996;37:813-822.
21. Bruening R, Kwong KK, Vevea MJ, Hochberg FH, Cher L, Harsh GR, Niemi PT, Weisskoff RM, Rosen BR. Echo-planar MR determination of relative cerebral blood volume in human brain tumours: T1 versus T2. Am J Neuroradiol 1996;17:831-840. (Pubitemid 126499953)
22. Singh A, Haris M, Rathore D, Purwar A, Sarma M, Bayu G, Husain N, Rathore RK, Gupta RK. Quantification of physiological and hemodynamic indices using T1 dynamic contrast-enhanced MRI in intracranial mass lesions. J Magn Reson Imaging 2007;26:871-880. (Pubitemid 47548145)
23. Li KL, Zhu XP, Waterton J, Jackson A. Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumours. J Magn Reson Imaging 2000;12:347-357. (Pubitemid 30612881)
24. Lüdemann L, Hamm B, Zimmer C. Pharmacokinetic analysis of glioma compartments with dynamic Gd-DTPA enhanced magnetic resonance imaging. Magn Reson Imaging 2000;18:1201-1214. (Pubitemid 32121436)
25. Fritz-Hansen T, Rostrup E, Larsson HB, Sondergaard L, Ring P, Henriksen O. Measurement of the arterial concentration of Gd-DTPA using MRI: a step towards quantitative perfusion imaging. Magn Reson Med 1996;36:225-231. (Pubitemid 26271742)
26. Mills SJ, Patankar TA, Haroon HA, Baleriaux D, Swindell R, Jackson A. Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma? Am J Neuroradiol 2006;27:853-858.
27. Patankar TF, Haroon HA, Mills SJ, Baleriaux D, Buckley DL, Parker GJ, Jackson A. Is volume transfer coefficient (Ktrans) related to histologic grade in human gliomas ? Am J Neuroradiol 2005;26:2455-2465.