Soluble adhesion molecules and angiotensin-converting enzyme in dementia

Neurobiology of Disease

Volumn 26, Issue 1, 2007, Pages 27-35

  Nielsen, Henrietta M ^a   Londos, Elisabet ^a   Minthon, Lennart ^a   Janciauskiene, Sabina M ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Adhesion molecules; Alzheimer's disease; Angiotensin converting enzyme; Blood brain barrier; Dementia with Lewy bodies; Endothelium; Inflammation; Intercellular adhesion molecule 1; Platelet endothelial adhesion molecule 1; Vascular cell adhesion molecule 1

Indexed keywords

CD31 ANTIGEN; CELL ADHESION MOLECULE; DIPEPTIDYL CARBOXYPEPTIDASE; INTERCELLULAR ADHESION MOLECULE 1; SOLUBLE CD31 ANTIGEN; SOLUBLE INTERCELLULAR ADHESION MOLECULE 1; SOLUBLE VASCULAR CELL ADHESION MOLECULE 1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CELL ACTIVATION; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DEMENTIA; DIFFUSE LEWY BODY DISEASE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AGING; ALLELES; ALZHEIMER DISEASE; ANTIGENS, CD31; APOLIPOPROTEIN E4; BLOOD PRESSURE; BLOOD-BRAIN BARRIER; COGNITION; DEMENTIA; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LEWY BODY DISEASE; MALE; MIDDLE AGED; NEURAL CELL ADHESION MOLECULES; PEPTIDYL-DIPEPTIDASE A; PERMEABILITY; PSYCHIATRIC STATUS RATING SCALES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33947205974     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.11.011     Document Type: Article

References (93)

1. Akiyama H., Kawamata T., Yamada T., Tooyama I., Ishii T., and McGeer P.L. Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders. Acta Neuropathol. (Berl.) 85 (1993) 628-634
2. Bevilacqua M.P. Endothelial-leukocyte adhesion molecules. Annu. Rev. Immunol. 11 (1993) 767-804
3. Blankenberg S., Rupprecht H.J., Bickel C., Peetz D., Hafner G., Tiret L., and Meyer J. Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation 104 (2001) 1336-1342
4. Blankenberg S., Barbaux S., and Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis 170 (2003) 191-203
5. Blasko I., Lederer W., Oberbauer H., Walch T., Kemmler G., Hinterhuber H., Marksteiner J., and Humpel C. Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias. Dementia Geriatr. Cognit. Disord. 21 (2006) 9-15
6. Blennow K., Fredman P., Wallin A., Gottfries C.G., Karlsson I., Svennerholm I., and Wikkelso L. Protein analysis in cerebrospinal fluid. II. Reference values derived from healthy individuals 18-88 years of age. Eur. Neurol. 33 (1993) 129-133
7. Breteler M.M. Vascular involvement in cognitive decline and dementia. Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study. Ann. N. Y. Acad. Sci. 903 (2000) 457-465
8. Buckley C.D., Doyonnas R., Newton J.P., Blystone S.D., Brown E.J., Watt S.M., and Simmons D.L. Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1. J. Cell Sci. 109 Pt. 2 (1996) 437-445
9. Cacquevel M., Lebeurrier N., Cheenne S., and Vivien D. Cytokines in neuroinflammation and Alzheimer's disease. Curr. Drug Targets 5 (2004) 529-534
10. Carlos T.M., and Harlan J.M. Leukocyte-endothelial adhesion molecules. Blood 84 (1994) 2068-2101
11. Casserly I., and Topol E. Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet 363 (2004) 1139-1146
12. Chen N.X., O'Neill K.D., Niwa T., and Moe S.M. Signal transduction of beta2m-induced expression of VCAM-1 and COX-2 in synovial fibroblasts. Kidney Int. 61 (2002) 414-424
13. Cheng Z.J., Vapaatalo H., and Mervaala E. Angiotensin II and vascular inflammation. Med. Sci. Monit. 11 (2005) RA194-RA205
14. Cotran R.S., and Mayadas-Norton T. Endothelial adhesion molecules in health and disease. Pathol. Biol. (Paris) 46 (1998) 164-170
15. Das U.N. Is angiotensin-II an endogenous pro-inflammatory molecule?. Med. Sci. Monit. 11 (2005) RA155-RA162
16. DeKosky S.T., Ikonomovic M.D., Wang X., Farlow M., Wisniewski S., Lopez O.L., Becker J.T., Saxton J., Klunk W.E., Sweet R., Kaufer D.I., and Kamboh M.I. Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment. Ann. Neurol. 53 (2003) 81-90
17. Dustin M.L., Rothlein R., Bhan A.K., Dinarello C.A., and Springer T.A. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137 (1986) 245-254
18. Ehlers M.R., and Riordan J.F. Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry 28 (1989) 5311-5318
19. Engelberg H. Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial. Dementia Geriatr. Cognit. Disord. 18 (2004) 278-298
20. Engelhart M.J., Geerlings M.I., Meijer J., Kiliaan A., Ruitenberg A., vanSwieten J.C., Stijnen T., Hofman A., Witteman J.C., and Breteler M.M. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study. Arch. Neurol. 61 (2004) 668-672
21. Fabry Z., Waldschmidt M.M., Hendrickson D., Keiner J., Love-Homan L., Takei F., and Hart M.N. Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55. J. Neuroimmunol. 36 (1992) 1-11
22. Farkas E., and Luiten P.G. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64 (2001) 575-611
23. Fassbender K., Bertsch T., Mielke O., Muhlhauser F., and Hennerici M. Adhesion molecules in cerebrovascular diseases. Evidence for an inflammatory endothelial activation in cerebral large- and small-vessel disease. Stroke 30 (1999) 1647-1650
24. Fawcett J., Buckley C., Holness C.L., Bird I.N., Spragg J.H., Saunders J., Harris A., and Simmons D.L. Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts. J. Cell Biol. 128 (1995) 1229-1241
25. Folstein M.F., Folstein S.E., and McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975) 189-198
26. Fratiglioni L., Launer L.J., Andersen K., Breteler M.M., Copeland J.R., Dartigues J.F., Lobo A., Martinez-Lage J., Soininen H., and Hofman A. Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54 (2000) S10-S15
27. Frohman E.M., Frohman T.C., Gupta S., de Fougerolles A., and van den Noort S. Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease. J. Neurol. Sci. 106 (1991) 105-111
28. Galimberti D., Schoonenboom N., Scheltens P., Fenoglio C., Venturelli E., Pijnenburg Y.A., Bresolin N., and Scarpini E. Intrathecal chemokine levels in Alzheimer disease and frontotemporal lobar degeneration. Neurology 66 (2006) 146-147
29. Gamble J.R., Bradley S., Noack L., and Vadas M.A. TGF-beta and endothelial cells inhibit VCAM-1 expression on human vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 15 (1995) 949-955
30. Giasson B.I., Duda J.E., Murray I.V., Chen Q., Souza J.M., Hurtig H.I., Ischiropoulos H., Trojanowski J.Q., and Lee V.M. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290 (2000) 985-989
31. Giri R., Shen Y., Stins M., Du Yan S., Schmidt A.M., Stern D., Kim K.S., Zlokovic B., and Kalra V.K. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am. J. Physiol.: Cell Physiol. 279 (2000) C1772-C1781
32. Greenberg S.M., Gurol M.E., Rosand J., and Smith E.E. Amyloid angiopathy-related vascular cognitive impairment. Stroke 35 (2004) 2616-2619
33. Hu J., Miyatake F., Aizu Y., Nakagawa H., Nakamura S., Tamaoka A., Takahash R., Urakami K., and Shoji M. Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. Neurosci. Lett. 277 (1999) 65-67
34. Hwang S.J., Ballantyne C.M., Sharrett A.R., Smith L.C., Davis C.E., Gotto Jr. A.M., and Boerwinkle E. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation 96 (1997) 4219-4225
35. Isojima D., Togo T., Kosaka K., Fujishiro H., Akatsu H., Katsuse O., Iritani S., Matsumoto T., and Hirayasu Y. Vascular complications in dementia with Lewy bodies: a postmortem study. Neuropathology 26 (2006) 293-297
36. Jellinger K.A. Prevalence of vascular lesions in dementia with Lewy bodies. A postmortem study. J. Neural Transm. 110 (2003) 771-778
37. Jenco J.M., Rawlingson A., Daniels B., and Morris A.J. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry 37 (1998) 4901-4909
38. Kehoe P.G., Russ C., McIlory S., Williams H., Holmans P., Holmes C., Liolitsa D., Vahidassr D., Powell J., McGleenon B., Liddell M., Plomin R., Dynan K., Williams N., Neal J., Cairns N.J., Wilcock G., Passmore P., Lovestone S., Williams J., and Owen M.J. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat. Genet. 21 (1999) 71-72
39. Kehoe P.G., Katzov H., Feuk L., Bennet A.M., Johansson B., Wiman B., de Faire U., Cairns N.J., Wilcock G.K., Brookes A.J., Blennow K., and Prince J.A. Haplotypes extending across ACE are associated with Alzheimer's disease. Hum. Mol. Genet. 12 (2003) 859-867
40. Kienzle G., and von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum. 41 (1998) 1296-1305
41. Klegeris A., Giasson B.I., Zhang H., Maguire J., Pelech S., and McGeer P.L. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. FASEB J. 20 (2006) 2000-2008
42. Lee S.J., Drabik K., Van Wagoner N.J., Lee S., Choi C., Dong Y., and Benveniste E.N. ICAM-1-induced expression of proinflammatory cytokines in astrocytes: involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. J. Immunol. 165 (2000) 4658-4666
43. Levesque J.P., Takamatsu Y., Nilsson S.K., Haylock D.N., and Simmons P.J. Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood 98 (2001) 1289-1297
44. Londos E., Passant U., Brun A., and Gustafson L. Clinical Lewy body dementia and the impact of vascular components. Int. J. Geriatr. Psychiatry 15 (2000) 40-49
45. Losy J., Niezgoda A., and Wender M. Increased serum levels of soluble PECAM-1 in multiple sclerosis patients with brain gadolinium-enhancing lesions. J. Neuroimmunol. 99 (1999) 169-172
46. Maes O.C., Kravitz S., Mawal Y., Su H., Liberman A., Mehindate K., Berlin D., Sahlas D.J., Chertkow H.M., Bergman H., Melmed C., and Schipper H.M. Characterization of alpha(1)-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma. Neurobiol. Dis 24 1 (2006) 89-100
47. Matucci-Cerinic M., Jaffa A., and Kahaleh B. Angiotensin converting enzyme: an in vivo and in vitro marker of endothelial injury. J. Lab. Clin. Med. 120 (1992) 428-433
48. McKeith I.G., Galasko D., Kosaka K., Perry E.K., Dickson D.W., Hansen L.A., Salmon D.P., Lowe J., Mirra S.S., Byrne E.J., Lennox G., Quinn N.P., Edwardson J.A., Ince P.G., Bergeron C., Burns A., Miller B.L., Lovestone S., Collerton D., Jansen E.N., Ballard C., de Vos R.A., Wilcock G.K., Jellinger K.A., and Perry R.H. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47 (1996) 1113-1124
49. McKeith I., Mintzer J., Aarsland D., Burn D., Chiu H., Cohen-Mansfield J., Dickson D., Dubois B., Duda J.E., Feldman H., Gauthier S., Halliday G., Lawlor B., Lippa C., Lopez O.L., Carlos Machado J., O'Brien J., Playfer J., and Reid W. Dementia with Lewy bodies. Lancet Neurol. 3 (2004) 19-28
50. McKeith I.G., Dickson D.W., Lowe J., Emre M., O'Brien J.T., Feldman H., Cummings J., Duda J.E., Lippa C., Perry E.K., Aarsland D., Arai H., Ballard C.G., Boeve B., Burn D.J., Costa D., Del Ser T., Dubois B., Galasko D., Gauthier S., Goetz C.G., Gomez-Tortosa E., Halliday G., Hansen L.A., Hardy J., Iwatsubo T., Kalaria R.N., Kaufer D., Kenny R.A., Korczyn A., Kosaka K., Lee V.M., Lees A., Litvan I., Londos E., Lopez O.L., Minoshima S., Mizuno Y., Molina J.A., Mukaetova-Ladinska E.B., Pasquier F., Perry R.H., Schulz J.B., Trojanowski J.Q., and Yamada M. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65 (2005) 1863-1872
51. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (1984) 939-944
52. Meng Y., Baldwin C.T., Bowirrat A., Waraska K., Inzelberg R., Friedland R.P., and Farrer L.A. Association of polymorphisms in the angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community. Am. J. Hum. Genet. 78 (2006) 871-877
53. Mohs R.C., Rosen W.G., and Davis K.L. The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy. Psychopharmacol. Bull. 19 (1983) 448-450
54. Morisaki N., Saito I., Tamura K., Tashiro J., Masuda M., Kanzaki T., Watanabe S., Masuda Y., and Saito Y. New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis 131 (1997) 43-48
55. Nagel T., Resnick N., Atkinson W.J., Dewey Jr. C.F., and Gimbrone Jr. M.A. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J. Clin. Invest. 94 (1994) 885-891
56. Ophir G., Amariglio N., Jacob-Hirsch J., Elkon R., Rechavi G., and Michaelson D.M. Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade. Neurobiol. Dis. 20 (2005) 709-718
57. Os I., Djurovic S., Seljeflot I., and Berg K. Transforming growth factor (TGF)-beta1 inversely related to vascular cell adhesion molecule-1 in postmenopausal women with coronary artery disease. A possible mechanism for the putative cardioprotective role of TGF-beta1?. J. Intern. Med. 251 (2002) 223-227
58. Ott A., Breteler M.M., van Harskamp F., Claus J.J., van der Cammen T.J., Grobbee D.E., and Hofman A. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ 310 (1995) 970-973
59. Park S.K., Yang W.S., Lee S.K., Ahn H., Park J.S., Hwang O., and Lee J.D. TGF-beta(1) down-regulates inflammatory cytokine-induced VCAM-1 expression in cultured human glomerular endothelial cells. Nephrol. Dial. Transplant 15 (2000) 596-604
60. Pigott R., Dillon L.P., Hemingway I.H., and Gearing A.J. Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem. Biophys. Res. Commun. 187 (1992) 584-589
61. Pletnikova O., West N., Lee M.K., Rudow G.L., Skolasky R.L., Dawson T.M., Marsh L., and Troncoso J.C. Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiol. Aging 26 (2005) 1183-1192
62. Ratnavalli E., Brayne C., Dawson K., and Hodges J.R. The prevalence of frontotemporal dementia. Neurology 58 (2002) 1615-1621
63. Rentzos M., Michalopoulou M., Nikolaou C., Cambouri C., Rombos A., Dimitrakopoulos A., and Vassilopoulos D. The role of soluble intercellular adhesion molecules in neurodegenerative disorders. J. Neurol. Sci. 228 (2005) 129-135
64. Rhodin J.A., and Thomas T. A vascular connection to Alzheimer's disease. Microcirculation 8 (2001) 207-220
65. Rhodin J.A., Thomas T.N., Clark L., Garces A., and Bryant M. In vivo cerebrovascular actions of amyloid beta-peptides and the protective effect of conjugated estrogens. J. Alzheimer's Dis. 5 (2003) 275-286
66. Rieckmann P., Nunke K., Burchhardt M., Albrecht M., Wiltfang J., Ulrich M., and Felgenhauer K. Soluble intercellular adhesion molecule-1 in cerebrospinal fluid: an indicator for the inflammatory impairment of the blood-cerebrospinal fluid barrier. J. Neuroimmunol. 47 (1993) 133-140
67. Roebuck K.A., and Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J. Leukocyte Biol. 66 (1999) 876-888
68. Roher A.E., Esh C., Rahman A., Kokjohn T.A., and Beach T.G. Atherosclerosis of cerebral arteries in Alzheimer disease. Stroke 35 (2004) 2623-2627
69. Roses A.D. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu. Rev. Med. 47 (1996) 387-400
70. Rota E., Bellone G., Rocca P., Bergamasco B., Emanuelli G., and Ferrero P. Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients. Neurol. Sci. 27 (2006) 33-39
71. Rothlein R., Mainolfi E.A., Czajkowski M., and Marlin S.D. A form of circulating ICAM-1 in human serum. J. Immunol. 147 (1991) 3788-3793
72. Schleimer R.P., Sterbinsky S.A., Kaiser J., Bickel C.A., Klunk D.A., Tomioka K., Newman W., Luscinskas F.W., Gimbrone Jr. M.A., McIntyre B.W., et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J. Immunol. 148 (1992) 1086-1092
73. Sharief M.K., Noori M.A., Ciardi M., Cirelli A., and Thompson E.J. Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage. J. Neuroimmunol. 43 (1993) 15-21
74. Singleton A.B., Wharton A., O'Brien K.K., Walker M.P., McKeith I.G., Ballard C.G., O'Brien J., Perry R.H., Ince P.G., Edwardson J.A., and Morris C.M. Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies. Dement. Geriatr. Cogn. Disord. 14 (2002) 167-175
75. Sleegers K., den Heijer T., van Dijk E.J., Hofman A., Bertoli-Avella A.M., Koudstaal P.J., Breteler M.M., and van Duijn C.M. ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala. Neurobiol. Aging 26 (2005) 1153-1159
76. Sobel R.A., Mitchell M.E., and Fondren G. Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am. J. Pathol. 136 (1990) 1309-1316
77. Springer T.A. Adhesion receptors of the immune system. Nature 346 (1990) 425-434
78. Stamler J.S. Alzheimer's disease. A radical vascular connection. Nature 380 (1996) 108-111
79. Strittmatter W.J., Saunders A.M., Goedert M., Weisgraber K.H., Dong L.M., Jakes R., Huang D.Y., Pericak-Vance M., Schmechel D., and Roses A.D. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc. Natl. Acad Sci. U. S. A. 91 (1994) 11183-11186
80. Su G.C., Arendash G.W., Kalaria R.N., Bjugstad K.B., and Mullan M. Intravascular infusions of soluble beta-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage. Brain Res. 818 (1999) 105-117
81. Suo Z., Tan J., Placzek A., Crawford F., Fang C., and Mullan M. Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. Brain Res. 807 (1998) 110-117
82. Tamo W., Imaizumi T., Tanji K., Yoshida H., Mori F., Yoshimoto M., Takahashi H., Fukuda I., Wakabayashi K., and Satoh K. Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels. Neurosci. Lett. 326 (2002) 5-8
83. Thomas T., Thomas G., McLendon C., Sutton T., and Mullan M. beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380 (1996) 168-171
84. Trojano M., Avolio C., Simone I.L., Defazio G., Manzari C., De Robertis F., Calo A., and Livrea P. Soluble intercellular adhesion molecule-1 in serum and cerebrospinal fluid of clinically active relapsing-remitting multiple sclerosis: correlation with Gd-DTPA magnetic resonance imaging-enhancement and cerebrospinal fluid findings. Neurology 47 (1996) 1535-1541
85. Trojano M., Avolio C., Ruggieri M., De Robertis F., Giuliani F., Paolicelli D., and Livrea P. Soluble intercellular adhesion molecule-I (sICAM-I) in serum and cerebrospinal fluid of demyelinating diseases of the central and peripheral nervous system. Mult. Scler. 4 (1998) 39-44
86. Tsuang D.W., Wilson R.K., Lopez O.L., Luedecking-Zimmer E.K., Leverenz J.B., DeKosky S.T., Kamboh M.I., and Hamilton R.L. Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology 64 (2005) 509-513
87. Winkler M.K., and Beveniste E.N. Transforming growth factor-beta inhibition of cytokine induced vascular cell adhesion molecule-1 expression in human astrocytes. Glia 22 (1998) 171-179
88. Xu P.T., Li Y.J., Qin X.J., Scherzer C.R., Xu H., Schmechel D.E., Hulette C.M., Ervin J., Gullans S.R., Haines J., Pericak-Vance M.A., and Gilbert J.R. Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Neurobiol. Dis. 21 (2006) 256-275
89. Yoshimoto M., Iwai A., Kang D., Otero D.A., Xia Y., and Saitoh T. NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation. Proc. Natl. Acad Sci. U. S. A. 92 (1995) 9141-9145
90. Zetterberg H., Andreasen N., and Blennow K. Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease. Neurosci. Lett. 367 (2004) 194-196
91. Zlokovic B.V. Clearing amyloid through the blood-brain barrier. J. Neurochem. 89 (2004) 807-811
92. Zubenko G.S., Volicer L., Direnfeld L.K., Freeman M., Langlais P.J., and Nixon R.A. Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy. Brain Res. 328 (1985) 215-221
93. Zuliani, G., Ranzini, M., Guerra, G., Rossi, L., Munari, M.R., Zurlo, A., Volpato, S., Atti, A.R., Ble, A., Fellin, R., in press. Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia. J. Psychiatr. Res. (2006 Apr. 3) [Epub ahead of print].