-
1
-
-
77949300796
-
11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study
-
J.O. Rinne, D.J. Brooks, M.N. Rossor, N.C. Fox, R. Bullock, and W.E. Klunk et al. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study Lancet Neurol 9 2010 363 372
-
(2010)
Lancet Neurol
, vol.9
, pp. 363-372
-
-
Rinne, J.O.1
Brooks, D.J.2
Rossor, M.N.3
Fox, N.C.4
Bullock, R.5
Klunk, W.E.6
-
2
-
-
84873026509
-
Toward the treatment and prevention of Alzheimer's disease: Rational strategies and recent progress
-
S. Gandy, and S.T. DeKosky Toward the treatment and prevention of Alzheimer's disease: Rational strategies and recent progress Annu Rev Med 64 2013 367 383
-
(2013)
Annu Rev Med
, vol.64
, pp. 367-383
-
-
Gandy, S.1
Dekosky, S.T.2
-
3
-
-
55949117032
-
Frequent amyloid deposition without significant cognitive impairment among the elderly
-
H.J. Aizenstein, R.D. Nebes, J.A. Saxton, J.C. Price, C.A. Mathis, and N.D. Tsopelas et al. Frequent amyloid deposition without significant cognitive impairment among the elderly Arch Neurol 65 2008 1509 1517
-
(2008)
Arch Neurol
, vol.65
, pp. 1509-1517
-
-
Aizenstein, H.J.1
Nebes, R.D.2
Saxton, J.A.3
Price, J.C.4
Mathis, C.A.5
Tsopelas, N.D.6
-
4
-
-
84896396356
-
Chronic traumatic encephalopathy
-
(in press)
-
Gandy S, Ikonomovic MD, Mitsis E, Elder G, Ahlers ST, Barth J, et al. (in press): Chronic traumatic encephalopathy. Molecular Neurodegen.
-
Molecular Neurodegen
-
-
Gandy, S.1
Ikonomovic, M.D.2
Mitsis, E.3
Elder, G.4
Ahlers, S.T.5
Barth, J.6
-
5
-
-
51749103554
-
Natural human antibodies to amyloid beta peptide
-
P. Szabo, N. Relkin, and M.E. Weksler Natural human antibodies to amyloid beta peptide Autoimmun Rev 7 2008 415 420
-
(2008)
Autoimmun Rev
, vol.7
, pp. 415-420
-
-
Szabo, P.1
Relkin, N.2
Weksler, M.E.3
-
6
-
-
84872152042
-
Mechanisms of action of naturally occurring antibodies against β-amyloid on microglia
-
M. Gold, D. Mengel, S. Röskam, R. Dodel, and J.P. Bach Mechanisms of action of naturally occurring antibodies against β-amyloid on microglia J Neuroinflammation 10 2013 5
-
(2013)
J Neuroinflammation
, vol.10
, pp. 5
-
-
Gold, M.1
Mengel, D.2
Röskam, S.3
Dodel, R.4
Bach, J.P.5
-
7
-
-
84875514732
-
Regulatory innovation and drug development for early-stage Alzheimer's disease
-
N. Kozauer, and R. Katz Regulatory innovation and drug development for early-stage Alzheimer's disease N Engl J Med 368 2013 1169 1171
-
(2013)
N Engl J Med
, vol.368
, pp. 1169-1171
-
-
Kozauer, N.1
Katz, R.2
-
8
-
-
84873641792
-
Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype
-
M. Thambisetty, Y. An, M. Nalls, J. Sojkova, S. Swaminathan, and Y. Zhou et al. Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype Biol Psychiatry 73 2013 422 428
-
(2013)
Biol Psychiatry
, vol.73
, pp. 422-428
-
-
Thambisetty, M.1
An, Y.2
Nalls, M.3
Sojkova, J.4
Swaminathan, S.5
Zhou, Y.6
-
9
-
-
84873673141
-
CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease
-
S. Gandy, V. Haroutunian, S.T. DeKosky, M. Sano, and E.E. Schadt CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease Biol Psychiatry 73 2013 393 395
-
(2013)
Biol Psychiatry
, vol.73
, pp. 393-395
-
-
Gandy, S.1
Haroutunian, V.2
Dekosky, S.T.3
Sano, M.4
Schadt, E.E.5
-
10
-
-
42649097901
-
The effects of aging, injury and disease on microglial function: A case for cellular senescence
-
K.R. Miller, and W.J. Streit The effects of aging, injury and disease on microglial function: A case for cellular senescence Neuron Glia Biol 3 2007 245 253
-
(2007)
Neuron Glia Biol
, vol.3
, pp. 245-253
-
-
Miller, K.R.1
Streit, W.J.2
-
11
-
-
84872057940
-
TREM2 variants in Alzheimer's disease
-
R. Guerreiro, A. Wojtas, J. Bras, M. Carrasquillo, E. Rogaeva, and E. Majounie et al. TREM2 variants in Alzheimer's disease N Engl J Med 368 2013 117 127
-
(2013)
N Engl J Med
, vol.368
, pp. 117-127
-
-
Guerreiro, R.1
Wojtas, A.2
Bras, J.3
Carrasquillo, M.4
Rogaeva, E.5
Majounie, E.6
-
12
-
-
84872088087
-
Variant of TREM2 associated with the risk of Alzheimer's disease
-
T. Jonsson, H. Stefansson, S. Steinberg, I. Jonsdottir, P.V. Jonsson, and J. Snaedal et al. Variant of TREM2 associated with the risk of Alzheimer's disease N Engl J Med 368 2013 107 116
-
(2013)
N Engl J Med
, vol.368
, pp. 107-116
-
-
Jonsson, T.1
Stefansson, H.2
Steinberg, S.3
Jonsdottir, I.4
Jonsson, P.V.5
Snaedal, J.6
-
13
-
-
84876907931
-
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
-
B. Zhang, C. Gaiteri, L.G. Bodea, Z. Wang, J. McElwee, and A.A. Podtelezhnikov et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease Cell 153 2013 707 720
-
(2013)
Cell
, vol.153
, pp. 707-720
-
-
Zhang, B.1
Gaiteri, C.2
Bodea, L.G.3
Wang, Z.4
McElwee, J.5
Podtelezhnikov, A.A.6
-
14
-
-
74949127437
-
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia
-
S.A. Grathwohl, R.E. Kälin, T. Bolmont, S. Prokop, G. Winkelmann, and S.A. Kaeser et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia Nat Neurosci 12 2009 1361 1363
-
(2009)
Nat Neurosci
, vol.12
, pp. 1361-1363
-
-
Grathwohl, S.A.1
Kälin, R.E.2
Bolmont, T.3
Prokop, S.4
Winkelmann, G.5
Kaeser, S.A.6
-
15
-
-
84870932482
-
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
-
J. vom Berg, S. Prokop, K.R. Miller, J. Obst, R.E. Kälin, and I. Lopategui-Cabezas et al. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline Nat Med 18 2012 1812 1819
-
(2012)
Nat Med
, vol.18
, pp. 1812-1819
-
-
Vom Berg, J.1
Prokop, S.2
Miller, K.R.3
Obst, J.4
Kälin, R.E.5
Lopategui-Cabezas, I.6
-
16
-
-
79251560289
-
CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice
-
Y. Zhu, H. Hou, K. Rezai-Zadeh, B. Giunta, A. Ruscin, and C. Gemma et al. CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice J Neurosci 31 2011 1355 1365
-
(2011)
J Neurosci
, vol.31
, pp. 1355-1365
-
-
Zhu, Y.1
Hou, H.2
Rezai-Zadeh, K.3
Giunta, B.4
Ruscin, A.5
Gemma, C.6
-
17
-
-
55049142500
-
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
-
L. Bertram, C. Lange, K. Mullin, M. Parkinson, M. Hsiao, and M.F. Hogan et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE Am J Hum Genet 83 2008 623 632
-
(2008)
Am J Hum Genet
, vol.83
, pp. 623-632
-
-
Bertram, L.1
Lange, C.2
Mullin, K.3
Parkinson, M.4
Hsiao, M.5
Hogan, M.F.6
-
18
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
-
A.C. Naj, G. Jun, G.W. Beecham, L.S. Wang, B.N. Vardarajan, and J. Buros et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease Nat Genet 43 2011 436 441
-
(2011)
Nat Genet
, vol.43
, pp. 436-441
-
-
Naj, A.C.1
Jun, G.2
Beecham, G.W.3
Wang, L.S.4
Vardarajan, B.N.5
Buros, J.6
-
19
-
-
84878433339
-
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
A. Griciuc, A. Serrano-Pozo, A.R. Parrado, A.N. Lesinski, C.N. Asselin, and K. Mullin et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta Neuron 78 2013 631 643
-
(2013)
Neuron
, vol.78
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozo, A.2
Parrado, A.R.3
Lesinski, A.N.4
Asselin, C.N.5
Mullin, K.6
-
20
-
-
84873087532
-
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
-
M.T. Heneka, M.P. Kummer, A. Stutz, A. Delekate, S. Schwartz, and A. Vieira-Saecker et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice Nature 493 2013 674 678
-
(2013)
Nature
, vol.493
, pp. 674-678
-
-
Heneka, M.T.1
Kummer, M.P.2
Stutz, A.3
Delekate, A.4
Schwartz, S.5
Vieira-Saecker, A.6
-
21
-
-
80051831092
-
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease
-
96ra76
-
J.T. Dudley, M. Sirota, M. Shenoy, R.K. Pai, S. Roedder, and A.P. Chiang et al. Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease Sci Transl Med 3 2011 96ra76
-
(2011)
Sci Transl Med
, vol.3
-
-
Dudley, J.T.1
Sirota, M.2
Shenoy, M.3
Pai, R.K.4
Roedder, S.5
Chiang, A.P.6
-
22
-
-
77949669251
-
Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals
-
S.H. Kim, P.E. Fraser, D. Westaway St, P.H. George-Hyslop, M.E. Ehrlich, and S. Gandy Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals J Neurosci 30 2010 3870 3875
-
(2010)
J Neurosci
, vol.30
, pp. 3870-3875
-
-
Kim, S.H.1
Fraser, P.E.2
Westaway St, D.3
George-Hyslop, P.H.4
Ehrlich, M.E.5
Gandy, S.6
-
23
-
-
84896389573
-
WIP1104. Behavioral deficits in APP transgenic mice reversed by mGluR inhibitor with pro-neurogenic, Aβ-reducing, and anxiolytic properties [abstract]
-
S. Gandy, J.W. Steele, S.W. Lee, D. Clemenson, R. Gadient, and P. Wedel et al. WIP1104. Behavioral deficits in APP transgenic mice reversed by mGluR inhibitor with pro-neurogenic, Aβ-reducing, and anxiolytic properties [abstract] Ann Neurol 72 2012 S126
-
(2012)
Ann Neurol
, vol.72
, pp. 126
-
-
Gandy, S.1
Steele, J.W.2
Lee, S.W.3
Clemenson, D.4
Gadient, R.5
Wedel, P.6
-
24
-
-
84876006819
-
Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology
-
G. Krabbe, A. Halle, V. Matyash, J.L. Rinnenthal, G.D. Eom, and U. Bernhardt et al. Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology PLoS One 8 2013 e60921
-
(2013)
PLoS One
, vol.8
, pp. 60921
-
-
Krabbe, G.1
Halle, A.2
Matyash, V.3
Rinnenthal, J.L.4
Eom, G.D.5
Bernhardt, U.6
|