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Volumn 101, Issue 12, 2003, Pages 4797-4801

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CELL RECEPTOR; ENDOTHELIAL PROTEIN C RECEPTOR; ENZYME PRECURSOR; PROTEIN C; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; THAPSIGARGIN; UNCLASSIFIED DRUG;

EID: 0038115229     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-12-3680     Document Type: Article
Times cited : (105)

References (37)
  • 1
    • 0035799374 scopus 로고    scopus 로고
    • Antiinflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke
    • Shibata M, Kumar SR, Amar A, et al. Antiinflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001;103:1799-1805.
    • (2001) Circulation , vol.103 , pp. 1799-1805
    • Shibata, M.1    Kumar, S.R.2    Amar, A.3
  • 2
    • 0035992710 scopus 로고    scopus 로고
    • Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke
    • Griffin JH, Zlokovic BV, Fernández JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002:39:197-205.
    • (2002) Semin Hematol , vol.39 , pp. 197-205
    • Griffin, J.H.1    Zlokovic, B.V.2    Fernández, J.A.3
  • 3
    • 0034660464 scopus 로고    scopus 로고
    • Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation
    • Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood. 2000;95:3781-3787.
    • (2000) Blood , vol.95 , pp. 3781-3787
    • Mizutani, A.1    Okajima, K.2    Uchiba, M.3    Noguchi, T.4
  • 4
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Ely EW, Wright TJ, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699-709.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Ely, E.W.2    Wright, T.J.3
  • 5
    • 0033578475 scopus 로고    scopus 로고
    • Prospective study of markers of hemostatic function with risk of ischemic stroke
    • The Atherosclerosis Risk in Communities (ARIC) Study Investigators
    • Folsom AR, Rosamond WD, Shahar E, et al. Prospective study of markers of hemostatic function with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Circulation. 1999;100:736-742.
    • (1999) Circulation , vol.100 , pp. 736-742
    • Folsom, A.R.1    Rosamond, W.D.2    Shahar, E.3
  • 6
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
    • Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem. 2001;276:11199-11203.
    • (2001) J Biol Chem , vol.276 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3    DeHoff, B.4    Grinnell, B.W.5
  • 7
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002;296:1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 8
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu TKH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.H.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 9
    • 0029979497 scopus 로고    scopus 로고
    • Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells
    • Hwa JJ, Ghibaudi L, Williams P, et al. Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells. Circ Res. 1996;78:581-588.
    • (1996) Circ Res , vol.78 , pp. 581-588
    • Hwa, J.J.1    Ghibaudi, L.2    Williams, P.3
  • 10
    • 0029929603 scopus 로고    scopus 로고
    • Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
    • Böhm SK, Kong W, Brömme D, et al. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J. 1996;314:1009-1016.
    • (1996) Biochem J , vol.314 , pp. 1009-1016
    • Böhm, S.K.1    Kong, W.2    Brömme, D.3
  • 14
    • 0033574978 scopus 로고    scopus 로고
    • The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins and capillaries
    • Ye X, Fukudome K, Tsuneyoshi N, et al. The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins and capillaries. Biochem Biophys Res Comm. 1999;259:671-677.
    • (1999) Biochem Biophys Res Comm , vol.259 , pp. 671-677
    • Ye, X.1    Fukudome, K.2    Tsuneyoshi, N.3
  • 15
    • 0035896608 scopus 로고    scopus 로고
    • Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor
    • Liaw PCY, Mather T, Oganesyan N, Ferrell GL, Esmon CT. Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. J Biol Chem. 2001;276:8364-8370.
    • (2001) J Biol Chem , vol.276 , pp. 8364-8370
    • Liaw, P.C.Y.1    Mather, T.2    Oganesyan, N.3    Ferrell, G.L.4    Esmon, C.T.5
  • 16
    • 0037352279 scopus 로고    scopus 로고
    • Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    • Cheng T, Liu D, Griffin JH, et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003;9:338-342.
    • (2003) Nat Med , vol.9 , pp. 338-342
    • Cheng, T.1    Liu, D.2    Griffin, J.H.3
  • 17
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;14;407:258-264.
    • (2000) Nature , vol.14 , Issue.407 , pp. 258-264
    • Coughlin, S.R.1
  • 18
    • 0034609557 scopus 로고    scopus 로고
    • Porteolysis of the exodomain of recombinant protease-activated receptors: Prediction of receptor activation or inactivation by MALDI mass spectrometry
    • Loew D, Perrault C, Morales M, et al. Porteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry. Biochemistry. 2000;39:10812-10822.
    • (2000) Biochemistry , vol.39 , pp. 10812-10822
    • Loew, D.1    Perrault, C.2    Morales, M.3
  • 19
    • 0031032080 scopus 로고    scopus 로고
    • Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va
    • Gale AJ, Sun X., Heeb MJ, Griffin JH. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va. Protein Sci. 1997;1:132-140.
    • (1997) Protein Sci , vol.1 , pp. 132-140
    • Gale, A.J.1    Sun, X.2    Heeb, M.J.3    Griffin, J.H.4
  • 21
    • 0032529151 scopus 로고    scopus 로고
    • Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
    • Mackic JB, Stins M, McComb JG, et al. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998;102:734-743.
    • (1998) J Clin Invest , vol.102 , pp. 734-743
    • Mackic, J.B.1    Stins, M.2    McComb, J.G.3
  • 22
    • 0021895138 scopus 로고
    • A new generation of calcium indicators with greatly improved fluorescence properties
    • Grynkiewicz G, Poenie M, Tsien RY. A new generation of calcium indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440-3450.
    • (1985) J Biol Chem , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 23
    • 0025237291 scopus 로고
    • Alteration of intracellular fura-2 fluorescence by viscosity: A simple correction
    • Poenie M. Alteration of intracellular fura-2 fluorescence by viscosity: a simple correction. Cell Calcium. 1994;11:85-91.
    • (1994) Cell Calcium , vol.11 , pp. 85-91
    • Poenie, M.1
  • 26
    • 0028965735 scopus 로고
    • Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinase
    • Fleming I, Fisslthaler B, Busse R. Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinase. Circ Res. 1995;75:522-529.
    • (1995) Circ Res , vol.75 , pp. 522-529
    • Fleming, I.1    Fisslthaler, B.2    Busse, R.3
  • 27
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood-brain barrier
    • Abbott NJ, Romero IA. Transporting therapeutics across the blood-brain barrier. Mol Med Today. 1996;2:106-113.
    • (1996) Mol Med Today , vol.2 , pp. 106-113
    • Abbott, N.J.1    Romero, I.A.2
  • 28
    • 0030175606 scopus 로고    scopus 로고
    • Permeability of the blood-brain barrier by the bradykinin agonist, RMP-7: Evidence for a sensitive, auto-regulated, receptor-mediated system
    • Bartus RT, Elliott P, Hayward N, Dean R, McEwen EL, Fisher SK. Permeability of the blood-brain barrier by the bradykinin agonist, RMP-7: evidence for a sensitive, auto-regulated, receptor-mediated system. Immunopharmacology. 1996;33:270-278.
    • (1996) Immunopharmacology , vol.33 , pp. 270-278
    • Bartus, R.T.1    Elliott, P.2    Hayward, N.3    Dean, R.4    McEwen, E.L.5    Fisher, S.K.6
  • 30
    • 0032033139 scopus 로고    scopus 로고
    • The regulation of vascular function by P2 receptors: Multiple sites and multiple receptors
    • Boarder MR, Hourani SMO. The regulation of vascular function by P2 receptors: multiple sites and multiple receptors. Trends Pharmacol Sci. 1998;19:99-107.
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 99-107
    • Boarder, M.R.1    Hourani, S.M.O.2
  • 31
    • 0031893838 scopus 로고    scopus 로고
    • Molecular structure and assembly of the tight junction
    • DenkerBM, Nigam SK. Molecular structure and assembly of the tight junction. Am J Physiol. 1998;274:F1-9.
    • (1998) Am J Physiol , vol.274
    • Denker, B.M.1    Nigam, S.K.2
  • 32
    • 0033962411 scopus 로고    scopus 로고
    • Inflammatory mediators and modulation of blood-brain barrier permeability
    • Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol. 2000;20:131-147.
    • (2000) Cell Mol Neurobiol , vol.20 , pp. 131-147
    • Abbott, N.J.1
  • 33
    • 0036284832 scopus 로고    scopus 로고
    • Calcium modulation of adherens and tight junction function: A potential mechanism for blood-brain barrier disruption after stroke
    • Brown RC, Davis TP. Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke. Stroke. 2002:33:1706-1711.
    • (2002) Stroke , vol.33 , pp. 1706-1711
    • Brown, R.C.1    Davis, T.P.2
  • 34
    • 0033986324 scopus 로고    scopus 로고
    • An assay for high-sensitivity detection of thrombin activity and determination of proteases activating or inactivating protease-activated receptors
    • Altrogge LM, Monard D. An assay for high-sensitivity detection of thrombin activity and determination of proteases activating or inactivating protease-activated receptors. Anal Biochem. 2000;277:33-45.
    • (2000) Anal Biochem , vol.277 , pp. 33-45
    • Altrogge, L.M.1    Monard, D.2
  • 35
    • 0038081426 scopus 로고    scopus 로고
    • 2+ exchange and its implication for calcium homeostasis in primary cultured rat brain microvascular endothelial cells
    • 2+ exchange and its implication for calcium homeostasis in primary cultured rat brain microvascular endothelial cells. J Physiol (Lond). 1999;515:147-155.
    • (1999) J Physiol (Lond) , vol.515 , pp. 147-155
    • Dömötör, E.1    Abbott, N.J.2    Adam-Vizi, V.3
  • 36
    • 0026757051 scopus 로고
    • Activation of MAP kinases by calcium-dependent and calcium-independent pathways
    • Chao TSO, Byron KL, Lee KM, Villereal M, Rosner MR. Activation of MAP kinases by calcium-dependent and calcium-independent pathways. J Biol Chem. 1992;267:19876-19883.
    • (1992) J Biol Chem , vol.267 , pp. 19876-19883
    • Chao, T.S.O.1    Byron, K.L.2    Lee, K.M.3    Villereal, M.4    Rosner, M.R.5
  • 37
    • 23544452734 scopus 로고    scopus 로고
    • Activated protein C acts directly on human brain endothelial cells and is a potent mitogen on human brain vascular smooth muscle cells
    • Benzakour O, Fernandez JA, Griffin JH, Zlokovic BZ. Activated protein C acts directly on human brain endothelial cells and is a potent mitogen on human brain vascular smooth muscle cells. 28th Int Stroke Conf Abstract: P89.
    • 28th Int Stroke Conf Abstract
    • Benzakour, O.1    Fernandez, J.A.2    Griffin, J.H.3    Zlokovic, B.Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.