Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo

Annals of Neurology

Volumn 68, Issue 6, 2010, Pages 835-844

  Zheng, Ping Pin ^a   Romme, Edwin ^a   Van Der Spek, Peter J ^a   Dirven, Clemens M F ^a   Willemsen, Rob ^a   Kros, Johan M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 1;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CIRCULATION; BRAIN EDEMA; CONTROLLED STUDY; GENETIC CONSERVATION; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; KNOCKOUT GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD31; AQUAPORIN 4; BLOOD-BRAIN BARRIER; DOWN-REGULATION; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRONECTINS; GLIOBLASTOMA; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MODELS, ANIMAL; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VIDEO RECORDING; ZEBRAFISH;

EID: 78650887526     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22318     Document Type: Article

References (48)

1. Hawkins BT, Davis TP., The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005; 57: 173-185.
2. Hartsock A, Nelson WJ., Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 2008; 1778: 660-669.
3. Zheng PP, Severijnen LA, van der Weiden M, et al. A crucial role of caldesmon in vascular development in vivo. Cardiovasc Res 2009; 81: 362-369.
4. Dejana E, Corada M, Lampugnani MG., Endothelial cell-to-cell junctions. FASEB J 1995; 9: 910-918.
5. Papadopoulos MC, Verkman AS., Aquaporin-4 and brain edema. Pediatr Nephrol 2007; 22: 778-784.
6. Manel N, Kim FJ, Kinet S, et al. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 2003; 115: 449-459.
7. Takata K, Kasahara T, Kasahara M, et al. Erythrocyte/HepG2-type glucose transporter is concentrated in cells of blood-tissue barriers. Biochem Biophys Res Commun 1990; 173: 67-73.
8. Augustin R., The protein family of glucose transport facilitators: it's not only about glucose after all. IUBMB Life 2010; 62: 315-333.
9. Harik SI, Kalaria RN, Andersson L, et al. Immunocytochemical localization of the erythroid glucose transporter: abundance in tissues with barrier functions. J Neurosci 1990; 10: 3862-3872.
10. Papadopoulos MC, Saadoun S, Woodrow CJ, et al. Occludin expression in microvessels of neoplastic and non-neoplastic human brain. Neuropathol Appl Neurobiol 2001; 27: 384-395.
11. Sawada T, Kato Y, Kobayashi M, Takekekawa Y., Immunohistochemical study of tight junction-related protein in neovasculature in astrocytic tumor. Brain Tumor Pathol 2000; 17: 1-6.
12. Liebner S, Fischmann A, Rascher G, et al. Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme. Acta Neuropathol 2000; 100: 323-331.
13. Harik SI, Roessmann U., The erythrocyte-type glucose transporter in blood vessels of primary and metastatic brain tumors. Ann Neurol 1991; 29: 487-491.
14. Nitta T, Hata M, Gotoh S, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 2003; 161: 653-660.
15. Montero-Balaguer M, Swirsding K, Orsenigo F, et al. Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos. PLoS One 2009; 4: e5772.
16. Jensen PJ, Gitlin JD, Carayannopoulos MO., GLUT1 deficiency links nutrient availability and apoptosis during embryonic development. J Biol Chem 2006; 281: 13382-13387.
17. Wang D, Pascual JM, Yang H, et al. A mouse model for Glut-1 haploinsufficiency. Hum Mol Genet 2006; 15: 1169-1179.
18. Ohtsuki S, Kikkawa T, Hori S, Terasaki T., Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice. Biol Pharm Bull 2006; 29: 1587-1591.
19. Stainier DY, Fishman MC., Patterning the zebrafish heart tube: acquisition of anteroposterior polarity. Dev Biol 1992; 153: 91-101.
20. Weinstein BM, Fishman MC., Cardiovascular morphogenesis in zebrafish. Cardiovasc Res 1996; 31 Spec No: E17-E24.
21. Waters KM, Pounds JG, Thrall BD., Data merging for integrated microarray and proteomic analysis. Brief Funct Genomic Proteomic 2006; 5: 261-272.
22. Shyu AB, Wilkinson MF, van Hoof A., Messenger RNA regulation: to translate or to degrade. EMBO J 2008; 27: 471-481.
23. Zheng PP, van der Weiden M, Kros JM., Differential expression of Hela-type caldesmon in tumour neovascularization: a new marker of angiogenic endothelial cells. J Pathol 2005; 205: 408-414.
24. Zheng PP, van der Weiden M, Kros JM., Hela l-CaD is implicated in the migration of endothelial cells/endothelial progenitor cells in human neoplasms. Cell Adh Migr 2007; 1: 84-91.
25. Zheng PP, Weiden M, Sillevis Smitt PA, et al. Hela /-CaD undergoes a DNA replication-associated switch in localization from the cytoplasm to the nuclei of endothelial cells/endothelial progenitor cells in human tumor vasculature. Cancer Biol Ther 2007; 6: 886-890.
26. Zheng PP, Sieuwerts AM, Luider TM, et al. Differential expression of splicing variants of the human caldesmon gene (CALD1) in glioma neovascularization versus normal brain microvasculature. Am J Pathol 2004; 164: 2217-2228.
27. Zheng PP, Severijnen LA, Willemsen R, Kros JM., Images in cardiovascular medicine. Functional cardiac phenotypes in zebrafish caldesmon morphants: a digital motion analysis. Circulation 2009; 120: e145-e146.
28. Zheng PP, Severijnen LA, Willemsen R, Kros JM., Different patterns of circulatory shunting in zebrafish caldesmon morphants: a digital motion analysis. Heart Lung Circ 2010; 19: 251-252.
29. Kamoun WS, Ley CD, Farrar CT, et al. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol 2009; 27: 2542-2552.
30. Borges N, Sarmento A, Azevedo I., Dynamics of experimental vasogenic brain oedema in the rat: changes induced by adrenergic drugs. J Auton Pharmacol 1999; 19: 209-217.
31. Jeong JY, Kwon HB, Ahn JC, et al. Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res Bull 2008; 75: 619-628.
32. Brembeck FH, Rosario M, Birchmeier W., Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 2006; 16: 51-59.
33. Liebner S, Corada M, Bangsow T, et al. Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol 2008; 183: 409-417.
34. Daneman R, Agalliu D, Zhou L, et al. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A 2009; 106: 641-646.
35. Stenman JM, Rajagopal J, Carroll TJ, et al. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 2008; 322: 1247-1250.
36. Nag S, Manias JL, Stewart DJ., Pathology and new players in the pathogenesis of brain edema. Acta Neuropathol 2009; 118: 197-217.
37. Kuroiwa T, Cahn R, Juhler M, et al. Role of extracellular proteins in the dynamics of vasogenic brain edema. Acta Neuropathol 1985; 66: 3-11.
38. Hellal F, Bonnefont-Rousselot D, Croci N, et al. Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury. Neurosci Lett 2004; 357: 21-24.
39. Pankov R, Yamada KM., Fibronectin at a glance. J Cell Sci 2002; 115: 3861-3863.
40. Jones TR, Ruoslahti E, Schold SC, Bigner DD., Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas. Cancer Res 1982; 42: 168-177.
41. Tait MJ, Saadoun S, Bell BA, Papadopoulos MC., Water movements in the brain: role of aquaporins. Trends Neurosci 2008; 31: 37-43.
42. Warth A, Kroger S, Wolburg H., Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol 2004; 107: 311-318.
43. Papadopoulos MC, Saadoun S, Binder DK, et al. Molecular mechanisms of brain tumor edema. Neuroscience 2004; 129: 1011-1020.
44. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, et al. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 1997; 17: 171-180.
45. Lawson ND, Weinstein BM., In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol 2002; 248: 307-318.
46. Habeck H, Odenthal J, Walderich B, et al. Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Curr Biol 2002; 12: 1405-1412.
47. Carmeliet P, Lampugnani MG, Moons L, et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999; 98: 147-157.
48. Reulen HJ, Graham R, Spatz M, Klatzo I., Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurg 1977; 46: 24-35.