How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment

Advances in Experimental Medicine and Biology

Volumn 796, Issue , 2014, Pages 55-74

  Mondal, Sayan ^a   Khelashvili, George ^a   Johner, Niklaus ^a   Weinstein, Harel ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cholesterol GPCR binding; Continuum elastic theory; CTMD; DHA; Dopamine receptor; Functional microdomains in GPCRs; GPCR; Hydrophobic mismatch; Lipid protein interactions; Membrane deformation energy; Molecular dynamics simulations; Oligomerization; Residual exposure; Residual mismatch; Rhodopsin; Serotonin receptor; Structure and remodeling of lipid membranes; Structure function relations in GPCRs; Transmembrane proteins

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LIGAND; MEMBRANE RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CROSS COUPLING REACTION; DIMERIZATION; HYDROPHOBICITY; LIGAND BINDING; LIPID COMPOSITION; LIPID MEMBRANE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEMBRANE BINDING; MEMBRANE MODEL; MICROENVIRONMENT; MOLECULAR DYNAMICS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; RESIDUE ANALYSIS; STRUCTURE ANALYSIS; BIOENERGY; CELL MEMBRANE; COMPUTER ANALYSIS; ENERGY COST; HUMAN; MEMBRANE PROTEIN INTERACTION; MEMBRANE REMODELING; MOLECULAR MODEL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; SURFACE PROPERTY;

EID: 84934439289     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-7-7423-0_4     Document Type: Article

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