Role of group-conserved residues in the helical core of β2-adrenergic receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 17, 2007, Pages 7027-7032

  Chelikani, Prashen ^a   Hornak, Viktor ^b   Eilers, Markus ^b   Reeves, Phillip J ^c   Smith, Steven O ^b   RajBhandary, Uttam L ^a   Khorana, H Gobind ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

G protein coupled receptors; Helix packing; Molecular modeling; Rhodopsin; Site directed mutagenesis

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; MUTANT PROTEIN; CYCLIC AMP; LIGAND; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; COS CELLS; CYCLIC AMP; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; LIGANDS; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249861899     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702024104     Document Type: Article

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