메뉴 건너뛰기




Volumn 1126, Issue , 2014, Pages 55-82

Regulation of alternative pre-mRNA splicing

Author keywords

Alternative splicing; Isoforms; Pre mRNA splicing; RNA binding proteins; Transcriptome

Indexed keywords

MESSENGER RNA PRECURSOR; RNA BINDING PROTEIN; TRANSCRIPTOME;

EID: 84934435678     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-980-2_5     Document Type: Article
Times cited : (18)

References (156)
  • 2
    • 79960981599 scopus 로고    scopus 로고
    • Targeting RNA to treat neuromuscular disease
    • Muntoni F, Wood MJ (2011) Targeting RNA to treat neuromuscular disease. Nat Rev Drug Discov 10:621-637
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 621-637
    • Muntoni, F.1    Wood, M.J.2
  • 3
    • 84864390703 scopus 로고    scopus 로고
    • Pre-mRNA splicing in disease and therapeutics
    • Singh RK, Cooper TA (2012) Pre-mRNA splicing in disease and therapeutics. Trends Mol Med 18:472-482
    • (2012) Trends Mol Med , vol.18 , pp. 472-482
    • Singh, R.K.1    Cooper, T.A.2
  • 4
    • 42449098125 scopus 로고    scopus 로고
    • Splicing regulation: From a parts list of regulatory elements to an integrated splicing code
    • Wang Z, Burge CB (2008) Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA 14:802-813
    • (2008) RNA , vol.14 , pp. 802-813
    • Wang, Z.1    Burge, C.B.2
  • 5
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: New insights from global analyses
    • Blencowe BJ (2006) Alternative splicing: new insights from global analyses. Cell 126:37-47
    • (2006) Cell , vol.126 , pp. 37-47
    • Blencowe, B.J.1
  • 6
    • 76149130971 scopus 로고    scopus 로고
    • Alternative splicing: Global insights
    • Hallegger M, Llorian M, Smith CW (2010) Alternative splicing: global insights. FEBS J 277:856-866
    • (2010) FEBS J , vol.277 , pp. 856-866
    • Hallegger, M.1    Llorian, M.2    Smith, C.W.3
  • 7
    • 77952029221 scopus 로고    scopus 로고
    • Deciphering the splicing code
    • Barash Y, Calarco JA, Gao W et al (2010) Deciphering the splicing code. Nature 465: 53-59
    • (2010) Nature , vol.465 , pp. 53-59
    • Barash, Y.1    Calarco, J.A.2    Gao, W.3
  • 8
    • 77954838957 scopus 로고    scopus 로고
    • Integrative modeling defi nes the Nova splicing- regulatory network and its combinatorial controls
    • Zhang C, Frias MA, Mele A et al (2010) Integrative modeling defi nes the Nova splicing- regulatory network and its combinatorial controls. Science 329:439-443
    • (2010) Science , vol.329 , pp. 439-443
    • Zhang, C.1    Frias, M.A.2    Mele, A.3
  • 9
    • 78650961149 scopus 로고    scopus 로고
    • Epigenetics in alternative pre-mRNA splicing
    • Luco RF, Allo M, Schor IE et al (2012) Epigenetics in alternative pre-mRNA splicing. Cell 144:16-26
    • (2012) Cell , vol.144 , pp. 16-26
    • Luco, R.F.1    Allo, M.2    Schor, I.E.3
  • 10
    • 0001468848 scopus 로고    scopus 로고
    • Splicing of precursors to mRNAs by spliceosomes
    • Gestetland R, Cech T, Atkins J (eds) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Burge C, Tuschl T, Sharp P (1999) Splicing of precursors to mRNAs by spliceosomes. In: Gestetland R, Cech T, Atkins J (eds) The RNA world. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 525-560
    • (1999) The RNA World , pp. 525-560
    • Burge, C.1    Tuschl, T.2    Sharp, P.3
  • 11
    • 84873022115 scopus 로고    scopus 로고
    • Pick one, but be quick: 5 splice sites and the problems of too many choices
    • Roca X, Krainer AR, Eperon IC (2013) Pick one, but be quick: 5? splice sites and the problems of too many choices. Genes Dev 27:129-144
    • (2013) Genes Dev , vol.27 , pp. 129-144
    • Roca, X.1    Krainer, A.R.2    Eperon, I.C.3
  • 12
    • 77951120000 scopus 로고    scopus 로고
    • Alternative splicing and evolution: Diversifi cation, exon defi nition and function
    • Keren H, Lev-Maor G, Ast G (2010) Alternative splicing and evolution: diversifi cation, exon defi nition and function. Nat Rev Genet 11:345-355
    • (2010) Nat Rev Genet , vol.11 , pp. 345-355
    • Keren, H.1    Lev-Maor, G.2    Ast, G.3
  • 13
    • 42449129287 scopus 로고    scopus 로고
    • Searching for splicing motifs
    • Chasin LA (2007) Searching for splicing motifs. Adv Exp Med Biol 623:85-106
    • (2007) Adv Exp Med Biol , vol.623 , pp. 85-106
    • Chasin, L.A.1
  • 14
    • 2642525438 scopus 로고    scopus 로고
    • Computational defi nition of sequence motifs governing constitutive exon splicing
    • Zhang XH, Chasin LA (2004) Computational defi nition of sequence motifs governing constitutive exon splicing. Genes Dev 18:1241-1250
    • (2004) Genes Dev , vol.18 , pp. 1241-1250
    • Zhang, X.H.1    Chasin, L.A.2
  • 15
    • 80051562607 scopus 로고    scopus 로고
    • Quantitative evaluation of all hexamers as exonic splicing elements
    • Ke S, Shang S, Kalachikov SM et al (2011) Quantitative evaluation of all hexamers as exonic splicing elements. Genome Res 21:1360-1374
    • (2011) Genome Res , vol.21 , pp. 1360-1374
    • Ke, S.1    Shang, S.2    Kalachikov, S.M.3
  • 17
    • 33745207758 scopus 로고    scopus 로고
    • Comparative analysis identifi es exonic splicing regulatory sequences: The complex defi nition of enhancers and silencers
    • Goren A, Ram O, Amit M et al (2006) Comparative analysis identifi es exonic splicing regulatory sequences: the complex defi nition of enhancers and silencers. Mol Cell 22:769-781
    • (2006) Mol Cell , vol.22 , pp. 769-781
    • Goren, A.1    Ram, O.2    Amit, M.3
  • 18
    • 84867234474 scopus 로고    scopus 로고
    • Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules
    • Wang Y, Ma M, Xiao X et al (2012) Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules. Nat Struct Mol Biol 19:1044-1052
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 1044-1052
    • Wang, Y.1    Ma, M.2    Xiao, X.3
  • 19
    • 84871401549 scopus 로고    scopus 로고
    • Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms
    • Erkelenz S, Mueller WF, Evans MS et al (2013) Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms. RNA 19:96-102
    • (2013) RNA , vol.19 , pp. 96-102
    • Erkelenz, S.1    Mueller, W.F.2    Evans, M.S.3
  • 20
    • 79952105381 scopus 로고    scopus 로고
    • Understanding splicing regulation through RNA splicing maps
    • Witten JT, Ule J (2011) Understanding splicing regulation through RNA splicing maps. Trends Genet 27:89-97
    • (2011) Trends Genet , vol.27 , pp. 89-97
    • Witten, J.T.1    Ule, J.2
  • 21
    • 0026644140 scopus 로고
    • The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: Multiprotein complexes at an exon pseudo-5 splice site control U1 snRNP binding
    • Siebel CW, Fresco LD, Rio DC (1992) The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5? splice site control U1 snRNP binding. Genes Dev 6:1386-1401
    • (1992) Genes Dev , vol.6 , pp. 1386-1401
    • Siebel, C.W.1    Fresco, L.D.2    Rio, D.C.3
  • 22
    • 0035970031 scopus 로고    scopus 로고
    • Caspase-2 pre-mRNA alternative splicing: Identifi cation of an intronic element containing a decoy 3 acceptor site
    • Cote J, Dupuis S, Jiang Z et al (2001) Caspase-2 pre-mRNA alternative splicing: identifi cation of an intronic element containing a decoy 3? acceptor site. Proc Natl Acad Sci USA 98:938-943
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 938-943
    • Cote, J.1    Dupuis, S.2    Jiang, Z.3
  • 23
    • 0036544858 scopus 로고    scopus 로고
    • A new type of mutation causes a splicing defect in ATM
    • Pagani F, Buratti E, Stuani C et al (2002) A new type of mutation causes a splicing defect in ATM. Nat Genet 30:426-429
    • (2002) Nat Genet , vol.30 , pp. 426-429
    • Pagani, F.1    Buratti, E.2    Stuani, C.3
  • 24
    • 10044274340 scopus 로고    scopus 로고
    • Infl uence of RNA secondary structure on the pre-mRNA splicing process
    • Buratti E, Baralle FE (2004) Infl uence of RNA secondary structure on the pre-mRNA splicing process. Mol Cell Biol 24:10505-10514
    • (2004) Mol Cell Biol , vol.24 , pp. 10505-10514
    • Buratti, E.1    Baralle, F.E.2
  • 25
    • 47949120992 scopus 로고    scopus 로고
    • Conserved RNA secondary structures promote alternative splicing
    • Shepard PJ, Hertel KJ (2008) Conserved RNA secondary structures promote alternative splicing. RNA 14:1463-1469
    • (2008) RNA , vol.14 , pp. 1463-1469
    • Shepard, P.J.1    Hertel, K.J.2
  • 26
    • 37349056702 scopus 로고    scopus 로고
    • Pre-mRNA secondary structures infl uence exon recognition
    • Hiller M, Zhang Z, Backofen R et al (2007) Pre-mRNA secondary structures infl uence exon recognition. PLoS Genet 3:e204
    • (2007) PLoS Genet , vol.3
    • Hiller, M.1    Zhang, Z.2    Backofen, R.3
  • 27
    • 33846925650 scopus 로고    scopus 로고
    • Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes
    • Singh NN, Singh RN, Androphy EJ (2007) Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes. Nucleic Acids Res 35:371-389
    • (2007) Nucleic Acids Res , vol.35 , pp. 371-389
    • Singh, N.N.1    Singh, R.N.2    Androphy, E.J.3
  • 28
    • 0033591225 scopus 로고    scopus 로고
    • 5 splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10
    • Grover A, Houlden H, Baker M et al (1999) 5? splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10. J Biol Chem 274:15134-15143
    • (1999) J Biol Chem , vol.274 , pp. 15134-15143
    • Grover, A.1    Houlden, H.2    Baker, M.3
  • 29
    • 0344629426 scopus 로고    scopus 로고
    • A stem structure in fi broblast growth factor receptor 2 transcripts mediates celltype- specifi c splicing by approximating intronic control elements
    • Baraniak AP, Lasda EL, Wagner EJ et al (2003) A stem structure in fi broblast growth factor receptor 2 transcripts mediates celltype- specifi c splicing by approximating intronic control elements. Mol Cell Biol 23: 9327-9337
    • (2003) Mol Cell Biol , vol.23 , pp. 9327-9337
    • Baraniak, A.P.1    Lasda, E.L.2    Wagner, E.J.3
  • 30
    • 26244435561 scopus 로고    scopus 로고
    • Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures
    • Graveley BR (2005) Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures. Cell 123:65-73
    • (2005) Cell , vol.123 , pp. 65-73
    • Graveley, B.R.1
  • 31
    • 36849015934 scopus 로고    scopus 로고
    • A regulator of Dscam mutually exclusive splicing fi delity
    • Olson S, Blanchette M, Park J et al (2007) A regulator of Dscam mutually exclusive splicing fi delity. Nat Struct Mol Biol 14:1134-1140
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 1134-1140
    • Olson, S.1    Blanchette, M.2    Park, J.3
  • 32
    • 84871753158 scopus 로고    scopus 로고
    • An RNA architectural locus control region involved in Dscam mutually exclusive splicing
    • Wang X, Li G, Yang Y et al (2012) An RNA architectural locus control region involved in Dscam mutually exclusive splicing. Nat Commun 3:1255
    • (2012) Nat Commun , vol.3 , pp. 1255
    • Wang, X.1    Li, G.2    Yang, Y.3
  • 33
    • 79551653312 scopus 로고    scopus 로고
    • RNA secondary structure in mutually exclusive splicing
    • Yang Y, Zhan L, Zhang W et al (2011) RNA secondary structure in mutually exclusive splicing. Nat Struct Mol Biol 18:159-168
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 159-168
    • Yang, Y.1    Zhan, L.2    Zhang, W.3
  • 34
    • 34249278470 scopus 로고    scopus 로고
    • Control of alternative RNA splicing and gene expression by eukaryotic riboswitches
    • Cheah MT, Wachter A, Sudarsan N et al (2007) Control of alternative RNA splicing and gene expression by eukaryotic riboswitches. Nature 447:497-500
    • (2007) Nature , vol.447 , pp. 497-500
    • Cheah, M.T.1    Wachter, A.2    Sudarsan, N.3
  • 35
    • 0024299506 scopus 로고
    • Effects of RNA secondary structure on alternative splicing of pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?
    • Eperon LP, Graham IR, Griffi ths AD et al (1988) Effects of RNA secondary structure on alternative splicing of pre-mRNA: is folding limited to a region behind the transcribing RNA polymerase? Cell 54:393-401
    • (1988) Cell , vol.54 , pp. 393-401
    • Eperon, L.P.1    Graham, I.R.2    Griffiths, A.D.3
  • 36
    • 0024594710 scopus 로고
    • Mutually exclusive splicing of alpha-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing
    • Smith CW, Nadal-Ginard B (1989) Mutually exclusive splicing of alpha-tropomyosin exons enforced by an unusual lariat branch point location: implications for constitutive splicing. Cell 56:749-758
    • (1989) Cell , vol.56 , pp. 749-758
    • Smith, C.W.1    Nadal-Ginard, B.2
  • 37
    • 0028895417 scopus 로고
    • Exon recognition in vertebrate splicing
    • Berget SM (1995) Exon recognition in vertebrate splicing. J Biol Chem 270:2411-2414
    • (1995) J Biol Chem , vol.270 , pp. 2411-2414
    • Berget, S.M.1
  • 38
    • 1642473041 scopus 로고    scopus 로고
    • How prevalent is functional alternative splicing in the human genome?
    • Sorek R, Shamir R, Ast G (2004) How prevalent is functional alternative splicing in the human genome? Trends Genet 20:68-71
    • (2004) Trends Genet , vol.20 , pp. 68-71
    • Sorek, R.1    Shamir, R.2    Ast, G.3
  • 39
    • 22144486964 scopus 로고    scopus 로고
    • Subdivision of large introns in Drosophila by recursive splicing at nonexonic elements
    • Burnette JM, Miyamoto-Sato E, Schaub MA et al (2005) Subdivision of large introns in Drosophila by recursive splicing at nonexonic elements. Genetics 170:661-674
    • (2005) Genetics , vol.170 , pp. 661-674
    • Burnette, J.M.1    Miyamoto-Sato, E.2    Schaub, M.A.3
  • 40
    • 69949132191 scopus 로고    scopus 로고
    • Chromatin organization marks exon-intron structure
    • Schwartz S, Meshorer E, Ast G (2009) Chromatin organization marks exon-intron structure. Nat Struct Mol Biol 16:990-995
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 990-995
    • Schwartz, S.1    Meshorer, E.2    Ast, G.3
  • 41
    • 69949124307 scopus 로고    scopus 로고
    • Nucleosome positioning as a determinant of exon recognition
    • Tilgner H, Nikolaou C, Althammer S et al (2009) Nucleosome positioning as a determinant of exon recognition. Nat Struct Mol Biol 16:996-1001
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 996-1001
    • Tilgner, H.1    Nikolaou, C.2    Althammer, S.3
  • 42
    • 0027143943 scopus 로고
    • A splicing enhancer in the human fi bronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding
    • Lavigueur A, La Branche H, Kornblihtt AR et al (1993) A splicing enhancer in the human fi bronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev 7:2405-2417
    • (1993) Genes Dev , vol.7 , pp. 2405-2417
    • Lavigueur, A.1    La Branche, H.2    Kornblihtt, A.R.3
  • 43
    • 0032538791 scopus 로고    scopus 로고
    • A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers
    • Graveley BR, Hertel KJ, Maniatis T (1998) A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. EMBO J 17:6747-6756
    • (1998) EMBO J , vol.17 , pp. 6747-6756
    • Graveley, B.R.1    Hertel, K.J.2    Maniatis, T.3
  • 44
    • 0029069220 scopus 로고
    • Interactions between the terminal bases of mammalian introns are retained in inosine-containing premRNAs
    • Scadden ADJ, Smith CWJ (1995) Interactions between the terminal bases of mammalian introns are retained in inosine-containing premRNAs. EMBO J 14:3236-3246
    • (1995) EMBO J , vol.14 , pp. 3236-3246
    • Adj, S.1    Cwj, S.2
  • 45
    • 0033529064 scopus 로고    scopus 로고
    • Regulation of alternative splicing by RNA editing
    • Rueter SM, Dawson TR, Emeson RB (1999) Regulation of alternative splicing by RNA editing. Nature 399:75-80
    • (1999) Nature , vol.399 , pp. 75-80
    • Rueter, S.M.1    Dawson, T.R.2    Emeson, R.B.3
  • 47
    • 84860779086 scopus 로고    scopus 로고
    • Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
    • Dominissini D, Moshitch-Moshkovitz S, Schwartz S et al (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485:201-206
    • (2012) Nature , vol.485 , pp. 201-206
    • Dominissini, D.1    Moshitch-Moshkovitz, S.2    Schwartz, S.3
  • 48
    • 80455176999 scopus 로고    scopus 로고
    • CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
    • Shukla S, Kavak E, Gregory M et al (2011) CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. Nature 479:74-79
    • (2011) Nature , vol.479 , pp. 74-79
    • Shukla, S.1    Kavak, E.2    Gregory, M.3
  • 49
    • 77952473473 scopus 로고    scopus 로고
    • The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing
    • Kishore S, Khanna A, Zhang Z et al (2010) The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. Hum Mol Genet 19: 1153-1164
    • (2010) Hum Mol Genet , vol.19 , pp. 1153-1164
    • Kishore, S.1    Khanna, A.2    Zhang, Z.3
  • 50
    • 30844442607 scopus 로고    scopus 로고
    • The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C
    • Kishore S, Stamm S (2006) The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science 311:230-232
    • (2006) Science , vol.311 , pp. 230-232
    • Kishore, S.1    Stamm, S.2
  • 51
    • 8644278829 scopus 로고    scopus 로고
    • Identifi cation of alternative splicing regulators by RNA interference in Drosophila
    • Park JW, Parisky K, Celotto AM et al (2004) Identifi cation of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci USA 101:15974-15979
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15974-15979
    • Park, J.W.1    Parisky, K.2    Celotto, A.M.3
  • 52
    • 79951715071 scopus 로고    scopus 로고
    • Regulation of alternative splicing by the core spliceosomal machinery
    • Saltzman AL, Pan Q, Blencowe BJ (2011) Regulation of alternative splicing by the core spliceosomal machinery. Genes Dev 25: 373-384
    • (2011) Genes Dev , vol.25 , pp. 373-384
    • Saltzman, A.L.1    Pan, Q.2    Blencowe, B.J.3
  • 53
    • 84873031838 scopus 로고    scopus 로고
    • Differentially expressed, variant U1 snRNAs regulate gene expression in human cells
    • O'Reilly D, Dienstbier M, Cowley SA et al (2012) Differentially expressed, variant U1 snRNAs regulate gene expression in human cells. Genome Res 23:281-291
    • (2012) Genome Res , vol.23 , pp. 281-291
    • O'Reilly, D.1    Dienstbier, M.2    Cowley, S.A.3
  • 54
    • 0025743575 scopus 로고
    • Functional expression of cloned human splicing factor SF2: Homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators
    • Krainer AR, Mayeda A, Kozak D et al (1991) Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell 66:383-394
    • (1991) Cell , vol.66 , pp. 383-394
    • Krainer, A.R.1    Mayeda, A.2    Kozak, D.3
  • 55
    • 0025324948 scopus 로고
    • A protein factor, ASF, controls cell-specifi c alternative splicing of SV40 early pre-mRNA in vitro
    • Ge H, Manley JL (1990) A protein factor, ASF, controls cell-specifi c alternative splicing of SV40 early pre-mRNA in vitro. Cell 62:25-34
    • (1990) Cell , vol.62 , pp. 25-34
    • Ge, H.1    Manley, J.L.2
  • 56
    • 0030013179 scopus 로고    scopus 로고
    • Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
    • Kanopka A, Muhlemann O, Akusjarvi G (1996) Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA. Nature 381:535-538
    • (1996) Nature , vol.381 , pp. 535-538
    • Kanopka, A.1    Muhlemann, O.2    Akusjarvi, G.3
  • 57
    • 58249093940 scopus 로고    scopus 로고
    • The SR protein family of splicing factors: Master regulators of gene expression
    • Long JC, Caceres JF (2009) The SR protein family of splicing factors: master regulators of gene expression. Biochem J 417:15-27
    • (2009) Biochem J , vol.417 , pp. 15-27
    • Long, J.C.1    Caceres, J.F.2
  • 59
    • 0026716104 scopus 로고
    • SR proteins: A conserved family of pre-mRNA splicing factors
    • Zahler AM, Lane WS, Stolk JA et al (1992) SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev 6:837-847
    • (1992) Genes Dev , vol.6 , pp. 837-847
    • Zahler, A.M.1    Lane, W.S.2    Stolk, J.A.3
  • 60
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Luhrmann R (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136:701-718
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Luhrmann, R.3
  • 61
    • 64749099643 scopus 로고    scopus 로고
    • SR protein family members display diverse activities in the formation of nascent and mature mRNPs in vivo
    • Sapra AK, Ankö M-L, Grishina I et al (2009) SR protein family members display diverse activities in the formation of nascent and mature mRNPs in vivo. Mol cell 34: 179-190
    • (2009) Mol Cell , vol.34 , pp. 179-190
    • Sapra, A.K.1    Ankö, M.-L.2    Grishina, I.3
  • 62
    • 0029064220 scopus 로고
    • The human splicing factors ASF/SF2 and SC35 possess distinct, functionally signifi cant RNA binding specifi cities
    • Tacke R, Manley JL (1995) The human splicing factors ASF/SF2 and SC35 possess distinct, functionally signifi cant RNA binding specifi cities. EMBO J 14:3540-3551
    • (1995) EMBO J , vol.14 , pp. 3540-3551
    • Tacke, R.1    Manley, J.L.2
  • 63
    • 0032128255 scopus 로고    scopus 로고
    • Identifi cation of functional exonic splicing enhancer motifs recognized by individual SR proteins
    • Liu HX, Zhang M, Krainer AR (1998) Identifi cation of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev 12:1998-2012
    • (1998) Genes Dev , vol.12 , pp. 1998-2012
    • Liu, H.X.1    Zhang, M.2    Krainer, A.R.3
  • 64
    • 84860268701 scopus 로고    scopus 로고
    • The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes
    • Änkö M-L, Müller-McNicoll M, Brandl H et al (2012) The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Genome Biol 13:R17
    • (2012) Genome Biol , vol.13
    • Änkö, M.-L.1    Müller-Mcnicoll, M.2    Brandl, H.3
  • 65
    • 0034743627 scopus 로고    scopus 로고
    • The role of U2AF35 and U2AF65 in enhancerdependent splicing
    • Graveley BR, Hertel KJ, Maniatis T (2001) The role of U2AF35 and U2AF65 in enhancerdependent splicing. RNA 7:806-818
    • (2001) RNA , vol.7 , pp. 806-818
    • Graveley, B.R.1    Hertel, K.J.2    Maniatis, T.3
  • 66
    • 1142310938 scopus 로고    scopus 로고
    • Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock
    • Shin C, Feng Y, Manley JL (2004) Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. Nature 427:553-558
    • (2004) Nature , vol.427 , pp. 553-558
    • Shin, C.1    Feng, Y.2    Manley, J.L.3
  • 67
    • 0036848091 scopus 로고    scopus 로고
    • The SR protein SRp38 represses splicing in M phase cells
    • Shin C, Manley JL (2002) The SR protein SRp38 represses splicing in M phase cells. Cell 111:407-417
    • (2002) Cell , vol.111 , pp. 407-417
    • Shin, C.1    Manley, J.L.2
  • 68
    • 53549089314 scopus 로고    scopus 로고
    • Phosphorylation switches the general splicing repressor SRp38 to a sequence-specifi c activator
    • Feng Y, Chen M, Manley JL (2008) Phosphorylation switches the general splicing repressor SRp38 to a sequence-specifi c activator. Nat Struct Mol Biol 15:1040-1048
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 1040-1048
    • Feng, Y.1    Chen, M.2    Manley, J.L.3
  • 69
    • 84861161751 scopus 로고    scopus 로고
    • Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins
    • Huelga SC, Vu AQ, Arnold JD et al (2012) Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. Cell Rep 1:167-178
    • (2012) Cell Rep , vol.1 , pp. 167-178
    • Huelga, S.C.1    Vu, A.Q.2    Arnold, J.D.3
  • 70
    • 34347384211 scopus 로고    scopus 로고
    • A posttranscriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
    • Boutz PL, Stoilov P, Li Q et al (2007) A posttranscriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev 21:1636-1652
    • (2007) Genes Dev , vol.21 , pp. 1636-1652
    • Boutz, P.L.1    Stoilov, P.2    Li, Q.3
  • 71
    • 62849102677 scopus 로고    scopus 로고
    • Auto- and cross-regulation of the hnRNP L proteins by alternative splicing
    • Rossbach O, Hung LH, Schreiner S et al (2009) Auto- and cross-regulation of the hnRNP L proteins by alternative splicing. Mol Cell Biol 29:1442-1451
    • (2009) Mol Cell Biol , vol.29 , pp. 1442-1451
    • Rossbach, O.1    Hung, L.H.2    Schreiner, S.3
  • 72
    • 56749164864 scopus 로고    scopus 로고
    • Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines
    • Castle JC, Zhang C, Shah JK et al (2008) Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nat Genet 40: 1416-1425
    • (2008) Nat Genet , vol.40 , pp. 1416-1425
    • Castle, J.C.1    Zhang, C.2    Shah, J.K.3
  • 73
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang ET, Sandberg R, Luo S et al (2008) Alternative isoform regulation in human tissue transcriptomes. Nature 456:470-476
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1    Sandberg, R.2    Luo, S.3
  • 74
    • 84865201988 scopus 로고    scopus 로고
    • Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins
    • Wang ET, Cody NA, Jog S et al (2012) Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell 150:710-724
    • (2012) Cell , vol.150 , pp. 710-724
    • Wang, E.T.1    Cody, N.A.2    Jog, S.3
  • 75
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249:505-510
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 76
    • 67650484984 scopus 로고    scopus 로고
    • Rapid and systematic analysis of the RNA recognition specifi cities of RNA-binding proteins
    • Ray D, Kazan H, Chan ET et al (2009) Rapid and systematic analysis of the RNA recognition specifi cities of RNA-binding proteins. Nat Biotechnol 27:667-670
    • (2009) Nat Biotechnol , vol.27 , pp. 667-670
    • Ray, D.1    Kazan, H.2    Chan, E.T.3
  • 77
    • 84871410405 scopus 로고    scopus 로고
    • The evolutionary landscape of alternative splicing in vertebrate species
    • Barbosa-Morais NL, Irimia M, Pan Q et al (2012) The evolutionary landscape of alternative splicing in vertebrate species. Science 338:1587-1593
    • (2012) Science , vol.338 , pp. 1587-1593
    • Barbosa-Morais, N.L.1    Irimia, M.2    Pan, Q.3
  • 78
    • 84871436996 scopus 로고    scopus 로고
    • Evolutionary dynamics of gene and isoform regulation in Mammalian tissues
    • Merkin J, Russell C, Chen P, Burge CB (2012) Evolutionary dynamics of gene and isoform regulation in Mammalian tissues. Science 338:1593-1599
    • (2012) Science , vol.338 , pp. 1593-1599
    • Merkin, J.1    Russell, C.2    Chen, P.3    Burge, C.B.4
  • 79
    • 0032435862 scopus 로고    scopus 로고
    • Alternative splicing of premRNA: Developmental consequences and mechanisms of regulation
    • Lopez AJ (1998) Alternative splicing of premRNA: developmental consequences and mechanisms of regulation. Annu Rev Genet 32:279-305
    • (1998) Annu Rev Genet , vol.32 , pp. 279-305
    • Lopez, A.J.1
  • 80
    • 77956342570 scopus 로고    scopus 로고
    • Position-dependent alternative splicing activity revealed by global profi ling of alternative splicing events regulated by PTB
    • Llorian M, Schwartz S, Clark TA et al (2010) Position-dependent alternative splicing activity revealed by global profi ling of alternative splicing events regulated by PTB. Nat Struct Mol Biol 17:1114-1123
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1114-1123
    • Llorian, M.1    Schwartz, S.2    Clark, T.A.3
  • 81
    • 0027374048 scopus 로고
    • Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifi cally expressed in the developing motor system
    • Buckanovich RJ, Posner JB, Darnell RB (1993) Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifi cally expressed in the developing motor system. Neuron 11:657-672
    • (1993) Neuron , vol.11 , pp. 657-672
    • Buckanovich, R.J.1    Posner, J.B.2    Darnell, R.B.3
  • 82
    • 69449093703 scopus 로고    scopus 로고
    • Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein
    • Calarco JA, Superina S, O'Hanlon D et al (2009) Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell 138:898-910
    • (2009) Cell , vol.138 , pp. 898-910
    • Calarco, J.A.1    Superina, S.2    O'Hanlon, D.3
  • 83
    • 61649087689 scopus 로고    scopus 로고
    • ESRP1 and ESRP2 are epithelial cell-typespecifi c regulators of FGFR2 splicing
    • Warzecha CC, Sato TK, Nabet B et al (2009) ESRP1 and ESRP2 are epithelial cell-typespecifi c regulators of FGFR2 splicing. Mol Cell 33:591-601
    • (2009) Mol Cell , vol.33 , pp. 591-601
    • Warzecha, C.C.1    Sato, T.K.2    Nabet, B.3
  • 84
    • 34547212309 scopus 로고    scopus 로고
    • The MicroRNA miR-124 promotes neuronal differentiation by triggering brainspecifi c alternative pre-mRNA splicing
    • Makeyev EV, Zhang J, Carrasco MA et al (2007) The MicroRNA miR-124 promotes neuronal differentiation by triggering brainspecifi c alternative pre-mRNA splicing. Mol Cell 27:435-448
    • (2007) Mol Cell , vol.27 , pp. 435-448
    • Makeyev, E.V.1    Zhang, J.2    Carrasco, M.A.3
  • 85
    • 34547205013 scopus 로고    scopus 로고
    • Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1
    • Spellman R, Llorian M, Smith CW (2007) Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1. Mol Cell 27:420-434
    • (2007) Mol Cell , vol.27 , pp. 420-434
    • Spellman, R.1    Llorian, M.2    Smith, C.W.3
  • 86
    • 84857653757 scopus 로고    scopus 로고
    • PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2
    • Zheng S, Gray EE, Chawla G et al (2012) PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2. Nat Neurosci 15:381-388, S1
    • (2012) Nat Neurosci , vol.15 , pp. 381-388
    • Zheng, S.1    Gray, E.E.2    Chawla, G.3
  • 87
    • 84864020005 scopus 로고    scopus 로고
    • Ptbp2 represses adult-specifi c splicing to regulate the generation of neuronal precursors in the embryonic brain
    • Licatalosi DD, Yano M, Fak JJ et al (2012) Ptbp2 represses adult-specifi c splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev 26:1626-1642
    • (2012) Genes Dev , vol.26 , pp. 1626-1642
    • Licatalosi, D.D.1    Yano, M.2    Fak, J.J.3
  • 88
    • 84877943805 scopus 로고    scopus 로고
    • A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator Polypyrimidine Tract Binding Protein in the heart
    • Ye J, Llorian M, Cardona M et al (2013) A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator Polypyrimidine Tract Binding Protein in the heart. J Cell Sci 126:1682-1691
    • (2013) J Cell Sci , vol.126 , pp. 1682-1691
    • Ye, J.1    Llorian, M.2    Cardona, M.3
  • 89
    • 84863393843 scopus 로고    scopus 로고
    • The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
    • Anczukow O, Rosenberg AZ, Akerman M et al (2012) The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol 19:220-228
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 220-228
    • Anczukow, O.1    Rosenberg, A.Z.2    Akerman, M.3
  • 90
    • 33847630730 scopus 로고    scopus 로고
    • The gene encoding the splicing factor SF2/ASF is a proto-oncogene
    • Karni R, de Stanchina E, Lowe SW et al (2007) The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol 14:185-193
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 185-193
    • Karni, R.1    De Stanchina, E.2    Lowe, S.W.3
  • 91
    • 58149492467 scopus 로고    scopus 로고
    • A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
    • Kalsotra A, Xiao X, Ward AJ et al (2008) A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci USA 105:20333-20338
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20333-20338
    • Kalsotra, A.1    Xiao, X.2    Ward, A.J.3
  • 92
    • 77950513681 scopus 로고    scopus 로고
    • MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development
    • Kalsotra A, Wang K, Li PF et al (2010) MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development. Genes Dev 24:653-658
    • (2010) Genes Dev , vol.24 , pp. 653-658
    • Kalsotra, A.1    Wang, K.2    Li, P.F.3
  • 93
    • 77952306763 scopus 로고    scopus 로고
    • MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing
    • Goers ES, Purcell J, Voelker RB et al (2010) MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing. Nucleic Acids Res 38:2467-2484
    • (2010) Nucleic Acids Res , vol.38 , pp. 2467-2484
    • Goers, E.S.1    Purcell, J.2    Voelker, R.B.3
  • 94
    • 0034282958 scopus 로고    scopus 로고
    • Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy
    • Miller JW, Urbinati CR, Teng-Umnuay P et al (2000) Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy. EMBO J 19: 4439-4448
    • (2000) EMBO J , vol.19 , pp. 4439-4448
    • Miller, J.W.1    Urbinati, C.R.2    Teng-Umnuay, P.3
  • 95
    • 34948834723 scopus 로고    scopus 로고
    • Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation
    • Kuyumcu-Martinez NM, Wang GS, Cooper TA (2007) Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation. Mol Cell 28:68-78
    • (2007) Mol Cell , vol.28 , pp. 68-78
    • Kuyumcu-Martinez, N.M.1    Wang, G.S.2    Cooper, T.A.3
  • 96
    • 77956927823 scopus 로고    scopus 로고
    • The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
    • Tripathi V, Ellis JD, Shen Z et al (2010) The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 39:925-938
    • (2010) Mol Cell , vol.39 , pp. 925-938
    • Tripathi, V.1    Ellis, J.D.2    Shen, Z.3
  • 97
    • 4444272979 scopus 로고    scopus 로고
    • Cell signalling and the control of pre-mRNA splicing
    • Shin C, Manley JL (2004) Cell signalling and the control of pre-mRNA splicing. Nat Rev Mol Cell Biol 5:727-738
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 727-738
    • Shin, C.1    Manley, J.L.2
  • 98
    • 42449123286 scopus 로고    scopus 로고
    • Regulation of alternative splicing by signal transduction pathways
    • Lynch KW (2007) Regulation of alternative splicing by signal transduction pathways. Adv Exp Med Biol 623:161-174
    • (2007) Adv Exp Med Biol , vol.623 , pp. 161-174
    • Lynch, K.W.1
  • 99
    • 79961172897 scopus 로고    scopus 로고
    • Degrade, move, regroup: Signaling control of splicing proteins
    • Heyd F, Lynch KW (2011) Degrade, move, regroup: signaling control of splicing proteins. Trends Biochem Sci 36:397-404
    • (2011) Trends Biochem Sci , vol.36 , pp. 397-404
    • Heyd, F.1    Lynch, K.W.2
  • 100
    • 0034989361 scopus 로고    scopus 로고
    • Cascades of transcriptional induction during human lymphocyte activation
    • Ellisen LW, Palmer RE, Maki RG et al (2001) Cascades of transcriptional induction during human lymphocyte activation. Eur J Cell Biol 80:321-328
    • (2001) Eur J Cell Biol , vol.80 , pp. 321-328
    • Ellisen, L.W.1    Palmer, R.E.2    Maki, R.G.3
  • 101
    • 0033607212 scopus 로고    scopus 로고
    • Activation changes the spectrum but not the diversity of genes expressed by T cells
    • Teague TK, Hildeman D, Kedl RM et al (1999) Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci USA 96:12691-12696
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12691-12696
    • Teague, T.K.1    Hildeman, D.2    Kedl, R.M.3
  • 102
    • 48749100692 scopus 로고    scopus 로고
    • Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL
    • Oberdoerffer S, Moita LF, Neems D et al (2008) Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science 321:686-691
    • (2008) Science , vol.321 , pp. 686-691
    • Oberdoerffer, S.1    Moita, L.F.2    Neems, D.3
  • 103
    • 77957377260 scopus 로고    scopus 로고
    • Phosphorylationdependent regulation of PSF by GSK3 controls CD45 alternative splicing
    • Heyd F, Lynch KW (2010) Phosphorylationdependent regulation of PSF by GSK3 controls CD45 alternative splicing. Mol Cell 40:126-137
    • (2010) Mol Cell , vol.40 , pp. 126-137
    • Heyd, F.1    Lynch, K.W.2
  • 104
    • 79957784833 scopus 로고    scopus 로고
    • Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly
    • Cho S, Hoang A, Sinha R et al (2011) Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci USA 108:8233-8238
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 8233-8238
    • Cho, S.1    Hoang, A.2    Sinha, R.3
  • 105
    • 83455263848 scopus 로고    scopus 로고
    • WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing
    • Amin EM, Oltean S, Hua J et al (2011) WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. Cancer Cell 20:768-780
    • (2011) Cancer Cell , vol.20 , pp. 768-780
    • Amin, E.M.1    Oltean, S.2    Hua, J.3
  • 106
    • 84864910082 scopus 로고    scopus 로고
    • The Akt- SRPK- SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus
    • Zhou Z, Qiu J, Liu W et al (2012) The Akt- SRPK- SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell 47: 422-433
    • (2012) Mol Cell , vol.47 , pp. 422-433
    • Zhou, Z.1    Qiu, J.2    Liu, W.3
  • 107
  • 108
    • 0028329195 scopus 로고
    • An RNAbinding protein associated with Src through its SH2 and SH3 domains in mitosis
    • Taylor SJ, Shalloway D (1994) An RNAbinding protein associated with Src through its SH2 and SH3 domains in mitosis. Nature 368:867-871
    • (1994) Nature , vol.368 , pp. 867-871
    • Taylor, S.J.1    Shalloway, D.2
  • 109
    • 0031451912 scopus 로고    scopus 로고
    • STAR, a gene family involved in signal transduction and activation of RNA
    • Vernet C, Artzt K (1997) STAR, a gene family involved in signal transduction and activation of RNA. Trends Genet 13:479-484
    • (1997) Trends Genet , vol.13 , pp. 479-484
    • Vernet, C.1    Artzt, K.2
  • 110
    • 0037069651 scopus 로고    scopus 로고
    • Signaldependent regulation of splicing via phosphorylation of Sam68
    • Matter N, Herrlich P, König H (2002) Signaldependent regulation of splicing via phosphorylation of Sam68. Nature 420:691-695
    • (2002) Nature , vol.420 , pp. 691-695
    • Matter, N.1    Herrlich, P.2    König, H.3
  • 111
    • 30044441988 scopus 로고    scopus 로고
    • The human SWI/SNF subunit Brm is a regulator of alternative splicing
    • Batsché E, Yaniv M, Muchardt C (2006) The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol 13:22-29
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 22-29
    • Batsché, E.1    Yaniv, M.2    Muchardt, C.3
  • 112
    • 33645220093 scopus 로고    scopus 로고
    • Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion
    • Cheng C, Sharp PA (2006) Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol 26:362-370
    • (2006) Mol Cell Biol , vol.26 , pp. 362-370
    • Cheng, C.1    Sharp, P.A.2
  • 113
    • 77955662560 scopus 로고    scopus 로고
    • An alternative splicing network links cell-cycle control to apoptosis
    • Moore MJ, Wang Q, Kennedy CJ et al (2010) An alternative splicing network links cell-cycle control to apoptosis. Cell 142:625-636
    • (2010) Cell , vol.142 , pp. 625-636
    • Moore, M.J.1    Wang, Q.2    Kennedy, C.J.3
  • 114
    • 33947712084 scopus 로고    scopus 로고
    • The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
    • Paronetto MP, Achsel T, Massiello A et al (2007) The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J Cell Biol 176:929-939
    • (2007) J Cell Biol , vol.176 , pp. 929-939
    • Paronetto, M.P.1    Achsel, T.2    Massiello, A.3
  • 115
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 116
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon AS, Hagan S, Rath O et al (2007) MAP kinase signalling pathways in cancer. Oncogene 26:3279-3290
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3
  • 117
    • 0034693877 scopus 로고    scopus 로고
    • Role of Src expression and activation in human cancer
    • Irby RB, Yeatman TJ (2000) Role of Src expression and activation in human cancer. Oncogene 19:5636-5642
    • (2000) Oncogene , vol.19 , pp. 5636-5642
    • Irby, R.B.1    Yeatman, T.J.2
  • 118
    • 0346363605 scopus 로고    scopus 로고
    • Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68
    • Paronetto MP, Venables JP, Elliott DJ et al (2003) Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68. Oncogene 22:8707-8715
    • (2003) Oncogene , vol.22 , pp. 8707-8715
    • Paronetto, M.P.1    Venables, J.P.2    Elliott, D.J.3
  • 119
    • 0035691667 scopus 로고    scopus 로고
    • Exon identity established through differential antagonism between exonic splicing silencerbound hnRNP A1 and enhancer-bound SR proteins
    • Zhu J, Mayeda A, Krainer AR (2001) Exon identity established through differential antagonism between exonic splicing silencerbound hnRNP A1 and enhancer-bound SR proteins. Mol Cell 8:1351-1361
    • (2001) Mol Cell , vol.8 , pp. 1351-1361
    • Zhu, J.1    Mayeda, A.2    Krainer, A.R.3
  • 120
    • 0026655649 scopus 로고
    • The spliceosome assembly pathway in mammalian extracts
    • Jamison SF, Crow A, Garcia-Blanco MA (1992) The spliceosome assembly pathway in mammalian extracts. Mol Cell Biol 12: 4279-4287
    • (1992) Mol Cell Biol , vol.12 , pp. 4279-4287
    • Jamison, S.F.1    Crow, A.2    Garcia-Blanco, M.A.3
  • 121
    • 0026263756 scopus 로고
    • An ATPindependent complex commits pre-mRNA to the mammalian spliceosome assembly pathway
    • Michaud S, Reed R (1991) An ATPindependent complex commits pre-mRNA to the mammalian spliceosome assembly pathway. Genes Dev 5:2534-2546
    • (1991) Genes Dev , vol.5 , pp. 2534-2546
    • Michaud, S.1    Reed, R.2
  • 122
    • 0027215924 scopus 로고
    • A functional association between the 5 and 3 splice site is established in the earliest prespliceosome complex (E) in mammals
    • Michaud S, Reed R (1993) A functional association between the 5? and 3? splice site is established in the earliest prespliceosome complex (E) in mammals. Genes Dev 7:1008-1020
    • (1993) Genes Dev , vol.7 , pp. 1008-1020
    • Michaud, S.1    Reed, R.2
  • 123
    • 23744484618 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein blocks the 5 splice site-dependent assembly of U2AF and the prespliceosomal e complex
    • Sharma S, Falick AM, Black DL (2005) Polypyrimidine tract binding protein blocks the 5? splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol Cell 19:485-496
    • (2005) Mol Cell , vol.19 , pp. 485-496
    • Sharma, S.1    Falick, A.M.2    Black, D.L.3
  • 124
    • 0027137934 scopus 로고
    • Specifi c interactions between proteins implicated in splice site selection and regulated alternative splicing
    • Wu JY, Maniatis T (1993) Specifi c interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75:1061-1070
    • (1993) Cell , vol.75 , pp. 1061-1070
    • Wu, J.Y.1    Maniatis, T.2
  • 125
    • 0037121924 scopus 로고    scopus 로고
    • The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5 splice sites
    • Forch P, Puig O, Martinez C et al (2002) The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5? splice sites. EMBO J 21:6882-6892
    • (2002) EMBO J , vol.21 , pp. 6882-6892
    • Forch, P.1    Puig, O.2    Martinez, C.3
  • 126
    • 0029055472 scopus 로고
    • Distinct binding specifi cities and functions of higher eukaryotic polypyrimidine tractbinding proteins
    • Singh R, Valcarcel J, Green MR (1995) Distinct binding specifi cities and functions of higher eukaryotic polypyrimidine tractbinding proteins. Science 268:1173-1176
    • (1995) Science , vol.268 , pp. 1173-1176
    • Singh, R.1    Valcarcel, J.2    Green, M.R.3
  • 127
    • 4143078172 scopus 로고    scopus 로고
    • Commitment to splice site pairing coincides with A complex formation
    • Lim SR, Hertel KJ (2004) Commitment to splice site pairing coincides with A complex formation. Mol Cell 15:477-483
    • (2004) Mol Cell , vol.15 , pp. 477-483
    • Lim, S.R.1    Hertel, K.J.2
  • 128
    • 59449100357 scopus 로고    scopus 로고
    • Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex
    • Kotlajich MV, Crabb TL, Hertel KJ (2009) Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex. Mol Cell Biol 29:1072-1082
    • (2009) Mol Cell Biol , vol.29 , pp. 1072-1082
    • Kotlajich, M.V.1    Crabb, T.L.2    Hertel, K.J.3
  • 129
    • 84864940859 scopus 로고    scopus 로고
    • The transition in spliceosome assembly from complex e to complex A purges surplus U1 snRNPs from alternative splice sites
    • Hodson MJ, Hudson AJ, Cherny D et al (2012) The transition in spliceosome assembly from complex E to complex A purges surplus U1 snRNPs from alternative splice sites. Nucleic Acids Res 40:6850-6862
    • (2012) Nucleic Acids Res , vol.40 , pp. 6850-6862
    • Hodson, M.J.1    Hudson, A.J.2    Cherny, D.3
  • 130
    • 57649231776 scopus 로고    scopus 로고
    • Dynamic regulation of alternative splicing by silencers that modulate 5 splice site competition
    • Yu Y, Maroney PA, Denker JA et al (2008) Dynamic regulation of alternative splicing by silencers that modulate 5? splice site competition. Cell 135:1224-1236
    • (2008) Cell , vol.135 , pp. 1224-1236
    • Yu, Y.1    Maroney, P.A.2    Denker, J.A.3
  • 131
    • 8644268780 scopus 로고    scopus 로고
    • A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly
    • Shen H, Green MR (2004) A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly. Mol Cell 16:363-373
    • (2004) Mol Cell , vol.16 , pp. 363-373
    • Shen, H.1    Green, M.R.2
  • 132
    • 33745609509 scopus 로고    scopus 로고
    • RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans
    • Shen H, Green MR (2006) RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes Dev 20:1755-1765
    • (2006) Genes Dev , vol.20 , pp. 1755-1765
    • Shen, H.1    Green, M.R.2
  • 133
    • 79952504644 scopus 로고    scopus 로고
    • Ordered and dynamic assembly of single spliceosomes
    • Hoskins AA, Friedman LJ, Gallagher SS et al (2011) Ordered and dynamic assembly of single spliceosomes. Science 331:1289-1295
    • (2011) Science , vol.331 , pp. 1289-1295
    • Hoskins, A.A.1    Friedman, L.J.2    Gallagher, S.S.3
  • 134
    • 46449086933 scopus 로고    scopus 로고
    • Both catalytic steps of nuclear pre-mRNA splicing are reversible
    • Tseng CK, Cheng SC (2008) Both catalytic steps of nuclear pre-mRNA splicing are reversible. Science 320:1782-1784
    • (2008) Science , vol.320 , pp. 1782-1784
    • Tseng, C.K.1    Cheng, S.C.2
  • 135
    • 0037013146 scopus 로고    scopus 로고
    • Splicing regulation at the second catalytic step by Sex-lethal involves 3 splice site recognition by SPF45
    • Lallena MJ, Chalmers KJ, Llamazares S et al (2002) Splicing regulation at the second catalytic step by Sex-lethal involves 3? splice site recognition by SPF45. Cell 109:285-296
    • (2002) Cell , vol.109 , pp. 285-296
    • Lallena, M.J.1    Chalmers, K.J.2    Llamazares, S.3
  • 136
    • 77950870601 scopus 로고    scopus 로고
    • Exon defi nition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes
    • Schneider M, Will CL, Anokhina M et al (2010) Exon defi nition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Mol Cell 38:223-235
    • (2010) Mol Cell , vol.38 , pp. 223-235
    • Schneider, M.1    Will, C.L.2    Anokhina, M.3
  • 137
    • 53149145051 scopus 로고    scopus 로고
    • RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon defi nition
    • Bonnal S, Martinez C, Forch P et al (2008) RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon defi nition. Mol Cell 32:81-95
    • (2008) Mol Cell , vol.32 , pp. 81-95
    • Bonnal, S.1    Martinez, C.2    Forch, P.3
  • 138
    • 33749515475 scopus 로고    scopus 로고
    • An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition
    • House AE, Lynch KW (2006) An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition. Nat Struct Mol Biol 13:937-944
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 937-944
    • House, A.E.1    Lynch, K.W.2
  • 139
    • 38849187162 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein controls the transition from exon defi nition to an intron defi ned spliceosome
    • Sharma S, Kohlstaedt LA, Damianov A et al (2008) Polypyrimidine tract binding protein controls the transition from exon defi nition to an intron defi ned spliceosome. Nat Struct Mol Biol 15:183-191
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 183-191
    • Sharma, S.1    Kohlstaedt, L.A.2    Damianov, A.3
  • 140
    • 79951996054 scopus 로고    scopus 로고
    • U1 snRNA directly interacts with polypyrimidine tract-binding protein during splicing repression
    • Sharma S, Maris C, Allain FH et al (2011) U1 snRNA directly interacts with polypyrimidine tract-binding protein during splicing repression. Mol Cell 41:579-588
    • (2011) Mol Cell , vol.41 , pp. 579-588
    • Sharma, S.1    Maris, C.2    Allain, F.H.3
  • 141
    • 23744492690 scopus 로고    scopus 로고
    • Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon defi nition
    • Izquierdo JM, Majos N, Bonnal S et al (2005) Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon defi nition. Mol Cell 19:475-484
    • (2005) Mol Cell , vol.19 , pp. 475-484
    • Izquierdo, J.M.1    Majos, N.2    Bonnal, S.3
  • 142
    • 84876820281 scopus 로고    scopus 로고
    • HnRNP L and HnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly
    • Chiou N-T, Shankarling G, Lynch KW (2013) HnRNP L and HnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly. Mol Cell 49:972-982
    • (2013) Mol Cell , vol.49 , pp. 972-982
    • Chiou, N.-T.1    Shankarling, G.2    Lynch, K.W.3
  • 143
    • 74749089043 scopus 로고    scopus 로고
    • Context-dependent regulatory mechanism of the splicing factor hnRNP L
    • Motta-Mena LB, Heyd F, Lynch KW (2010) Context-dependent regulatory mechanism of the splicing factor hnRNP L. Mol Cell 37: 223-234
    • (2010) Mol Cell , vol.37 , pp. 223-234
    • Motta-Mena, L.B.1    Heyd, F.2    Lynch, K.W.3
  • 144
    • 79960594889 scopus 로고    scopus 로고
    • Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes
    • Lim KH, Ferraris L, Filloux ME et al (2011) Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes. Proc Natl Acad Sci USA 108:11093-11098
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11093-11098
    • Lim, K.H.1    Ferraris, L.2    Filloux, M.E.3
  • 145
    • 0344420060 scopus 로고    scopus 로고
    • Dystrophin and mutations: One gene, several proteins, multiple phenotypes
    • Muntoni F, Torelli S, Ferlini A (2003) Dystrophin and mutations: one gene, several proteins, multiple phenotypes. Lancet Neurol 2:731-740
    • (2003) Lancet Neurol , vol.2 , pp. 731-740
    • Muntoni, F.1    Torelli, S.2    Ferlini, A.3
  • 146
    • 63449141811 scopus 로고    scopus 로고
    • Effi cacy of systemic morpholino exonskipping in Duchenne dystrophy dogs
    • Yokota T, Lu Q-L, Partridge T et al (2009) Effi cacy of systemic morpholino exonskipping in Duchenne dystrophy dogs. Ann Neurol 65:667-676
    • (2009) Ann Neurol , vol.65 , pp. 667-676
    • Yokota, T.1    Lu, Q.-L.2    Partridge, T.3
  • 147
    • 0033033434 scopus 로고    scopus 로고
    • A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy
    • Lorson CL, Hahnen E, Androphy EJ et al (1999) A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. Proc Natl Acad Sci USA 96:6307-6311
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6307-6311
    • Lorson, C.L.1    Hahnen, E.2    Androphy, E.J.3
  • 148
    • 77957312146 scopus 로고    scopus 로고
    • Repair of pre-mRNA splicing: Prospects for a therapy for spinal muscular atrophy
    • Nlend Nlend R, Meyer K, Schümperli D (2010) Repair of pre-mRNA splicing: prospects for a therapy for spinal muscular atrophy. RNA Biol 7:430-440
    • (2010) RNA Biol , vol.7 , pp. 430-440
    • Nlend Nlend, R.1    Meyer, K.2    Schümperli, D.3
  • 149
    • 0037388256 scopus 로고    scopus 로고
    • Bifunctional antisense oligonucleotides provide a trans -acting splicing enhancer that stimulates SMN2 gene expression in patient fi broblasts
    • Skordis LA, Dunckley MG, Yue B et al (2003) Bifunctional antisense oligonucleotides provide a trans -acting splicing enhancer that stimulates SMN2 gene expression in patient fi broblasts. Proc Natl Acad Sci USA 100:4114-4119
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4114-4119
    • Skordis, L.A.1    Dunckley, M.G.2    Yue, B.3
  • 150
    • 0037313165 scopus 로고    scopus 로고
    • Correction of disease-associated exon skipping by synthetic exon-specifi c activators
    • Cartegni L, Krainer AR (2003) Correction of disease-associated exon skipping by synthetic exon-specifi c activators. Nat Struct Biol 10:120-125
    • (2003) Nat Struct Biol , vol.10 , pp. 120-125
    • Cartegni, L.1    Krainer, A.R.2
  • 151
    • 32044445564 scopus 로고    scopus 로고
    • Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron
    • Singh NK, Singh NN, Androphy EJ et al (2006) Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron. Mol Cell Biol 26:1333-1346
    • (2006) Mol Cell Biol , vol.26 , pp. 1333-1346
    • Singh, N.K.1    Singh, N.N.2    Androphy, E.J.3
  • 152
    • 77955894067 scopus 로고    scopus 로고
    • Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model
    • Hua Y, Sahashi K, Hung G et al (2010) Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes Dev 24: 1634-1644
    • (2010) Genes Dev , vol.24 , pp. 1634-1644
    • Hua, Y.1    Sahashi, K.2    Hung, G.3
  • 153
    • 79952348568 scopus 로고    scopus 로고
    • Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy
    • Passini MA, Bu J, Richards AM et al (2011) Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy. Sci Transl Med 3: 72ra18
    • (2011) Sci Transl Med , vol.3
    • Ma, P.1    Bu, J.2    Richards, A.M.3
  • 154
    • 0026062392 scopus 로고
    • Does steric interference between splice sites block the splicing of a short c-src neuron-specifi c exon in nonneuronal cells?
    • Black DL (1991) Does steric interference between splice sites block the splicing of a short c-src neuron-specifi c exon in nonneuronal cells? Genes Dev 5:389-402
    • (1991) Genes Dev , vol.5 , pp. 389-402
    • Black, D.L.1
  • 155
    • 27644455141 scopus 로고    scopus 로고
    • Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals
    • Underwood JG, Boutz PL, Dougherty JD et al (2005) Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Mol Cell Biol 25:10005-10016
    • (2005) Mol Cell Biol , vol.25 , pp. 10005-10016
    • Underwood, J.G.1    Boutz, P.L.2    Dougherty, J.D.3
  • 156
    • 34447536429 scopus 로고    scopus 로고
    • Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract
    • Matlin AJ, Southby J, Gooding C et al (2007) Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract. RNA 13:1214-1223
    • (2007) RNA , vol.13 , pp. 1214-1223
    • Matlin, A.J.1    Southby, J.2    Gooding, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.