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Volumn 14, Issue 5, 2008, Pages 802-813

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

Author keywords

Context dependence; Pre mRNA splicing; Splicing code; Splicing factor; Splicing regulation

Indexed keywords

MESSENGER RNA; RNA BINDING PROTEIN; TAU PROTEIN; RNA PRECURSOR;

EID: 42449098125     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.876308     Document Type: Review
Times cited : (779)

References (147)
  • 1
    • 0141457246 scopus 로고    scopus 로고
    • Control of HIV-1 env RNA splicing and transport: Investigating the role of hnRNP A1 in exon splicing silencer (ESS3a) function
    • Asai, K., Platt, C., and Cochrane, A. 2003. Control of HIV-1 env RNA splicing and transport: Investigating the role of hnRNP A1 in exon splicing silencer (ESS3a) function. Virology 314: 229-242.
    • (2003) Virology , vol.314 , pp. 229-242
    • Asai, K.1    Platt, C.2    Cochrane, A.3
  • 2
    • 0028895417 scopus 로고
    • Exon recognition in vertebrate splicing
    • Berget, S.M. 1995. Exon recognition in vertebrate splicing. J. Biol. Chem. 270: 2411-2414.
    • (1995) J. Biol. Chem , vol.270 , pp. 2411-2414
    • Berget, S.M.1
  • 3
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black, D.L. 2003. Mechanisms of alternative pre-messenger RNA splicing. Annu. Rev. Biochem. 72: 291-336.
    • (2003) Annu. Rev. Biochem , vol.72 , pp. 291-336
    • Black, D.L.1
  • 4
    • 22344458119 scopus 로고    scopus 로고
    • Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila
    • Blanchette, M., Green, R.E., Brenner, S.E., and Rio, D.C. 2005. Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. Genes & Dev. 19: 1306-1314.
    • (2005) Genes & Dev , vol.19 , pp. 1306-1314
    • Blanchette, M.1    Green, R.E.2    Brenner, S.E.3    Rio, D.C.4
  • 5
    • 34547211817 scopus 로고    scopus 로고
    • The long unwinding road of RNA helicases
    • Bleichert, F. and Baserga, S.J. 2007. The long unwinding road of RNA helicases. Mol. Cell 27: 339-352.
    • (2007) Mol. Cell , vol.27 , pp. 339-352
    • Bleichert, F.1    Baserga, S.J.2
  • 6
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: New insights from global analyses
    • Blencowe, B.J. 2006. Alternative splicing: New insights from global analyses. Cell 126: 37-47.
    • (2006) Cell , vol.126 , pp. 37-47
    • Blencowe, B.J.1
  • 7
    • 34347384211 scopus 로고    scopus 로고
    • A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
    • Boutz, P.L., Stoilov, P., Li, Q., Lin, C.H., Chawla, G., Ostrow, K., Shiue, L., Ares Jr., M., and Black, D.L. 2007. A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes & Dev. 21: 1636-1652.
    • (2007) Genes & Dev , vol.21 , pp. 1636-1652
    • Boutz, P.L.1    Stoilov, P.2    Li, Q.3    Lin, C.H.4    Chawla, G.5    Ostrow, K.6    Shiue, L.7    Ares Jr., M.8    Black, D.L.9
  • 8
    • 0035369805 scopus 로고    scopus 로고
    • Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing
    • doi: 10.1093/nar/29.11.2338
    • Brudno, M., Gelfand, M.S., Spengler, S., Zorn, M., Dubchak, I., and Conboy, J.G. 2001. Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing. Nucleic Acids Res. 29: 2338-2348. doi: 10.1093/nar/29.11.2338.
    • (2001) Nucleic Acids Res , vol.29 , pp. 2338-2348
    • Brudno, M.1    Gelfand, M.S.2    Spengler, S.3    Zorn, M.4    Dubchak, I.5    Conboy, J.G.6
  • 9
    • 1642458353 scopus 로고    scopus 로고
    • RNA folding affects the recruitment of SR proteins by mouse and human polypurinic enhancer elements in the fibronectin EDA exon
    • Buratti, E., Muro, A.F., Giombi, M., Gherbassi, D., Iaconcig, A., and Baralle, F.E. 2004. RNA folding affects the recruitment of SR proteins by mouse and human polypurinic enhancer elements in the fibronectin EDA exon. Mol. Cell. Biol. 24: 1387-1400.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 1387-1400
    • Buratti, E.1    Muro, A.F.2    Giombi, M.3    Gherbassi, D.4    Iaconcig, A.5    Baralle, F.E.6
  • 10
    • 34547830368 scopus 로고    scopus 로고
    • SR protein-mediated inhibition of CFTR exon 9 inclusion: Molecular characterization of the intronic splicing silencer
    • doi: 10.1093/nar/gkm444
    • Buratti, E., Stuani, C., De Prato, G., and Baralle, F.E. 2007. SR protein-mediated inhibition of CFTR exon 9 inclusion: Molecular characterization of the intronic splicing silencer. Nucleic Acids Res. 35: 4359-4368. doi: 10.1093/nar/gkm444.
    • (2007) Nucleic Acids Res , vol.35 , pp. 4359-4368
    • Buratti, E.1    Stuani, C.2    De Prato, G.3    Baralle, F.E.4
  • 12
    • 0035941211 scopus 로고    scopus 로고
    • Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H′/F/2H9 family
    • Caputi, M. and Zahler, A.M. 2001. Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H′/F/2H9 family. J. Biol. Chem. 276: 43850-43859.
    • (2001) J. Biol. Chem , vol.276 , pp. 43850-43859
    • Caputi, M.1    Zahler, A.M.2
  • 13
    • 0036207384 scopus 로고    scopus 로고
    • Listening to silence and understanding nonsense: Exonic mutations that affect splicing
    • Cartegni, L., Chew, S.L., and Krainer, A.R. 2002. Listening to silence and understanding nonsense: Exonic mutations that affect splicing. Nat. Rev. Genet. 3: 285-298.
    • (2002) Nat. Rev. Genet , vol.3 , pp. 285-298
    • Cartegni, L.1    Chew, S.L.2    Krainer, A.R.3
  • 14
    • 0042242582 scopus 로고    scopus 로고
    • ESEfinder: A web resource to identify exonic splicing enhancers
    • doi: 10.1093/nar/gkg616
    • Cartegni, L., Wang, J., Zhu, Z., Zhang, M.Q., and Krainer, A.R. 2003. ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Res. 31: 3568-3571. doi: 10.1093/nar/gkg616.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3568-3571
    • Cartegni, L.1    Wang, J.2    Zhu, Z.3    Zhang, M.Q.4    Krainer, A.R.5
  • 15
    • 0028963667 scopus 로고
    • Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing
    • Cascino, I., Fiucci, G., Papoff, G., and Ruberti, G. 1995. Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. J. Immunol. 154: 2706-2713.
    • (1995) J. Immunol , vol.154 , pp. 2706-2713
    • Cascino, I.1    Fiucci, G.2    Papoff, G.3    Ruberti, G.4
  • 16
    • 42449129287 scopus 로고    scopus 로고
    • Searching for splicing motifs
    • eds. B.J. Blencowe and B.R. Graveley, pp, Landes Biosciences, Austin, TX
    • Chasin, L. 2007. Searching for splicing motifs. In Alternative splicing in the postgenomic era (eds. B.J. Blencowe and B.R. Graveley), pp. 85-106. Landes Biosciences, Austin, TX.
    • (2007) Alternative splicing in the postgenomic era , pp. 85-106
    • Chasin, L.1
  • 17
    • 0033105787 scopus 로고    scopus 로고
    • Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat β-tropomyosin gene
    • Chen, C.D., Kobayashi, R., and Helfman, D.M. 1999. Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat β-tropomyosin gene. Genes & Dev. 13: 593-606.
    • (1999) Genes & Dev , vol.13 , pp. 593-606
    • Chen, C.D.1    Kobayashi, R.2    Helfman, D.M.3
  • 18
    • 0032953308 scopus 로고    scopus 로고
    • hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells
    • Chou, M.Y., Rooke, N., Turck, C.W., and Black, D.L. 1999. hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol. Cell. Biol. 19: 69-77.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 69-77
    • Chou, M.Y.1    Rooke, N.2    Turck, C.W.3    Black, D.L.4
  • 19
    • 0033634948 scopus 로고    scopus 로고
    • Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing
    • Chou, M.Y., Underwood, J.G., Nikolic, J., Luu, M.H., and Black, D.L. 2000. Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Mol. Cell 5: 949-957.
    • (2000) Mol. Cell , vol.5 , pp. 949-957
    • Chou, M.Y.1    Underwood, J.G.2    Nikolic, J.3    Luu, M.H.4    Black, D.L.5
  • 20
    • 0037012922 scopus 로고    scopus 로고
    • Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays
    • Clark, T.A., Sugnet, C.W., and Ares Jr., M. 2002. Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays. Science 296: 907-910.
    • (2002) Science , vol.296 , pp. 907-910
    • Clark, T.A.1    Sugnet, C.W.2    Ares Jr., M.3
  • 21
    • 0030988942 scopus 로고    scopus 로고
    • Identification of a new class of exonic splicing enhancers by in vivo selection
    • Coulter, L.R., Landree, M.A., and Cooper, T.A. 1997. Identification of a new class of exonic splicing enhancers by in vivo selection. Mol. Cell. Biol. 17: 2143-2150.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 2143-2150
    • Coulter, L.R.1    Landree, M.A.2    Cooper, T.A.3
  • 22
    • 0042658190 scopus 로고    scopus 로고
    • Nuclear mRNA export: Insights from virology
    • Cullen, B.R. 2003. Nuclear mRNA export: Insights from virology. Trends Biochem. Sci. 28: 419-424.
    • (2003) Trends Biochem. Sci , vol.28 , pp. 419-424
    • Cullen, B.R.1
  • 23
    • 0037135580 scopus 로고    scopus 로고
    • Tau exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5′ and 3′ splice sites
    • D'Souza, I. and Schellenberg, G.D. 2002. Tau exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5′ and 3′ splice sites. J. Biol. Chem. 277: 26587-26599.
    • (2002) J. Biol. Chem , vol.277 , pp. 26587-26599
    • D'Souza, I.1    Schellenberg, G.D.2
  • 24
    • 33745132168 scopus 로고    scopus 로고
    • Functional coupling of RNAP II transcription to spliceosome assembly
    • Das, R., Dufu, K., Romney, B., Feldt, M., Elenko, M., and Reed, R. 2006. Functional coupling of RNAP II transcription to spliceosome assembly. Genes & Dev. 20: 1100-1109.
    • (2006) Genes & Dev , vol.20 , pp. 1100-1109
    • Das, R.1    Dufu, K.2    Romney, B.3    Feldt, M.4    Elenko, M.5    Reed, R.6
  • 25
    • 34250363024 scopus 로고    scopus 로고
    • SR proteins function in coupling RNAP II transcription to pre-mRNA splicing
    • Das, R., Yu, J., Zhang, Z., Gygi, M.P., Krainer, A.R., Gygi, S.P., and Reed, R. 2007. SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Mol. Cell 26: 867-881.
    • (2007) Mol. Cell , vol.26 , pp. 867-881
    • Das, R.1    Yu, J.2    Zhang, Z.3    Gygi, M.P.4    Krainer, A.R.5    Gygi, S.P.6    Reed, R.7
  • 26
    • 33750596100 scopus 로고    scopus 로고
    • RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20
    • de la Mata, M. and Kornblihtt, A.R. 2006. RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20. Nat. Struct. Mol. Biol. 13: 973-980.
    • (2006) Nat. Struct. Mol. Biol , vol.13 , pp. 973-980
    • de la Mata, M.1    Kornblihtt, A.R.2
  • 28
    • 20444376179 scopus 로고    scopus 로고
    • fruitless splicing specifies male courtship behavior in Drosophila
    • Demir, E. and Dickson, B.J. 2005. fruitless splicing specifies male courtship behavior in Drosophila. Cell 121: 785-794.
    • (2005) Cell , vol.121 , pp. 785-794
    • Demir, E.1    Dickson, B.J.2
  • 29
    • 33747085899 scopus 로고    scopus 로고
    • NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: A novel mode of RNA recognition
    • doi: 10.1093/nar/gkl488
    • Dominguez, C. and Allain, F.H. 2006. NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: A novel mode of RNA recognition. Nucleic Acids Res. 34: 3634-3645. doi: 10.1093/nar/gkl488.
    • (2006) Nucleic Acids Res , vol.34 , pp. 3634-3645
    • Dominguez, C.1    Allain, F.H.2
  • 30
    • 33747634776 scopus 로고    scopus 로고
    • Stabilization of the tau exon 10 stem-loop alters pre-mRNA splicing
    • Donahue, C.P., Muratore, C., Wu, J.Y., Kosik, K.S., and Wolfe, M.S. 2006. Stabilization of the tau exon 10 stem-loop alters pre-mRNA splicing. J. Biol. Chem. 281: 23302-23306.
    • (2006) J. Biol. Chem , vol.281 , pp. 23302-23306
    • Donahue, C.P.1    Muratore, C.2    Wu, J.Y.3    Kosik, K.S.4    Wolfe, M.S.5
  • 31
    • 0037047644 scopus 로고    scopus 로고
    • Predictive identification of exonic splicing enhancers in human genes
    • Fairbrother, W.G., Yeh, R.F., Sharp, P.A., and Burge, C.B. 2002. Predictive identification of exonic splicing enhancers in human genes. Science 297: 1007-1013.
    • (2002) Science , vol.297 , pp. 1007-1013
    • Fairbrother, W.G.1    Yeh, R.F.2    Sharp, P.A.3    Burge, C.B.4
  • 32
    • 0033230855 scopus 로고    scopus 로고
    • Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle
    • Fischer, U., Pollard, V.W., Luhrmann, R., Teufel, M., Michael, M.W., Dreyfuss, G., and Malim, M.H. 1999. Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle. Nucleic Acids Res. 27: 4128-4134.
    • (1999) Nucleic Acids Res , vol.27 , pp. 4128-4134
    • Fischer, U.1    Pollard, V.W.2    Luhrmann, R.3    Teufel, M.4    Michael, M.W.5    Dreyfuss, G.6    Malim, M.H.7
  • 33
    • 10944220623 scopus 로고    scopus 로고
    • Towards a splicing code
    • Fu, X.D. 2004. Towards a splicing code. Cell 119: 736-738.
    • (2004) Cell , vol.119 , pp. 736-738
    • Fu, X.D.1
  • 34
    • 42449129086 scopus 로고    scopus 로고
    • Human branch point consensus sequence is yUnAy
    • PMID: 18285363. doi: 10.1093/nar/gkn073
    • Gao, K., Masuda, A., Matsuura, T., and Ohno, K. 2008. Human branch point consensus sequence is yUnAy. Nucleic Acids Res. PMID: 18285363. doi: 10.1093/nar/gkn073.
    • (2008) Nucleic Acids Res
    • Gao, K.1    Masuda, A.2    Matsuura, T.3    Ohno, K.4
  • 35
    • 33846467191 scopus 로고    scopus 로고
    • Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array
    • doi: 10.1186/1471-2164-7- 325
    • Gardina, P.J., Clark, T.A., Shimada, B., Staples, M.K., Yang, Q., Veitch, J., Schweitzer, A., Awad, T., Sugnet, C., Dee, S., et al. 2006. Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics 7: 325. doi: 10.1186/1471-2164-7- 325.
    • (2006) BMC Genomics , vol.7 , pp. 325
    • Gardina, P.J.1    Clark, T.A.2    Shimada, B.3    Staples, M.K.4    Yang, Q.5    Veitch, J.6    Schweitzer, A.7    Awad, T.8    Sugnet, C.9    Dee, S.10
  • 36
    • 33745207758 scopus 로고    scopus 로고
    • Comparative analysis identifies exonic splicing regulatory sequences - The complex definition of enhancers and silencers
    • Goren, A., Ram, O., Amit, M., Keren, H., Lev-Maor, G., Vig, I., Pupko, T., and Ast, G. 2006. Comparative analysis identifies exonic splicing regulatory sequences - The complex definition of enhancers and silencers. Mol. Cell 22: 769-781.
    • (2006) Mol. Cell , vol.22 , pp. 769-781
    • Goren, A.1    Ram, O.2    Amit, M.3    Keren, H.4    Lev-Maor, G.5    Vig, I.6    Pupko, T.7    Ast, G.8
  • 37
    • 0033835333 scopus 로고    scopus 로고
    • Sorting out the complexity of SR protein functions
    • Graveley, B.R. 2000. Sorting out the complexity of SR protein functions. RNA 6: 1197-1211.
    • (2000) RNA , vol.6 , pp. 1197-1211
    • Graveley, B.R.1
  • 38
    • 26244435561 scopus 로고    scopus 로고
    • Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures
    • Graveley, B.R. 2005. Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures. Cell 123: 65-73.
    • (2005) Cell , vol.123 , pp. 65-73
    • Graveley, B.R.1
  • 39
    • 0032038213 scopus 로고    scopus 로고
    • Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing
    • Graveley, B.R. and Maniatis, T. 1998. Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. Mol. Cell 1: 765-771.
    • (1998) Mol. Cell , vol.1 , pp. 765-771
    • Graveley, B.R.1    Maniatis, T.2
  • 40
    • 0032538791 scopus 로고    scopus 로고
    • A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers
    • Graveley, B.R., Hertel, K.J., and Maniatis, T. 1998. A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. EMBO J. 17: 6747-6756.
    • (1998) EMBO J , vol.17 , pp. 6747-6756
    • Graveley, B.R.1    Hertel, K.J.2    Maniatis, T.3
  • 41
    • 21844480060 scopus 로고    scopus 로고
    • A combinatorial code for splicing silencing: UAGG and GGGG motifs
    • doi: 10.1371/journal.pbio.0030158
    • Han, K., Yeo, G., An, P., Burge, C.B., and Grabowski, P.J. 2005. A combinatorial code for splicing silencing: UAGG and GGGG motifs. PLoS Biol. 3: e158. doi: 10.1371/journal.pbio.0030158.
    • (2005) PLoS Biol , vol.3
    • Han, K.1    Yeo, G.2    An, P.3    Burge, C.B.4    Grabowski, P.J.5
  • 42
    • 0034968747 scopus 로고    scopus 로고
    • A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA
    • Hastings, M.L., Wilson, C.M., and Munroe, S.H. 2001. A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA 7: 859-874.
    • (2001) RNA , vol.7 , pp. 859-874
    • Hastings, M.L.1    Wilson, C.M.2    Munroe, S.H.3
  • 43
    • 14744290800 scopus 로고    scopus 로고
    • RS domains contact the pre-mRNA throughout spliceosome assembly
    • Hertel, K.J. and Graveley, B.R. 2005. RS domains contact the pre-mRNA throughout spliceosome assembly. Trends Biochem. Sci. 30: 115-118.
    • (2005) Trends Biochem. Sci , vol.30 , pp. 115-118
    • Hertel, K.J.1    Graveley, B.R.2
  • 44
    • 33745220323 scopus 로고    scopus 로고
    • Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns
    • doi: 10.1371/journal.pbio.0040147
    • Hicks, M.J., Yang, C.R., Kotlajich, M.V., and Hertel, K.J. 2006. Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns. PLoS Biol. 4: e147. doi: 10.1371/journal.pbio.0040147.
    • (2006) PLoS Biol , vol.4
    • Hicks, M.J.1    Yang, C.R.2    Kotlajich, M.V.3    Hertel, K.J.4
  • 45
    • 10044282898 scopus 로고    scopus 로고
    • A systems view of mRNP biology
    • Hieronymus, H. and Silver, P.A. 2004. A systems view of mRNP biology. Genes & Dev. 18: 2845-2860.
    • (2004) Genes & Dev , vol.18 , pp. 2845-2860
    • Hieronymus, H.1    Silver, P.A.2
  • 46
    • 37349056702 scopus 로고    scopus 로고
    • Pre-mRNA secondary structures influence exon recognition
    • doi: 10.1371/journal.pgen.0030204
    • Hiller, M., Zhang, Z., Backofen, R., and Stamm, S. 2007. Pre-mRNA secondary structures influence exon recognition. PLoS Genet. 3: e204. doi: 10.1371/journal.pgen.0030204.
    • (2007) PLoS Genet , vol.3
    • Hiller, M.1    Zhang, Z.2    Backofen, R.3    Stamm, S.4
  • 47
    • 0036318541 scopus 로고    scopus 로고
    • Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72
    • Honig, A., Auboeuf, D., Parker, M.M., O'Malley, B.W., and Berget, S.M. 2002. Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. Mol. Cell. Biol. 22: 5698-5707.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 5698-5707
    • Honig, A.1    Auboeuf, D.2    Parker, M.M.3    O'Malley, B.W.4    Berget, S.M.5
  • 48
    • 38349138834 scopus 로고    scopus 로고
    • Regulation of alternative splicing: More than just the ABCs
    • House, AE. and Lynch, KW. 2008. Regulation of alternative splicing: More than just the ABCs. J. Biol. Chem. 283: 1217-1221.
    • (2008) J. Biol. Chem , vol.283 , pp. 1217-1221
    • House, A.E.1    Lynch, K.W.2
  • 49
    • 0028308631 scopus 로고
    • Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element
    • Huh, G.S. and Hynes, R.O. 1994. Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes & Dev. 8: 1561-1574.
    • (1994) Genes & Dev , vol.8 , pp. 1561-1574
    • Huh, G.S.1    Hynes, R.O.2
  • 50
    • 21244469877 scopus 로고    scopus 로고
    • Intronic CA-repeat and CA-rich elements: A new class of regulators of mammalian alternative splicing
    • Hui, J., Hung, L.H., Heiner, M., Schreiner, S., Neumuller, N., Reither, G., Haas, S.A., and Bindereif, A. 2005. Intronic CA-repeat and CA-rich elements: A new class of regulators of mammalian alternative splicing. EMBO J. 24: 1988-1998.
    • (2005) EMBO J , vol.24 , pp. 1988-1998
    • Hui, J.1    Hung, L.H.2    Heiner, M.3    Schreiner, S.4    Neumuller, N.5    Reither, G.6    Haas, S.A.7    Bindereif, A.8
  • 51
    • 38649129366 scopus 로고    scopus 로고
    • Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis
    • Hung, L.H., Heiner, M., Hui, J., Schreiner, S., Benes, V., and Bindereif, A. 2007. Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis. RNA 14: 284-296.
    • (2007) RNA , vol.14 , pp. 284-296
    • Hung, L.H.1    Heiner, M.2    Hui, J.3    Schreiner, S.4    Benes, V.5    Bindereif, A.6
  • 52
    • 17044427579 scopus 로고    scopus 로고
    • Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers
    • Ibrahim el, C., Schaal, T.D., Hertel, K.J., Reed, R., and Maniatis, T. 2005. Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proc. Natl. Acad. Sci. 102: 5002-5007.
    • (2005) Proc. Natl. Acad. Sci , vol.102 , pp. 5002-5007
    • Ibrahim el, C.1    Schaal, T.D.2    Hertel, K.J.3    Reed, R.4    Maniatis, T.5
  • 53
    • 33947720465 scopus 로고    scopus 로고
    • Global analysis of alternative splicing during T-cell activation
    • Ip, J.Y., Tong, A., Pan, Q., Topp, J.D., Blencowe, B.J., and Lynch, K.W. 2007. Global analysis of alternative splicing during T-cell activation. RNA 13: 563-572.
    • (2007) RNA , vol.13 , pp. 563-572
    • Ip, J.Y.1    Tong, A.2    Pan, Q.3    Topp, J.D.4    Blencowe, B.J.5    Lynch, K.W.6
  • 55
    • 0034705034 scopus 로고    scopus 로고
    • The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain
    • Jensen, K.B., Musunuru, K., Lewis, H.A., Burley, S.K., and Darnell, R.B. 2000. The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain. Proc. Natl. Acad. Sci. 97: 5740-5745.
    • (2000) Proc. Natl. Acad. Sci , vol.97 , pp. 5740-5745
    • Jensen, K.B.1    Musunuru, K.2    Lewis, H.A.3    Burley, S.K.4    Darnell, R.B.5
  • 56
    • 0037450704 scopus 로고    scopus 로고
    • A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG
    • Jin, Y., Suzuki, H., Maegawa, S., Endo, H., Sugano, S., Hashimoto, K., Yasuda, K., and Inoue, K. 2003. A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG. EMBO J. 22: 905-912.
    • (2003) EMBO J , vol.22 , pp. 905-912
    • Jin, Y.1    Suzuki, H.2    Maegawa, S.3    Endo, H.4    Sugano, S.5    Hashimoto, K.6    Yasuda, K.7    Inoue, K.8
  • 58
    • 0042671357 scopus 로고    scopus 로고
    • Pre-mRNA splicing: Awash in a sea of proteins
    • Jurica, M.S. and Moore, M.J. 2003. Pre-mRNA splicing: Awash in a sea of proteins. Mol. Cell 12: 5-14.
    • (2003) Mol. Cell , vol.12 , pp. 5-14
    • Jurica, M.S.1    Moore, M.J.2
  • 59
    • 33746609827 scopus 로고    scopus 로고
    • Intronic alternative splicing regulators identified by comparative genomics in nematodes
    • doi: 10.1371/journal.pcbi.0020086
    • Kabat, J.L., Barberan-Soler, S., McKenna, P., Clawson, H., Farrer, T., and Zahler, A.M. 2006. Intronic alternative splicing regulators identified by comparative genomics in nematodes. PLoS Comput. Biol. 2: e86. doi: 10.1371/journal.pcbi.0020086.
    • (2006) PLoS Comput. Biol , vol.2
    • Kabat, J.L.1    Barberan-Soler, S.2    McKenna, P.3    Clawson, H.4    Farrer, T.5    Zahler, A.M.6
  • 60
    • 0030013179 scopus 로고    scopus 로고
    • Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
    • Kanopka, A., Muhlemann, O., and Akusjarvi, G. 1996. Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA. Nature 381: 535-538.
    • (1996) Nature , vol.381 , pp. 535-538
    • Kanopka, A.1    Muhlemann, O.2    Akusjarvi, G.3
  • 61
    • 33847665554 scopus 로고    scopus 로고
    • An intronic element contributes to splicing repression in spinal muscular atrophy
    • Kashima, T., Rao, N., and Manley, J.L. 2007. An intronic element contributes to splicing repression in spinal muscular atrophy. Proc. Natl. Acad. Sci. 104: 3426-3431.
    • (2007) Proc. Natl. Acad. Sci , vol.104 , pp. 3426-3431
    • Kashima, T.1    Rao, N.2    Manley, J.L.3
  • 62
    • 33845275018 scopus 로고    scopus 로고
    • RIP-Chip: The isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts
    • Keene, J.D., Komisarow, J.M., and Friedersdorf, M.B. 2006. RIP-Chip: The isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts. Nat. Protoc. 1: 302-307.
    • (2006) Nat. Protoc , vol.1 , pp. 302-307
    • Keene, J.D.1    Komisarow, J.M.2    Friedersdorf, M.B.3
  • 63
    • 20444470310 scopus 로고    scopus 로고
    • Human-mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation
    • Kol, G., Lev-Maor, G., and Ast, G. 2005. Human-mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation. Hum. Mol. Genet. 14: 1559-1568.
    • (2005) Hum. Mol. Genet , vol.14 , pp. 1559-1568
    • Kol, G.1    Lev-Maor, G.2    Ast, G.3
  • 64
    • 25844443478 scopus 로고    scopus 로고
    • Insights into the mechanisms of splicing: More lessons from the ribosome
    • Konarska, M.M. and Query, C.C. 2005. Insights into the mechanisms of splicing: More lessons from the ribosome. Genes & Dev. 19: 2255-2260.
    • (2005) Genes & Dev , vol.19 , pp. 2255-2260
    • Konarska, M.M.1    Query, C.C.2
  • 66
    • 0036429269 scopus 로고    scopus 로고
    • Finding signals that regulate alternative splicing in the post-genomic era
    • reviews0008.1-0008.16. doi: 10.1186/gb-2002-3-11-reviews0008
    • Ladd, A.N. and Cooper, T.A. 2002. Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol. 3: reviews0008.1-0008.16. doi: 10.1186/gb-2002-3-11-reviews0008.
    • (2002) Genome Biol , vol.3
    • Ladd, A.N.1    Cooper, T.A.2
  • 67
    • 0037131311 scopus 로고    scopus 로고
    • RH70, a bidirectional RNA helicase, co-purifies with U1snRNP
    • Lee, C.G. 2002. RH70, a bidirectional RNA helicase, co-purifies with U1snRNP. J. Biol. Chem. 277: 39679-39683.
    • (2002) J. Biol. Chem , vol.277 , pp. 39679-39683
    • Lee, C.G.1
  • 68
    • 33846989782 scopus 로고    scopus 로고
    • Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements
    • doi: 10.1371/journal.pbio.0050040
    • Lee, J.A., Xing, Y., Nguyen, D., Xie, J., Lee, C.J., and Black, D.L. 2007. Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements. PLoS Biol. 5: e40. doi: 10.1371/journal.pbio.0050040.
    • (2007) PLoS Biol , vol.5
    • Lee, J.A.1    Xing, Y.2    Nguyen, D.3    Xie, J.4    Lee, C.J.5    Black, D.L.6
  • 69
    • 0035949674 scopus 로고    scopus 로고
    • A computational analysis of sequence features involved in recognition of short introns
    • Lim, L.P. and Burge, C.B. 2001. A computational analysis of sequence features involved in recognition of short introns. Proc. Natl. Acad. Sci. 98: 11193-11198.
    • (2001) Proc. Natl. Acad. Sci , vol.98 , pp. 11193-11198
    • Lim, L.P.1    Burge, C.B.2
  • 70
    • 4143078172 scopus 로고    scopus 로고
    • Commitment to splice site pairing coincides with A complex formation
    • Lim, S.R. and Hertel, K.J. 2004. Commitment to splice site pairing coincides with A complex formation. Mol. Cell 15: 477-483.
    • (2004) Mol. Cell , vol.15 , pp. 477-483
    • Lim, S.R.1    Hertel, K.J.2
  • 71
    • 0031806710 scopus 로고    scopus 로고
    • Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats
    • Lim, L.P. and Sharp, P.A. 1998. Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats. Mol. Cell. Biol. 18: 3900-3906.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 3900-3906
    • Lim, L.P.1    Sharp, P.A.2
  • 72
    • 0032128255 scopus 로고    scopus 로고
    • Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins
    • Liu, H.X., Zhang, M., and Krainer, A.R. 1998. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes & Dev. 12: 1998-2012.
    • (1998) Genes & Dev , vol.12 , pp. 1998-2012
    • Liu, H.X.1    Zhang, M.2    Krainer, A.R.3
  • 73
    • 0033963336 scopus 로고    scopus 로고
    • Exonic splicing enhancer motif recognized by human SC35 under splicing conditions
    • Liu, H.X., Chew, S.L., Cartegni, L., Zhang, M.Q., and Krainer, A.R. 2000. Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol. Cell. Biol. 20: 1063-1071.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 1063-1071
    • Liu, H.X.1    Chew, S.L.2    Cartegni, L.3    Zhang, M.Q.4    Krainer, A.R.5
  • 74
    • 34047187080 scopus 로고    scopus 로고
    • Genomic systematic evolution of ligands by exponential enrichment (Genomic SELEX) for the identification of protein-binding RNAs independent of their expression levels
    • Lorenz, C., von Pelchrzim, F., and Schroeder, R. 2006. Genomic systematic evolution of ligands by exponential enrichment (Genomic SELEX) for the identification of protein-binding RNAs independent of their expression levels. Nat. Protoc. 1: 2204-2212.
    • (2006) Nat. Protoc , vol.1 , pp. 2204-2212
    • Lorenz, C.1    von Pelchrzim, F.2    Schroeder, R.3
  • 75
    • 34547212309 scopus 로고    scopus 로고
    • The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
    • Makeyev, E.V., Zhang, J., Carrasco, M.A., and Maniatis, T. 2007. The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol. Cell 27: 435-448.
    • (2007) Mol. Cell , vol.27 , pp. 435-448
    • Makeyev, E.V.1    Zhang, J.2    Carrasco, M.A.3    Maniatis, T.4
  • 76
    • 33846701130 scopus 로고    scopus 로고
    • Complex splicing control of the human Thrombopoietin gene by intronic G runs
    • doi: 10.1093/nar/gkl965
    • Marcucci, R., Baralle, F.E., and Romano, M. 2007. Complex splicing control of the human Thrombopoietin gene by intronic G runs. Nucleic Acids Res. 35: 132-142. doi: 10.1093/nar/gkl965.
    • (2007) Nucleic Acids Res , vol.35 , pp. 132-142
    • Marcucci, R.1    Baralle, F.E.2    Romano, M.3
  • 77
    • 18344364099 scopus 로고    scopus 로고
    • Understanding alternative splicing: Toward a cellular code
    • Matlin, A.J., Clark, F., and Smith, C.W. 2005. Understanding alternative splicing: Toward a cellular code. Nat. Rev. Mol. Cell Biol. 6: 386-398.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , pp. 386-398
    • Matlin, A.J.1    Clark, F.2    Smith, C.W.3
  • 78
    • 0030743391 scopus 로고    scopus 로고
    • G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection
    • McCullough, A.J. and Berget, S.M. 1997. G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection. Mol. Cell. Biol. 17: 4562-4571.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 4562-4571
    • McCullough, A.J.1    Berget, S.M.2
  • 79
    • 0034461083 scopus 로고    scopus 로고
    • An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5′ splice sites
    • McCullough, A.J. and Berget, S.M. 2000. An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5′ splice sites. Mol. Cell. Biol. 20: 9225-9235.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 9225-9235
    • McCullough, A.J.1    Berget, S.M.2
  • 80
    • 16244412610 scopus 로고    scopus 로고
    • RNA structure analysis at single nucleotide resolution by selective 2′-hydroxyl acylation and primer extension (SHAPE)
    • Merino, E.J., Wilkinson, K.A., Coughlan, J.L., and Weeks, K.M. 2005. RNA structure analysis at single nucleotide resolution by selective 2′-hydroxyl acylation and primer extension (SHAPE). J. Am. Chem. Soc. 127: 4223-4231.
    • (2005) J. Am. Chem. Soc , vol.127 , pp. 4223-4231
    • Merino, E.J.1    Wilkinson, K.A.2    Coughlan, J.L.3    Weeks, K.M.4
  • 81
    • 0030969572 scopus 로고    scopus 로고
    • A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer
    • Min, H., Turck, C.W., Nikolic, J.M., and Black, D.L. 1997. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes & Dev. 11: 1023-1036.
    • (1997) Genes & Dev , vol.11 , pp. 1023-1036
    • Min, H.1    Turck, C.W.2    Nikolic, J.M.3    Black, D.L.4
  • 82
    • 13844314248 scopus 로고    scopus 로고
    • The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons
    • doi: 10.1093/nar/gki210
    • Minovitsky, S., Gee, S.L., Schokrpur, S., Dubchak, I., and Conboy, J.G. 2005. The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons. Nucleic Acids Res. 33: 714-724. doi: 10.1093/nar/gki210.
    • (2005) Nucleic Acids Res , vol.33 , pp. 714-724
    • Minovitsky, S.1    Gee, S.L.2    Schokrpur, S.3    Dubchak, I.4    Conboy, J.G.5
  • 83
    • 0032916285 scopus 로고    scopus 로고
    • Combinatorial control of a neuron-specific exon
    • Modafferi, E.F. and Black, D.L. 1999. Combinatorial control of a neuron-specific exon. RNA 5: 687-706.
    • (1999) RNA , vol.5 , pp. 687-706
    • Modafferi, E.F.1    Black, D.L.2
  • 84
    • 17544367787 scopus 로고    scopus 로고
    • Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities
    • doi: 10.1093/nar/gki338
    • Nakahata, S. and Kawamoto, S. 2005. Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities. Nucleic Acids Res. 33: 2078-2089. doi: 10.1093/nar/gki338.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2078-2089
    • Nakahata, S.1    Kawamoto, S.2
  • 85
    • 0028222873 scopus 로고
    • Construction of a novel database containing aberrant splicing mutations of mammalian genes
    • Nakai, K. and Sakamoto, H. 1994. Construction of a novel database containing aberrant splicing mutations of mammalian genes. Gene 141: 171-177.
    • (1994) Gene , vol.141 , pp. 171-177
    • Nakai, K.1    Sakamoto, H.2
  • 86
    • 0036674179 scopus 로고    scopus 로고
    • High-affinity hnRNP A1 binding sites and duplex-forming inverted repeats have similar effects on 5′ splice site selection in support of a common looping out and repression mechanism
    • Nasim, F.U., Hutchison, S., Cordeau, M., and Chabot, B. 2002. High-affinity hnRNP A1 binding sites and duplex-forming inverted repeats have similar effects on 5′ splice site selection in support of a common looping out and repression mechanism. RNA 8: 1078-1089.
    • (2002) RNA , vol.8 , pp. 1078-1089
    • Nasim, F.U.1    Hutchison, S.2    Cordeau, M.3    Chabot, B.4
  • 87
    • 33947305594 scopus 로고    scopus 로고
    • Ultra-conserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay
    • Ni, J.Z., Grate, L., Donohue, J.P., Preston, C., Nobida, N., O'Brien, G., Shiue, L., Clark, T.A., Blume, J.E., and Ares Jr., M. 2007. Ultra-conserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. Genes & Dev. 21: 708-718.
    • (2007) Genes & Dev , vol.21 , pp. 708-718
    • Ni, J.Z.1    Grate, L.2    Donohue, J.P.3    Preston, C.4    Nobida, N.5    O'Brien, G.6    Shiue, L.7    Clark, T.A.8    Blume, J.E.9    Ares Jr., M.10
  • 88
    • 0344198459 scopus 로고    scopus 로고
    • The spliceosome: The most complex macromolecular machine in the cell?
    • Nilsen, T.W. 2003. The spliceosome: The most complex macromolecular machine in the cell? Bioessays 25: 1147-1149.
    • (2003) Bioessays , vol.25 , pp. 1147-1149
    • Nilsen, T.W.1
  • 91
    • 8644278829 scopus 로고    scopus 로고
    • Identification of alternative splicing regulators by RNA interference in Drosophila
    • Park, J.W., Parisky, K., Celotto, A.M., Reenan, R.A., and Graveley, B.R. 2004. Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. 101: 15974-15979.
    • (2004) Proc. Natl. Acad. Sci , vol.101 , pp. 15974-15979
    • Park, J.W.1    Parisky, K.2    Celotto, A.M.3    Reenan, R.A.4    Graveley, B.R.5
  • 93
    • 34748855702 scopus 로고    scopus 로고
    • Rapid, transcript-specific changes in splicing in response to environmental stress
    • Pleiss, J.A., Whitworth, G.B., Bergkessel, M., and Guthrie, C. 2007a. Rapid, transcript-specific changes in splicing in response to environmental stress. Mol. Cell 27: 928-937.
    • (2007) Mol. Cell , vol.27 , pp. 928-937
    • Pleiss, J.A.1    Whitworth, G.B.2    Bergkessel, M.3    Guthrie, C.4
  • 94
    • 34247255773 scopus 로고    scopus 로고
    • Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components
    • doi: 10.1371/journal.pbio.0050090
    • Pleiss, J.A., Whitworth, G.B., Bergkessel, M., and Guthrie, C. 2007b. Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components. PLoS Biol. 5: e90. doi: 10.1371/journal.pbio.0050090.
    • (2007) PLoS Biol , vol.5
    • Pleiss, J.A.1    Whitworth, G.B.2    Bergkessel, M.3    Guthrie, C.4
  • 96
    • 0036237290 scopus 로고    scopus 로고
    • Positive and negative modulation of human immunodeficiency virus type 1 Rev function by cis and trans regulators of viral RNA splicing
    • Pongoski, J., Asai, K., and Cochrane, A. 2002. Positive and negative modulation of human immunodeficiency virus type 1 Rev function by cis and trans regulators of viral RNA splicing. J. Virol. 76: 5108-5120.
    • (2002) J. Virol , vol.76 , pp. 5108-5120
    • Pongoski, J.1    Asai, K.2    Cochrane, A.3
  • 97
    • 22544469467 scopus 로고    scopus 로고
    • Silencers regulate both constitutive and alternative splicing events in mammals
    • Pozzoli, U. and Sironi, M. 2005. Silencers regulate both constitutive and alternative splicing events in mammals. Cell. Mol. Life Sci. 62: 1579-1604.
    • (2005) Cell. Mol. Life Sci , vol.62 , pp. 1579-1604
    • Pozzoli, U.1    Sironi, M.2
  • 98
    • 19344374094 scopus 로고    scopus 로고
    • TREX, SR proteins and export of mRNA
    • Reed, R. and Cheng, H. 2005. TREX, SR proteins and export of mRNA. Curr. Opin. Cell Biol. 17: 269-273.
    • (2005) Curr. Opin. Cell Biol , vol.17 , pp. 269-273
    • Reed, R.1    Cheng, H.2
  • 99
    • 0025879563 scopus 로고
    • Regulation of Drosophila P element transposition
    • Rio, D.C. 1991. Regulation of Drosophila P element transposition. Trends Genet. 7: 282-287.
    • (1991) Trends Genet , vol.7 , pp. 282-287
    • Rio, D.C.1
  • 100
    • 0025098474 scopus 로고
    • Exon definition may facilitate splice site selection in RNAs with multiple exons
    • Robberson, B.L., Cote, G.J., and Berget, S.M. 1990. Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol. Cell. Biol. 10: 84-94.
    • (1990) Mol. Cell. Biol , vol.10 , pp. 84-94
    • Robberson, B.L.1    Cote, G.J.2    Berget, S.M.3
  • 101
    • 3142755891 scopus 로고    scopus 로고
    • MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb
    • Robson-Dixon, N.D. and Garcia-Blanco, M.A. 2004. MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb. J. Biol. Chem. 279: 29075-29084.
    • (2004) J. Biol. Chem , vol.279 , pp. 29075-29084
    • Robson-Dixon, N.D.1    Garcia-Blanco, M.A.2
  • 102
    • 0345276470 scopus 로고    scopus 로고
    • A conserved signal-responsive sequence mediates activationinduced alternative splicing of CD45
    • Rothrock, C., Cannon, B., Hahm, B., and Lynch, K.W. 2003. A conserved signal-responsive sequence mediates activationinduced alternative splicing of CD45. Mol. Cell 12: 1317-1324.
    • (2003) Mol. Cell , vol.12 , pp. 1317-1324
    • Rothrock, C.1    Cannon, B.2    Hahm, B.3    Lynch, K.W.4
  • 103
    • 23844471326 scopus 로고    scopus 로고
    • HnRNP L represses exon splicing via a regulated exonic splicing silencer
    • Rothrock, C.R., House, A.E., and Lynch, K.W. 2005. HnRNP L represses exon splicing via a regulated exonic splicing silencer. EMBO J. 24: 2792-2802.
    • (2005) EMBO J , vol.24 , pp. 2792-2802
    • Rothrock, C.R.1    House, A.E.2    Lynch, K.W.3
  • 104
    • 33947653234 scopus 로고    scopus 로고
    • Sequence features responsible for intron retention in human
    • doi: 10.1186/1471-2164-8-59
    • Sakabe, N.J. and de Souza, S.J. 2007. Sequence features responsible for intron retention in human. BMC Genomics 8: 59. doi: 10.1186/1471-2164-8-59.
    • (2007) BMC Genomics , vol.8 , pp. 59
    • Sakabe, N.J.1    de Souza, S.J.2
  • 105
    • 0032947182 scopus 로고    scopus 로고
    • Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA
    • Schaal, T.D. and Maniatis, T. 1999. Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Mol. Cell. Biol. 19: 261-273.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 261-273
    • Schaal, T.D.1    Maniatis, T.2
  • 106
    • 34250313662 scopus 로고    scopus 로고
    • Members of the heterogeneous nuclear ribonucleoprotein H family activate splicing of an HIV-1 splicing substrate by promoting formation of ATP-dependent spliceosomal complexes
    • Schaub, M.C., Lopez, S.R., and Caputi, M. 2007. Members of the heterogeneous nuclear ribonucleoprotein H family activate splicing of an HIV-1 splicing substrate by promoting formation of ATP-dependent spliceosomal complexes. J. Biol. Chem. 282: 13617-13626.
    • (2007) J. Biol. Chem , vol.282 , pp. 13617-13626
    • Schaub, M.C.1    Lopez, S.R.2    Caputi, M.3
  • 107
    • 23744484618 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein blocks the 5′ splice site-dependent assembly of U2AF and the prespliceosomal E complex
    • Sharma, S., Falick, A.M., and Black, D.L. 2005. Polypyrimidine tract binding protein blocks the 5′ splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol. Cell 19: 485-496.
    • (2005) Mol. Cell , vol.19 , pp. 485-496
    • Sharma, S.1    Falick, A.M.2    Black, D.L.3
  • 108
    • 41049106907 scopus 로고    scopus 로고
    • Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing
    • doi: 10.1371/journal.pone.0000854
    • Shaw, S.D., Chakrabarti, S., Ghosh, G., and Krainer, A.R. 2007. Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. PLoS ONE 2: e854. doi: 10.1371/journal.pone.0000854.
    • (2007) PLoS ONE , vol.2
    • Shaw, S.D.1    Chakrabarti, S.2    Ghosh, G.3    Krainer, A.R.4
  • 109
    • 33745609509 scopus 로고    scopus 로고
    • RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans
    • Shen, H. and Green, M.R. 2006. RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes & Dev. 20: 1755-1765.
    • (2006) Genes & Dev , vol.20 , pp. 1755-1765
    • Shen, H.1    Green, M.R.2
  • 110
    • 1242316952 scopus 로고    scopus 로고
    • Arginine-serine-rich domains bound at splicing enhancers contact the branch-point to promote prespliceosome assembly
    • Shen, H., Kan, J.L., and Green, M.R. 2004. Arginine-serine-rich domains bound at splicing enhancers contact the branch-point to promote prespliceosome assembly. Mol. Cell 13: 367-376.
    • (2004) Mol. Cell , vol.13 , pp. 367-376
    • Shen, H.1    Kan, J.L.2    Green, M.R.3
  • 111
    • 0036848091 scopus 로고    scopus 로고
    • The SR protein SRp38 represses splicing in M phase cells
    • Shin, C. and Manley, J.L. 2002. The SR protein SRp38 represses splicing in M phase cells. Cell 111: 407-417.
    • (2002) Cell , vol.111 , pp. 407-417
    • Shin, C.1    Manley, J.L.2
  • 112
    • 4444272979 scopus 로고    scopus 로고
    • Cell signalling and the control of prem-RNA splicing
    • Shin, C. and Manley, J.L. 2004. Cell signalling and the control of prem-RNA splicing. Nat. Rev. Mol. Cell Biol. 5: 727-738.
    • (2004) Nat. Rev. Mol. Cell Biol , vol.5 , pp. 727-738
    • Shin, C.1    Manley, J.L.2
  • 113
    • 1142310938 scopus 로고    scopus 로고
    • Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock
    • Shin, C., Feng, Y., and Manley, J.L. 2004. Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. Nature 427: 553-558.
    • (2004) Nature , vol.427 , pp. 553-558
    • Shin, C.1    Feng, Y.2    Manley, J.L.3
  • 114
    • 0026644140 scopus 로고
    • The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: Multiprotein complexes at an exon pseudo-5′ splice site control U1 snRNP binding
    • Siebel, C.W., Fresco, L.D., and Rio, D.C. 1992. The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: Multiprotein complexes at an exon pseudo-5′ splice site control U1 snRNP binding. Genes & Dev. 6: 1386-1401.
    • (1992) Genes & Dev , vol.6 , pp. 1386-1401
    • Siebel, C.W.1    Fresco, L.D.2    Rio, D.C.3
  • 115
    • 0028146254 scopus 로고
    • Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI
    • Siebel, C.W., Kanaar, R., and Rio, D.C. 1994. Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. Genes & Dev. 8: 1713-1725.
    • (1994) Genes & Dev , vol.8 , pp. 1713-1725
    • Siebel, C.W.1    Kanaar, R.2    Rio, D.C.3
  • 116
    • 0028914042 scopus 로고
    • Soma-specific expression and cloning of PSI, a negative regulator of P element premRNA splicing
    • Siebel, C.W., Admon, A., and Rio, D.C. 1995. Soma-specific expression and cloning of PSI, a negative regulator of P element premRNA splicing. Genes & Dev. 9: 269-283.
    • (1995) Genes & Dev , vol.9 , pp. 269-283
    • Siebel, C.W.1    Admon, A.2    Rio, D.C.3
  • 117
    • 32044445564 scopus 로고    scopus 로고
    • Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron
    • Singh, N.K., Singh, N.N., Androphy, E.J., and Singh, R.N. 2006. Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron. Mol. Cell. Biol. 26: 1333-1346.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 1333-1346
    • Singh, N.K.1    Singh, N.N.2    Androphy, E.J.3    Singh, R.N.4
  • 118
    • 0038486897 scopus 로고    scopus 로고
    • Intronic sequences flanking alternatively spliced exons are conserved between human and mouse
    • Sorek, R. and Ast, G. 2003. Intronic sequences flanking alternatively spliced exons are conserved between human and mouse. Genome Res. 13: 1631-1637.
    • (2003) Genome Res , vol.13 , pp. 1631-1637
    • Sorek, R.1    Ast, G.2
  • 120
    • 27944446829 scopus 로고    scopus 로고
    • Srinivasan, K., Shiue, L., Hayes, J.D., Centers, R., Fitzwater, S., Loewen, R., Edmondson, L.R., Bryant, J., Smith, M., Rommelfanger, C., et al. 2005. Detection and measurement of alternative splicing using splicing-sensitive microarrays. Methods 37: 345-359.
    • Srinivasan, K., Shiue, L., Hayes, J.D., Centers, R., Fitzwater, S., Loewen, R., Edmondson, L.R., Bryant, J., Smith, M., Rommelfanger, C., et al. 2005. Detection and measurement of alternative splicing using splicing-sensitive microarrays. Methods 37: 345-359.
  • 121
    • 33751361304 scopus 로고    scopus 로고
    • Inference of splicing regulatory activities by sequence neighborhood analysis
    • doi: 10.1371/journal.pgen.0020191
    • Stadler, M.B., Shomron, N., Yeo, G.W., Schneider, A., Xiao, X., and Burge, C.B. 2006. Inference of splicing regulatory activities by sequence neighborhood analysis. PLoS Genet. 2: e191. doi: 10.1371/journal.pgen.0020191.
    • (2006) PLoS Genet , vol.2
    • Stadler, M.B.1    Shomron, N.2    Yeo, G.W.3    Schneider, A.4    Xiao, X.5    Burge, C.B.6
  • 123
    • 33644913421 scopus 로고    scopus 로고
    • Role of viral splicing elements and cellular RNA binding proteins in regulation of HIV-1 alternative RNA splicing
    • Stoltzfus, C.M. and Madsen, J.M. 2006. Role of viral splicing elements and cellular RNA binding proteins in regulation of HIV-1 alternative RNA splicing. Curr. HIV Res. 4: 43-55.
    • (2006) Curr. HIV Res , vol.4 , pp. 43-55
    • Stoltzfus, C.M.1    Madsen, J.M.2
  • 125
    • 0033846543 scopus 로고    scopus 로고
    • Multiple splicing defects in an intronic false exon
    • Sun, H. and Chasin, L.A. 2000. Multiple splicing defects in an intronic false exon. Mol. Cell. Biol. 20: 6414-6425.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 6414-6425
    • Sun, H.1    Chasin, L.A.2
  • 126
    • 0028805223 scopus 로고
    • Selection of novel exon recognition elements from a pool of random sequences
    • Tian, H. and Kole, R. 1995. Selection of novel exon recognition elements from a pool of random sequences. Mol. Cell. Biol. 15: 6291-6298.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 6291-6298
    • Tian, H.1    Kole, R.2
  • 127
    • 33749262968 scopus 로고    scopus 로고
    • Genome-wide analysis of mRNAs bound to the histone stem-loop binding protein
    • Townley-Tilson, W.H., Pendergrass, S.A., Marzluff, W.F., and Whitfield, M.L. 2006. Genome-wide analysis of mRNAs bound to the histone stem-loop binding protein. RNA 12: 1853-1867.
    • (2006) RNA , vol.12 , pp. 1853-1867
    • Townley-Tilson, W.H.1    Pendergrass, S.A.2    Marzluff, W.F.3    Whitfield, M.L.4
  • 128
    • 0242497663 scopus 로고    scopus 로고
    • CLIP identifies Nova-regulated RNA networks in the brain
    • Ule, J., Jensen, K.B., Ruggiu, M., Mele, A., Ule, A., and Darnell, R.B. 2003. CLIP identifies Nova-regulated RNA networks in the brain. Science 302: 1212-1215.
    • (2003) Science , vol.302 , pp. 1212-1215
    • Ule, J.1    Jensen, K.B.2    Ruggiu, M.3    Mele, A.4    Ule, A.5    Darnell, R.B.6
  • 130
    • 27644455141 scopus 로고    scopus 로고
    • Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals
    • Underwood, J.G., Boutz, P.L., Dougherty, J.D., Stoilov, P., and Black, D.L. 2005. Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Mol. Cell. Biol. 25: 10005-10016.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 10005-10016
    • Underwood, J.G.1    Boutz, P.L.2    Dougherty, J.D.3    Stoilov, P.4    Black, D.L.5
  • 131
    • 34347379534 scopus 로고    scopus 로고
    • A comprehensive computational characterization of conserved mammalian intronic sequences reveals conserved motifs associated with constitutive and alternative splicing
    • Voelker, R.B. and Berglund, J.A. 2007. A comprehensive computational characterization of conserved mammalian intronic sequences reveals conserved motifs associated with constitutive and alternative splicing. Genome Res. 17: 1023-1033.
    • (2007) Genome Res , vol.17 , pp. 1023-1033
    • Voelker, R.B.1    Berglund, J.A.2
  • 133
    • 10944256767 scopus 로고    scopus 로고
    • Systematic identification and analysis of exonic splicing silencers
    • Wang, Z., Rolish, M.E., Yeo, G., Tung, V., Mawson, M., and Burge, C.B. 2004. Systematic identification and analysis of exonic splicing silencers. Cell 119: 831-845.
    • (2004) Cell , vol.119 , pp. 831-845
    • Wang, Z.1    Rolish, M.E.2    Yeo, G.3    Tung, V.4    Mawson, M.5    Burge, C.B.6
  • 134
    • 33745501015 scopus 로고    scopus 로고
    • General and specific functions of exonic splicing silencers in splicing control
    • Wang, Z., Xiao, X., Van Nostrand, E., and Burge, C.B. 2006. General and specific functions of exonic splicing silencers in splicing control. Mol. Cell 23: 61-70.
    • (2006) Mol. Cell , vol.23 , pp. 61-70
    • Wang, Z.1    Xiao, X.2    Van Nostrand, E.3    Burge, C.B.4
  • 135
    • 36248932588 scopus 로고    scopus 로고
    • MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T
    • Warf, M.B. and Berglund, J.A. 2007. MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T. RNA 13: 2238-2251.
    • (2007) RNA , vol.13 , pp. 2238-2251
    • Warf, M.B.1    Berglund, J.A.2
  • 136
    • 33645213731 scopus 로고    scopus 로고
    • Spliceosome structure and function
    • eds. R.F. Gesteland et al, pp, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Will, C. and Lührmann, R. 2007. Spliceosome structure and function. In The RNA world (eds. R.F. Gesteland et al.), pp. 369-400. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (2007) The RNA world , pp. 369-400
    • Will, C.1    Lührmann, R.2
  • 137
    • 36749057933 scopus 로고    scopus 로고
    • Coevolutionary networks of splicing cis-regulatory elements
    • Xiao, X., Wang, Z., Jang, M., and Burge, C.B. 2007. Coevolutionary networks of splicing cis-regulatory elements. Proc. Natl. Acad. Sci. 104: 18583-18588.
    • (2007) Proc. Natl. Acad. Sci , vol.104 , pp. 18583-18588
    • Xiao, X.1    Wang, Z.2    Jang, M.3    Burge, C.B.4
  • 138
    • 0035912224 scopus 로고    scopus 로고
    • A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels
    • Xie, J. and Black, D.L. 2001. A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels. Nature 410: 936-939.
    • (2001) Nature , vol.410 , pp. 936-939
    • Xie, J.1    Black, D.L.2
  • 140
    • 2442441507 scopus 로고    scopus 로고
    • Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals
    • Yeo, G. and Burge, C.B. 2004. Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals. J. Comput. Biol. 11: 377-394.
    • (2004) J. Comput. Biol , vol.11 , pp. 377-394
    • Yeo, G.1    Burge, C.B.2
  • 141
    • 8144225362 scopus 로고    scopus 로고
    • Variation in sequence and organization of splicing regulatory elements in vertebrate genes
    • Yeo, G., Hoon, S., Venkatesh, B., and Burge, C.B. 2004. Variation in sequence and organization of splicing regulatory elements in vertebrate genes. Proc. Natl. Acad. Sci. 101: 15700-15705.
    • (2004) Proc. Natl. Acad. Sci , vol.101 , pp. 15700-15705
    • Yeo, G.1    Hoon, S.2    Venkatesh, B.3    Burge, C.B.4
  • 142
    • 14544277546 scopus 로고    scopus 로고
    • Identification and analysis of alternative splicing events conserved in human and mouse
    • Yeo, G.W., Van Nostrand, E., Holste, D., Poggio, T., and Burge, C.B. 2005. Identification and analysis of alternative splicing events conserved in human and mouse. Proc. Natl. Acad. Sci. 102: 2850-2855.
    • (2005) Proc. Natl. Acad. Sci , vol.102 , pp. 2850-2855
    • Yeo, G.W.1    Van Nostrand, E.2    Holste, D.3    Poggio, T.4    Burge, C.B.5
  • 143
    • 34249696543 scopus 로고    scopus 로고
    • Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements
    • doi: 10.1371/journal.pgen.0030085
    • Yeo, G.W., Nostrand, E.L., and Liang, T.Y. 2007. Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements. PLoS Genet. 3: e85. doi: 10.1371/journal.pgen.0030085.
    • (2007) PLoS Genet , vol.3
    • Yeo, G.W.1    Nostrand, E.L.2    Liang, T.Y.3
  • 144
    • 2642525438 scopus 로고    scopus 로고
    • Computational definition of sequence motifs governing constitutive exon splicing
    • Zhang, X.H. and Chasin, L.A. 2004. Computational definition of sequence motifs governing constitutive exon splicing. Genes & Dev. 18: 1241-1250.
    • (2004) Genes & Dev , vol.18 , pp. 1241-1250
    • Zhang, X.H.1    Chasin, L.A.2
  • 145
    • 1842635464 scopus 로고    scopus 로고
    • Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression
    • Zheng, Z.M. 2004. Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. J. Biomed. Sci. 11: 278-294.
    • (2004) J. Biomed. Sci , vol.11 , pp. 278-294
    • Zheng, Z.M.1
  • 146
    • 0037068447 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of the human spliceosome
    • Zhou, Z., Licklider, L.J., Gygi, S.P., and Reed, R. 2002. Comprehensive proteomic analysis of the human spliceosome. Nature 419: 182-185.
    • (2002) Nature , vol.419 , pp. 182-185
    • Zhou, Z.1    Licklider, L.J.2    Gygi, S.P.3    Reed, R.4
  • 147
    • 0035691667 scopus 로고    scopus 로고
    • Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins
    • Zhu, J., Mayeda, A., and Krainer, A.R. 2001. Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Mol. Cell 8: 1351-1361.
    • (2001) Mol. Cell , vol.8 , pp. 1351-1361
    • Zhu, J.1    Mayeda, A.2    Krainer, A.R.3


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