Both catalytic steps of nuclear pre-mRNA splicing are reversible

Science

Volumn 320, Issue 5884, 2008, Pages 1782-1784

  Tseng, Chi Kang ^a,b   Cheng, Soo Chen ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR RNA; RIBONUCLEOPROTEIN;

CATALYSIS; EUKARYOTE; FUNGUS; GENE; PROTEIN; RNA;

ARTICLE; CATALYSIS; HYDROLYSIS; INTRON; PRIORITY JOURNAL; RNA SPLICING; SPLICEOSOME; TITRIMETRY; TRANSESTERIFICATION;

CATALYSIS; CATIONS, DIVALENT; CELL NUCLEUS; DEAD-BOX RNA HELICASES; ESTERIFICATION; EXONS; INTRONS; POTASSIUM CHLORIDE; RNA PRECURSORS; RNA SPLICING; RNA, FUNGAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPLICEOSOMES;

EUKARYOTA; FUNGI;

EID: 46449086933     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1158993     Document Type: Article

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16. We are grateful to T. Nilsen for critical comments and help on the manuscript. We also thank M. M. Konarska and C. Query for reading the manuscript and H. Wilson for English editing. This work was supported by a grant from Academia Sinica and National Science Council (Taiwan) grant NSC95-2321-B-001- 014.