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Volumn 17, Issue 9, 2010, Pages 1114-1123

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

Author keywords

[No Author keywords available]

Indexed keywords

POLYPYRIMIDINE TRACT BINDING PROTEIN; PYRIMIDINE;

EID: 77956342570     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1881     Document Type: Article
Times cited : (207)

References (70)
  • 1
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches
    • Chen, M. & Manley, J.L. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat. Rev. Mol. Cell Biol. 10, 741-754 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 2
    • 18344364099 scopus 로고    scopus 로고
    • Understanding alternative splicing: Towards a cellular code
    • Matlin, A.J., Clark, F. & Smith, C.W. Understanding alternative splicing: towards a cellular code. Nat. Rev. Mol. Cell Biol. 6, 386-398 (2005).
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 386-398
    • Matlin, A.J.1    Clark, F.2    Smith, C.W.3
  • 3
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: New insights from global analyses
    • Blencowe, B.J. Alternative splicing: new insights from global analyses. Cell 126, 37-47 (2006).
    • (2006) Cell , vol.126 , pp. 37-47
    • Blencowe, B.J.1
  • 4
    • 42449098125 scopus 로고    scopus 로고
    • Splicing regulation: From a parts list of regulatory elements to an integrated splicing code
    • Wang, Z. & Burge, C.B. Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA 14, 802-813 (2008).
    • (2008) RNA , vol.14 , pp. 802-813
    • Wang, Z.1    Burge, C.B.2
  • 5
    • 77952029221 scopus 로고    scopus 로고
    • Deciphering the splicing code
    • Barash, Y. et al. Deciphering the splicing code. Nature 465, 53-59 (2010).
    • (2010) Nature , vol.465 , pp. 53-59
    • Barash, Y.1
  • 6
    • 56749164864 scopus 로고    scopus 로고
    • Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines
    • Castle, J.C. et al. Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nat. Genet. 40, 1416-1425 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 1416-1425
    • Castle, J.C.1
  • 7
    • 58149492467 scopus 로고    scopus 로고
    • A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
    • Kalsotra, A. et al. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc. Natl. Acad. Sci. USA 105, 20333-20338 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 20333-20338
    • Kalsotra, A.1
  • 8
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang, E.T. et al. Alternative isoform regulation in human tissue transcriptomes. Nature 456, 470-476 (2008).
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1
  • 9
    • 0035038207 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein antagonizes exon defnition
    • Wagner, E.J. & Garcia-Blanco, M.A. Polypyrimidine tract binding protein antagonizes exon defnition. Mol. Cell. Biol. 21, 3281-3288 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3281-3288
    • Wagner, E.J.1    Garcia-Blanco, M.A.2
  • 10
    • 32344437827 scopus 로고    scopus 로고
    • Novel modes of splicing repression by PTB
    • Spellman, R. & Smith, C.W. Novel modes of splicing repression by PTB. Trends Biochem. Sci. 31, 73-76 (2006).
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 73-76
    • Spellman, R.1    Smith, C.W.2
  • 11
    • 49349112872 scopus 로고    scopus 로고
    • Polypyrimidine-tract-binding protein: A multifunctional RNA-binding protein
    • Sawicka, K., Bushell, M., Spriggs, K.A. & Willis, A.E. Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein. Biochem. Soc. Trans. 36, 641-647 (2008).
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 641-647
    • Sawicka, K.1    Bushell, M.2    Spriggs, K.A.3    Willis, A.E.4
  • 12
    • 25444486174 scopus 로고    scopus 로고
    • Structure of PTB bound to RNA: Specifc binding and implications for splicing regulation
    • Oberstrass, F.C. et al. Structure of PTB bound to RNA: specifc binding and implications for splicing regulation. Science 309, 2054-2057 (2005).
    • (2005) Science , vol.309 , pp. 2054-2057
    • Oberstrass, F.C.1
  • 13
    • 0041372953 scopus 로고    scopus 로고
    • Multiple RRMs contribute to RNA binding specifcity and affnity for polypyrimidine tract binding protein
    • Perez, I., McAfee, J.G. & Patton, J.G. Multiple RRMs contribute to RNA binding specifcity and affnity for polypyrimidine tract binding protein. Biochemistry 36, 11881-11890 (1997).
    • (1997) Biochemistry , vol.36 , pp. 11881-11890
    • Perez, I.1    McAfee, J.G.2    Patton, J.G.3
  • 14
    • 73249131626 scopus 로고    scopus 로고
    • Next-generation SELEX identifes sequence and structural determinants of splicing factor binding in human pre-mRNA sequence
    • Reid, D.C. et al. Next-generation SELEX identifes sequence and structural determinants of splicing factor binding in human pre-mRNA sequence. RNA 15, 2385-2397 (2009).
    • (2009) RNA , vol.15 , pp. 2385-2397
    • Reid, D.C.1
  • 16
    • 0030777180 scopus 로고    scopus 로고
    • A neuron-specifc splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specifc PTB counterpart
    • Ashiya, M. & Grabowski, P.J. A neuron-specifc splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specifc PTB counterpart. RNA 3, 996-1015 (1997).
    • (1997) RNA , vol.3 , pp. 996-1015
    • Ashiya, M.1    Grabowski, P.J.2
  • 17
    • 0031985529 scopus 로고    scopus 로고
    • Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated α-tropomyosin exon
    • Gooding, C., Roberts, G.C. & Smith, C.W. Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated α-tropomyosin exon. RNA 4, 85-100 (1998).
    • (1998) RNA , vol.4 , pp. 85-100
    • Gooding, C.1    Roberts, G.C.2    Smith, C.W.3
  • 18
    • 0030878682 scopus 로고    scopus 로고
    • Mutation of PTB binding sites causes misregulation of alternative 3′ splice site selection in vivo
    • Perez, I., Lin, C.H., McAfee, J.G. & Patton, J.G. Mutation of PTB binding sites causes misregulation of alternative 3′ splice site selection in vivo. RNA 3, 764-778 (1997).
    • (1997) RNA , vol.3 , pp. 764-778
    • Perez, I.1    Lin, C.H.2    McAfee, J.G.3    Patton, J.G.4
  • 19
    • 0029295295 scopus 로고
    • Regulation of alternative 3′ splice site selection by constitutive splicing factors
    • Lin, C.H. & Patton, J.G. Regulation of alternative 3′ splice site selection by constitutive splicing factors. RNA 1, 234-245 (1995).
    • (1995) RNA , vol.1 , pp. 234-245
    • Lin, C.H.1    Patton, J.G.2
  • 20
    • 0029055472 scopus 로고
    • Distinct binding specifcities and functions of higher eukaryotic polypyrimidine tract-binding proteins
    • Singh, R., Valcarcel, J. & Green, M.R. Distinct binding specifcities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science 268, 1173-1176 (1995).
    • (1995) Science , vol.268 , pp. 1173-1176
    • Singh, R.1    Valcarcel, J.2    Green, M.R.3
  • 21
    • 23744492690 scopus 로고    scopus 로고
    • Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon defnition
    • Izquierdo, J.M. et al. Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon defnition. Mol. Cell 19, 475-484 (2005).
    • (2005) Mol. Cell , vol.19 , pp. 475-484
    • Izquierdo, J.M.1
  • 22
    • 23744484618 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein blocks the 5′ splice site-dependent assembly of U2AF and the prespliceosomal e complex
    • Sharma, S., Falick, A.M. & Black, D.L. Polypyrimidine tract binding protein blocks the 5′ splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol. Cell 19, 485-496 (2005).
    • (2005) Mol. Cell , vol.19 , pp. 485-496
    • Sharma, S.1    Falick, A.M.2    Black, D.L.3
  • 23
    • 38849187162 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein controls the transition from exon defnition to an intron defned spliceosome
    • Sharma, S., Kohlstaedt, L.A., Damianov, A., Rio, D.C. & Black, D.L. Polypyrimidine tract binding protein controls the transition from exon defnition to an intron defned spliceosome. Nat. Struct. Mol. Biol. 15, 183-191 (2008).
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 183-191
    • Sharma, S.1    Kohlstaedt, L.A.2    Damianov, A.3    Rio, D.C.4    Black, D.L.5
  • 24
    • 0033634948 scopus 로고    scopus 로고
    • Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specifc splicing
    • Chou, M.Y., Underwood, J.G., Nikolic, J., Luu, M.H. & Black, D.L. Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specifc splicing. Mol. Cell 5, 949-957 (2000).
    • (2000) Mol. Cell , vol.5 , pp. 949-957
    • Chou, M.Y.1    Underwood, J.G.2    Nikolic, J.3    Luu, M.H.4    Black, D.L.5
  • 25
    • 34447536429 scopus 로고    scopus 로고
    • Repression of α-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract
    • Matlin, A.J., Southby, J., Gooding, C. & Smith, C.W. Repression of α-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract. RNA 13, 1214-1223 (2007).
    • (2007) RNA , vol.13 , pp. 1214-1223
    • Matlin, A.J.1    Southby, J.2    Gooding, C.3    Smith, C.W.4
  • 26
    • 33644861782 scopus 로고    scopus 로고
    • A splicing repressor domain in polypyrimidine tract-binding protein
    • Robinson, F. & Smith, C.W. A splicing repressor domain in polypyrimidine tract-binding protein. J. Biol. Chem. 281, 800-806 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 800-806
    • Robinson, F.1    Smith, C.W.2
  • 27
    • 34347384211 scopus 로고    scopus 로고
    • A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
    • Boutz, P.L. et al. A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev. 21, 1636-1652 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1636-1652
    • Boutz, P.L.1
  • 28
    • 48149096726 scopus 로고    scopus 로고
    • MADS: A new and improved method for analysis of differential alternative splicing by exon-tiling microarrays
    • Xing, Y. et al. MADS: a new and improved method for analysis of differential alternative splicing by exon-tiling microarrays. RNA 14, 1470-1479 (2008).
    • (2008) RNA , vol.14 , pp. 1470-1479
    • Xing, Y.1
  • 29
    • 0032938851 scopus 로고    scopus 로고
    • Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3′-terminal exon
    • Lou, H., Helfman, D.M., Gagel, R.F. & Berget, S.M. Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3′-terminal exon. Mol. Cell. Biol. 19, 78-85 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 78-85
    • Lou, H.1    Helfman, D.M.2    Gagel, R.F.3    Berget, S.M.4
  • 30
    • 34447525136 scopus 로고    scopus 로고
    • HnRNP I/PTB can antagonize the splicing repressor activity of SRp30c
    • Paradis, C. et al. hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c. RNA 13, 1287-1300 (2007).
    • (2007) RNA , vol.13 , pp. 1287-1300
    • Paradis, C.1
  • 31
    • 72149117411 scopus 로고    scopus 로고
    • Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping
    • Xue, Y. et al. Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol. Cell 36, 996-1006 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 996-1006
    • Xue, Y.1
  • 32
    • 33749056769 scopus 로고    scopus 로고
    • An RNA map predicting Nova-dependent splicing regulation
    • Ule, J. et al. An RNA map predicting Nova-dependent splicing regulation. Nature 444, 580-586 (2006).
    • (2006) Nature , vol.444 , pp. 580-586
    • Ule, J.1
  • 33
    • 67349097457 scopus 로고    scopus 로고
    • Cancer-associated regulation of alternative splicing
    • Venables, J.P. et al. Cancer-associated regulation of alternative splicing. Nat. Struct. Mol. Biol. 16, 670-676 (2009).
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 670-676
    • Venables, J.P.1
  • 34
    • 59649107040 scopus 로고    scopus 로고
    • An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
    • Yeo, G.W. et al. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat. Struct. Mol. Biol. 16, 130-137 (2009).
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 130-137
    • Yeo, G.W.1
  • 35
    • 51949111100 scopus 로고    scopus 로고
    • Defning the regulatory network of the tissue-specifc splicing factors Fox-1 and Fox-2
    • Zhang, C. et al. Defning the regulatory network of the tissue-specifc splicing factors Fox-1 and Fox-2. Genes Dev. 22, 2550-2563 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 2550-2563
    • Zhang, C.1
  • 36
    • 76249102027 scopus 로고    scopus 로고
    • Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy
    • Du, H. et al. Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy. Nat. Struct. Mol. Biol. 17, 187-193 (2010).
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 187-193
    • Du, H.1
  • 37
    • 34547205013 scopus 로고    scopus 로고
    • Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1
    • Spellman, R., Llorian, M. & Smith, C.W. Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1. Mol. Cell 27, 420-434 (2007).
    • (2007) Mol. Cell , vol.27 , pp. 420-434
    • Spellman, R.1    Llorian, M.2    Smith, C.W.3
  • 38
    • 65349168979 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis
    • Yamamoto, M.L. et al. Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis. Blood 113, 3363-3370 (2009).
    • (2009) Blood , vol.113 , pp. 3363-3370
    • Yamamoto, M.L.1
  • 39
    • 34547632484 scopus 로고    scopus 로고
    • Discovery of tissue-specifc exons using comprehensive human exon microarrays
    • Clark, T.A. et al. Discovery of tissue-specifc exons using comprehensive human exon microarrays. Genome Biol. 8, R64 (2007).
    • (2007) Genome Biol. , vol.8
    • Clark, T.A.1
  • 40
    • 26244462463 scopus 로고    scopus 로고
    • Alternative splicing-when two's a crowd
    • Smith, C.W. Alternative splicing-when two's a crowd. Cell 123, 1-3 (2005).
    • (2005) Cell , vol.123 , pp. 1-3
    • Smith, C.W.1
  • 41
    • 0037064145 scopus 로고    scopus 로고
    • Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts
    • Mendell, J.T., ap Rhys, C.M. & Dietz, H.C. Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. Science 298, 419-422 (2002).
    • (2002) Science , vol.298 , pp. 419-422
    • Mendell, J.T.1    Ap Rhys, C.M.2    Dietz, H.C.3
  • 42
    • 33846067524 scopus 로고    scopus 로고
    • PANTHER version 6: Protein sequence and function evolution data with expanded representation of biological pathways
    • Mi, H., Guo, N., Kejariwal, A. & Thomas, P.D. PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways. Nucleic Acids Res. 35, D247-D252 (2007).
    • (2007) Nucleic Acids Res. , vol.35
    • Mi, H.1    Guo, N.2    Kejariwal, A.3    Thomas, P.D.4
  • 43
    • 34547212309 scopus 로고    scopus 로고
    • The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specifc alternative pre-mRNA splicing
    • Makeyev, E.V., Zhang, J., Carrasco, M.A. & Maniatis, T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specifc alternative pre-mRNA splicing. Mol. Cell 27, 435-448 (2007).
    • (2007) Mol. Cell , vol.27 , pp. 435-448
    • Makeyev, E.V.1    Zhang, J.2    Carrasco, M.A.3    Maniatis, T.4
  • 44
    • 23044431574 scopus 로고    scopus 로고
    • Nova regulates brain-specifc splicing to shape the synapse
    • Ule, J. et al. Nova regulates brain-specifc splicing to shape the synapse. Nat. Genet. 37, 844-852 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 844-852
    • Ule, J.1
  • 45
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk, H.R. et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233 (2008).
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1
  • 46
    • 47849097478 scopus 로고    scopus 로고
    • Alternative splicing in colon, bladder, and prostate cancer identifed by exon array analysis
    • Thorsen, K. et al. Alternative splicing in colon, bladder, and prostate cancer identifed by exon array analysis. Mol. Cell. Proteomics 7, 1214-1224 (2008).
    • (2008) Mol. Cell. Proteomics , vol.7 , pp. 1214-1224
    • Thorsen, K.1
  • 47
    • 34547489950 scopus 로고    scopus 로고
    • Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro
    • He, X. et al. Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene 26, 4961-4968 (2007).
    • (2007) Oncogene , vol.26 , pp. 4961-4968
    • He, X.1
  • 48
    • 50649091392 scopus 로고    scopus 로고
    • Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner
    • Wang, C. et al. Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner. J. Biol. Chem. 283, 20277-20287 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 20277-20287
    • Wang, C.1
  • 49
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • David, C.J., Chen, M., Assanah, M., Cannoll, P. & Manley, J.L. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463, 364-368 (2010).
    • (2010) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3    Cannoll, P.4    Manley, J.L.5
  • 50
    • 33745048938 scopus 로고    scopus 로고
    • A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones
    • Gooding, C. et al. A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones. Genome Biol. 7, R1 (2006).
    • (2006) Genome Biol. , vol.7
    • Gooding, C.1
  • 51
    • 77952306763 scopus 로고    scopus 로고
    • MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing
    • Goers, E.S., Purcell, J., Voelker, R.B., Gates, D.P. & Berglund, J.A. MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing. Nucleic Acids Res. 38, 2467-2484 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. 2467-2484
    • Goers, E.S.1    Purcell, J.2    Voelker, R.B.3    Gates, D.P.4    Berglund, J.A.5
  • 52
    • 0037450704 scopus 로고    scopus 로고
    • A vertebrate RNA-binding protein Fox-1 regulates tissue-specifc splicing via the pentanucleotide GCAUG
    • Jin, Y. et al. A vertebrate RNA-binding protein Fox-1 regulates tissue-specifc splicing via the pentanucleotide GCAUG. EMBO J. 22, 905-912 (2003).
    • (2003) EMBO J. , vol.22 , pp. 905-912
    • Jin, Y.1
  • 53
    • 12844278103 scopus 로고    scopus 로고
    • Identifcation of putative new splicing targets for ETR-3 using sequences identifed by systematic evolution of ligands by exponential enrichment
    • Faustino, N.A. & Cooper, T.A. Identifcation of putative new splicing targets for ETR-3 using sequences identifed by systematic evolution of ligands by exponential enrichment. Mol. Cell. Biol. 25, 879-887 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 879-887
    • Faustino, N.A.1    Cooper, T.A.2
  • 54
    • 33745207758 scopus 로고    scopus 로고
    • Comparative analysis identifes exonic splicing regulatory sequences-the complex defnition of enhancers and silencers
    • Goren, A. et al. Comparative analysis identifes exonic splicing regulatory sequences-the complex defnition of enhancers and silencers. Mol. Cell 22, 769-781 (2006).
    • (2006) Mol. Cell , vol.22 , pp. 769-781
    • Goren, A.1
  • 55
    • 0036810248 scopus 로고    scopus 로고
    • RNAi-mediated PTB depletion leads to enhanced exon defnition
    • Wagner, E.J. & Garcia-Blanco, M.A. RNAi-mediated PTB depletion leads to enhanced exon defnition. Mol. Cell 10, 943-949 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 943-949
    • Wagner, E.J.1    Garcia-Blanco, M.A.2
  • 56
    • 0032962535 scopus 로고    scopus 로고
    • HnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer
    • Del Gatto-Konczak, F., Olive, M., Gesnel, M.C. & Breathnach, R. hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer. Mol. Cell. Biol. 19, 251-260 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 251-260
    • Del Gatto-Konczak, F.1    Olive, M.2    Gesnel, M.C.3    Breathnach, R.4
  • 57
    • 34548133209 scopus 로고    scopus 로고
    • Downstream intronic splicing enhancers
    • Venables, J.P. Downstream intronic splicing enhancers. FEBS Lett. 581, 4127-4131 (2007).
    • (2007) FEBS Lett. , vol.581 , pp. 4127-4131
    • Venables, J.P.1
  • 58
    • 0037121924 scopus 로고    scopus 로고
    • The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5′ splice sites
    • Forch, P., Puig, O., Martinez, C., Seraphin, B. & Valcarcel, J. The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5′ splice sites. EMBO J. 21, 6882-6892 (2002).
    • (2002) EMBO J. , vol.21 , pp. 6882-6892
    • Forch, P.1    Puig, O.2    Martinez, C.3    Seraphin, B.4    Valcarcel, J.5
  • 59
    • 33748372311 scopus 로고    scopus 로고
    • A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain
    • Rideau, A.P. et al. A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain. Nat. Struct. Mol. Biol. 13, 839-848 (2006).
    • (2006) Nat. Struct. Mol. Biol. , vol.13 , pp. 839-848
    • Rideau, A.P.1
  • 60
    • 0346124413 scopus 로고    scopus 로고
    • Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay
    • Wollerton, M.C., Gooding, C., Wagner, E.J., Garcia-Blanco, M.A. & Smith, C.W. Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay. Mol. Cell 13, 91-100 (2004).
    • (2004) Mol. Cell , vol.13 , pp. 91-100
    • Wollerton, M.C.1    Gooding, C.2    Wagner, E.J.3    Garcia-Blanco, M.A.4    Smith, C.W.5
  • 61
    • 58149094780 scopus 로고    scopus 로고
    • A nonsense exon in the Tpm1 gene is silenced by hnRNP H and F
    • Coles, J.L., Hallegger, M. & Smith, C.W. A nonsense exon in the Tpm1 gene is silenced by hnRNP H and F. RNA 15, 33-43 (2009).
    • (2009) RNA , vol.15 , pp. 33-43
    • Coles, J.L.1    Hallegger, M.2    Smith, C.W.3
  • 62
    • 0033052101 scopus 로고    scopus 로고
    • Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA
    • Hunt, S.L. & Jackson, R.J. Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA. RNA 5, 344-359 (1999).
    • (1999) RNA , vol.5 , pp. 344-359
    • Hunt, S.L.1    Jackson, R.J.2
  • 63
    • 4344627862 scopus 로고    scopus 로고
    • Regulated tissue-specific alternative splicing of enhanced green fluorescent protein transgenes conferred by α-tropomyosin regulatory elements in transgenic mice
    • Ellis, P.D., Smith, C.W. & Kemp, P. Regulated tissue-specific alternative splicing of enhanced green fluorescent protein transgenes conferred by α-tropomyosin regulatory elements in transgenic mice. J. Biol. Chem. 279, 36660-36669 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 36660-36669
    • Ellis, P.D.1    Smith, C.W.2    Kemp, P.3
  • 64
    • 63549096870 scopus 로고    scopus 로고
    • Alu exonization events reveal features required for precise recognition of exons by the splicing machinery
    • Schwartz, S. et al. Alu exonization events reveal features required for precise recognition of exons by the splicing machinery. PLOS Comput. Biol. 5, e1000300 (2009).
    • (2009) PLOS Comput. Biol. , vol.5
    • Schwartz, S.1
  • 65
    • 0023651307 scopus 로고
    • RNA splice junctions of different classes of eukaryotes: Sequence statistics and functional implications in gene expression
    • Shapiro, M.B. & Senapathy, P. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 15, 7155-7174 (1987).
    • (1987) Nucleic Acids Res. , vol.15 , pp. 7155-7174
    • Shapiro, M.B.1    Senapathy, P.2
  • 66
    • 1942469356 scopus 로고    scopus 로고
    • Comparative analysis detects dependencies among the 5′ splice-site positions
    • Carmel, I., Tal, S., Vig, I. & Ast, G. Comparative analysis detects dependencies among the 5′ splice-site positions. RNA 10, 828-840 (2004).
    • (2004) RNA , vol.10 , pp. 828-840
    • Carmel, I.1    Tal, S.2    Vig, I.3    Ast, G.4
  • 67
    • 2442441507 scopus 로고    scopus 로고
    • Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals
    • Yeo, G. & Burge, C.B. Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals. J. Comput. Biol. 11, 377-394 (2004).
    • (2004) J. Comput. Biol. , vol.11 , pp. 377-394
    • Yeo, G.1    Burge, C.B.2
  • 68
    • 38049029652 scopus 로고    scopus 로고
    • Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes
    • Schwartz, S.H. et al. Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes. Genome Res. 18, 88-103 (2008).
    • (2008) Genome Res. , vol.18 , pp. 88-103
    • Schwartz, S.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.