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Volumn 32, Issue , 1998, Pages 279-305

Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation

Author keywords

Doublesex; PTB; Sex lethal; SR proteins; U2AF

Indexed keywords

MESSENGER RNA PRECURSOR;

EID: 0032435862     PISSN: 00664197     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genet.32.1.279     Document Type: Review
Times cited : (545)

References (149)
  • 1
    • 0030911051 scopus 로고    scopus 로고
    • Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals
    • Abovich N, Rosbash M. 1997. Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89:403-12
    • (1997) Cell , vol.89 , pp. 403-412
    • Abovich, N.1    Rosbash, M.2
  • 3
    • 0031033741 scopus 로고    scopus 로고
    • The alternative splicing factor PSI regulates P-element third intron splicing in vivo
    • Adams MD, Tarng RS, Rio DC. 1997. The alternative splicing factor PSI regulates P-element third intron splicing in vivo. Genes Dev. 11:129-38
    • (1997) Genes Dev. , vol.11 , pp. 129-138
    • Adams, M.D.1    Tarng, R.S.2    Rio, D.C.3
  • 4
    • 0027315258 scopus 로고
    • The Drosophila sex determination gene snf is utilized for the establishment of the female-specific splicing of Sex lethal
    • Albrecht EB, Salz HK. 1993. The Drosophila sex determination gene snf is utilized for the establishment of the female-specific splicing of Sex lethal. Genetics 134:801-7
    • (1993) Genetics , vol.134 , pp. 801-807
    • Albrecht, E.B.1    Salz, H.K.2
  • 5
    • 0024255702 scopus 로고
    • The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein
    • Amrein H, Gorman, M, Nöthiger R. 1988. The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Cell 55:1025-35
    • (1988) Cell , vol.55 , pp. 1025-1035
    • Amrein, H.1    Gorman, M.2    Nöthiger, R.3
  • 6
    • 0030777180 scopus 로고    scopus 로고
    • A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein
    • Ashiya M, Grabowski PJ. 1997. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein. RNA 3:996-1015
    • (1997) RNA , vol.3 , pp. 996-1015
    • Ashiya, M.1    Grabowski, P.J.2
  • 7
    • 0345073486 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 8
    • 0032571313 scopus 로고    scopus 로고
    • Differential muscle-type expression of the Drosophila troponin T gene. A 3 base pair microexon is involved in visceral and adult hypodermic muscle specification
    • Benoist P, Mas JA, Marco R, Cervera M. 1998. Differential muscle-type expression of the Drosophila troponin T gene. A 3 base pair microexon is involved in visceral and adult hypodermic muscle specification. J. Biol. Chem. 273:7538-46
    • (1998) J. Biol. Chem. , vol.273 , pp. 7538-7546
    • Benoist, P.1    Mas, J.A.2    Marco, R.3    Cervera, M.4
  • 9
    • 0028895417 scopus 로고
    • Exon recognition in vertebrate splicing
    • Berget SM. 1995. Exon recognition in vertebrate splicing. J. Biol. Chem. 270: 2411-14
    • (1995) J. Biol. Chem. , vol.270 , pp. 2411-2414
    • Berget, S.M.1
  • 10
    • 0030696675 scopus 로고    scopus 로고
    • The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC
    • Berglund JA, Chua K, Abovich N, Reed R, Rosbash M. 1997. The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Cell 89:781-87
    • (1997) Cell , vol.89 , pp. 781-787
    • Berglund, J.A.1    Chua, K.2    Abovich, N.3    Reed, R.4    Rosbash, M.5
  • 11
    • 0028870384 scopus 로고
    • Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing
    • Bernstein M, Lersch RA, Subramanyan L, Cline TW. 1995. Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing. Genetics 139:631-48
    • (1995) Genetics , vol.139 , pp. 631-648
    • Bernstein, M.1    Lersch, R.A.2    Subramanyan, L.3    Cline, T.W.4
  • 12
    • 0026062392 scopus 로고
    • Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?
    • Black DL. 1991. Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells? Genes Dev. 5:389-402
    • (1991) Genes Dev. , vol.5 , pp. 389-402
    • Black, D.L.1
  • 13
    • 0026748223 scopus 로고
    • Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro
    • Black DL. 1992. Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro. Cell 69:795-807
    • (1992) Cell , vol.69 , pp. 795-807
    • Black, D.L.1
  • 14
    • 0029382603 scopus 로고
    • Finding splice sites within a wilderness of RNA
    • Black DL. 1995. Finding splice sites within a wilderness of RNA. RNA 1:763-71
    • (1995) RNA , vol.1 , pp. 763-771
    • Black, D.L.1
  • 15
    • 0023667001 scopus 로고
    • Regulation of sexual differentiation in D. Melanogaster via alternative splicing of RNA from the transformer gene
    • Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M. 1987. Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene. Cell 50:739-47
    • (1987) Cell , vol.50 , pp. 739-747
    • Boggs, R.T.1    Gregor, P.2    Idriss, S.3    Belote, J.M.4    McKeown, M.5
  • 16
    • 0027282044 scopus 로고
    • bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
    • Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, et al. 1993. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608
    • (1993) Cell , vol.74 , pp. 597-608
    • Boise, L.H.1    Gonzalez-Garcia, M.2    Postema, C.E.3    Ding, L.4    Lindsten, T.5
  • 17
    • 0028205863 scopus 로고
    • Evolutionary conservation of the structure and expression of alternatively spliced Ultra-bithorax isoforms from Drosophila
    • Bomze HM, Lopez AJ. 1994. Evolutionary conservation of the structure and expression of alternatively spliced Ultra-bithorax isoforms from Drosophila. Genetics 136:965-77
    • (1994) Genetics , vol.136 , pp. 965-977
    • Bomze, H.M.1    Lopez, A.J.2
  • 18
    • 0026036279 scopus 로고
    • Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster
    • Bopp D, Bell LR, Cline TW, Schedl P. 1991. Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster. Genes Dev. 5:403-15
    • (1991) Genes Dev. , vol.5 , pp. 403-415
    • Bopp, D.1    Bell, L.R.2    Cline, T.W.3    Schedl, P.4
  • 19
    • 0027242285 scopus 로고
    • Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis
    • Bopp D, Horabin JI, Lersch RA, Cline TW, Schedl P. 1993. Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis. Development 118:797-812
    • (1993) Development , vol.118 , pp. 797-812
    • Bopp, D.1    Horabin, J.I.2    Lersch, R.A.3    Cline, T.W.4    Schedl, P.5
  • 20
    • 0026864939 scopus 로고
    • Germline intronic and exonic mutations in the Wilm's tumour gene (WT1) affecting urogenital development
    • Bruening W, Bardeesy N, Silverman BL, Cohn RA, Machin, et al. 1992. Germline intronic and exonic mutations in the Wilm's tumour gene (WT1) affecting urogenital development. Nat. Genet. 1:144-48
    • (1992) Nat. Genet. , vol.1 , pp. 144-148
    • Bruening, W.1    Bardeesy, N.2    Silverman, B.L.3    Cohn, R.A.4    Machin5
  • 21
    • 0029093742 scopus 로고
    • Enhancer dependent interaction between 5′ and 3′ splice sites in trans
    • Bruzik J, Maniatis T. 1995. Enhancer dependent interaction between 5′ and 3′ splice sites in trans. Proc. Natl. Acad. Sci. USA 92:7056-59
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7056-7059
    • Bruzik, J.1    Maniatis, T.2
  • 22
    • 0029824122 scopus 로고    scopus 로고
    • An intron splicing enhancer containing a G-rich repeat facilitates inclusion of a vertebrate micro-exon
    • Carlo T, Sterner DA, Berget SM. 1996. An intron splicing enhancer containing a G-rich repeat facilitates inclusion of a vertebrate micro-exon. RNA 2:342-53
    • (1996) RNA , vol.2 , pp. 342-353
    • Carlo, T.1    Sterner, D.A.2    Berget, S.M.3
  • 23
    • 0030279439 scopus 로고    scopus 로고
    • Directing alternative splicing: Cast and scenarios
    • Chabot B. 1996. Directing alternative splicing: cast and scenarios. Trends Genet. 12:472-78
    • (1996) Trends Genet. , vol.12 , pp. 472-478
    • Chabot, B.1
  • 24
    • 0023096261 scopus 로고
    • Recognition of mutant and cryptic 5′ splice sites by the U1 small nuclear ribonucleoprotein in vitro
    • Chabot B, Steitz JA. 1987. Recognition of mutant and cryptic 5′ splice sites by the U1 small nuclear ribonucleoprotein in vitro. Mol. Cell. Biol. 7:698-707
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 698-707
    • Chabot, B.1    Steitz, J.A.2
  • 25
    • 0028800302 scopus 로고
    • Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro
    • Chan RC, Black DL. 1995. Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol. Cell. Biol. 15:6377-85
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6377-6385
    • Chan, R.C.1    Black, D.L.2
  • 26
    • 0030872401 scopus 로고    scopus 로고
    • The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream
    • Chan RC, Black DL. 1997. The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol. Cell. Biol. 17:4667-76
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4667-4676
    • Chan, R.C.1    Black, D.L.2
  • 27
    • 0028274042 scopus 로고
    • Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule
    • Cheng J, Zhou T, Liu C, Shapiro JP, Brauer MJ, et al. 1994. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263:1759-62
    • (1994) Science , vol.263 , pp. 1759-1762
    • Cheng, J.1    Zhou, T.2    Liu, C.3    Shapiro, J.P.4    Brauer, M.J.5
  • 28
    • 0029006578 scopus 로고
    • A two-step mechanism for 5′ and 3′ splice site pairing
    • Chiara MD, Reed R. 1995. A two-step mechanism for 5′ and 3′ splice site pairing. Nature 375:510-13
    • (1995) Nature , vol.375 , pp. 510-513
    • Chiara, M.D.1    Reed, R.2
  • 29
    • 0030300044 scopus 로고    scopus 로고
    • Vive la différence: Males vs females in flies vs worms
    • Cline TW, Meyer BJ. 1996. Vive la différence: males vs females in flies vs worms. Annu. Rev. Genet. 30:637-702
    • (1996) Annu. Rev. Genet. , vol.30 , pp. 637-702
    • Cline, T.W.1    Meyer, B.J.2
  • 30
    • 0027532430 scopus 로고
    • Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila
    • Coschigano KT, Wensink PC. 1993. Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila. Genes Dev. 7:42-54
    • (1993) Genes Dev. , vol.7 , pp. 42-54
    • Coschigano, K.T.1    Wensink, P.C.2
  • 31
    • 0029831071 scopus 로고    scopus 로고
    • A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions
    • Dauwalder B, Amaya-Manzanares F, Mattox W. 1996. A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. Proc. Natl. Acad. Sci. USA 93:9004-9
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9004-9009
    • Dauwalder, B.1    Amaya-Manzanares, F.2    Mattox, W.3
  • 32
    • 0029166382 scopus 로고
    • Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon
    • Del Gatto F, Breathnach R. 1995. Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol. Cell. Biol. 15:4825-34
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4825-4834
    • Del Gatto, F.1    Breathnach, R.2
  • 33
    • 0029785082 scopus 로고    scopus 로고
    • Sex-lethal interacts with splicing factors in vitro and in vivo
    • Deshpande G, Samuels M, Schedl P. 1996. Sex-lethal interacts with splicing factors in vitro and in vivo. Mol. Cell. Biol. 16:5036-47
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5036-5047
    • Deshpande, G.1    Samuels, M.2    Schedl, P.3
  • 34
    • 0027321180 scopus 로고
    • Novel delayed-early and highly insulin-induced growth response genes: Identification of HRS, a potential regulator of alternative pre-mRNA splicing
    • Diamond RH, Du K, Lee VM, Mohn KL, Haber BA, et al. 1993. Novel delayed-early and highly insulin-induced growth response genes: identification of HRS, a potential regulator of alternative pre-mRNA splicing. J. Biol. Chem. 268: 15185-92
    • (1993) J. Biol. Chem. , vol.268 , pp. 15185-15192
    • Diamond, R.H.1    Du, K.2    Lee, V.M.3    Mohn, K.L.4    Haber, B.A.5
  • 35
    • 0028336758 scopus 로고
    • A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA
    • Dirksen WP, Hampson RK, Sun Q, Rottman FM. 1994. A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA. J. Biol. Chem. 269:6431-36
    • (1994) J. Biol. Chem. , vol.269 , pp. 6431-6436
    • Dirksen, W.P.1    Hampson, R.K.2    Sun, Q.3    Rottman, F.M.4
  • 36
    • 0031010393 scopus 로고    scopus 로고
    • HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver
    • Du K, Peng Y, Greenbaum LE, Haber BA, Taub R. 1997. HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver. Mol. Cell. Biol. 17:4096-104
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4096-4104
    • Du, K.1    Peng, Y.2    Greenbaum, L.E.3    Haber, B.A.4    Taub, R.5
  • 37
    • 0029147928 scopus 로고
    • Regulated subcellular distribution of the NR1 subunit of the NMDA receptor
    • Ehlers MD, Tingley WG, Huganir RL. 1995. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science 269:1734-37
    • (1995) Science , vol.269 , pp. 1734-1737
    • Ehlers, M.D.1    Tingley, W.G.2    Huganir, R.L.3
  • 39
    • 0028096639 scopus 로고
    • Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing
    • Epstein JA, Glaser T, Cai J, Jepeal L, Walton DS, Maas RL. 1994. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev. 8:2022-34
    • (1994) Genes Dev. , vol.8 , pp. 2022-2034
    • Epstein, J.A.1    Glaser, T.2    Cai, J.3    Jepeal, L.4    Walton, D.S.5    Maas, R.L.6
  • 40
    • 0027396943 scopus 로고
    • The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain
    • Erdman SE, Burtis KC. 1993. The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain. EMBO J. 12:527-35
    • (1993) EMBO J. , vol.12 , pp. 527-535
    • Erdman, S.E.1    Burtis, K.C.2
  • 41
    • 0029563927 scopus 로고
    • Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues
    • Faura M, Renau-Piqueras J, Bachs O, Bosser R. 1995. Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues. Biochem. Biophys. Res. Commun. 217:554-60
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , pp. 554-560
    • Faura, M.1    Renau-Piqueras, J.2    Bachs, O.3    Bosser, R.4
  • 42
    • 0028266440 scopus 로고
    • The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein
    • Flickinger TW, Salz HK. 1994. The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein. Genes Dev. 8:914-25
    • (1994) Genes Dev. , vol.8 , pp. 914-925
    • Flickinger, T.W.1    Salz, H.K.2
  • 43
    • 0031258105 scopus 로고    scopus 로고
    • Alternatively spliced variants: A new view of the integrin cytoplasmic domain
    • Fornaro M, Languino LR. 1997. Alternatively spliced variants: a new view of the integrin cytoplasmic domain. Matrix Biol. 16:185-93
    • (1997) Matrix Biol. , vol.16 , pp. 185-193
    • Fornaro, M.1    Languino, L.R.2
  • 44
    • 0029372979 scopus 로고
    • The superfamily of arginine/serine-rich splicing factors
    • Fu XD. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1:663-80
    • (1995) RNA , vol.1 , pp. 663-680
    • Fu, X.D.1
  • 45
    • 0026599345 scopus 로고
    • The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3′ splice site
    • Fu XD, Maniatis T. 1992. The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3′ splice site. Proc. Natl. Acad. Sci. USA 89:1725-29
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1725-1729
    • Fu, X.D.1    Maniatis, T.2
  • 46
    • 0026437581 scopus 로고
    • General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5′ and 3′ splice site selection
    • Fu XD, Mayeda A, Maniatis T, Krainer AR. 1992. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5′ and 3′ splice site selection. Proc. Natl. Acad. Sci. USA 89:11224-28
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11224-11228
    • Fu, X.D.1    Mayeda, A.2    Maniatis, T.3    Krainer, A.R.4
  • 47
    • 0030998715 scopus 로고    scopus 로고
    • The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A
    • Gallego ME, Gattoni R, Stevenin J, Marie J, Expert-Bezancon A. 1997. The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A. EMBO J. 16:1772-84
    • (1997) EMBO J. , vol.16 , pp. 1772-1784
    • Gallego, M.E.1    Gattoni, R.2    Stevenin, J.3    Marie, J.4    Expert-Bezancon, A.5
  • 48
    • 0025827463 scopus 로고
    • Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators
    • Ge H, Zuo P, Manley JL. 1991. Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell 66:373-82
    • (1991) Cell , vol.66 , pp. 373-382
    • Ge, H.1    Zuo, P.2    Manley, J.L.3
  • 49
    • 0031894413 scopus 로고    scopus 로고
    • The Drosophila splicing regulator Sex-lethal directly inhibits translation of male-specific lethal 2 mRNA
    • Gebauer F, Merendino L, Hentze M, Valcarcel J. 1998. The Drosophila splicing regulator Sex-lethal directly inhibits translation of male-specific lethal 2 mRNA. RNA 4:142-50
    • (1998) RNA , vol.4 , pp. 142-150
    • Gebauer, F.1    Merendino, L.2    Hentze, M.3    Valcarcel, J.4
  • 50
    • 0031985529 scopus 로고    scopus 로고
    • Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon
    • Gooding C, Roberts GC, Smith CW. 1998. Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon. RNA 4:85-100
    • (1998) RNA , vol.4 , pp. 85-100
    • Gooding, C.1    Roberts, G.C.2    Smith, C.W.3
  • 51
    • 0024512392 scopus 로고
    • The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins
    • Goralski TJ, Edstrom JE, Baker BS. 1989. The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins. Cell 56:1011-18
    • (1989) Cell , vol.56 , pp. 1011-1018
    • Goralski, T.J.1    Edstrom, J.E.2    Baker, B.S.3
  • 52
    • 0032549748 scopus 로고    scopus 로고
    • Splicing regulation in neurons: Tinkering with cell-specific control
    • Grabowski PJ. 1998. Splicing regulation in neurons: tinkering with cell-specific control. Cell 92:709-12
    • (1998) Cell , vol.92 , pp. 709-712
    • Grabowski, P.J.1
  • 53
    • 0025287327 scopus 로고
    • The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA
    • Granadino B, Campuzano S, Sanchez L. 1990. The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA. EMBO J. 9:2597-602
    • (1990) EMBO J. , vol.9 , pp. 2597-2602
    • Granadino, B.1    Campuzano, S.2    Sanchez, L.3
  • 54
    • 0029909309 scopus 로고    scopus 로고
    • The gene fl(2)d is needed for the sex-specific splicing of transformer pre-mRNA but not for double-sex pre-mRNA in Drosophila melanogaster
    • Granadino B, Peñalva LO, Sanchez L. 1996. The gene fl(2)d is needed for the sex-specific splicing of transformer pre-mRNA but not for double-sex pre-mRNA in Drosophila melanogaster. Mol. Gen. Genet. 253:26-31
    • (1996) Mol. Gen. Genet. , vol.253 , pp. 26-31
    • Granadino, B.1    Peñalva, L.O.2    Sanchez, L.3
  • 56
    • 0030723110 scopus 로고    scopus 로고
    • Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo
    • Hammond LE, Rudner DZ, Kanaar R, Rio DC. 1997. Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo. Mol. Cell. Biol. 17: 7260-67
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7260-7267
    • Hammond, L.E.1    Rudner, D.Z.2    Kanaar, R.3    Rio, D.C.4
  • 57
    • 0344074646 scopus 로고    scopus 로고
    • Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors
    • Hanamura A, Caceres JF, Mayeda A, Franza BR, Krainer AR. 1998. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA 4:430-44
    • (1998) RNA , vol.4 , pp. 430-444
    • Hanamura, A.1    Caceres, J.F.2    Mayeda, A.3    Franza, B.R.4    Krainer, A.R.5
  • 58
    • 0026612305 scopus 로고
    • RNA specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B proteins
    • Harper DS, Fresco LD, Keene JD. 1992. RNA specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B proteins. Nucleic Acids Res. 20:3645-50
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3645-3650
    • Harper, D.S.1    Fresco, L.D.2    Keene, J.D.3
  • 59
    • 0025745243 scopus 로고
    • Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro
    • Hedley ML, Maniatis T. 1991. Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65:579-86
    • (1991) Cell , vol.65 , pp. 579-586
    • Hedley, M.L.1    Maniatis, T.2
  • 60
    • 0029114121 scopus 로고
    • The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences
    • Heinrichs V, Baker BS. 1995. The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J. 14:3987-4000
    • (1995) EMBO J. , vol.14 , pp. 3987-4000
    • Heinrichs, V.1    Baker, B.S.2
  • 61
    • 0031031053 scopus 로고    scopus 로고
    • In vivo analysis of the functional domains of the Drosophila splicing regulator RBP1
    • Heinrichs V, Baker BS. 1997. In vivo analysis of the functional domains of the Drosophila splicing regulator RBP1. Proc. Natl. Acad. Sci. USA 94:115-20
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 115-120
    • Heinrichs, V.1    Baker, B.S.2
  • 62
    • 0031972648 scopus 로고    scopus 로고
    • Regulation of sex-specific selection of fruitless 5′ splice sites by transformer and transformer-2
    • Heinrichs V, Ryner LC, Baker BS. 1998. Regulation of sex-specific selection of fruitless 5′ splice sites by transformer and transformer-2. Mol. Cell. Biol. 18:450-58
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 450-458
    • Heinrichs, V.1    Ryner, L.C.2    Baker, B.S.3
  • 63
    • 0029615321 scopus 로고
    • The gene virilizer is required for female-specilic splicing controlled by Sxl, the master gene for sexual development in Drosophila
    • Hilfiker A, Amrein H, Dubendorfer A, Schneiter R, Nothiger R. 1995. The gene virilizer is required for female-specilic splicing controlled by Sxl, the master gene for sexual development in Drosophila. Development 121:4017-26
    • (1995) Development , vol.121 , pp. 4017-4026
    • Hilfiker, A.1    Amrein, H.2    Dubendorfer, A.3    Schneiter, R.4    Nothiger, R.5
  • 64
    • 0027090479 scopus 로고
    • 65, to the 3′ splice site by a network of interactions spanning the exon
    • 65, to the 3′ splice site by a network of interactions spanning the exon. Genes Dev. 6:2554-68
    • (1992) Genes Dev. , vol.6 , pp. 2554-2568
    • Hoffman, B.E.1    Grabowski, P.J.2
  • 65
    • 0027424123 scopus 로고
    • Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5′ splice site
    • Horabin JI, Schedl P. 1993. Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5′ splice site. Mol. Cell. Biol. 13:7734-46
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7734-7746
    • Horabin, J.I.1    Schedl, P.2
  • 66
    • 0025815671 scopus 로고
    • Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila
    • Hoshijima K, Inoue K, Higuchi I, Sakamoto H, Shimura Y. 1991. Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila. Science 252:833-36
    • (1991) Science , vol.252 , pp. 833-836
    • Hoshijima, K.1    Inoue, K.2    Higuchi, I.3    Sakamoto, H.4    Shimura, Y.5
  • 67
    • 0025363553 scopus 로고
    • Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript
    • Inoue K, Hoshijima K, Sakamoto H, Shimura Y. 1990. Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript. Nature 344:461-63
    • (1990) Nature , vol.344 , pp. 461-463
    • Inoue, K.1    Hoshijima, K.2    Sakamoto, H.3    Shimura, Y.4
  • 68
    • 0028881190 scopus 로고
    • Cell type-specific expression of hn-RNP proteins
    • Kamma H, Portman DS, Dreyfuss G. 1995. Cell type-specific expression of hn-RNP proteins. Exp. Cell Res. 221:187-96
    • (1995) Exp. Cell Res. , vol.221 , pp. 187-196
    • Kamma, H.1    Portman, D.S.2    Dreyfuss, G.3
  • 69
    • 0027445241 scopus 로고
    • The conserved pre-mRNA splicing factor U2AF from Drosophila: Requirement for viability
    • Kanaar R, Roche SE, Beall EL, Green MR, Rio DC. 1993. The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability. Science 262:569-73
    • (1993) Science , vol.262 , pp. 569-573
    • Kanaar, R.1    Roche, S.E.2    Beall, E.L.3    Green, M.R.4    Rio, D.C.5
  • 70
    • 0029115921 scopus 로고
    • Interaction of the Sex Lethal RNA binding domains with RNA
    • Kanaar R, Lee AL, Rudner DZ, Wemmer DE, Rio DC. 1995. Interaction of the Sex Lethal RNA binding domains with RNA. EMBO J. 14:4530-39
    • (1995) EMBO J. , vol.14 , pp. 4530-4539
    • Kanaar, R.1    Lee, A.L.2    Rudner, D.Z.3    Wemmer, D.E.4    Rio, D.C.5
  • 71
    • 0030013179 scopus 로고    scopus 로고
    • SR proteins that are essential for generic pre-mRNA splicing inhibit splicing of a regulated adenovirus pre-mRNA
    • Kanopka A, Mühlemann O, Akusjärvi G. 1996. SR proteins that are essential for generic pre-mRNA splicing inhibit splicing of a regulated adenovirus pre-mRNA. Nature 381:535-38
    • (1996) Nature , vol.381 , pp. 535-538
    • Kanopka, A.1    Mühlemann, O.2    Akusjärvi, G.3
  • 72
    • 0028289188 scopus 로고
    • Protein-protein interactions and 5′ splice site recognition in mammalian mRNA precursors
    • Kohtz JD, Jamison SF, Will CL, Zuo P, Luhrmann R, et al. 1994. Protein-protein interactions and 5′ splice site recognition in mammalian mRNA precursors. Nature 368:119-24
    • (1994) Nature , vol.368 , pp. 119-124
    • Kohtz, J.D.1    Jamison, S.F.2    Will, C.L.3    Zuo, P.4    Luhrmann, R.5
  • 73
    • 0029936745 scopus 로고    scopus 로고
    • The fibronectin gene as a model for splicing and transcription studies
    • Kornblihtt AR, Pesce CG, Alonso CR, Cramer P, Srebrow A, et al. 1996. The fibronectin gene as a model for splicing and transcription studies. FASEB J. 10:248-57
    • (1996) FASEB J. , vol.10 , pp. 248-257
    • Kornblihtt, A.R.1    Pesce, C.G.2    Alonso, C.R.3    Cramer, P.4    Srebrow, A.5
  • 74
    • 0029891101 scopus 로고    scopus 로고
    • The structure and function of proteins involved in mammalian pre-mRNA splicing
    • Kramer A. 1996. The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu. Rev. Biochem. 65:367-409
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 367-409
    • Kramer, A.1
  • 75
    • 0027143943 scopus 로고
    • A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding
    • Lavigueur A, LaBranche H, Kornblihtt AR, Chabot B. 1993. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev. 7:2405-17
    • (1993) Genes Dev. , vol.7 , pp. 2405-2417
    • Lavigueur, A.1    Labranche, H.2    Kornblihtt, A.R.3    Chabot, B.4
  • 76
    • 0029295295 scopus 로고
    • Regulation of alternative 3′ splice site selection by constitutive splicing factors
    • Lin CH, Patton JG. 1995. Regulation of alternative 3′ splice site selection by constitutive splicing factors. RNA 1:234-45
    • (1995) RNA , vol.1 , pp. 234-245
    • Lin, C.H.1    Patton, J.G.2
  • 77
    • 0032032013 scopus 로고    scopus 로고
    • Aberrant RNA processing in a neurodegenerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis
    • Lin CLG, Bristol LA, Jin L, Dykes-Hoberg M, Crawford T, et al. 1998. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron 20:589-602
    • (1998) Neuron , vol.20 , pp. 589-602
    • Lin, C.L.G.1    Bristol, L.A.2    Jin, L.3    Dykes-Hoberg, M.4    Crawford, T.5
  • 80
    • 0029586670 scopus 로고
    • Developmental role of transcription factor isoforms generated by alternative splicing
    • Lopez AJ. 1995. Developmental role of transcription factor isoforms generated by alternative splicing. Dev. Biol. 172:396-411
    • (1995) Dev. Biol. , vol.172 , pp. 396-411
    • Lopez, A.J.1
  • 81
    • 0030067593 scopus 로고    scopus 로고
    • An intron enhancer recognized by splicing factors activates polyadenylation
    • Lou H, Gagel RF, Berget SM. 1996. An intron enhancer recognized by splicing factors activates polyadenylation. Genes Dev. 10:208-19
    • (1996) Genes Dev. , vol.10 , pp. 208-219
    • Lou, H.1    Gagel, R.F.2    Berget, S.M.3
  • 82
    • 0028926275 scopus 로고
    • Synergistic interactions between two distinct elements of a regulated splicing enhancer
    • Lynch KW, Maniatis T. 1995. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev 9:284-93
    • (1995) Genes Dev , vol.9 , pp. 284-293
    • Lynch, K.W.1    Maniatis, T.2
  • 83
    • 0029858338 scopus 로고    scopus 로고
    • Assembly of specific protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer
    • Lynch KW, Maniatis T. 1996. Assembly of specific protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev. 10:2089-101
    • (1996) Genes Dev. , vol.10 , pp. 2089-2101
    • Lynch, K.W.1    Maniatis, T.2
  • 84
    • 0029585464 scopus 로고
    • The developmental consequences of alternate splicing in sex determination and differentiation in Drosophila
    • MacDougall C, Harbison D, Bownes M. 1995. The developmental consequences of alternate splicing in sex determination and differentiation in Drosophila. Dev. Biol. 172:353-76
    • (1995) Dev. Biol. , vol.172 , pp. 353-376
    • Macdougall, C.1    Harbison, D.2    Bownes, M.3
  • 86
    • 0029767662 scopus 로고    scopus 로고
    • SR proteins and splicing control
    • Manley JL, Tacke R. 1996. SR proteins and splicing control. Genes Dev. 10: 1569-79
    • (1996) Genes Dev. , vol.10 , pp. 1569-1579
    • Manley, J.L.1    Tacke, R.2
  • 87
    • 0028061367 scopus 로고
    • Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins
    • Mayeda A, Munroe SH, Caceres JF, Krainer AR. 1994. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J. 13:5483-95
    • (1994) EMBO J. , vol.13 , pp. 5483-5495
    • Mayeda, A.1    Munroe, S.H.2    Caceres, J.F.3    Krainer, A.R.4
  • 88
    • 0028867814 scopus 로고
    • The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event
    • Min H, Chan RC, Black DL, 1995. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev. 9:2659-71
    • (1995) Genes Dev. , vol.9 , pp. 2659-2671
    • Min, H.1    Chan, R.C.2    Black, D.L.3
  • 89
    • 0030969572 scopus 로고    scopus 로고
    • A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer
    • Min H, Turck CW, Nikolic JM, Black DL. 1997. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev. 11: 1023-36
    • (1997) Genes Dev. , vol.11 , pp. 1023-1036
    • Min, H.1    Turck, C.W.2    Nikolic, J.M.3    Black, D.L.4
  • 90
    • 0028919596 scopus 로고
    • Binding of a cell-type-specific RNA splicing factor to its target regulatory sequence
    • Nandabalan K, Roeder GS. 1995. Binding of a cell-type-specific RNA splicing factor to its target regulatory sequence. Mol. Cell. Biol. 15:1953-60
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1953-1960
    • Nandabalan, K.1    Roeder, G.S.2
  • 91
    • 0345073465 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 92
    • 0023732920 scopus 로고
    • Genetic evidence that the sans-fille locus is involved in Drosophila sex determination
    • Oliver B, Perrimon N, Mahowald A. 1988. Genetic evidence that the sans-fille locus is involved in Drosophila sex determination. Genetics 120:159-71
    • (1988) Genetics , vol.120 , pp. 159-171
    • Oliver, B.1    Perrimon, N.2    Mahowald, A.3
  • 93
    • 0027378159 scopus 로고
    • Sex-lethal, master and slave: A hierarchy of germ line sex determination in Drosophila
    • Oliver B, Kim Y-J, Baker BS. 1993. Sex-lethal, master and slave: a hierarchy of germ line sex determination in Drosophila. Development 119:897-908
    • (1993) Development , vol.119 , pp. 897-908
    • Oliver, B.1    Kim, Y.-J.2    Baker, B.S.3
  • 95
    • 0030878682 scopus 로고    scopus 로고
    • Mutation of PTB binding sites causes misregulation of alternative 3′ splice site selection in vivo
    • Perez I, Lin CH, McAfee JG, Patton JG. 1997. Mutation of PTB binding sites causes misregulation of alternative 3′ splice site selection in vivo. RNA 3:764-78
    • (1997) RNA , vol.3 , pp. 764-778
    • Perez, I.1    Lin, C.H.2    McAfee, J.G.3    Patton, J.G.4
  • 96
    • 0032076126 scopus 로고    scopus 로고
    • Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy
    • Phillips AV, Timchenko LT, Cooper TA. 1998. Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 280:737-41
    • (1998) Science , vol.280 , pp. 737-741
    • Phillips, A.V.1    Timchenko, L.T.2    Cooper, T.A.3
  • 97
    • 0029842637 scopus 로고    scopus 로고
    • Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B″ that are encoded separately in human, potato and yeast
    • Polycarpou-Schwartz M, Gunderson SI, Kandel-Lewis S, Seraphin B, Mattaj IW. 1996. Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B″ that are encoded separately in human, potato and yeast. RNA 2:11-23
    • (1996) RNA , vol.2 , pp. 11-23
    • Polycarpou-Schwartz, M.1    Gunderson, S.I.2    Kandel-Lewis, S.3    Seraphin, B.4    Mattaj, I.W.5
  • 98
    • 0029144216 scopus 로고
    • A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer
    • Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA. 1995. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol. Cell. Biol. 15:4898-907
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4898-4907
    • Ramchatesingh, J.1    Zahler, A.M.2    Neugebauer, K.M.3    Roth, M.B.4    Cooper, T.A.5
  • 99
    • 0029933504 scopus 로고    scopus 로고
    • Initial recognition and pairing during pre-mRNA splicing
    • Reed R. 1996. Initial recognition and pairing during pre-mRNA splicing. Curr. Opin. Genet. Dev. 6:215-20
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 215-220
    • Reed, R.1
  • 100
    • 0344211253 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 101
    • 0345073463 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 102
    • 0029814786 scopus 로고    scopus 로고
    • Mutations in the small sub-unit of the Drosophila U2AF splicing factor cause lethality and developmental defects
    • Rudner DZ, Kanaar R, Breger KS, Rio DC. 1996. Mutations in the small sub-unit of the Drosophila U2AF splicing factor cause lethality and developmental defects. Proc. Natl. Acad. Sci. USA 93: 10333-37
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10333-10337
    • Rudner, D.Z.1    Kanaar, R.2    Breger, K.S.3    Rio, D.C.4
  • 103
    • 0032054197 scopus 로고    scopus 로고
    • Molecular genetic analysis of the heterodimeric splicing factor U2AF: The RS domain on either the large or small Drosophila subunit is dispensable in vivo
    • Rudner DZ, Breger KS, Rio DC. 1998. Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo. Genes Dev. 12:1010-21
    • (1998) Genes Dev. , vol.12 , pp. 1010-1021
    • Rudner, D.Z.1    Breger, K.S.2    Rio, D.C.3
  • 104
    • 0031924788 scopus 로고    scopus 로고
    • Interaction between subunitsof heterodimeric splicing factor U2AF is essential in vivo
    • Rudner DZ, Kanaar R, Breger KS, Rio DC. 1998. Interaction between subunitsof heterodimeric splicing factor U2AF is essential in vivo. Mol. Cell. Biol. 18:1765-73
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1765-1773
    • Rudner, D.Z.1    Kanaar, R.2    Breger, K.S.3    Rio, D.C.4
  • 105
    • 0023834880 scopus 로고
    • A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly
    • Ruskin B, Zamore PD, Green MR. 1988. A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell 52:207-19
    • (1988) Cell , vol.52 , pp. 207-219
    • Ruskin, B.1    Zamore, P.D.2    Green, M.R.3
  • 106
    • 0030010743 scopus 로고    scopus 로고
    • Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle
    • Ryan KJ, Cooper TA. 1996. Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol. Cell. Biol. 16:4014-23
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4014-4023
    • Ryan, K.J.1    Cooper, T.A.2
  • 107
    • 0025988927 scopus 로고
    • Regulation of doublesex pre-mRNA processing occurs by 3′-splice site activation
    • Ryner LC, Baker BS. 1991. Regulation of doublesex pre-mRNA processing occurs by 3′-splice site activation. Genes Dev. 5:2071-85
    • (1991) Genes Dev. , vol.5 , pp. 2071-2085
    • Ryner, L.C.1    Baker, B.S.2
  • 108
    • 0026450913 scopus 로고
    • Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product
    • Sakamoto H, Inoue K, Higuchi I, Ono Y, Shimura Y. 1992. Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product. Nucleic Acids Res. 20:5533-40
    • (1992) Nucleic Acids Res. , vol.20 , pp. 5533-5540
    • Sakamoto, H.1    Inoue, K.2    Higuchi, I.3    Ono, Y.4    Shimura, Y.5
  • 109
    • 0026605186 scopus 로고
    • The genetic analysis of snf: A Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma
    • Salz HK. 1992. The genetic analysis of snf: a Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma. Genetics 130:547-54
    • (1992) Genetics , vol.130 , pp. 547-554
    • Salz, H.K.1
  • 110
    • 0029780502 scopus 로고    scopus 로고
    • Both loss-of-function and gain-of-function mutations in snf define a role for snRNP proteins in regulating Sex-lethal pre-mRNA splicing in Drosophila development
    • Salz HK, Flickinger TW. 1996. Both loss-of-function and gain-of-function mutations in snf define a role for snRNP proteins in regulating Sex-lethal pre-mRNA splicing in Drosophila development. Genetics 144:95-108
    • (1996) Genetics , vol.144 , pp. 95-108
    • Salz, H.K.1    Flickinger, T.W.2
  • 112
    • 0029896830 scopus 로고    scopus 로고
    • Molecular diversity of myofibrillar proteins: Gene regulation and functional significance
    • Schiafino S, Reggiani C. 1996. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol. Rev. 76:371-423
    • (1996) Physiol. Rev. , vol.76 , pp. 371-423
    • Schiafino, S.1    Reggiani, C.2
  • 114
    • 0028831527 scopus 로고
    • Identification and characterization of three members of the human SR family of pre-mRNA splicing factors
    • Screaton GR, Caceres JF, Mayeda A, Bell MV, Plebanski M, et al. 1995. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J. 14: 4336-49
    • (1995) EMBO J. , vol.14 , pp. 4336-4349
    • Screaton, G.R.1    Caceres, J.F.2    Mayeda, A.3    Bell, M.V.4    Plebanski, M.5
  • 115
    • 0030602837 scopus 로고    scopus 로고
    • An alternatively spliced C. Elegans ced-4 RNA encodes a novel cell death inhibitor
    • Shaham S, Horvitz HR. 1996. An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell 86:201-8
    • (1996) Cell , vol.86 , pp. 201-208
    • Shaham, S.1    Horvitz, H.R.2
  • 116
    • 0032054745 scopus 로고    scopus 로고
    • A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth
    • Sherman L, Wainwright D, Ponta H, Herrlich P. 1998. A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth. Genes Dev. 12:1058-71
    • (1998) Genes Dev. , vol.12 , pp. 1058-1071
    • Sherman, L.1    Wainwright, D.2    Ponta, H.3    Herrlich, P.4
  • 117
    • 0027196278 scopus 로고
    • Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants
    • Shi E, Kan M, Xu J, Wang F, Hou J, McKeehan WL. 1993. Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. Mol. Cell. Biol. 13:3907-18
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3907-3918
    • Shi, E.1    Kan, M.2    Xu, J.3    Wang, F.4    Hou, J.5    McKeehan, W.L.6
  • 118
    • 0026644140 scopus 로고
    • The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: Multiprotein complexes at an exon pseudo-5′ splice site control U1 snRNP binding
    • Siebel CW, Fesco LD, Rio DC. 1992. The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5′ splice site control U1 snRNP binding. Genes Dev. 6:1386-401
    • (1992) Genes Dev. , vol.6 , pp. 1386-1401
    • Siebel, C.W.1    Fesco, L.D.2    Rio, D.C.3
  • 119
    • 0028146254 scopus 로고
    • Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI
    • Siebel CW, Kanaar R, Rio DC. 1994. Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. Genes Dev. 8:1713-25
    • (1994) Genes Dev. , vol.8 , pp. 1713-1725
    • Siebel, C.W.1    Kanaar, R.2    Rio, D.C.3
  • 120
    • 0028914042 scopus 로고
    • Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing
    • Siebel CW, Admon A, Rio DC. 1995. Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes Dev. 9:269-83
    • (1995) Genes Dev. , vol.9 , pp. 269-283
    • Siebel, C.W.1    Admon, A.2    Rio, D.C.3
  • 121
    • 0029055472 scopus 로고
    • Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
    • Singh R, Valcarcel J, Green MR. 1995. Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science 268:1173-76
    • (1995) Science , vol.268 , pp. 1173-1176
    • Singh, R.1    Valcarcel, J.2    Green, M.R.3
  • 122
    • 0024378075 scopus 로고
    • Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage
    • Sosnowski BA, Belote JM, McKeown M. 1989. Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage. Cell 58:449-59
    • (1989) Cell , vol.58 , pp. 449-459
    • Sosnowski, B.A.1    Belote, J.M.2    McKeown, M.3
  • 123
    • 0028006713 scopus 로고
    • SR proteins promote the first specific recognition of pre-mRNA and are present together with U1 snRNP in a general splicing enhancer complex
    • Staknis D, Reed R. 1994. SR proteins promote the first specific recognition of pre-mRNA and are present together with U1 snRNP in a general splicing enhancer complex. Mol. Cell. Biol. 14:7670-82
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7670-7682
    • Staknis, D.1    Reed, R.2
  • 124
    • 0032489021 scopus 로고    scopus 로고
    • Mechanical devices of the spliceosome: Motors, clocks, springs and things
    • Staley JP, Guthne C. 1998. Mechanical devices of the spliceosome: motors, clocks, springs and things. Cell 92:315-26
    • (1998) Cell , vol.92 , pp. 315-326
    • Staley, J.P.1    Guthne, C.2
  • 125
    • 0024198983 scopus 로고
    • Sex determination in Drosophila: The X chromosomal gene liz is required for Sxl activity
    • Steinmann-Zwicky M. 1988. Sex determination in Drosophila: the X chromosomal gene liz is required for Sxl activity. EMBO J. 7:3889-98
    • (1988) EMBO J. , vol.7 , pp. 3889-3898
    • Steinmann-Zwicky, M.1
  • 127
    • 0028175730 scopus 로고
    • Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster: Evidence from elimination, substitution, and ectopic expression of specific isoforms
    • Subramaniam V, Bomze HM, Lopez AJ. 1994. Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster: evidence from elimination, substitution, and ectopic expression of specific isoforms. Genetics 136:979-91
    • (1994) Genetics , vol.136 , pp. 979-991
    • Subramaniam, V.1    Bomze, H.M.2    Lopez, A.J.3
  • 128
    • 0027715743 scopus 로고
    • General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer
    • Sun Q, Hampson RK, Krainer AR, Rottman FM. 1993. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev. 7:2598-608
    • (1993) Genes Dev. , vol.7 , pp. 2598-2608
    • Sun, Q.1    Hampson, R.K.2    Krainer, A.R.3    Rottman, F.M.4
  • 129
    • 0029064220 scopus 로고
    • The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities
    • Tacke R, Manley JL. 1995. The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J. 14: 3540-51
    • (1995) EMBO J. , vol.14 , pp. 3540-3551
    • Tacke, R.1    Manley, J.L.2
  • 130
    • 0031037690 scopus 로고    scopus 로고
    • Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer
    • Tacke R, Chen Y, Manley JL. 1997. Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc. Natl. Acad. Sci. USA 94:1148-53
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1148-1153
    • Tacke, R.1    Chen, Y.2    Manley, J.L.3
  • 131
    • 0032478506 scopus 로고    scopus 로고
    • Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing
    • Tacke R, Thyama M, Manley JL. 1998. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 93:139
    • (1998) Cell , vol.93 , pp. 139
    • Tacke, R.1    Thyama, M.2    Manley, J.L.3
  • 132
    • 0026579802 scopus 로고
    • Positive control of pre-mRNA splicing in vitro
    • Tian M, Maniatis T. 1992. Positive control of pre-mRNA splicing in vitro. Science 256:237-40
    • (1992) Science , vol.256 , pp. 237-240
    • Tian, M.1    Maniatis, T.2
  • 133
    • 0027185151 scopus 로고
    • A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA
    • Tian M, Maniatis T. 1993. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74: 105-14
    • (1993) Cell , vol.74 , pp. 105-114
    • Tian, M.1    Maniatis, T.2
  • 134
    • 0028025033 scopus 로고
    • A splicing enhancer exhibits both constitutive and regulated activities
    • Tian M, Maniatis T. 1994. A splicing enhancer exhibits both constitutive and regulated activities. Genes Dev. 8:1703-12
    • (1994) Genes Dev. , vol.8 , pp. 1703-1712
    • Tian, M.1    Maniatis, T.2
  • 135
    • 0027400786 scopus 로고
    • The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA
    • Valcárcel J, Singh R, Zamore PD, Green MR. 1993. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. Nature 362:171-75
    • (1993) Nature , vol.362 , pp. 171-175
    • Valcárcel, J.1    Singh, R.2    Zamore, P.D.3    Green, M.R.4
  • 136
    • 0030595187 scopus 로고    scopus 로고
    • Interaction of the U2AF65 RS region with pre-mRNA of the branch point and promotion of base pairing with U2 snRNA
    • Valcárcel J, Gaur RK, Singh R, Green MR. 1996. Interaction of the U2AF65 RS region with pre-mRNA of the branch point and promotion of base pairing with U2 snRNA. Science 273:1706-9
    • (1996) Science , vol.273 , pp. 1706-1709
    • Valcárcel, J.1    Gaur, R.K.2    Singh, R.3    Green, M.R.4
  • 137
    • 0029860454 scopus 로고    scopus 로고
    • An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity
    • Vogan KJ, Underbill DA, Gros P. 1996. An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity. Mol. Cell. Biol. 16:6677-86
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6677-6686
    • Vogan, K.J.1    Underbill, D.A.2    Gros, P.3
  • 138
    • 0028170519 scopus 로고
    • The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation
    • Wang J, Bell LR. 1994. The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation. Genes Dev. 8:2072-85
    • (1994) Genes Dev. , vol.8 , pp. 2072-2085
    • Wang, J.1    Bell, L.R.2
  • 139
    • 0031009398 scopus 로고    scopus 로고
    • Regulation of pre-mRNA splicing in metazoa
    • Wang J, Manley JL. 1997. Regulation of pre-mRNA splicing in metazoa. Curr. Opin. Genet. Dev. 7:205-11
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 205-211
    • Wang, J.1    Manley, J.L.2
  • 140
    • 0029988272 scopus 로고    scopus 로고
    • Cell-and stage-specific splicing events resolved in specialized neurons of the rat cerebellum
    • Wang Z, Grabowski PJ. 1996. Cell-and stage-specific splicing events resolved in specialized neurons of the rat cerebellum. RNA 2:1241-53
    • (1996) RNA , vol.2 , pp. 1241-1253
    • Wang, Z.1    Grabowski, P.J.2
  • 141
    • 0029258817 scopus 로고
    • Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity
    • Wang Z, Hoffman HM, Grabowski PJ. 1995. Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity. RNA 1:21-35
    • (1995) RNA , vol.1 , pp. 21-35
    • Wang, Z.1    Hoffman, H.M.2    Grabowski, P.J.3
  • 142
    • 0027288912 scopus 로고
    • The role of exon sequences in splice site selection
    • Watakabe A, Tanaka K, Shimura Y. 1993. The role of exon sequences in splice site selection. Genes Dev. 7:407-18
    • (1993) Genes Dev. , vol.7 , pp. 407-418
    • Watakabe, A.1    Tanaka, K.2    Shimura, Y.3
  • 143
    • 0027137934 scopus 로고
    • Specific interactions between proteins implicated in splice site selection and regulated alternative splicing
    • Wu JY, Maniatis T. 1993. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75:1061-70
    • (1993) Cell , vol.75 , pp. 1061-1070
    • Wu, J.Y.1    Maniatis, T.2
  • 144
    • 0027175502 scopus 로고
    • The cardiac troponin-T alternative exon contains a novel purine-rich positive splicing element
    • Xu RS, Teng J, Cooper TA. 1993. The cardiac troponin-T alternative exon contains a novel purine-rich positive splicing element. Mol. Cell. Biol. 13:3660-74
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3660-3674
    • Xu, R.S.1    Teng, J.2    Cooper, T.A.3
  • 145
    • 0030598838 scopus 로고    scopus 로고
    • An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments
    • Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW, Fuchs E. 1996. An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell 86:655-65
    • (1996) Cell , vol.86 , pp. 655-665
    • Yang, Y.1    Dowling, J.2    Yu, Q.C.3    Kouklis, P.4    Cleveland, D.W.5    Fuchs, E.6
  • 146
    • 0026569967 scopus 로고
    • Cloning and domain structure of the mammalian splicing factor U2AF
    • Zamore PD, Patton JG, Green MR. 1992. Cloning and domain structure of the mammalian splicing factor U2AF. Nature 355:609-14
    • (1992) Nature , vol.355 , pp. 609-614
    • Zamore, P.D.1    Patton, J.G.2    Green, M.R.3
  • 147
  • 148
    • 0029954587 scopus 로고    scopus 로고
    • Essential nucleotides direct neuron-specific splicing of γ2 premRNA
    • Zhang L, Ashiya M, Sherman TG, Grabowski PJ. 1996. Essential nucleotides direct neuron-specific splicing of γ2 premRNA. RNA 2:682-98
    • (1996) RNA , vol.2 , pp. 682-698
    • Zhang, L.1    Ashiya, M.2    Sherman, T.G.3    Grabowski, P.J.4
  • 149
    • 0029665533 scopus 로고    scopus 로고
    • The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing
    • Zuo P, Maniatis T. 1996. The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev. 10:1356-68
    • (1996) Genes Dev. , vol.10 , pp. 1356-1368
    • Zuo, P.1    Maniatis, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.