An ONIOM and MD Investigation of Possible Monofunctional Activity of Human 8-Oxoguanine-DNA Glycosylase (hOgg1)

Journal of Physical Chemistry B

Volumn 119, Issue 25, 2015, Pages 8013-8023

  Kellie, Jennifer L ^a   Wilson, Katie A ^a   Wetmore, Stacey D ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOINFORMATICS; CHEMICAL ACTIVATION; DNA; ENZYMES; MOLECULAR DYNAMICS; MOLECULES; NUCLEOPHILES; PROTEINS; REACTION KINETICS;

ACTIVATION STEPS; BASE EXCISION REPAIRS; BIFUNCTIONAL ACTIVITY; CATALYTIC PATHWAYS; DNA-PROTEIN COMPLEXES; EXPERIMENTAL KINETICS; MOLECULAR DYNAMICS SIMULATIONS; REACTION PATHWAYS;

ENZYME ACTIVITY;

DNA; DNA GLYCOSYLTRANSFERASE; OXOGUANINE GLYCOSYLASE 1, HUMAN; PROTON; SOLVENT; WATER;

BIOLOGICAL MODEL; CHEMISTRY; ENERGY TRANSFER; ENZYME ACTIVE SITE; GLYCOSYLATION; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; QUANTUM THEORY;

CATALYTIC DOMAIN; DNA; DNA GLYCOSYLASES; ENERGY TRANSFER; GLYCOSYLATION; HUMANS; HYDROGEN BONDING; MODELS, GENETIC; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTONS; QUANTUM THEORY; SOLVENTS; WATER;

EID: 84933074351     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/acs.jpcb.5b04051     Document Type: Article

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