Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

Nature

Volumn 434, Issue 7033, 2005, Pages 612-618

  Banerjee, Anirban ^a   Yang, Wei ^a   Karplus, Martin ^a,b   Verdine, Gregory L ^a  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITÉ LOUIS PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; FREE ENERGY; MOLECULAR STRUCTURE; MUTAGENESIS; OXIDATION; X RAY ANALYSIS;

COVALENT TRAPPING STRATEGY; LESION DISCRIMINATION; NUCLEOBASES; X-RAY STRUCTURE;

DNA;

8 HYDROXYGUANINE; 8 OXOGUANINE DNA GLYCOSYLASE 1; DNA GLYCOSYLTRANSFERASE; GUANINE; NUCLEIC ACID BASE; UNCLASSIFIED DRUG; 8-HYDROXYGUANINE; DISULFIDE; DNA; DRUG DERIVATIVE; OXOGUANINE GLYCOSYLASE 1, HUMAN;

DNA;

ARTICLE; CALCULATION; COMPARATIVE STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DNA DAMAGE; DNA HELIX; ENERGY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; GENE INSERTION; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTAGENICITY; OXIDATION; PRIORITY JOURNAL; X RAY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; DNA REPAIR; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; DNA; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; GUANINE; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 15844379169     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03458     Document Type: Article

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