Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase

Biochemistry

Volumn 42, Issue 6, 2003, Pages 1564-1572

  Norman, Derek P G ^a   Chung, Sang J ^a   Verdine, Gregory L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANTS;

BIOCHEMISTRY; CATALYST ACTIVITY; CONFORMATIONS; CRYSTAL STRUCTURE; DNA; ENZYME KINETICS; MOLECULAR STRUCTURE; MUTAGENESIS; PROTEINS;

AMINO ACIDS;

8 OXOGUANINE GLYCOSYLASE; AMINO ACID; ASPARAGINE; ASPARTIC ACID; DNA GLYCOSYLTRANSFERASE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; GLYCOSIDE; LYSINE; NUCLEIC ACID BASE; PROLINE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BIOCHEMISTRY; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA DAMAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME STRUCTURE; EXCISION REPAIR; HUMAN; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ASPARAGINE; ASPARTIC ACID; BINDING SITES; CATALYSIS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DNA; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME STABILITY; GLUTAMIC ACID; GLUTAMINE; HEAT; HUMANS; HYDROLYSIS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; N-GLYCOSYL HYDROLASES; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 0037452513     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026823d     Document Type: Article

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