The R46Q, R131Q and R154H polymorphs of human DNA glycosylase/β-lyase hOgg1 severely distort the active site and DNA recognition site but do not cause unfolding

Journal of the American Chemical Society

Volumn 131, Issue 27, 2009, Pages 9506-9515

  Anderson, Peter C ^a   Daggett, Valerie ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8-OXOGUANINE; ACTIVE SITE; CELLULAR DAMAGE; CHEMICAL ENVIRONMENT; DNA ADDUCT; DNA RECOGNITION; DNA-REPAIR ENZYMES; DYNAMICAL EFFECTS; ENZYME ACTIVE SITES; HUMAN CANCER; MOLECULAR DYNAMICS SIMULATIONS; MUTATION SITES; NUCLEOPHILIC ATTACK; OXIDATIVE DAMAGE; PHOSPHATE BACKBONE; REACTIVE OXYGEN SPECIES; RECOGNITION SITE; SIDE CHAINS; STRAND BREAKS; STRUCTURAL CHANGE; STRUCTURAL DATA; STRUCTURAL EFFECT; SUBSTRATE RECOGNITION SITES; SUBSTRATE SPECIFICITY;

AMINES; DNA; ENZYMES; MOLECULAR DYNAMICS; NUCLEIC ACIDS; OXYGEN; POLYMORPHISM;

GENES;

8 OXOGUANINE GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; LYSINE; NUCLEOPHILE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DNA STRUCTURE; ENZYME ACTIVITY; MOLECULAR DYNAMICS; OXIDATION; SIMULATION;

CATALYTIC DOMAIN; COMPUTER SIMULATION; DNA GLYCOSYLASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYMORPHISM, GENETIC; PROTEIN FOLDING;

EID: 67650468432     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja809726e     Document Type: Article

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