Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: Biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket

Nucleic Acids Research

Volumn 32, Issue 2, 2004, Pages 570-578

  van der Kemp, Patricia Auffret ^a   Charbonnier, Jean Baptiste ^a,b   Audebert, Marc ^a   Boiteux, Serge ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b DIF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; AMINO ACID; DNA; DNA GLYCOSYLTRANSFERASE; LYASE; MUTANT PROTEIN; PROTEIN OGG1; PURINE; PYRIMIDINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CATALYSIS; CONTROLLED STUDY; DNA CONTENT; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME DEGRADATION; HUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; WILD TYPE;

BINDING SITES; CATALYSIS; CIRCULAR DICHROISM; DNA; DNA GLYCOSYLASES; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GUANINE; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; RIFAMPIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1342285213     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh224     Document Type: Article

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