Promiscuous DNA alkyladenine glycosylase dramatically favors a bound lesion over undamaged adenine

Biophysical Chemistry

Volumn 152, Issue 1-3, 2010, Pages 118-127

  Alexandrova, Anastassia N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alkyladenine DNA Glycosylase; Free energy perturbation; Specificity; Thermodynamics

Indexed keywords

ADENINE; DNA ADENINE GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; HYPOXANTHINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CALCULATION; DEAMINATION; DENSITY FUNCTIONAL THEORY; HUMAN; HYDROGEN BOND; KINETICS; MONTE CARLO METHOD; MUTATION; PRIORITY JOURNAL; SIMULATION; THERMODYNAMICS;

ADENINE; BINDING SITES; DNA; DNA GLYCOSYLASES; DNA REPAIR; HUMANS; HYPOXANTHINE; MONTE CARLO METHOD; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

EID: 78149279933     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2010.08.007     Document Type: Article

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