Hedgehog interacting protein in the mature brain: Membrane-associated and soluble forms

Molecular and Cellular Neuroscience

Volumn 25, Issue 2, 2004, Pages 323-333

  Coulombe, J ^a   Traiffort, E ^a   Loulier, K ^a   Faure, H ^a   Ruat, M ^b  

^a 91198 Cedex   (France)

^b LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE GM1; HEDGEHOG INTERACTING PROTEIN; MEMBRANE PROTEIN; REGULATOR PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BRAIN CELL; BRAIN MATURATION; BRAIN REGION; CELL DIFFERENTIATION; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL MEMBRANE; CHO CELLS; CRICETINAE; CULTURE MEDIA, CONDITIONED; G(M1) GANGLIOSIDE; HEDGEHOG PROTEINS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE MICRODOMAINS; MICE; NEURONS; PROTEIN STRUCTURE, TERTIARY; RATS; RNA, MESSENGER; SOLUBILITY; SUBCELLULAR FRACTIONS; TRANS-ACTIVATORS;

ERINACEIDAE; RODENTIA;

EID: 1542512393     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2003.10.024     Document Type: Article

References (52)

1. Allendoerfer K.L., Dudek H. Translation of developmental biology into therapeutics: the hedgehog signaling pathway and neurodegenerative diseases. Curr. Opin. Investig. Drugs. 3:2002;1742-1744.
2. Ango F., Albani-Torregrossa S., Joly C., Robbe D., Michel J.M., Pin J.P., Bockaert J., Fagni L. A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells. Neuropharmacology. 38:1999;793-803.
3. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., Struhl K. Short protocols in Molecular Biology. 2nd ed. 1992;Wiley, New York.
4. Balemans W., Van Hul W. Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev. Biol. 250:2002;231-250.
5. Bellaiche Y., The I., Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature. 394:1998;85-88.
6. Berman D.M., Karhadkar S.S., Hallahan A.R., Pritchard J.I., Eberhart C.G., Watkins D.N., Chen J.K., Cooper M.K., Taipale J., Olson J.M., Beachy P.A. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science. 297:2002;1559-1561.
7. Brown D.A., London E. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 275:2000;17221-17224.
8. Burke R., Nellen D., Bellotto M., Hafen E., Senti K.A., Dickson B.J., Basler K. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell. 99:1999;803-815.
9. Charron F., Stein E., Jeong J., McMahon A.P., Tessier-Lavigne M. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell. 113:2003;11-23.
10. Charytoniuk D., Traiffort E., Hantraye P., Hermel J.M., Galdes A., Ruat M. Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone. Eur. J. Neurosci. 16:2002;2351-2357.
11. Charytoniuk D.A., Porcel B., Rodriguez J.A., Faure H., Ruat M., Traiffort E. Sonic Hedgehog signaling in the developing and adult brain. J. Physiol. (Paris). 96:2002;9-16.
12. Chen J.K., Taipale J., Young K.E., Maiti T., Beachy P.A. Small molecule modulation of Smoothened activity. Proc. Natl. Acad. Sci. U. S. A. 99:2002;14071-14076.
13. Chuang P.T., McMahon A.P. Vertebrate hedgehog signalling modulated by induction of a hedgehog-binding protein. Nature. 397:1999;617-621.
14. Chuang P.T., Kawcak T., McMahon A.P. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 17:2003;342-347.
15. Cobourne M.T., Sharpe P.T. Expression and regulation of hedgehog-interacting protein during early tooth development. Connect. Tissue Res. 43:2002;143-147.
16. Cooper M.K., Porter J.A., Young K.E., Beachy P.A. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 280:1998;1603-1607.
17. Dahmane N., Ruiz-i-Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development. 126:1999;3089-3100.
18. Dass B., Iravani M.M., Jackson M.J., Engber T.M., Galdes A., Jenner P. Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-treated common marmosets. Neuroscience. 114:2002;99-109.
19. De Olmos J., Hardy H., Heimer L. The afferent connections of the main and the accessory olfactory bulb formations in the rat: an experimental HRP-study. J. Comp. Neurol. 181:1978;213-244.
20. Engber T.M., Wang S., Huang C., Reilly J., Galdes A., Mahanthappa N. Sonic hedgehog is neuroprotective in the adult striatum in vivo. Soc. Neurosci. Abst. 25:1999;1534.
21. Ericson J., Morton S., Kawakami A., Roelink H., Jessell T.M. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell. 87:1996;661-673.
22. Frank-Kamenetsky M., Zhang X.M., Bottega S., Guicherit O., Wichterle H., Dudek H., Bumcrot D., Wang F.Y., Jones S., Shulok J., Rubin L.L., Porter J.A. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J. Biol. 1:2002;1-19.
23. Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., Scott M.P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 10:1996;301-312.
24. Goodrich L.V., Milenkovic L., Higgins K.M., Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 277:1997;1109-1113.
25. Guy R.K. Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Proc. Natl. Acad. Sci. U. S. A. 97:2000;7307-7312.
26. Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15:2001;3059-3087.
27. Lai K., Kaspar B.K., Gage F.H., Schaffer D.V. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat. Neurosci. 6:2003;21-27.
28. Lee C.S., Buttitta L., Fan C.M. Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc. Natl. Acad. Sci. U. S. A. 98:2001;11347-11352.
29. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
30. Ma Y., Erkner A., Gong R., Yao S., Taipale J., Basler K., Beachy P. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 111:2002;63-75.
31. Marti E., Bovolenta P. Sonic hedgehog in CNS development: one signal, multiple outputs. Trends Neurosci. 25:2002;89-96.
32. Mary S., Gomeza J., Prezeau L., Bockaert J., Pin J.P. A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C. J. Biol. Chem. 273:1998;425-432.
33. Mellstrom B., Cena V., Lamas M., Perales C., Gonzalez C., Naranjo J.R. Gas1 is induced during and participates in excitotoxic neuronal death. Mol. Cell. Neurosci. 19:2002;417-429.
34. Pepinsky R.B., Zeng C., Wen D., Rayhorn P., Baker D.P., Williams K.P., Bixler S.A., Ambrose C.M., Garber E.A., Miatkowski K., Taylor F.R., Wang E.A., Galdes A. Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273:1998;14037-14045.
35. Pepinsky R.B., Shapiro R.I., Wang S., Chakraborty A., Gill A., Lepage D.J., Wen D., Rayhorn P., Horan G.S., Taylor F.R., Garber E.A., Galdes A., Engber T.M. Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. J. Pharm. Sci. 91:2002;371-387.
36. Reilly J.O., Karavanova I.D., Williams K.P., Mahanthappa N.K., Allendoerfer K.L. Cooperative effects of Sonic Hedgehog and NGF on basal forebrain cholinergic neurons. Mol. Cell. Neurosci. 19:2002;88-96.
37. Ruiz i Altaba A., Palma V., Dahmane N. Hedgehog-Gli signaling and the growth of the brain. Nat. Neurosci. 3:2002;24-33.
38. Ruiz i Altaba A., Sanchez P., Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat. Rev. Cancer. 2:2002;361-372.
39. Swindle C.S., Tran K.T., Johnson T.D., Banerjee P., Mayes A.M., Griffith L., Wells A. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. J. Cell. Biol. 154:2001;459-468.
40. Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of smoothened. Nature. 418:2002;892-896.
41. Takagi J., Beglova N., Yalamanchili P., Blacklow S.C., Springer T.A. Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proc. Natl. Acad. Sci. U. S. A. 98:2001;11175-11180.
42. Taylor F.R., Wen D., Garber E.A., Carmillo A.N., Baker D.P., Arduini R.M., Williams K.P., Weinreb P.H., Rayhorn P., Hronowski X., Whitty A., Day E.S., Boriack-Sjodin A., Shapiro R.I., Galdes A., Pepinsky R.B. Enhanced potency of human sonic hedgehog by hydrophobic modification. Biochemistry. 40:2001;4359-4371.
43. Traiffort E., Charytoniuk D.A., Faure H., Ruat M. Regional distribution of sonic hedgehog, patched, and smoothened mRNA in the adult rat brain. J. Neurochem. 70:1998;1327-1330.
44. Traiffort E., Charytoniuk D., Watroba L., Faure H., Sales N., Ruat M. Discrete localizations of hedgehog signalling compotents in the developing and adult rat nervous system. Eur. J. Neurosci. 11:1999;3199-3214.
45. Traiffort E., Moya K.L., Faure H., Hassig R., Ruat M. High expression and anterograde axonal transport of aminoterminal Sonic Hedgehog in the adult hamster brain. Eur. J. Neurosci. 14:2001;839-850.
46. Treier M.S., O'Connell S., Gleiberman A., Price J., Szeto D.P., Burgess R., Chuang P.T., McMahon A.P., Rosenfeld M.G. Hedgehog signaling is required for pituitary gland development. Development. 128:2001;377-386.
47. Tsuboi K., Shults C.W. Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease. Exp. Neurol. 173:2002;95-104.
48. Watkins D.N., Berman D.M., Burkholder S.G., Wang B., Beachy P.A., Baylin S.B. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 422:2003;313-317.
49. Wechsler-Reya R.J., Scott M. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 22:1999;103-114.
50. Wetmore C. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models. Curr. Opin. Genet. Dev. 13:2003;34-42.
51. Williams J.A., Guicherit O.M., Zaharian B.I., Xu Y., Chai L., Wichterle H., Kon C., Gatchalian C., Porter J.A., Rubin L.L., Wang F.Y. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc. Natl. Acad. Sci. U. S. A. 100:2003;4616-4621.
52. Zeng X., Goetz J.A., Suber L.M., Scott W.J. Jr., Schreiner C.M., Robbins D.J. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature. 411:2001;716-720.