Acquired resistance to the hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma

Journal of the American Academy of Dermatology

Volumn 71, Issue 5, 2014, Pages 1005-1008

  Brinkhuizen, Tjinta ^a   Reinders, Marie G ^a   Van Geel, Michel ^a   Hendriksen, Annelot J L ^a   Paulussen, Aimée D C ^a   Winnepenninckx, Véronique J ^a   Keymeulen, Kristien B ^a   Soetekouw, Patricia M M B ^a,b   Van Steensel, Maurice A M ^a,c   Mosterd, Klara ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Sport Medical Center   (Netherlands)

^c INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; SONIC HEDGEHOG PROTEIN; VISMODEGIB; ANILIDE; ANTINEOPLASTIC AGENT; G PROTEIN COUPLED RECEPTOR; PYRIDINE DERIVATIVE; SMO PROTEIN, HUMAN;

ADVANCED CANCER; AGED; BASAL CELL CARCINOMA; CANCER LOCALIZATION; CANCER RECURRENCE; CANCER REGRESSION; CANCER RESISTANCE; CANCER RISK; CANCER SIZE; CASE REPORT; DNA DETERMINATION; DNA ISOLATION; DRUG WITHDRAWAL; EXON; FEMALE; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; LETTER; LYMPHEDEMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PAPULE; PRIORITY JOURNAL; SCAR; SKIN BIOPSY; SKIN NODULE; TUMOR INVASION; CARCINOMA, BASAL CELL; DRUG RESISTANCE; GENETICS; NUCLEOTIDE SEQUENCE; SKIN NEOPLASMS; TUMOR RECURRENCE;

AGED; ANILIDES; ANTINEOPLASTIC AGENTS; CARCINOMA, BASAL CELL; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; NEOPLASM RECURRENCE, LOCAL; PYRIDINES; RECEPTORS, G-PROTEIN-COUPLED; SKIN NEOPLASMS;

EID: 84922480709     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2014.08.001     Document Type: Article

References (5)

1. Bath-Hextall FJ, Perkins W, Bong J, Williams HC. Interventions for basal cell carcinoma of the skin. Cochrane Database of Systematic Reviews (Online) 2007:CD003412.
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5. Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367:1694-703.