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Volumn 8, Issue 4, 2015, Pages 4795-4807

The role of MTDH/AEG-1 in the progression of cancer

Author keywords

Cancer progression; Carcinogenesis; MTDH AEG 1; Signaling pathway; Target therapy

Indexed keywords

BETA CATENIN; DOXORUBICIN; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METADHERIN; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDES AND PROTEINS; PHOSPHATIDYLINOSITOL 3 KINASE; TAMOXIFEN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84931275215     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (73)

References (97)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • [1] Hanahan D and Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0037118589 scopus 로고    scopus 로고
    • Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH
    • [2] Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ and Fisher PB. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Onco-gene 2002; 21: 3592-3602.
    • (2002) Onco-Gene , vol.21 , pp. 3592-3602
    • Su, Z.Z.1    Kang, D.C.2    Chen, Y.3    Pekarskaya, O.4    Chao, W.5    Volsky, D.J.6    Fisher, P.B.7
  • 3
    • 20444389341 scopus 로고    scopus 로고
    • Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1
    • [3] Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ and Fisher PB. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005; 353: 8-15.
    • (2005) Gene , vol.353 , pp. 8-15
    • Kang, D.C.1    Su, Z.Z.2    Sarkar, D.3    Emdad, L.4    Volsky, D.J.5    Fisher, P.B.6
  • 4
    • 84902345916 scopus 로고    scopus 로고
    • Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review)
    • [4] Huang Y and Li LP. Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review). Oncol Lett 2014; 8: 493-501.
    • (2014) Oncol Lett , vol.8 , pp. 493-501
    • Huang, Y.1    Li, L.P.2
  • 5
    • 1842634484 scopus 로고    scopus 로고
    • Metadherin, a cell surface protein in breast tumors that mediates lung metastasis
    • [5] Brown DM and Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004; 5: 365-374.
    • (2004) Cancer Cell , vol.5 , pp. 365-374
    • Brown, D.M.1    Ruoslahti, E.2
  • 7
    • 1242339604 scopus 로고    scopus 로고
    • 3D3/lyric: A novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus
    • [7] Sutherland HG, Lam YW, Briers S, Lamond AI and Bickmore WA. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 2004; 294: 94-105.
    • (2004) Exp Cell Res , vol.294 , pp. 94-105
    • Sutherland, H.G.1    Lam, Y.W.2    Briers, S.3    Lamond, A.I.4    Bickmore, W.A.5
  • 8
    • 32944459561 scopus 로고    scopus 로고
    • Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: Implications for tumor progression and metastasis
    • [8] Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K and Fisher PB. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 2006; 66: 1509-1516.
    • (2006) Cancer Res , vol.66 , pp. 1509-1516
    • Emdad, L.1    Sarkar, D.2    Su, Z.Z.3    Randolph, A.4    Boukerche, H.5    Valerie, K.6    Fisher, P.B.7
  • 9
    • 34147165551 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1: Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration
    • [9] Emdad L, Sarkar D, Su ZZ, Lee SG, Kang DC, Bruce JN, Volsky DJ and Fisher PB. Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 2007; 114: 155-170.
    • (2007) Pharmacol Ther , vol.114 , pp. 155-170
    • Emdad, L.1    Sarkar, D.2    Su, Z.Z.3    Lee, S.G.4    Kang, D.C.5    Bruce, J.N.6    Volsky, D.J.7    Fisher, P.B.8
  • 11
    • 33751257780 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc
    • [11] Lee SG, Su ZZ, Emdad L, Sarkar D and Fisher PB. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci U S A 2006; 103: 17390-17395.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17390-17395
    • Lee, S.G.1    Su, Z.Z.2    Emdad, L.3    Sarkar, D.4    Fisher, P.B.5
  • 12
    • 84880927965 scopus 로고    scopus 로고
    • AEG-1/MTDH/LYRIC: Signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis
    • [12] Emdad L, Das SK, Dasgupta S, Hu B, Sarkar D and Fisher PB. AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis. Adv Cancer Res 2013; 120: 75-111.
    • (2013) Adv Cancer Res , vol.120 , pp. 75-111
    • Emdad, L.1    Das, S.K.2    Dasgupta, S.3    Hu, B.4    Sarkar, D.5    Fisher, P.B.6
  • 13
    • 39149100913 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
    • [13] Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF and Fisher PB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2008; 27: 1114-1121.
    • (2008) Oncogene , vol.27 , pp. 1114-1121
    • Lee, S.G.1    Su, Z.Z.2    Emdad, L.3    Sarkar, D.4    Franke, T.F.5    Fisher, P.B.6
  • 15
    • 70349094044 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1
    • [15] Li J, Yang L, Song L, Xiong H, Wang L, Yan X, Yuan J, Wu J and Li M. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009; 28: 3188-3196.
    • (2009) Oncogene , vol.28 , pp. 3188-3196
    • Li, J.1    Yang, L.2    Song, L.3    Xiong, H.4    Wang, L.5    Yan, X.6    Yuan, J.7    Wu, J.8    Li, M.9
  • 16
    • 84872044595 scopus 로고    scopus 로고
    • AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis
    • [16] Ke ZF, Mao X, Zeng C, He S, Li S and Wang LT. AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis. Med Oncol 2013; 30: 383.
    • (2013) Med Oncol , vol.30 , pp. 383
    • Ke, Z.F.1    Mao, X.2    Zeng, C.3    He, S.4    Li, S.5    Wang, L.T.6
  • 17
    • 70350447686 scopus 로고    scopus 로고
    • Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer
    • [17] Song L, Li W, Zhang H, Liao W, Dai T, Yu C, Ding X, Zhang L and Li J. Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 2009; 219: 317-326.
    • (2009) J Pathol , vol.219 , pp. 317-326
    • Song, L.1    Li, W.2    Zhang, H.3    Liao, W.4    Dai, T.5    Yu, C.6    Ding, X.7    Zhang, L.8    Li, J.9
  • 18
    • 84902953844 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response
    • [18] Zheng J, Li C, Wu X, Liu M, Sun X, Yang Y, Hao M, Sheng S, Sun Y, Zhang H, Long J, Liang Y and Hu C. Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response. Tumour Biol 2014; 35: 4219-4224.
    • (2014) Tumour Biol , vol.35 , pp. 4219-4224
    • Zheng, J.1    Li, C.2    Wu, X.3    Liu, M.4    Sun, X.5    Yang, Y.6    Hao, M.7    Sheng, S.8    Sun, Y.9    Zhang, H.10    Long, J.11    Liang, Y.12    Hu, C.13
  • 19
    • 40449089338 scopus 로고    scopus 로고
    • Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    • [19] Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ and Fisher PB. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 2008; 68: 1478-1484.
    • (2008) Cancer Res , vol.68 , pp. 1478-1484
    • Sarkar, D.1    Park, E.S.2    Emdad, L.3    Lee, S.G.4    Su, Z.Z.5    Fisher, P.B.6
  • 23
    • 68249158094 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling
    • [23] Khuda, II, Koide N, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T and Yokochi T. Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 2009; 128: e700-706.
    • (2009) Immunology , vol.128 , pp. e700-e706
    • Khuda, I.I.1    Koide, N.2    Noman, A.S.3    Dagvadorj, J.4    Tumurkhuu, G.5    Naiki, Y.6    Komatsu, T.7    Yoshida, T.8    Yokochi, T.9
  • 24
    • 83455221361 scopus 로고    scopus 로고
    • Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells
    • [24] Zhao Y, Kong X, Li X, Yan S, Yuan C, Hu W and Yang Q. Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells. PLoS One 2011; 6: e29363.
    • (2011) Plos One , vol.6
    • Zhao, Y.1    Kong, X.2    Li, X.3    Yan, S.4    Yuan, C.5    Hu, W.6    Yang, Q.7
  • 25
    • 79960317935 scopus 로고    scopus 로고
    • Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer
    • [25] Jian-bo X, Hui W, Yu-long H, Chang-hua Z, Long-juan Z, Shi-rong C and Wen-hua Z. Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 2011; 28: 455-462.
    • (2011) Med Oncol , vol.28 , pp. 455-462
    • Jian-Bo, X.1    Hui, W.2    Yu-Long, H.3    Chang-Hua, Z.4    Long-Juan, Z.5    Shi-Rong, C.6    Wen-Hua, Z.7
  • 26
    • 84880325345 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 interacts with beta-catenin and increases migration and invasion of colorectal carcinoma
    • [26] Zhang F, Yang Q, Meng F, Shi H, Li H, Liang Y and Han A. Astrocyte elevated gene-1 interacts with beta-catenin and increases migration and invasion of colorectal carcinoma. Mol Carcinog 2013; 52: 603-610.
    • (2013) Mol Carcinog , vol.52 , pp. 603-610
    • Zhang, F.1    Yang, Q.2    Meng, F.3    Shi, H.4    Li, H.5    Liang, Y.6    Han, A.7
  • 27
    • 84863086393 scopus 로고    scopus 로고
    • Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma
    • [27] Ge X, Lv X, Feng L, Liu X, Gao J, Chen N and Wang X. Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma. PLoS One 2012; 7: e39449.
    • (2012) Plos One , pp. 7
    • Ge, X.1    Lv, X.2    Feng, L.3    Liu, X.4    Gao, J.5    Chen, N.6    Wang, X.7
  • 28
    • 84863034803 scopus 로고    scopus 로고
    • Inhibition of metadherin sensitizes breast cancer cells to AZD6244
    • [28] Kong X, Moran MS, Zhao Y and Yang Q. Inhibition of metadherin sensitizes breast cancer cells to AZD6244. Cancer Biol Ther 2012; 13: 43-49.
    • (2012) Cancer Biol Ther , vol.13 , pp. 43-49
    • Kong, X.1    Moran, M.S.2    Zhao, Y.3    Yang, Q.4
  • 29
    • 84881549559 scopus 로고    scopus 로고
    • AEG-1 participates in TGF-beta1-induced EMT through p38 MAPK activation
    • [29] Wei J, Li Z, Chen W, Ma C, Zhan F, Wu W and Peng Y. AEG-1 participates in TGF-beta1-induced EMT through p38 MAPK activation. Cell Biol Int 2013; 37: 1016-1021.
    • (2013) Cell Biol Int , vol.37 , pp. 1016-1021
    • Wei, J.1    Li, Z.2    Chen, W.3    Ma, C.4    Zhan, F.5    Wu, W.6    Peng, Y.7
  • 30
    • 65549113479 scopus 로고    scopus 로고
    • Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis
    • [30] Yu C, Chen K, Zheng H, Guo X, Jia W, Li M, Zeng M, Li J and Song L. Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 2009; 30: 894-901.
    • (2009) Carcinogenesis , vol.30 , pp. 894-901
    • Yu, C.1    Chen, K.2    Zheng, H.3    Guo, X.4    Jia, W.5    Li, M.6    Zeng, M.7    Li, J.8    Song, L.9
  • 31
    • 84902544289 scopus 로고    scopus 로고
    • MTDH/AEG-1 contributes to central features of the neoplastic phenotype in bladder cancer
    • [31] Nikpour M, Emadi-Baygi M, Fischer U, Niegisch G, Schulz WA and Nikpour P. MTDH/AEG-1 contributes to central features of the neoplastic phenotype in bladder cancer. Urol Oncol 2014; 32: 670-677.
    • (2014) Urol Oncol , vol.32 , pp. 670-677
    • Nikpour, M.1    Emadi-Baygi, M.2    Fischer, U.3    Niegisch, G.4    Schulz, W.A.5    Nikpour, P.6
  • 33
    • 62149086700 scopus 로고    scopus 로고
    • Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells
    • [33] Liu H, Song X, Liu C, Xie L, Wei L and Sun R. Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. J Exp Clin Cancer Res 2009; 28: 19.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 19
    • Liu, H.1    Song, X.2    Liu, C.3    Xie, L.4    Wei, L.5    Sun, R.6
  • 34
    • 77953624680 scopus 로고    scopus 로고
    • Immunohisto-chemical analysis of Metadherin in proliferative and cancerous breast tissue
    • [34] Su P, Zhang Q and Yang Q. Immunohisto-chemical analysis of Metadherin in proliferative and cancerous breast tissue. Diagn Pathol 2010; 5: 38.
    • (2010) Diagn Pathol , vol.5 , pp. 38
    • Su, P.1    Zhang, Q.2    Yang, Q.3
  • 35
    • 84902463420 scopus 로고    scopus 로고
    • MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin
    • [35] Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G and Yang Q. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 2014; 33: 3119-3128.
    • (2014) Oncogene , vol.33 , pp. 3119-3128
    • Zhang, N.1    Wang, X.2    Huo, Q.3    Sun, M.4    Cai, C.5    Liu, Z.6    Hu, G.7    Yang, Q.8
  • 36
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • [36] Carmeliet P and Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 39
    • 79251475257 scopus 로고    scopus 로고
    • Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer
    • [39] Li C, Li R, Song H, Wang D, Feng T, Yu X, Zhao Y, Liu J, Wang Y and Geng J. Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. J Surg Oncol 2011; 103: 184-192.
    • (2011) J Surg Oncol , vol.103 , pp. 184-192
    • Li, C.1    Li, R.2    Song, H.3    Wang, D.4    Feng, T.5    Yu, X.6    Zhao, Y.7    Liu, J.8    Wang, Y.9    Geng, J.10
  • 41
    • 84862531654 scopus 로고    scopus 로고
    • Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression
    • [41] Sun S, Ke Z, Wang F, Li S, Chen W, Han A, Wang Z, Shi H, Wang LT and Chen X. Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Hum Pathol 2012; 43: 1051-1060.
    • (2012) Hum Pathol , vol.43 , pp. 1051-1060
    • Sun, S.1    Ke, Z.2    Wang, F.3    Li, S.4    Chen, W.5    Han, A.6    Wang, Z.7    Shi, H.8    Wang, L.T.9    Chen, X.10
  • 42
  • 44
    • 84865607737 scopus 로고    scopus 로고
    • Expression of metadherin/AEG-1 gene is positively related to orientation chemotaxis and adhesion of human hepatocellular carcinoma cell lines of different metastatic potentials
    • [44] Zhou Z, Deng H, Yan W, Huang H, Deng Y, Li Y and Tian D. Expression of metadherin/AEG-1 gene is positively related to orientation chemotaxis and adhesion of human hepatocellular carcinoma cell lines of different metastatic potentials. J Huazhong Univ Sci Technolog Med Sci 2012; 32: 353-357.
    • (2012) J Huazhong Univ Sci Technolog Med Sci , vol.32 , pp. 353-357
    • Zhou, Z.1    Deng, H.2    Yan, W.3    Huang, H.4    Deng, Y.5    Li, Y.6    Tian, D.7
  • 45
    • 84867980319 scopus 로고    scopus 로고
    • Clinical implications of AEG-1 in liver metastasis of colorectal cancer
    • [45] Jiang T, Zhu A, Zhu Y and Piao D. Clinical implications of AEG-1 in liver metastasis of colorectal cancer. Med Oncol 2012; 29: 2858-2863.
    • (2012) Med Oncol , vol.29 , pp. 2858-2863
    • Jiang, T.1    Zhu, A.2    Zhu, Y.3    Piao, D.4
  • 46
    • 84874091389 scopus 로고    scopus 로고
    • MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma
    • [46] Liu DC and Yang ZL. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. Diagn Cytopathol 2013; 41: 199-205.
    • (2013) Diagn Cytopathol , vol.41 , pp. 199-205
    • Liu, D.C.1    Yang, Z.L.2
  • 47
    • 79951858334 scopus 로고    scopus 로고
    • Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression
    • [47] Chen W, Ke Z, Shi H, Yang S and Wang L. Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression. Neoplasma 2010; 57: 522-529.
    • (2010) Neoplasma , vol.57 , pp. 522-529
    • Chen, W.1    Ke, Z.2    Shi, H.3    Yang, S.4    Wang, L.5
  • 48
    • 84907486055 scopus 로고    scopus 로고
    • Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis
    • [48] Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ and Kang Y. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 2014; 74: 5336-5347.
    • (2014) Cancer Res , vol.74 , pp. 5336-5347
    • Wan, L.1    Hu, G.2    Wei, Y.3    Yuan, M.4    Bronson, R.T.5    Yang, Q.6    Siddiqui, J.7    Pienta, K.J.8    Kang, Y.9
  • 50
    • 42649137241 scopus 로고    scopus 로고
    • Mechanisms of disease: Epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?
    • [50] Turley EA, Veiseh M, Radisky DC and Bissell MJ. Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol 2008; 5: 280-290.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 280-290
    • Turley, E.A.1    Veiseh, M.2    Radisky, D.C.3    Bissell, M.J.4
  • 51
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • [51] Zeisberg M and Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119: 1429-1437.
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 52
    • 79956200605 scopus 로고    scopus 로고
    • Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition
    • [52] Li X, Kong X, Huo Q, Guo H, Yan S, Yuan C, Moran MS, Shao C and Yang Q. Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci 2011; 102: 1151-1157.
    • (2011) Cancer Sci , vol.102 , pp. 1151-1157
    • Li, X.1    Kong, X.2    Huo, Q.3    Guo, H.4    Yan, S.5    Yuan, C.6    Moran, M.S.7    Shao, C.8    Yang, Q.9
  • 53
    • 84874735111 scopus 로고    scopus 로고
    • Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
    • [53] Ward A, Balwierz A, Zhang JD, Kublbeck M, Pawitan Y, Hielscher T, Wiemann S and Sahin O. Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene 2013; 32: 1173-1182.
    • (2013) Oncogene , vol.32 , pp. 1173-1182
    • Ward, A.1    Balwierz, A.2    Zhang, J.D.3    Kublbeck, M.4    Pawitan, Y.5    Hielscher, T.6    Wiemann, S.7    Sahin, O.8
  • 54
    • 84875862077 scopus 로고    scopus 로고
    • Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells
    • [54] Liu K, Guo L, Miao L, Bao W, Yang J, Li X, Xi T and Zhao W. Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells. Anticancer Drugs 2013; 24: 494-503.
    • (2013) Anticancer Drugs , vol.24 , pp. 494-503
    • Liu, K.1    Guo, L.2    Miao, L.3    Bao, W.4    Yang, J.5    Li, X.6    Xi, T.7    Zhao, W.8
  • 56
    • 84908565432 scopus 로고    scopus 로고
    • Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial-mesenchymal transition
    • [56] Tang J, Shen L, Yang Q and Zhang C. Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial-mesenchymal transition. Cell Prolif 2014; 47: 427-434.
    • (2014) Cell Prolif , vol.47 , pp. 427-434
    • Tang, J.1    Shen, L.2    Yang, Q.3    Zhang, C.4
  • 57
    • 84891826772 scopus 로고    scopus 로고
    • Metadherin regulates metastasis of squamous cell carcinoma of the head and neck via AKT signalling pathway-mediated epithelial-mesenchymal transition
    • [57] Yu C, Liu Y, Tan H, Li G, Su Z, Ren S, Zhu G, Tian Y, Qiu Y and Zhang X. Metadherin regulates metastasis of squamous cell carcinoma of the head and neck via AKT signalling pathway-mediated epithelial-mesenchymal transition. Cancer Lett 2014; 343: 258-267.
    • (2014) Cancer Lett , vol.343 , pp. 258-267
    • Yu, C.1    Liu, Y.2    Tan, H.3    Li, G.4    Su, Z.5    Ren, S.6    Zhu, G.7    Tian, Y.8    Qiu, Y.9    Zhang, X.10
  • 58
    • 80053135079 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor
    • [58] Sun W, Fan YZ, Xi H, Lu XS, Ye C and Zhang JT. Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: an unfavorable and independent prognostic factor. Oncol Rep 2011; 26: 1133-1142.
    • (2011) Oncol Rep , vol.26 , pp. 1133-1142
    • Sun, W.1    Fan, Y.Z.2    Xi, H.3    Lu, X.S.4    Ye, C.5    Zhang, J.T.6
  • 59
    • 84875813177 scopus 로고    scopus 로고
    • Expression characteristics of astrocyte elevated gene-1 (AEG-1) in tongue carcinoma and its correlation with poor prognosis
    • [59] Ke ZF, He S, Li S, Luo D, Feng C and Zhou W. Expression characteristics of astrocyte elevated gene-1 (AEG-1) in tongue carcinoma and its correlation with poor prognosis. Cancer Epidemiol 2013; 37: 179-185.
    • (2013) Cancer Epidemiol , vol.37 , pp. 179-185
    • Ke, Z.F.1    He, S.2    Li, S.3    Luo, D.4    Feng, C.5    Zhou, W.6
  • 60
    • 84865435507 scopus 로고    scopus 로고
    • Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival
    • [60] Zhou J, Li J, Wang Z, Yin C and Zhang W. Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival. Asia Pac J Clin Oncol 2012; 8: e42-48.
    • (2012) Asia Pac J Clin Oncol , vol.8 , pp. e42-e48
    • Zhou, J.1    Li, J.2    Wang, Z.3    Yin, C.4    Zhang, W.5
  • 63
    • 84898824571 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1: A novel independent prognostic biomarker for metastatic ovarian tumors
    • [63] Li C, Chen K, Cai J, Shi QT, Li Y, Li L, Song H, Qiu H, Qin Y and Geng JS. Astrocyte elevated gene-1: a novel independent prognostic biomarker for metastatic ovarian tumors. Tumour Biol 2014; 35: 3079-3085.
    • (2014) Tumour Biol , vol.35 , pp. 3079-3085
    • Li, C.1    Chen, K.2    Cai, J.3    Shi, Q.T.4    Li, Y.5    Li, L.6    Song, H.7    Qiu, H.8    Qin, Y.9    Geng, J.S.10
  • 64
    • 79960675826 scopus 로고    scopus 로고
    • Expression of astrocyte elevated gene-1: A novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer
    • [64] Song H, Li C, Lu R, Zhang Y and Geng J. Expression of astrocyte elevated gene-1: a novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer. Int J Gynecol Cancer 2010; 20: 1188-1196.
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 1188-1196
    • Song, H.1    Li, C.2    Lu, R.3    Zhang, Y.4    Geng, J.5
  • 65
    • 84896503548 scopus 로고    scopus 로고
    • Expression of AEG-1 and microvessel density correlates with metastasis and prognosis of oral squamous cell carcinoma
    • [65] Xia X, Du R, Zhao L, Sun W and Wang X. Expression of AEG-1 and microvessel density correlates with metastasis and prognosis of oral squamous cell carcinoma. Hum Pathol 2014; 45: 858-865.
    • (2014) Hum Pathol , vol.45 , pp. 858-865
    • Xia, X.1    Du, R.2    Zhao, L.3    Sun, W.4    Wang, X.5
  • 66
    • 84861989333 scopus 로고    scopus 로고
    • Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors
    • [66] Chen X, Dong K, Long M, Lin F, Wang X, Wei J, Ren J and Zhang H. Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors. Oncol Lett 2012; 4: 319-323.
    • (2012) Oncol Lett , vol.4 , pp. 319-323
    • Chen, X.1    Dong, K.2    Long, M.3    Lin, F.4    Wang, X.5    Wei, J.6    Ren, J.7    Zhang, H.8
  • 69
    • 79959712035 scopus 로고    scopus 로고
    • MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer
    • [69] Qian BJ, Yan F, Li N, Liu QL, Lin YH, Liu CM, Luo YP, Guo F and Li HZ. MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer. Cancer Immunol Immunother 2011; 60: 883-893.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 883-893
    • Qian, B.J.1    Yan, F.2    Li, N.3    Liu, Q.L.4    Lin, Y.H.5    Liu, C.M.6    Luo, Y.P.7    Guo, F.8    Li, H.Z.9
  • 70
    • 79958150318 scopus 로고    scopus 로고
    • Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment
    • [70] Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Thiel KW and Leslie KK. Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment. PLoS One 2011; 6: e20920.
    • (2011) Plos One , pp. 6
    • Meng, X.1    Brachova, P.2    Yang, S.3    Xiong, Z.4    Zhang, Y.5    Thiel, K.W.6    Leslie, K.K.7
  • 71
    • 84894078674 scopus 로고    scopus 로고
    • Knockdown of astrocyte elevated gene-1 inhibits tumor growth and modifies microRNAs expression profiles in human colorectal cancer cells
    • [71] Huang S, Wu B, Li D, Zhou W, Deng G, Zhang K and Li Y. Knockdown of astrocyte elevated gene-1 inhibits tumor growth and modifies microRNAs expression profiles in human colorectal cancer cells. Biochem Biophys Res Commun 2014; 444: 338-345.
    • (2014) Biochem Biophys Res Commun , vol.444 , pp. 338-345
    • Huang, S.1    Wu, B.2    Li, D.3    Zhou, W.4    Deng, G.5    Zhang, K.6    Li, Y.7
  • 72
    • 84867572569 scopus 로고    scopus 로고
    • MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2
    • [72] Yang Y, Wu J, Guan H, Cai J, Fang L, Li J and Li M. MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2. FEBS Lett 2012; 586: 3608-3612.
    • (2012) FEBS Lett , vol.586 , pp. 3608-3612
    • Yang, Y.1    Wu, J.2    Guan, H.3    Cai, J.4    Fang, L.5    Li, J.6    Li, M.7
  • 73
    • 84860718788 scopus 로고    scopus 로고
    • Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma
    • [73] Gong Z, Liu W, You N, Wang T, Wang X, Lu P, Zhao G, Yang P, Wang D and Dou K. Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma. Oncol Rep 2012; 27: 2073-2079.
    • (2012) Oncol Rep , vol.27 , pp. 2073-2079
    • Gong, Z.1    Liu, W.2    You, N.3    Wang, T.4    Wang, X.5    Lu, P.6    Zhao, G.7    Yang, P.8    Wang, D.9    Dou, K.10
  • 74
    • 84875102356 scopus 로고    scopus 로고
    • Metadherin is a prognostic predictor of hepatocellular carcinoma after curative hepatectomy
    • [74] Ahn S, Hyeon J and Park CK. Metadherin is a prognostic predictor of hepatocellular carcinoma after curative hepatectomy. Gut Liver 2013; 7: 206-212.
    • (2013) Gut Liver , vol.7 , pp. 206-212
    • Ahn, S.1    Hyeon, J.2    Park, C.K.3
  • 75
    • 84874097138 scopus 로고    scopus 로고
    • Deregulation of MTDH gene expression in gastric cancer
    • [75] Baygi ME and Nikpour P. Deregulation of MTDH gene expression in gastric cancer. Asian Pac J Cancer Prev 2012; 13: 2833-2836.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2833-2836
    • Baygi, M.E.1    Nikpour, P.2
  • 77
    • 84885291667 scopus 로고    scopus 로고
    • AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancers
    • [77] Huang W, Yang L, Liang S, Liu D, Chen X, Ma Z, Zhai S, Li P and Wang X. AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancers. Dig Dis Sci 2013; 58: 2873-2880.
    • (2013) Dig Dis Sci , vol.58 , pp. 2873-2880
    • Huang, W.1    Yang, L.2    Liang, S.3    Liu, D.4    Chen, X.5    Ma, Z.6    Zhai, S.7    Li, P.8    Wang, X.9
  • 78
    • 77956187799 scopus 로고    scopus 로고
    • Prognostic significance of AEG-1 expression in colorectal carcinoma
    • [78] Song H, Li C, Li R and Geng J. Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 2010; 25: 1201-1209.
    • (2010) Int J Colorectal Dis , vol.25 , pp. 1201-1209
    • Song, H.1    Li, C.2    Li, R.3    Geng, J.4
  • 79
    • 84861470722 scopus 로고    scopus 로고
    • Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines
    • [79] Gnosa S, Shen YM, Wang CJ, Zhang H, Stratmann J, Arbman G and Sun XF. Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. J Transl Med 2012; 10: 109.
    • (2012) J Transl Med , vol.10 , pp. 109
    • Gnosa, S.1    Shen, Y.M.2    Wang, C.J.3    Zhang, H.4    Stratmann, J.5    Arbman, G.6    Sun, X.F.7
  • 82
    • 82355168594 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma
    • [82] Liao WT, Guo L, Zhong Y, Wu YH, Li J and Song LB. Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma. J Transl Med 2011; 9: 205.
    • (2011) J Transl Med , vol.9 , pp. 205
    • Liao, W.T.1    Guo, L.2    Zhong, Y.3    Wu, Y.H.4    Li, J.5    Song, L.B.6
  • 83
    • 84876960888 scopus 로고    scopus 로고
    • Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: A microarray study
    • [83] Erdem H, Oktay M, Yildirim U, Uzunlar AK and Kayikci MA. Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study. Pol J Pathol 2013; 64: 28-32.
    • (2013) Pol J Pathol , vol.64 , pp. 28-32
    • Erdem, H.1    Oktay, M.2    Yildirim, U.3    Uzunlar, A.K.4    Kayikci, M.A.5
  • 84
    • 84901372953 scopus 로고    scopus 로고
    • MTDH mediates estrogen-independent growth and tamoxifen resistance by down-regulating PTEN in MCF-7 breast cancer cells
    • [84] Xu C, Kong X, Wang H, Zhang N, Ding X, Li X and Yang Q. MTDH mediates estrogen-independent growth and tamoxifen resistance by down-regulating PTEN in MCF-7 breast cancer cells. Cell Physiol Biochem 2014; 33: 1557-1567.
    • (2014) Cell Physiol Biochem , vol.33 , pp. 1557-1567
    • Xu, C.1    Kong, X.2    Wang, H.3    Zhang, N.4    Ding, X.5    Li, X.6    Yang, Q.7
  • 86
    • 79951775092 scopus 로고    scopus 로고
    • Clinical significance of astrocyte elevated gene-1 expression in human epithelial ovarian carcinoma
    • [86] Meng F, Luo C, Ma L, Hu Y and Lou G. Clinical significance of astrocyte elevated gene-1 expression in human epithelial ovarian carcinoma. Int J Gynecol Pathol 2011; 30: 145-150.
    • (2011) Int J Gynecol Pathol , vol.30 , pp. 145-150
    • Meng, F.1    Luo, C.2    Ma, L.3    Hu, Y.4    Lou, G.5
  • 87
    • 84862817214 scopus 로고    scopus 로고
    • Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma
    • [87] Li C, Li Y, Wang X, Wang Z, Cai J, Wang L, Zhao Y, Song H, Meng X, Ning X, Xu C, Lin M, Li L and Geng J. Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma. Histopathology 2012; 60: 953-963.
    • (2012) Histopathology , vol.60 , pp. 953-963
    • Li, C.1    Li, Y.2    Wang, X.3    Wang, Z.4    Cai, J.5    Wang, L.6    Zhao, Y.7    Song, H.8    Meng, X.9    Ning, X.10    Xu, C.11    Lin, M.12    Li, L.13    Geng, J.14
  • 88
    • 84871107583 scopus 로고    scopus 로고
    • The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility
    • [88] Yuan C, Li X, Yan S, Yang Q, Liu X and Kong B. The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility. PLoS One 2012; 7: e51561.
    • (2012) Plos One , pp. 7
    • Yuan, C.1    Li, X.2    Yan, S.3    Yang, Q.4    Liu, X.5    Kong, B.6
  • 89
    • 77951725566 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion
    • [89] Liu L, Wu J, Ying Z, Chen B, Han A, Liang Y, Song L, Yuan J, Li J and Li M. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res 2010; 70: 3750-3759.
    • (2010) Cancer Res , vol.70 , pp. 3750-3759
    • Liu, L.1    Wu, J.2    Ying, Z.3    Chen, B.4    Han, A.5    Liang, Y.6    Song, L.7    Yuan, J.8    Li, J.9    Li, M.10
  • 90
    • 77951879469 scopus 로고    scopus 로고
    • Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas
    • [90] Xia Z, Zhang N, Jin H, Yu Z, Xu G and Huang Z. Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas. Clin Neurol Neurosurg 2010; 112: 413-419.
    • (2010) Clin Neurol Neurosurg , vol.112 , pp. 413-419
    • Xia, Z.1    Zhang, N.2    Jin, H.3    Yu, Z.4    Xu, G.5    Huang, Z.6
  • 91
    • 84867528466 scopus 로고    scopus 로고
    • AEG-1 is associated with clinical outcome in neuroblastoma patients
    • [91] Liu HY, Liu CX, Han B, Zhang XY and Sun RP. AEG-1 is associated with clinical outcome in neuroblastoma patients. Cancer Biomark 2012; 11: 115-121.
    • (2012) Cancer Biomark , vol.11 , pp. 115-121
    • Liu, H.Y.1    Liu, C.X.2    Han, B.3    Zhang, X.Y.4    Sun, R.P.5
  • 92
    • 84904554760 scopus 로고    scopus 로고
    • Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer
    • [92] Yao Y, Gu X, Liu H, Wu G, Yuan D, Yang X and Song Y. Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer. Br J Cancer 2014; 111: 355-364.
    • (2014) Br J Cancer , vol.111 , pp. 355-364
    • Yao, Y.1    Gu, X.2    Liu, H.3    Wu, G.4    Yuan, D.5    Yang, X.6    Song, Y.7
  • 93
    • 84871584591 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling
    • [93] Liu B, Wu Y and Peng D. Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling. Oncol Lett 2013; 5: 505-510.
    • (2013) Oncol Lett , vol.5 , pp. 505-510
    • Liu, B.1    Wu, Y.2    Peng, D.3
  • 94
    • 84868119866 scopus 로고    scopus 로고
    • Expression of AEG-1 in human T-cell lymphoma enhances the risk of progression
    • [94] Yan J, Zhang M, Chen Q and Zhang X. Expression of AEG-1 in human T-cell lymphoma enhances the risk of progression. Oncol Rep 2012; 28: 2107-2114.
    • (2012) Oncol Rep , vol.28 , pp. 2107-2114
    • Yan, J.1    Zhang, M.2    Chen, Q.3    Zhang, X.4
  • 95
    • 84907186987 scopus 로고    scopus 로고
    • Metadherin interference inhibits proliferation and enhances chemo-sensitivity to doxorubicin in diffuse large B cell lymphoma
    • [95] Li PP, Feng LL, Chen N, Lu K, Meng XH, Ge XL, Lv X and Wang X. Metadherin interference inhibits proliferation and enhances chemo-sensitivity to doxorubicin in diffuse large B cell lymphoma. Int J Clin Exp Med 2014; 7: 2081-2086.
    • (2014) Int J Clin Exp Med , vol.7 , pp. 2081-2086
    • Li, P.P.1    Feng, L.L.2    Chen, N.3    Lu, K.4    Meng, X.H.5    Ge, X.L.6    Lv, X.7    Wang, X.8
  • 97
    • 84884475411 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 is associated with metastasis in head and neck squamous cell carcinoma through p65 phosphorylation and upregulation of MMP1
    • [97] Wang YP, Liu IJ, Chiang CP and Wu HC. Astrocyte elevated gene-1 is associated with metastasis in head and neck squamous cell carcinoma through p65 phosphorylation and upregulation of MMP1. Mol Cancer 2013; 12: 109.
    • (2013) Mol Cancer , vol.12 , pp. 109
    • Wang, Y.P.1    Liu, I.J.2    Chiang, C.P.3    Wu, H.C.4


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