MTDH/AEG-1 contributes to central features of the neoplastic phenotype in bladder cancer

Urologic Oncology: Seminars and Original Investigations

Volumn 32, Issue 5, 2014, Pages 670-677

  Nikpour, Mahnaz ^a,b   Emadi Baygi, Modjtaba ^c   Fischer, Ute ^a   Niegisch, Günter ^a   Schulz, Wolfgang A ^a   Nikpour, Parvaneh ^b,d,e  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHREKORD UNIVERSITY   (Iran)

^d ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Anchorage independent growth; Bladder cancer; Cell survival; MTDH AEG 1

Indexed keywords

CASPASE 3; CASPASE 7; LIPOCORTIN 5; MTDH AEG 1 PROTEIN; ONCOPROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CASP7 PROTEIN, HUMAN; CELL ADHESION MOLECULE; MTDH PROTEIN, HUMAN;

ADULT; AGED; ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; BLADDER CANCER; BLADDER CANCER CELL LINE; CANCER CELL; CANCER TISSUE; CELL CYCLE; CELL MIGRATION; CELL VIABILITY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SERUM; WOUND HEALING; BLADDER; BLADDER TUMOR; CELL MOTION; CELL SURVIVAL; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; METABOLISM; MIDDLE AGED; TUMOR CELL LINE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; APOPTOSIS; CASPASE 3; CASPASE 7; CELL ADHESION MOLECULES; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; RNA INTERFERENCE; RNA, SMALL INTERFERING; URINARY BLADDER; URINARY BLADDER NEOPLASMS; WOUND HEALING;

EID: 84902544289     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2013.11.005     Document Type: Article

References (31)

1. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277-300.
2. Nargund V.H., Tanabalan C.K., Kabir M.N. Management of non-muscle-invasive (superficial) bladder cancer. Semin Oncol 2012, 39:559-572.
3. Chang D.W., Gu J., Wu X. Germline prognostic markers for urinary bladder cancer: obstacles and opportunities. Urol Oncol 2012, 30:524-532.
4. Kang D.C., Su Z.Z., Sarkar D., Emdad L., Volsky D.J., Fisher P.B. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005, 353:8-15.
5. Emdad L., Sarkar D., Su Z.Z., et al. Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 2007, 114:155-170.
6. Li J., Zhang N., Song L.B., et al. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 2008, 14:3319-3326.
7. Song H., Li C., Li R., Geng J. Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 2010, 25:1201-1209.
8. Yoo B.K., Emdad L., Su Z.Z., et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009, 119:465-477.
9. Liu H., Song X., Liu C., Xie L., Wei L., Sun R. Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. J Exp Clin Cancer Res 2009, 28:19.
10. Emdad L., Sarkar D., Lee S.G., et al. Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol Cancer Ther 2010, 9:79-88.
11. Hu G., Wei Y., Kang Y. The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 2009, 15:5615-5620.
12. Yu C., Chen K., Zheng H., et al. Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 2009, 30:894-901.
13. Zhang X., Zhang N., Zhang M.X. Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression. Chin Med J (Engl) 2011, 124:3546-3550.
14. Song L., Li W., Zhang H., et al. Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 2009, 219:317-326.
15. Dokun O.Y., Florl A.R., Seifert H.H., Wolff I., Schulz W.A. Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer. Int J Cancer 2008, 123:2798-2807.
16. Emadi Baygi M., Soheili Z.S., Essmann F., et al. Slug/SNAI2 regulates cell proliferation and invasiveness of metastatic prostate cancer cell lines. Tumour Biol 2010, 31:297-307.
17. Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991, 139:271-279.
18. Janssen K., Pohlmann S., Janicke R.U., Schulze-Osthoff K., Fischer U. Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood 2007, 110:3662-3672.
19. Emadi-Baygi M., Soheili Z.S., Schmitz I., Sameie S., Schulz W.A. Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines. Cell Biol Toxicol 2010, 26:553-567.
20. Nawroth R., Stellwagen F., Schulz W.A., et al. S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer. PloS One 2011, 6:e27509.
21. Zhou J., Li J., Wang Z., Yin C., Zhang W. Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival. Asia Pac J Clin Oncol 2012, 8:e42-e48.
22. Meng X., Zhu D., Yang S., et al. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. J Biol Chem 2012, 287:4485-4491.
23. Hu G., Chong R.A., Yang Q., et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009, 15:9-20.
24. Sutherland H.G., Lam Y.W., Briers S., Lamond A.I., Bickmore W.A. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 2004, 294:94-105.
25. Brown D.M., Ruoslahti E. Metadherin a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004, 5:365-374.
26. Emdad L., Sarkar D., Su Z.Z., et al. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 2006, 66:1509-1516.
27. Kong X., Moran M.S., Zhao Y., Yang Q. Inhibition of metadherin sensitizes breast cancer cells to AZD6244. Cancer Biol Ther 2012, 13:43-49.
28. Lee S.G., Su Z.Z., Emdad L., Sarkar D., Franke T.F., Fisher P.B. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2008, 27:1114-1121.
29. Li J., Yang L., Song L., et al. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009, 28:3188-3196.
30. Drayton R.M., Catto J.W. Molecular mechanisms of cisplatin resistance in bladder cancer. Expert Rev Anticancer Ther 2012, 12:271-281.
31. Milhem M.M., Knutson T., Yang S., et al. Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients. J Cancer Sci Ther 2011, Suppl 5. 004.