Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue

Diagnostic Pathology

Volumn 5, Issue 1, 2010, Pages

  Su, Peng ^a   Zhang, Qinghui ^a   Yang, Qifeng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; HER2 PROTEIN, HUMAN; KI 67 ANTIGEN; MTDH PROTEIN, HUMAN; PARAFFIN; PROGESTERONE RECEPTOR; PROTEIN P53; TP53 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; BREAST TUMOR; CANCER INVASION; CASE CONTROL STUDY; CELL PROLIFERATION; CHEMISTRY; DISEASE COURSE; FEMALE; HUMAN; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CELL PROLIFERATION; DISEASE PROGRESSION; FEMALE; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; NEOPLASM INVASIVENESS; PARAFFIN EMBEDDING; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953624680     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-5-38     Document Type: Article

References (22)

1. Tavassoli FA, Devilee P. Intraductal proliferative lesions. Pathology and genetics of tumors of the breast and female genetic organs. 2003, Lyon: International Agency for Research on Cancer (IARC) Press.
2. Brown DM, Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004, 5(4):365-374. 10.1016/S1535-6108(04)00079-0, 15093543.
3. Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ, Fisher PB. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 2002, 21(22):3592-3602. 10.1038/sj.onc.1205445, 12032861.
4. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ, Fisher PB. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005, 353(1):8-15. 10.1016/j.gene.2005.04.006, 15927426.
5. Sutherland HG, Lam YW, Briers S, Lamond AI, Bickmore WA. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 2004, 294(1):94-105. 10.1016/j.yexcr.2003.11.020, 14980505.
6. Britt DE, Yang DF, Yang DQ, Flanagan D, Callanan H, Lim YP, Lin SH, Hixson DC. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 2004, 300(1):134-148. 10.1016/j.yexcr.2004.06.026, 15383321.
7. Su ZZ, Chen Y, Kang DC, Chao W, Simm M, Volsky DJ, Fisher PB. Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-alpha treatment. Gene 2003, 306:67-78. 10.1016/S0378-1119(03)00404-9, 12657468.
8. Hu G, Wei Y, Kang Y. The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 2009, 15(18):5615-5620. 10.1158/1078-0432.CCR-09-0049, 2747034, 19723648.
9. Lee SG, Su ZZ, Emdad L, Sarkar D, Fisher PB. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA 2006, 103(46):17390-17395. 10.1073/pnas.0608386103, 1859939, 17088530.
10. Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K, Fisher PB. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 2006, 66(3):1509-1516. 10.1158/0008-5472.CAN-05-3029, 16452207.
11. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2008, 27(8):1114-1121. 10.1038/sj.onc.1210713, 17704808.
12. Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, Place RF, Pookot D, Majid S, Igawa M, et al. Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 2007, 26(55):7647-7655. 10.1038/sj.onc.1210572, 17563745.
13. Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY, Wu J, Yuan J, Zhang HZ, Zeng MS, et al. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 2008, 14(11):3319-3326. 10.1158/1078-0432.CCR-07-4054, 18519759.
14. Lee SG, Jeon HY, Su ZZ, Richards JE, Vozhilla N, Sarkar D, Van Maerken T, Fisher PB. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 2009,
15. Song L, Li W, Zhang H, Liao W, Dai T, Yu C, Ding X, Zhang L, Li J. Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 2009, 219(3):317-326. 10.1002/path.2595, 19644957.
16. Yu C, Chen K, Zheng H, Guo X, Jia W, Li M, Zeng M, Li J, Song L. Overexpression of Astrocyte Elevated Gene-1 (AEG-1) Is Associated with Esophageal Squamous Cell Carcinoma (ESCC) Progression and Pathogenesis. Carcinogenesis 2009, 30(5):894-901. 10.1093/carcin/bgp064, 19304953.
17. Khuda II, Koide N, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 2009, 128(1 Suppl):e700-706. 10.1111/j.1365-2567.2009.03063.x, 2753960, 19740331.
18. Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL, Haffty BG, Kang Y. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009, 15(1):9-20. 10.1016/j.ccr.2008.11.013, 2676231, 19111877.
19. Greene FL, Page DL, Fleming ID. Breast Cancer in AJCC Cancer Staging Handbook. TNM Classification of Malignant Tumors. 2002, New York: Springer Verlag, 6.
20. Li J, Yang L, Song L, Xiong H, Wang L, Yan X, Yuan J, Wu J, Li M. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009, 28(36):3188-96. 10.1038/onc.2009.171, 19633686.
21. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 2008, 68(5):1478-1484. 10.1158/0008-5472.CAN-07-6164, 18316612.
22. Bharti AC, Aggarwal BB. Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol 2002, 64(5-6):883-888. 10.1016/S0006-2952(02)01154-1, 12213582.