The MTDH (-470G>A) Polymorphism Is Associated with Ovarian Cancer Susceptibility

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Yuan, Cunzhong ^a   Li, Xiao ^a   Yan, Shi ^a   Yang, Qifeng ^a   Liu, Xiaoyan ^a   Kong, Beihua ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLYCINE; METADHERIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CANCER GROWTH; CANCER RISK; CANCER STAGING; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC MODEL; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MARKER GENE; METADHERIN GENE; OVARY CANCER; PROTEIN EXPRESSION; RISK ASSESSMENT; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR DIFFERENTIATION; TUMOR VOLUME;

CELL ADHESION MOLECULES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; OVARIAN NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84871107583     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051561     Document Type: Article

References (36)

1. Siegel R, Naishadham D, Jemal A, (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29.
2. Risch HA, (1998) Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 90: 1774-1786.
3. Meindl A, Hellebrand H, Wiek C, Erven V, Wappenschmidt B, et al. (2010) Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet 42: 410-414.
4. Loveday C, Turnbull C, Ramsay E, Hughes D, Ruark E, et al. (2011) Germline mutations in RAD51D confer susceptibility to ovarian cancer. Nat Genet 43: 879-882.
5. Yin J, Lu K, Lin J, Wu L, Hildebrandt MA, et al. (2011) Genetic variants in TGF-beta pathway are associated with ovarian cancer risk. PLoS One 6: e25559.
6. Ma X, Zhang J, Liu S, Huang Y, Chen B, et al. (2011) Polymorphisms in the CASP8 gene and the risk of epithelial ovarian cancer. Gynecol Oncol 122: 554-559.
7. Permuth-Wey J, Kim D, Tsai YY, Lin HY, Chen YA, et al. (2011) LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. Cancer Res 71: 3896-3903.
8. Braem MG, Schouten LJ, Peeters PH, den Brandt PA, Onland-Moret NC, (2011) Genetic susceptibility to sporadic ovarian cancer: A systematic review. Biochim Biophys Acta 1816: 132-146.
9. Pelttari LM, Heikkinen T, Thompson D, Kallioniemi A, Schleutker J, et al. (2011) RAD51C is a susceptibility gene for ovarian cancer. Hum Mol Genet 20: 3278-3288.
10. Ramus SJ, Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, et al. (2012) Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Hum Mutat.
11. Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, et al. (2010) Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet 42: 880-884.
12. Goode EL, Chenevix-Trench G, Song H, Ramus SJ, Notaridou M, et al. (2010) A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet 42: 874-879.
13. Song H, Ramus SJ, Tyrer J, Bolton KL, Gentry-Maharaj A, et al. (2009) A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet 41: 996-1000.
14. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ, et al. (2005) Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353: 8-15.
15. Yu C, Chen K, Zheng H, Guo X, Jia W, et al. (2009) Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 30: 894-901.
16. Jian-bo X, Hui W, Yu-long H, Chang-hua Z, Long-juan Z, et al. (2011) Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 28: 455-462.
17. Chen W, Ke Z, Shi H, Yang S, Wang L, (2010) Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression. Neoplasma 57: 522-529.
18. Thirkettle HJ, Girling J, Warren AY, Mills IG, Sahadevan K, et al. (2009) LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res 15: 3003-3013.
19. Song L, Li W, Zhang H, Liao W, Dai T, et al. (2009) Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 219: 317-326.
20. Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, et al. (2009) Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 119: 465-477.
21. Brown DM, Ruoslahti E, (2004) Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5: 365-374.
22. Li J, Zhang N, Song LB, Liao WT, Jiang LL, et al. (2008) Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 14: 3319-3326.
23. Lee SG, Jeon HY, Su ZZ, Richards JE, Vozhilla N, et al. (2009) Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 28: 2476-2484.
24. Gnosa S, Shen YM, Wang CJ, Zhang H, Stratmann J, et al. (2012) Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. J Transl Med 10: 109.
25. Emdad L, Lee SG, Su ZZ, Jeon HY, Boukerche H, et al. (2009) Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci U S A 106: 21300-21305.
26. Zhao Y, Moran MS, Yang Q, Liu Q, Yuan C, et al. (2012) Metadherin regulates radioresistance in cervical cancer cells. Oncol Rep 27: 1520-1526.
27. Zhang B, Liu XX, He JR, Zhou CX, Guo M, et al. (2011) Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis 32: 2-9.
28. Hu G, Wei Y, Kang Y, (2009) The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 15: 5615-5620.
29. Srivastava J, Siddiq A, Emdad L, Santhekadur PK, Chen D, et al. (2012) Astrocyte elevated gene-1 (AEG-1) promotes hepatocarcinogenesis: Novel insights from a mouse model. Hepatology.
30. Li C, Li Y, Wang X, Wang Z, Cai J, et al. (2012) Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma. Histopathology 60: 953-963.
31. Zhao Y, Kong X, Li X, Yan S, Yuan C, et al. (2011) Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells. PLoS One 6: e29363.
32. Li C, Liu J, Lu R, Yu G, Wang X, et al. (2011) AEG-1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers. Int J Gynecol Cancer 21: 602-608.
33. Meng F, Luo C, Ma L, Hu Y, Lou G, (2011) Clinical significance of astrocyte elevated gene-1 expression in human epithelial ovarian carcinoma. Int J Gynecol Pathol 30: 145-150.
34. Liu X, Zhang N, Li X, Moran MS, Yuan C, et al. (2011) Identification of novel variants of metadherin in breast cancer. PLoS One 6: e17582.
35. Zhang N, Li X, Tao K, Jiang L, Ma T, et al. (2011) BCL-2 (-938C>A) polymorphism is associated with breast cancer susceptibility. BMC Med Genet 12: 48.
36. Yuan C, Jiao L, Yang L, Ying W, Hu Z, et al. (2008) The up-regulation of 14-3-3 proteins in Smad4 deficient epidermis and hair follicles at catagen. Proteomics 8: 2230-2243.