Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis

Cancer Biology and Therapy

Volumn 12, Issue 6, 2011, Pages 539-548

  Wang, Fen ^a   Ke, Zun Fu ^a   Sun, Shi Jun ^a   Chen, Wen Fang ^a   Yang, Shi Cong ^a   Li, Shu Hua ^a   Mao, Xiao Peng ^a   Wang, Lian Tang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Astrocyte elevated gene 1; Invasion; MMP 2; Osteosarcoma; Prognosis

Indexed keywords

GELATINASE A;

ADULT; ARTICLE; ASTROCYTE ELEVATED GENE 1; BONE METASTASIS; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CANCER TISSUE; CARCINOGENESIS; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS; ONCOGENE; OSTEOSARCOMA; OSTEOSARCOMA CELL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ADULT; BONE NEOPLASMS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MATRIX METALLOPROTEINASE 2; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; OSTEOSARCOMA; PROGNOSIS; RNA INTERFERENCE; YOUNG ADULT;

EID: 80052849589     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.6.16301     Document Type: Article

References (47)

1. Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma and Ewing's sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res 2007; 459:40-7; PMID: 17414166; DOI: 10.1097/ BLO.0b013e318059b8c9.
2. Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology and End Results Program. Cancer 2009; 115:1531-43; PMID: 19197972; DOI: 10.1002/cncr.24121.
3. Stiller CA, Bielack SS, Jundt G, Steliarova-Foucher E. Bone tumours in European children and adolescents 1978-1997. Report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42:2124-35; PMID: 16919776; DOI: 10.1016/j.ejca.2006.05.015.
4. Bacci G, Ferrari S, Longhi A, Forni C, Giacomini S, Lari S, et al. Relationship between dose-intensity of treatment and outcome for patients with osteosarcoma of the extremity treated with neoadjuvant chemotherapy. Oncol Rep 2001; 8:883-8; PMID: 11410803.
5. Kager L, Zoubek A, Potschger U, Kastner U, Flege S, Kempf-Bielack B, et al. Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. J Clin Oncol 2003; 21:2011-8; PMID: 12743156; DOI: 10.1200/JCO.2003.08.132.
6. Bacci G, Briccoli A, Ferrari S, Saeter G, Donati D, Longhi A, et al. Neoadjuvant chemotherapy for osteosarcoma of the extremities with synchronous lung metastases: treatment with cisplatin, adriamycin and high dose of methotrexate and ifosfamide. Oncol Rep 2000; 7:339-46; PMID: 10671683.
7. Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A, Picci P. Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer 2006; 106:1154-61; PMID: 16421923; DOI: 10.1002/cncr.21724.
8. Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, et al. Prognostic factors in highgrade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 2002; 20:776-90; PMID: 11821461; DOI: 10.1200/JCO.20.3.776.
9. Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ, et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 2002; 21:3592-602; PMID: 12032861; DOI: 10.1038/sj.onc.1205445.
10. Su ZZ, Chen Y, Kang DC, Chao W, Simm M, Volsky DJ, et al. Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-alpha treatment. Gene 2003; 306:67-78; PMID: 12657468; DOI: 10.1016/S0378- 1119(03)00404-9.
11. Britt DE, Yang DF, Yang DQ, Flanagan D, Callanan H, Lim YP, et al. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 2004; 300:134-48; PMID: 15383321; DOI: 10.1016/j.yexcr.2004.06.026.
12. Brown DM, Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004; 5:365-74; PMID: 15093543; DOI: 10.1016/S1535-6108(04)00079-0.
13. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ, Fisher PB. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005; 353:8-15; PMID: 15927426; DOI: 10.1016/j. gene.2005.04.006.
14. Jian-Bo X, Hui W, Yu-Long H, Chang-Hua Z, Long- Juan Z, Shi-Rong C, et al. Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 2011; 28\:455-62; PMID: 20300973; DOI: 10.1007/s12032-010-9475-6.
15. Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, et al. Knockdown of astrocyteelevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 2007; 26:7647-55; PMID: 17563745; DOI: 10.1038/ sj.onc.1210572.
16. Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY, et al. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 2008; 14:3319-26; PMID: 18519759; DOI: 10.1158/1078-0432.CCR-07-4054.
17. Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poorprognosis breast cancer. Cancer Cell 2009; 15:9-20; PMID: 19111877; DOI: 10.1016/j.ccr.2008.11.013.
18. Lee SG, Jeon HY, Su ZZ, Richards JE, Vozhilla N, Sarkar D, et al. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 2009; 28:2476-84; PMID: 19448665; DOI: 10.1038/ onc.2009.93.
19. Liu H, Song X, Liu C, Xie L, Wei L, Sun R. Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. J Exp Clin Cancer Res 2009; 28:19; PMID: 19216799; DOI: 10.1186/1756-9966-28-19.
20. Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, Mukhopadhyay ND, et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009; 119:465-77; PMID: 19221438; DOI: 10.1172/JCI36460.
21. Yu C, Chen K, Zheng H, Guo X, Jia W, Li M, et al. Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 2009; 30:894-901; PMID: 19304953; DOI: 10.1093/ carcin/bgp064.
22. Emdad L, Sarkar D, Lee SG, Su ZZ, Yoo BK, Dash R, et al. Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol Cancer Ther 2010; 9:79- 88; PMID: 20053777; DOI: 10.1158/1535-7163. MCT-09-0752.
23. Liu L, Wu J, Ying Z, Chen B, Han A, Liang Y, et al. Astrocyte elevated gene-1 upregulates matrix metalloproteinase- 9 and induces human glioma invasion. Cancer Res 2010; 70:3750-9; PMID: 20388776; DOI: 10.1158/0008-5472. CAN-09-3838.
24. Xia Z, Zhang N, Jin H, Yu Z, Xu G, Huang Z. Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas. Clin Neurol Neurosurg 2010; 112:413-9; PMID: 20236756; DOI: 10.1016/j. clineuro.2010.02.007.
25. Emdad L, Sarkar D, Su ZZ, Lee SG, Kang DC, Bruce JN, et al. Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 2007; 114:155-70; PMID: 17397930; DOI: 10.1016/j.pharmthera. 2007.01.010.
26. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2008; 27:1114-21; PMID: 17704808; DOI: 10.1038/ sj.onc.1210713.
27. Emdad L, Lee SG, Su ZZ, Jeon HY, Boukerche H, Sarkar D, et al. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci USA 2009; 106:21300-5; PMID: 19940250; DOI: 10.1073/pnas.0910936106.
28. Hu G, Wei Y, Kang Y. The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 2009; 15:5615-20; PMID: 19723648; DOI: 10.1158/1078-0432.CCR-09-0049.
29. Sarkar D, Emdad L, Lee SG, Yoo BK, Su ZZ, Fisher PB. Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes. Cancer Res 2009; 69:8529-35; PMID: 19903854; DOI: 10.1158/0008-5472.CAN- 09-1846.
30. Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, et al. Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci USA 2009; 106:12938-43; PMID: 19622726; DOI: 10.1073/ pnas.0901451106.
31. Lee SG, Su ZZ, Emdad L, Sarkar D, Fisher PB. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol- 3-kinase and c-Myc. Proc Natl Acad Sci USA 2006; 103:17390-5; PMID: 17088530; DOI: 10.1073/ pnas.0608386103.
32. Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K, et al. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 2006; 66:1509-16; PMID: 16452207; DOI: 10.1158/0008-5472.CAN-05-3029.
33. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 2008; 68:1478-84; PMID: 18316612; DOI: 10.1158/0008- 5472.CAN-07-6164.
34. Cho HJ, Lee TS, Park JB, Park KK, Choe JY, Sin DI, et al. Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J Biochem Mol Biol 2007; 40:1069-76; PMID: 18047805; DOI: 10.5483/ BMBRep.2007.40.6.1069.
35. Hauben EI, Arends J, Vandenbroucke JP, van Asperen CJ, Van Marck E, Hogendoorn PC. Multiple primary malignancies in osteosarcoma patients. Incidence and predictive value of osteosarcoma subtype for cancer syndromes related with osteosarcoma. Eur J Hum Genet 2003; 11:611-8; PMID: 12891382; DOI: 10.1038/sj.ejhg.5201012.
36. Thompson RC Jr, Cheng EY, Clohisy DR, Perentesis J, Manivel C, Le CT. Results of treatment for metastatic osteosarcoma with neoadjuvant chemotherapy and surgery. Clin Orthop Relat Res 2002; 240-7; PMID: 11953615; DOI: 10.1097/00003086-200204000- 00028.
37. Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997; 89:1260-70; PMID: 9293916; DOI: 10.1093/jnci/89.17.1260.
38. Ortega N, Behonick D, Stickens D, Werb Z. How proteases regulate bone morphogenesis. Ann NY Acad Sci 2003; 995:109-16; PMID: 12814943; DOI: 10.1111/ j.1749-6632.2003.tb03214.x.
39. Kähäri VM, Saarialho-Kere U. Matrix metalloproteinases and their inhibitors in tumour growth and invasion. Ann Med 1999; 31:34-45; PMID: 10219712; DOI: 10.3109/07853899909019260.
40. Klein G, Vellenga E, Fraaije MW, Kamps WA, de Bont ES. The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g., acute leukemia. Crit Rev Oncol Hematol 2004; 50:87-100; PMID: 15157658; DOI: 10.1016/j.critrevonc.2003.09.001.
41. Huang SC, Ho CT, Lin-Shiau SY, Lin JK. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through downregulating nuclear factor-kappaB and c-Jun. Biochem Pharmacol 2005; 69:221-32; PMID: 15627474; DOI: 10.1016/j.bcp.2004.09.019.
42. Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, et al. Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKCdelta signal transduction. Oncogene 2004; 23:1845-53; PMID: 14661062; DOI: 10.1038/sj.onc.1207307.
43. Tingting R, Wei G, Changliang P, Xinchang L, Yi Y. Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. Cancer Biol Ther 2010; Epub ahead of print; PMID: 20592496; DOI: 10.4161/cbt.10.3.12349.
44. Mori K, Le Goff B, Berreur M, Riet A, Moreau A, Blanchard F, et al. Human osteosarcoma cells express functional receptor activator of nuclear factorkappa B. J Pathol 2007; 211:555-62; PMID: 17323424; DOI: 10.1002/path.2140.
45. Jin S, Pang RP, Shen JN, Huang G, Wang J, Zhou JG. Grifolin induces apoptosis via inhibition of PI3K/ AKT signalling pathway in human osteosarcoma cells. Apoptosis 2007; 12:1317-26; PMID: 17333316; DOI: 10.1007/s10495-007-0062- z.
46. Liu B, Shi ZL, Feng J, Tao HM. Celecoxib, a cyclooxygenase- 2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via downregulation of PI3K/Akt. Cell Biol Int 2008; 32:494-501; PMID: 18078766; DOI: 10.1016/j.cellbi.2007.10.008.
47. Guimarães AP, Rocha RM, da Cunha IW, Guimarães GC, Carvalho AL, de Camargo B, et al. Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. Eur J Cancer 2010; 46:3307-15; PMID: 20594821; DOI: 10.1016/j. ejca.2010.06.004.