AEG-1/MTDH/LYRIC: Signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis.

Advances in Cancer Research

Volumn 120, Issue , 2013, Pages 75-111

  Emdad, Luni ^a,b   Das, Swadesh K ^a   Dasgupta, Santanu ^a,b   Hu, Bin ^a   Sarkar, Devanand ^a,b   Fisher, Paul B ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

AEG 1 MTDH LYRIC; Angiogenesis; Cancer progression; Downstream molecules; Interacting proteins; Signaling events

Indexed keywords

APC PROTEIN; BETA CATENIN; BRCA2 AND CDKN1A INTERACTING PROTEIN ALPHA; CASEIN KINASE I; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FRIZZLED PROTEIN; GAG PROTEIN; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROMYELOCYTIC LEUKEMIA ZINC FINGER PROTEIN; PROTEIN; PROTEIN KINASE B; PROTEIN RSR1; STAPHYLOCOCCAL NUCLEASE DOMAIN CONTAINING 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UBINUCLEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; WNT PROTEIN;

APOPTOSIS; ARTICLE; ASTROCYTE ELEVATED GENE 1; AUTOPHAGY; BLADDER CANCER; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER RESISTANCE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CHILDHOOD CANCER; COLORECTAL CANCER; ENDOMETRIUM CARCINOMA; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GALLBLADDER CARCINOMA; GENE FUNCTION; GENE OVEREXPRESSION; GLIOBLASTOMA; GLIOMA; HEAD AND NECK CANCER; HUMAN; KIDNEY CANCER; LARGE CELL LYMPHOMA; LARYNX SQUAMOUS CELL CARCINOMA; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; LYSINE RICH CEACAM1 COISOLATED GENE; MALIGNANT TRANSFORMATION; METADHERIN GENE; METASTASIS; MOLECULAR CLONING; NEUROBLASTOMA; NONHUMAN; OLIGODENDROGLIOMA; ONCOGENE; ONCOGENE C MYC; OSTEOSARCOMA; OVARY CARCINOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SALIVARY GLAND TUMOR; SIGNAL TRANSDUCTION; SOLID TUMOR; STOMACH CARCINOMA; T CELL LYMPHOMA; TONGUE CARCINOMA; TUMOR PROMOTION; TUMOR VASCULARIZATION;

AEG-1/MTDH/LYRIC; ANGIOGENESIS; CANCER PROGRESSION; DOWNSTREAM MOLECULES; INTERACTING PROTEINS; SIGNALING EVENTS;

ANIMALS; CELL ADHESION MOLECULES; CLONING, MOLECULAR; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASM INVASIVENESS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 84880927965     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-401676-7.00003-6     Document Type: Chapter

References (158)

1. An F.Q., Matsuda M., Fujii H., Matsumoto Y. Expression of vascular endothelial growth factor in surgical specimens of hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 2000, 126:153-160.
2. Anttila V., Wessman M., Kallela M., Palotie A. Towards an understanding of genetic predisposition to migraine. Genome Medicine 2011, 3:17.
3. Ash S.C., Yang D.Q., Britt D.E. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochemical and Biophysical Research Communications 2008, 371:333-338.
4. Bao B., Azmi A.S., Ali S., Ahmad A., Li Y., Banerjee S., et al. The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochimica et Biophysica Acta 2012, 1826:272-296.
5. Bartholomeusz C., Gonzalez-Angulo A.M. Targeting the PI3K signaling pathway in cancer therapy. Expert Opinion on Therapeutic Targets 2012, 16:121-130.
6. Baygi M.E., Nikpour P. Deregulation of MTDH gene expression in gastric cancer. Asian Pacific Journal of Cancer Prevention 2012, 13:2833-2836.
7. Bellacosa A., Kumar C.C., Di Cristofano A., Testa J.R. Activation of AKT kinases in cancer: Implications for therapeutic targeting. Advances in Cancer Research 2005, 94:29-86.
8. Ben-Neriah Y., Karin M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nature Immunology 2011, 12:715-723.
9. Bernardo M.V., Yelo E., Gimeno L., Campillo J.A., Parrado A. Identification of apoptosis-related PLZF target genes. Biochemical and Biophysical Research Communications 2007, 359:317-322.
10. Bhutia S.K., Kegelman T.P., Das S.K., Azab B., Su Z.Z., Lee S.G., et al. Astrocyte elevated gene-1 induces protective autophagy. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:22243-22248.
11. Blancher C., Moore J.W., Robertson N., Harris A.L. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. Cancer Research 2001, 61:7349-7355.
12. Blanco M.A., Aleckovic M., Hua Y., Li T., Wei Y., Xu Z., et al. Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. The Journal of Biological Chemistry 2011, 286:19982-19992.
13. Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001, 411:355-365.
14. Britt D.E., Yang D.F., Yang D.Q., Flanagan D., Callanan H., Lim Y.P., et al. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Experimental Cell Research 2004, 300:134-148.
15. Brown D.M., Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004, 5:365-374.
16. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96:857-868.
17. Cadoret A., Ovejero C., Terris B., Souil E., Levy L., Lamers W.H., et al. New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 2002, 21:8293-8301.
18. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
19. Carmeliet P., Jain R.K. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011, 473:298-307.
20. Carnemolla A., Fossale E., Agostoni E., Michelazzi S., Calligaris R., De Maso L., et al. Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease. The Journal of Biological Chemistry 2009, 284:18167-18173.
21. Caudy A.A., Ketting R.F., Hammond S.M., Denli A.M., Bathoorn A.M., Tops B.B., et al. A micrococcal nuclease homologue in RNAi effector complexes. Nature 2003, 425:411-414.
22. Chen L.F., Greene W.C. Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation. Journal of Molecular Medicine (Berlin) 2003, 81:549-557.
23. Chen W., Ke Z., Shi H., Yang S., Wang L. Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression. Neoplasma 2010, 57:522-529.
24. Chen D., Yoo B.K., Santhekadur P.K., Gredler R., Bhutia S.K., Das S.K., et al. Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma. Clinical Cancer Research 2011, 17:6693-6701.
25. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988, 1:623-634.
26. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127:469-480.
27. Clevers H., Nusse R. Wnt/beta-catenin signaling and disease. Cell 2012, 149:1192-1205.
28. Datta S.R., Brunet A., Greenberg M.E. Cellular survival: A play in three Akts. Genes & Development 1999, 13:2905-2927.
29. Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996, 87:1161-1169.
30. Doble A. The role of excitotoxicity in neurodegenerative disease: Implications for therapy. Pharmacology & Therapeutics 1999, 81:163-221.
31. Downward J. Targeting RAS signalling pathways in cancer therapy. Nature Reviews. Cancer 2003, 3:11-22.
32. Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Journal of Clinical Oncology 2002, 20:4368-4380.
33. Eddleston M., Mucke L. Molecular profile of reactive astrocytes-Implications for their role in neurologic disease. Neuroscience 1993, 54:15-36.
34. Emdad L., Lee S.G., Su Z.Z., Jeon H.Y., Boukerche H., Sarkar D., et al. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:21300-21305.
35. Emdad L., Sarkar D., Lee S.G., Su Z.Z., Yoo B.K., Dash R., et al. Astrocyte elevated gene-1: A novel target for human glioma therapy. Molecular Cancer Therapeutics 2010, 9:79-88.
36. Emdad L., Sarkar D., Su Z.Z., Randolph A., Boukerche H., Valerie K., et al. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: Implications for tumor progression and metastasis. Cancer Research 2006, 66:1509-1516.
37. Engeland C.E., Oberwinkler H., Schumann M., Krause E., Muller G.A., Krausslich H.G. The cellular protein lyric interacts with HIV-1 Gag. Journal of Virology 2011, 85:13322-13332.
38. Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Reviews. Genetics 2006, 7:606-619.
39. Fisher P.B. Enhancement of viral transformation and expression of the transformed phenotype by tumor promoters. Tumor promotion and cocarcinogenesis in vitro, mechanisms of tumor promotion 1984, 57-123. CRC Press, Inc, Florida. T.J. Slaga (Ed.).
40. Folkman J. Angiogenesis: An organizing principle for drug discovery?. Nature Reviews. Drug Discovery 2007, 6:273-286.
41. Furia B., Deng L., Wu K., Baylor S., Kehn K., Li H., et al. Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins. The Journal of Biological Chemistry 2002, 277:4973-4980.
42. Ge X., Lv X., Feng L., Liu X., Gao J., Chen N., et al. Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma. PLoS One 2012, 7:e39449.
43. Ghosh S., May M.J., Kopp E.B. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annual Review of Immunology 1998, 16:225-260.
44. Gilmore T.D. The Re1/NF-kappa B/I kappa B signal transduction pathway and cancer. Cancer Treatment and Research 2003, 115:241-265.
45. Gnosa S., Shen Y.M., Wang C.J., Zhang H., Stratmann J., Arbman G., et al. Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. Journal of Translational Medicine 2012, 10:109.
46. Gong Z., Liu W., You N., Wang T., Wang X., Lu P., et al. Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma. Oncology Reports 2012, 27:2073-2079.
47. Gupta G.P., Massague J. Cancer metastasis: Building a framework. Cell 2006, 127:679-695.
48. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
49. Hanahan D., Weinberg R.A. Hallmarks of cancer: The next generation. Cell 2011, 144:646-674.
50. Hayden M.S., Ghosh S. Signaling to NF-kappaB. Genes & Development 2004, 18:2195-2224.
51. Hayden M.S., Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008, 132:344-362.
52. Hayden M.S., Ghosh S. NF-kappaB in immunobiology. Cell Research 2011, 21:223-244.
53. Hayden M.S., Ghosh S. NF-kappaB, the first quarter-century: Remarkable progress and outstanding questions. Genes & Development 2012, 26:203-234.
54. Hennessy B.T., Smith D.L., Ram P.T., Lu Y., Mills G.B. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nature Reviews. Drug Discovery 2005, 4:988-1004.
55. Hu G., Chong R.A., Yang Q., Wei Y., Blanco M.A., Li F., et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009, 15:9-20.
56. Hu G., Wei Y., Kang Y. The multifaceted role of MTDH/AEG-1 in cancer progression. Clinical Cancer Research 2009, 15:5615-5620.
57. Huang W.C., Ju T.K., Hung M.C., Chen C.C. Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Molecular Cell 2007, 26:75-87.
58. Hui A.B., Bruce J.P., Alajez N.M., Shi W., Yue S., Perez-Ordonez B., et al. Significance of dysregulated metadherin and microRNA-375 in head and neck cancer. Clinical Cancer Research 2011, 17:7539-7550.
59. Jeon H.Y., Choi M., Howlett E.L., Vozhilla N., Yoo B.K., Lloyd J.A., et al. Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo. Gene Expression Patterns 2010, 10:361-367.
60. Jian-bo X., Hui W., Yu-long H., Chang-hua Z., Long-juan Z., Shi-rong C., et al. Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Medical Oncology 2011, 28:455-462.
61. Jiang B.H., Jiang G., Zheng J.Z., Lu Z., Hunter T., Vogt P.K. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth & Differentiation 2001, 12:363-369.
62. Jiang T., Zhu A., Zhu Y., Piao D. Clinical implications of AEG-1 in liver metastasis of colorectal cancer. Medical Oncology 2012, 29:2858-2863.
63. Kanarek N., Ben-Neriah Y. Regulation of NF-kappaB by ubiquitination and degradation of the IkappaBs. Immunological Reviews 2012, 246:77-94.
64. Kang D.C., Su Z.Z., Sarkar D., Emdad L., Volsky D.J., Fisher P.B. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005, 353:8-15.
65. Karin M., Cao Y., Greten F.R., Li Z.W. NF-kappaB in cancer: From innocent bystander to major culprit. Nature Reviews. Cancer 2002, 2:301-310.
66. Katz M., Amit I., Yarden Y. Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochimica et Biophysica Acta 2007, 1773:1161-1176.
67. Ke Z.F., He S., Li S., Luo D., Feng C., Zhou W. Expression characteristics of astrocyte elevated gene-1 (AEG-1) in tongue carcinoma and its correlation with poor prognosis. Cancer Epidemiology 2012, 37(2):179-185.
68. Ke Z.F., Mao X., Zeng C., He S., Li S., Wang L.T. AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis. Medical Oncology 2013, 30:383.
69. Khuda I.I., Koide N., Noman A.S., Dagvadorj J., Tumurkhuu G., Naiki Y., et al. Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 2009, 128:e700-e706.
70. Kikuno N., Shiina H., Urakami S., Kawamoto K., Hirata H., Tanaka Y., et al. Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 2007, 26:7647-7655.
71. Kong X., Moran M.S., Zhao Y., Yang Q. Inhibition of metadherin sensitizes breast cancer cells to AZD6244. Cancer Biology & Therapy 2012, 13:43-49.
72. Kumar A., Takada Y., Boriek A.M., Aggarwal B.B. Nuclear factor-kappaB: Its role in health and disease. Journal of Molecular Medicine (Berlin) 2004, 82:434-448.
73. Lee S.G., Jeon H.Y., Su Z.Z., Richards J.E., Vozhilla N., Sarkar D., et al. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 2009, 28:2476-2484.
74. Lee S.G., Kim K., Kegelman T.P., Dash R., Das S.K., Choi J.K., et al. Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity. Cancer Research 2011, 71:6514-6523.
75. Lee S.G., Su Z.Z., Emdad L., Sarkar D., Fisher P.B. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:17390-17395.
76. Lee S.G., Su Z.Z., Emdad L., Sarkar D., Franke T.F., Fisher P.B. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2008, 27:1114-1121.
77. Lee K., Zhang H., Qian D.Z., Rey S., Liu J.O., Semenza G.L. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:17910-17915.
78. Lerebours F., Vacher S., Andrieu C., Espie M., Marty M., Lidereau R., et al. NF-kappa B genes have a major role in inflammatory breast cancer. BMC Cancer 2008, 8:41.
79. Levine B., Klionsky D.J. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Developmental Cell 2004, 6:463-477.
80. Li X., Kong X., Huo Q., Guo H., Yan S., Yuan C., et al. Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Science 2011, 102:1151-1157.
81. Li C., Li R., Song H., Wang D., Feng T., Yu X., et al. Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. Journal of Surgical Oncology 2011, 103:184-192.
82. Li C., Li Y., Wang X., Wang Z., Cai J., Wang L., et al. Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma. Histopathology 2012, 60:953-963.
83. Li C., Liu J., Lu R., Yu G., Wang X., Zhao Y., et al. AEG-1 overexpression: A novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers. International Journal of Gynecological Cancer 2011, 21:602-608.
84. Li J., Yang L., Song L., Xiong H., Wang L., Yan X., et al. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009, 28:3188-3196.
85. Li J., Zhang N., Song L.B., Liao W.T., Jiang L.L., Gong L.Y., et al. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clinical Cancer Research 2008, 14:3319-3326.
86. Liang J., Zubovitz J., Petrocelli T., Kotchetkov R., Connor M.K., Han K., et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nature Medicine 2002, 8:1153-1160.
87. Liao W.T., Guo L., Zhong Y., Wu Y.H., Li J., Song L.B. Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma. Journal of Translational Medicine 2011, 9:205.
88. Ligthart L., de Vries B., Smith A.V., Ikram M.A., Amin N., Hottenga J.J., et al. Meta-analysis of genome-wide association for migraine in six population-based European cohorts. European Journal of Human Genetics 2011, 19:901-907.
89. Ling J., Kumar R. Crosstalk between NFkB and glucocorticoid signaling: A potential target of breast cancer therapy. Cancer Letters 2012, 322:119-126.
90. Liu H.Y., Liu C.X., Han B., Zhang X.Y., Sun R.P. AEG-1 is associated with clinical outcome in neuroblastoma patients. Cancer Biomarkers: Section A of Disease Markers 2012, 11:115-121.
91. Liu H., Song X., Liu C., Xie L., Wei L., Sun R. Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. Journal of Experimental & Clinical Cancer Research 2009, 28:19.
92. Liu Y., Su Z., Li G., Yu C., Ren S., Huang D., Fan S., Tian Y., Zhang X., Qiu Y. Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma. International Journal of Cancer 2013, 133(3):671-679.
93. Liu L., Wu J., Ying Z., Chen B., Han A., Liang Y., et al. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Research 2010, 70:3750-3759.
94. Liu D.C., Yang Z.L. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. Diagnostic Cytopathology 2013, 41(3):199-205.
95. Liu J., Yuan Y., Huan J., Shen Z. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Oncogene 2001, 20:336-345.
96. Lupo J., Conti A., Sueur C., Coly P.A., Coute Y., Hunziker W., et al. Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1). Experimental Cell Research 2012, 318:509-520.
97. MacDonald B.T., Tamai K., He X. Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Developmental Cell 2009, 17:9-26.
98. Majmundar A.J., Wong W.J., Simon M.C. Hypoxia-inducible factors and the response to hypoxic stress. Molecular Cell 2010, 40:294-309.
99. Maragakis N.J., Rothstein J.D. Mechanisms of disease: Astrocytes in neurodegenerative disease. Nature Clinical Practice. Neurology 2006, 2:679-689.
100. Marrogi A., Pass H.I., Khan M., Metheny-Barlow L.J., Harris C.C., Gerwin B.I. Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): In vitro antiproliferative effects of a COX-2 inhibitor. Cancer Research 2000, 60:3696-3700.
101. Mathew R., Karantza-Wadsworth V., White E. Role of autophagy in cancer. Nature Reviews. Cancer 2007, 7:961-967.
102. Meng X., Brachova P., Yang S., Xiong Z., Zhang Y., Thiel K.W., et al. Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment. PLoS One 2011, 6:e20920.
103. Noch E., Bookland M., Khalili K. Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma. Cancer Biology & Therapy 2011, 11:32-39.
104. Noguchi Y., Makino T., Yoshikawa T., Nomura K., Fukuzawa K., Matsumoto A., et al. The possible role of TNF-alpha and IL-2 in inducing tumor-associated metabolic alterations. Surgery Today 1996, 26:36-41.
105. Nolan G.P., Ghosh S., Liou H.C., Tempst P., Baltimore D. DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell 1991, 64:961-969.
106. Orentas R.J., Yang J.J., Wen X., Wei J.S., Mackall C.L., Khan J. Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers. Frontiers in Oncology 2012, 2:194.
107. Polakis P. The many ways of Wnt in cancer. Current Opinion in Genetics & Development 2007, 17:45-51.
108. Prasad S., Ravindran J., Aggarwal B.B. NF-kappaB and cancer: How intimate is this relationship. Molecular and Cellular Biochemistry 2010, 336:25-37.
109. Qian B.J., Yan F., Li N., Liu Q.L., Lin Y.H., Liu C.M., et al. MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer. Cancer Immunology, Immunotherapy 2011, 60:883-893.
110. Salminen A., Paimela T., Suuronen T., Kaarniranta K. Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90. Immunology Letters 2008, 117:9-15.
111. Sanchez-Tillo E., Liu Y., de Barrios O., Siles L., Fanlo L., Cuatrecasas M., et al. EMT-activating transcription factors in cancer: Beyond EMT and tumor invasiveness. Cellular and Molecular Life Sciences 2012, 69:3429-3456.
112. Sarkar D., Fisher P.B. AEG-1/MTDH/LYRIC: Clinical significance. Advances in Cancer Research 2013, in press.
113. Sarkar D., Park E.S., Emdad L., Lee S.G., Su Z.Z., Fisher P.B. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Research 2008, 68:1478-1484.
114. Semenza G.L. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010, 29:625-634.
115. Semenza G.L. Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy. Trends in Pharmacological Sciences 2012, 33:207-214.
116. Sherr C.J., Weber J.D. The ARF/p53 pathway. Current Opinion in Genetics & Development 2000, 10:94-99.
117. Song H., Li C., Li R., Geng J. Prognostic significance of AEG-1 expression in colorectal carcinoma. International Journal of Colorectal Disease 2010, 25:1201-1209.
118. Song H., Li C., Lu R., Zhang Y., Geng J. Expression of astrocyte elevated gene-1: A novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer. International Journal of Gynecological Cancer 2010, 20:1188-1196.
119. Song L., Li W., Zhang H., Liao W., Dai T., Yu C., et al. Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. The Journal of Pathology 2009, 219:317-326.
120. Srivastava J., Siddiq A., Emdad L., Santhekadur P.K., Chen D., Gredler R., et al. Astrocyte elevated gene-1 promotes hepatocarcinogenesis: Novel insights from a mouse model. Hepatology 2012, 56:1782-1791.
121. Stratmann A., Risau W., Plate K.H. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. The American Journal of Pathology 1998, 153:1459-1466.
122. Su Z.Z., Chen Y., Kang D.C., Chao W., Simm M., Volsky D.J., et al. Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-alpha treatment. Gene 2003, 306:67-78.
123. Su Z.Z., Kang D.C., Chen Y., Pekarskaya O., Chao W., Volsky D.J., et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 2002, 21:3592-3602.
124. Sun S., Ke Z., Wang F., Li S., Chen W., Han A., et al. Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Human Pathology 2012, 43:1051-1060.
125. Sutherland H.G., Lam Y.W., Briers S., Lamond A.I., Bickmore W.A. 3D3/lyric: A novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Experimental Cell Research 2004, 294:94-105.
126. Tan X., Apte U., Micsenyi A., Kotsagrelos E., Luo J.H., Ranganathan S., et al. Epidermal growth factor receptor: A novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology 2005, 129:285-302.
127. Tanaka S., Sugimachi K., Kameyama T., Maehara S., Shirabe K., Shimada M., et al. Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma. Hepatology 2003, 37:1122-1129.
128. Testa J.R., Bellacosa A. AKT plays a central role in tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:10983-10985.
129. Thirkettle H.J., Mills I.G., Whitaker H.C., Neal D.E. Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 2009, 28:3663-3670.
130. Tokunaga E., Nakashima Y., Yamashita N., Hisamatsu Y., Okada S., Akiyoshi S., et al. Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer. Breast Cancer 2012, 10.1007/s12282-012-0398-2.
131. Vanden Berghe W., De Bosscher K., Boone E., Plaisance S., Haegeman G. The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. The Journal of Biological Chemistry 1999, 274:32091-32098.
132. van der Saag P.T., Caldenhoven E., van de Stolpe A. Molecular mechanisms of steroid action: A novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors. The European Respiratory Journal. Supplement 1996, 22:146s-153s.
133. van Landeghem F.K., Weiss T., Oehmichen M., von Deimling A. Decreased expression of glutamate transporters in astrocytes after human traumatic brain injury. Journal of Neurotrauma 2006, 23:1518-1528.
134. Vartak-Sharma N., Ghorpade A. Astrocyte elevated gene-1 regulates astrocyte responses to neural injury: Implications for reactive astrogliosis and neurodegeneration. Journal of Neuroinflammation 2012, 9:195.
135. Vivanco I., Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Reviews. Cancer 2002, 2:489-501.
136. Wang N., Du X., Zang L., Song N., Yang T., Dong R., et al. Prognostic impact of Metadherin-SND1 interaction in colon cancer. Molecular Biology Reports 2012, 39:10497-10504.
137. Wang F., Ke Z.F., Sun S.J., Chen W.F., Yang S.C., Li S.H., et al. Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. Cancer Biology & Therapy 2011, 12:539-548.
138. Warr T., Ward S., Burrows J., Harding B., Wilkins P., Harkness W., et al. Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults. Genes, Chromosomes & Cancer 2001, 31:15-22.
139. Wei J., Pan X., Pei Z., Wang W., Qiu W., Shi Z., et al. The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury. The Journal of Trauma and Acute Care Surgery 2012, 73:654-660.
140. Weis S.M., Cheresh D.A. Tumor angiogenesis: Molecular pathways and therapeutic targets. Nature Medicine 2011, 17:1359-1370.
141. Xia Z., Zhang N., Jin H., Yu Z., Xu G., Huang Z. Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas. Clinical Neurology and Neurosurgery 2010, 112:413-419.
142. Yan J., Zhang M., Chen Q., Zhang X. Expression of AEG-1 in human T-cell lymphoma enhances the risk of progression. Oncology Reports 2012, 28:2107-2114.
143. Yang Z.Z., Tschopp O., Baudry A., Dummler B., Hynx D., Hemmings B.A. Physiological functions of protein kinase B/Akt. Biochemical Society Transactions 2004, 32:350-354.
144. Yang J., Valineva T., Hong J., Bu T., Yao Z., Jensen O.N., et al. Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome. Nucleic Acids Research 2007, 35:4485-4494.
145. Yap T.A., Garrett M.D., Walton M.I., Raynaud F., de Bono J.S., Workman P. Targeting the PI3K-AKT-mTOR pathway: Progress, pitfalls, and promises. Current Opinion in Pharmacology 2008, 8:393-412.
146. Yoo B.K., Chen D., Su Z.Z., Gredler R., Yoo J., Shah K., et al. Molecular mechanism of chemoresistance by astrocyte elevated gene-1. Cancer Research 2010, 70:3249-3258.
147. Yoo B.K., Emdad L., Lee S.G., Su Z.Z., Santhekadur P., Chen D., et al. Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacology & Therapeutics 2011, 130:1-8.
148. Yoo B.K., Emdad L., Su Z.Z., Villanueva A., Chiang D.Y., Mukhopadhyay N.D., et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. The Journal of Clinical Investigation 2009, 119:465-477.
149. Yoo B.K., Gredler R., Vozhilla N., Su Z.Z., Chen D., Forcier T., et al. Identification of genes conferring resistance to 5-fluorouracil. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:12938-12943.
150. Yoo B.K., Santhekadur P.K., Gredler R., Chen D., Emdad L., Bhutia S., et al. Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology 2011, 53:1538-1548.
151. Yu C., Chen K., Zheng H., Guo X., Jia W., Li M., et al. Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 2009, 30:894-901.
152. Yuan C., Li X., Yan S., Yang Q., Liu X., Kong B. The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility. PLoS One 2012, 7:e51561.
153. Zhang F., Yang Q., Meng F., Shi H., Li H., Liang Y., et al. Astrocyte elevated gene-1 interacts with beta-catenin and increases migration and invasion of colorectal carcinoma. Molecular Carcinogenesis 2012, 10.1002/mc.21894.
154. Zhao Y., Kong X., Li X., Yan S., Yuan C., Hu W., et al. Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells. PLoS One 2011, 6:e29363.
155. Zhong H., May M.J., Jimi E., Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Molecular Cell 2002, 9:625-636.
156. Zhou J., Li J., Wang Z., Yin C., Zhang W. Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival. Asia-Pacific Journal of Clinical Oncology 2012, 8:e42-e48.
157. Zhou B.P., Liao Y., Xia W., Spohn B., Lee M.H., Hung M.C. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology 2001, 3:245-252.
158. Zhu K., Dai Z., Pan Q., Wang Z., Yang G.H., Yu L., et al. Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clinical Cancer Research 2011, 17:7294-7302.