Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma

Oncology Reports

Volumn 27, Issue 6, 2012, Pages 2073-2079

  Gong, Zhenbin ^a,b   Liu, Weihui ^a   You, Nan ^a   Wang, Tao ^a   Wang, Xing ^a   Lu, Peng ^a   Zhao, G E ^a   Yang, Ping ^a   Wang, Desheng ^a   Dou, Kefeng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Center of Hepatobiliary Surgery of Lanzhou Army Region   (China)

Author keywords

Hepatitis B virus; Hepatocellular carcinoma; Metadherin; Prognosis; Progression

Indexed keywords

METADHERIN; ONCOPROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEPATITIS B; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL TIME;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CELL ADHESION MOLECULES; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84860718788     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1749     Document Type: Article

References (44)

1. El-Serag HB and Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576, 2007. (Pubitemid 46890874)
2. Farazi PA and DePinho RA: Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6: 674-687, 2006. (Pubitemid 44286000)
3. Parkin DM, Bray FI and Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer 37 (Suppl 8): S4-S66, 2001.
4. Ahn JY, Jung EY, Kwun HJ, Lee CW, Sung YC and Jang KL: Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53. J Gen Virol 83: 2765-2772, 2002. (Pubitemid 35276976)
5. Zhang JL, Zhao WG, Wu KL, et al: Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin. Arch Virol 150: 721-741, 2005.
6. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ and Fisher PB: Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353: 8-15, 2005. (Pubitemid 40805356)
7. Li J, Zhang N, Song LB, et al: Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 14: 3319-3326, 2008.
8. Li C, Li R, Song H, et al: Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. J Surg Oncol 103: 184-192, 2010.
9. Li J, Yang L, Song L, et al: Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 28: 3188-3196, 2009.
10. Hu G, Chong RA, Yang Q, et al: MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poorprognosis breast cancer. Cancer Cell 15: 9-20, 2009.
11. Baumann BC and Dorsey JF: Astrocyte-elevated gene-1 (AEG-1): glioblastoma's helping hand during times of hypoxia and glucose deprivation? Cancer Biol Ther 11: 40-42, 2011.
12. Noch E, Bookland M and Khalili K: Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma. Cancer Biol Ther 11: 32-39, 2011.
13. Xia Z, Zhang N, Jin H, Yu Z, Xu G and Huang Z: Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas. Clin Neurol Neurosurg 112: 413-419, 2010.
14. Lee SG, Jeon HY, Su ZZ, et al: Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 28: 2476-2484, 2009.
15. Liu H, Song X, Liu C, Xie L, Wei L and Sun R: Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. J Exp Clin Cancer Res 28: 19, 2009.
16. Xu J, Wu H, He Y, et al: Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 28: 455-462, 2011.
17. Song H, Li C, Li R and Geng J: Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 25: 1201-1209, 2010.
18. Wang F, Ke ZF, Sun SJ, et al: Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. Cancer Biol Ther 12: 539-548, 2011.
19. Sun W, Fan YZ, Xi H, Lu XS, Ye C and Zhang JT:Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: an unfavorable and independent prognostic factor. Oncol Rep 26: 1133-1142, 2011.
20. Nohata N, Hanazawa T, Kikkawa N, et al: Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). J Hum Genet 56: 595-601, 2011.
21. Meng X, Brachova P, Yang S, et al: Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment. PLoS One 6: e20920, 2011.
22. Meng F, Luo C, Ma L, Hu Y and Lou G: Clinical significance of astrocyte elevated gene-1 expression in human epithelial ovarian carcinoma. Int J Gynecol Pathol 30: 145-150, 2011.
23. Yu C, Chen K, Zheng H, et al: Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 30: 894-901, 2009.
24. Song L, Li W, Zhang H, et al: Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 219: 317-326, 2009.
25. Yoo BK, Emdad L, Su ZZ, et al: Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 119: 465-477, 2009.
26. Lee SG, Su ZZ, Emdad L, Sarkar D and Fisher PB: Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA 103: 17390-17395, 2006. (Pubitemid 44788979)
27. Emdad L, Sarkar D, Su ZZ, et al: Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 114: 155-170, 2007. (Pubitemid 46561534)
28. Kikuno N, Shiina H, Urakami S, et al: Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 26: 7647-7655, 2007. (Pubitemid 350224215)
29. Song H, Li C, Lu R, Zhang Y and Geng J: Expression of astrocyte elevated gene-1: a novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer. Int J Gynecol Cancer 20: 1188-1196, 2010.
30. Kao WY, Su CW, Chau GY, Lui WY, Wu CW and Wu JC: A comparison of prognosis between patients with hepatitis B and C virus-related hepatocellular carcinoma undergoing resection surgery. World J Surg 35: 858-867, 2011.
31. Lee YH and Yun Y: HBx protein of hepatitis B virus activates Jak1-STAT signaling. J Biol Chem 273: 25510-25515, 1998.
32. Cha MY, Kim CM, Park YM and Ryu WS: Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatology 39: 1683-1693, 2004.
33. Ding Q, Xia W, Liu JC, et al: Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of betacatenin. Mol Cell 19: 159-170, 2005. (Pubitemid 41019664)
34. Chin R, Nachbur U, Earnest-Silveira L, et al: Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus. Virus Res 147: 7-16, 2010.
35. Chin R, Earnest-Silveira L, Koeberlein B, et al: Failure of lamivudine to reverse hepatitis B virus-associated changes in ERK, Akt and cell cycle regulatory proteins. Antivir Ther 13: 221-230, 2008. (Pubitemid 351535373)
36. Chin R, Earnest-Silveira L, Koeberlein B, et al: Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis. J Hepatol 47: 325-337, 2007. (Pubitemid 47189604)
37. Kim HR, Lee SH and Jung G: The hepatitis B viral X protein activates NF-kappaB signaling pathway through the up-regulation of TBK1. FEBS Lett 584: 525-530, 2010.
38. Tanaka Y, Kanai F, Ichimura T, et al: The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1. Oncogene 25: 633-642, 2006. (Pubitemid 43164473)
39. Chung TW, Lee YC and Kim CH: Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J 18: 1123-1125, 2004. (Pubitemid 39561544)
40. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF and Fisher PB: Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27: 1114-1121, 2008. (Pubitemid 351253177)
41. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ and Fisher PB: Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68: 1478-1484, 2008. (Pubitemid 351346856)
42. Emdad L, Sarkar D, Su ZZ, et al: Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 66: 1509-1516, 2006. (Pubitemid 43259932)
43. Su P, Zhang Q and Yang Q: Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue. Diagn Pathol 5: 38, 2010.
44. Yoo BK, Gredler R, Vozhilla N, et al: Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci USA 106: 12938-12943, 2009.