Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1

Oncogene

Volumn 28, Issue 36, 2009, Pages 3188-3196

  Li, J ^a,b   Yang, L ^a,b   Song, L ^c   Xiong, H ^a,b   Wang, L ^a,b   Yan, X ^a,b   Yuan, J ^a,b   Wu, J ^a,b   Li, M ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

AEG 1; FOXO1; p27Kip1; p21Cip1

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; KI 67 ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FKHR;

ARTICLE; ASTROCYTE ELEVATED GENE 1; BREAST CANCER; CANCER GROWTH; CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DISEASE COURSE; ENZYME PHOSPHORYLATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMONES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME INHIBITORS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KI-67 ANTIGEN; MORPHOLINES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 70349094044     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.171     Document Type: Article

References (29)

1. Arden KC. (2007). FoxOs in tumor suppression and stem cell maintenance. Cell 128: 235-237.
2. Ash SC, Yang DQ, Britt DE. (2008). LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem Biophys Res Commun 371: 333-338.
3. Brown DM, Ruoslahti E. (2004). Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5: 365-374.
4. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo J, Hu LS et al. (1999). Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96: 857-868.
5. Cardozo T, Pagano M. (2004). The SCF ubiquitin ligase: insights into a molecular mechanism. Nat Rev Mol Cell Biol 5: 739-753.
6. Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NS, Lam EW et al. (2000). Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27 (KIP1). Mol Cell Biol 20: 9138-9148.
7. Doerfler W, Hohlweg U, Müller K, Remus R, Heller H, Hertz J. (2001). Foreign DNA integration perturbations of the genome-oncogenesis. Ann NY Acad Sci 945: 276-288.
8. Dong XY, Chen C, Sun X, Guo P, Vessella RL, Wang RX et al. (2006). FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer. Cancer Res 66: 6998-7006.
9. Emdad L, Sarkar D, Su ZZ, Lee SG, Kang DC, Bruce JN et al (2007). Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 114: 155-170.
10. Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K et al. (2006). Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 66: 1509-1516.
11. Frescas D, Pagano M. (2008). Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer : 438-449.
12. Greene FL, Page DL, Fleming ID. (2002). Breast Cancer in AJCC Cancer Staging Handbook. TNM Classification of Malignant Tumors, 6th edn. Springer Verlag: New York. pp 255-281.
13. Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen J et al. (2005). Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Pros Natl Acad Sci USA 102: 1649-1654.
14. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ, Fisher PB. (2005). Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353: 8-15.
15. Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y et al. (2007). Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer rogression through upregulation of FOXO3a activity. Oncogene 26: 7647-7655.
16. Lee SG, Su ZZ, Emdad L, Sarkar D, Fisher PB. (2006). Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Pros Natl Acad Sci USA 103: 17390-17395.
17. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB. (2008). Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27: 1114-1121.
18. Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY et al. (2008). Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 14: 3319-3326.
19. Liu J, Yuan Y, Huan J, Shen Z. (2001). Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Oncogene 20: 336-345.
20. Meng X, Fan J, Shen Z. (2007). Roles of BCCIP in chromosome stability and cytokinesis. Oncogene 26: 6253-6260.
21. Meng X, Lu H, Shen Z. (2004). BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Cell Cycle 3: 1457-1462.
22. Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR. (2000). Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 20: 8969-8982.
23. Rena G, Guo S, Cichy SC, Unterman TG, Cohen P. (1999). Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274: 17179-17183.
24. Roeb W, Boyer A, Cavenee WK, Arden KC. (2007). PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1. Pros Natl Acad Sci USA 104: 18085-18090.
25. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. (2008). Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68: 1478-1484.
26. Seoane J, Le HV, Shen L, Anderson SA, Massague J. (2004). Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223.
27. Tang ED, Nuñez G, Barr FG, Guan KL. (1999). Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 274: 16741-16746.
28. Trent RJ. (2006). Molecular Medicine, 3rd edn. Academic Press: St Louis, MO, USA. pp 93-96.
29. Ward EC, Hoekstra AV, Blok LJ, Hanifi-Moghaddam P, Lurain JR, Singh DK et al. (2008). The regulation and function of the forkhead transcription factor, Forkhead box O1, is dependent on the progesterone receptor in endometrial carcinoma. Endocrinology 149: 1942-1950.