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Oncology Letters
Volumn 8, Issue 2, 2014, Pages 493-501
Progress of cancer research on astrocyte elevated gene-1/Metadherin
Author keywords

Astrocyte elevated gene 1; Chemoresistance; Metadherin; Metastasis; Neoplasms
Indexed keywords

AURORA A KINASE; BETA CATENIN; COMPLEMENTARY DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; WNT PROTEIN;
EID: 84902345916     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2231     Document Type: Review
Times cited : (50)
References (100)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP and Massague J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 33746961739 scopus 로고    scopus 로고
    • Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy
    • Weinstein IB and Joe AK: Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 3: 448-457, 2006.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 448-457
    • Weinstein, I.B.1    Joe, A.K.2
  • 6
    • 34147165551 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1: Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration
    • Emdad L, Sarkar D, Su ZZ, et al: Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 114: 155-170, 2007.
    • (2007) Pharmacol Ther , vol.114 , pp. 155-170
    • Emdad, L.1    Sarkar, D.2    Su, Z.Z.3
  • 7
    • 57849091664 scopus 로고    scopus 로고
    • The metastasis problem gets stickier
    • Kwong LN and Chin L: The metastasis problem gets stickier. Cancer Cell 15: 1-2, 2009.
    • (2009) Cancer Cell , vol.15 , pp. 1-2
    • Kwong, L.N.1    Chin, L.2
  • 8
    • 0037118589 scopus 로고    scopus 로고
    • Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH
    • Su ZZ, Kang DC, Chen Y, et al: Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 21: 3592-3602, 2002.
    • (2002) Oncogene , vol.21 , pp. 3592-3602
    • Su, Z.Z.1    Kang, D.C.2    Chen, Y.3
  • 9
    • 20444389341 scopus 로고    scopus 로고
    • Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1
    • Kang DC, Su ZZ, Sarkar D, et al: Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353: 8-15, 2005.
    • (2005) Gene , vol.353 , pp. 8-15
    • Kang, D.C.1    Su, Z.Z.2    Sarkar, D.3
  • 10
    • 1842634484 scopus 로고    scopus 로고
    • Metadherin, a cell surface protein in breast tumors that mediates lung metastasis
    • Brown DM and Ruoslahti E: Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5: 365-374, 2004.
    • (2004) Cancer Cell , vol.5 , pp. 365-374
    • Brown, D.M.1    Ruoslahti, E.2
  • 11
    • 4644293462 scopus 로고    scopus 로고
    • Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells
    • Britt DE, Yang DF, Yang DQ, et al: Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 300: 134-148, 2004.
    • (2004) Exp Cell Res , vol.300 , pp. 134-148
    • Britt, D.E.1    Yang, D.F.2    Yang, D.Q.3
  • 12
    • 1242339604 scopus 로고    scopus 로고
    • 3D3/lyric: A novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus
    • Sutherland HG, Lam YW, Briers S, Lamond AI and Bickmore WA: 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 294: 94-105, 2004.
    • (2004) Exp Cell Res , vol.294 , pp. 94-105
    • Sutherland, H.G.1    Lam, Y.W.2    Briers, S.3    Lamond, A.I.4    Bickmore, W.A.5
  • 13
    • 70349459893 scopus 로고    scopus 로고
    • The multifaceted role of MTDH/AEG-1 in cancer progression
    • Hu G, Wei Y and Kang Y: The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 15: 5615-5620, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 5615-5620
    • Hu, G.1    Wei, Y.2    Kang, Y.3
  • 14
    • 0035057171 scopus 로고    scopus 로고
    • Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults
    • Warr T, Ward S, Burrows J, et al: Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults. Genes Chromosomes Cancer 31: 15-22, 2001.
    • (2001) Genes Chromosomes Cancer , vol.31 , pp. 15-22
    • Warr, T.1    Ward, S.2    Burrows, J.3
  • 15
    • 65649143486 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression
    • Yoo BK, Emdad L, Su ZZ, et al: Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 119: 465-577, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 465-577
    • Yoo, B.K.1    Emdad, L.2    Su, Z.Z.3
  • 16
    • 57849134562 scopus 로고    scopus 로고
    • MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer
    • Hu G, Chong RA, Yang Q, et al: MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 15: 9-20, 2009.
    • (2009) Cancer Cell , vol.15 , pp. 9-20
    • Hu, G.1    Chong, R.A.2    Yang, Q.3
  • 17
    • 84865607737 scopus 로고    scopus 로고
    • Expression of metadherin/AEG-1 gene is positively related to orientation chemotaxis and adhesion of human hepatocellular carcinoma cell lines of different metastatic potentials
    • Zhou Z, Deng H, Yan W, et al: Expression of metadherin/AEG-1 gene is positively related to orientation chemotaxis and adhesion of human hepatocellular carcinoma cell lines of different metastatic potentials. J Huazhong Univ Sci Technolog Med Sci 3: 353-357, 2012.
    • (2012) J Huazhong Univ Sci Technolog Med Sci , vol.3 , pp. 353-357
    • Zhou, Z.1    Deng, H.2    Yan, W.3
  • 18
    • 84867980319 scopus 로고    scopus 로고
    • Clinical implications of AEG-1 in liver metastasis of colorectal cancer
    • Jiang T, Zhu A, Zhu Y and Piao D: Clinical implications of AEG-1 in liver metastasis of colorectal cancer. Med Oncol 29: 2858-2863, 2012.
    • (2012) Med Oncol , vol.29 , pp. 2858-2863
    • Jiang, T.1    Zhu, A.2    Zhu, Y.3    Piao, D.4
  • 19
    • 84880927036 scopus 로고    scopus 로고
    • AEG-1/MTDH/LYRIC, the beginning: Initial cloning, structure, expression profile, and regulation of expression
    • Lee SG, Kang DC, Desalle R, Sarkar D and Fisher PB: AEG-1/MTDH/LYRIC, the beginning: initial cloning, structure, expression profile, and regulation of expression. Adv Cancer Res 120: 1-38, 2013.
    • (2013) Adv Cancer Res , vol.120 , pp. 1-38
    • Lee, S.G.1    Kang, D.C.2    Desalle, R.3    Sarkar, D.4    Fisher, P.B.5
  • 20
    • 84880927185 scopus 로고    scopus 로고
    • AEG-1/MTDH/LYRIC: Clinical significance
    • Sarkar D and Fisher PB: AEG-1/MTDH/LYRIC: clinical significance. Adv Cancer Res 120: 39-74, 2013.
    • (2013) Adv Cancer Res , vol.120 , pp. 39-74
    • Sarkar, D.1    Fisher, P.B.2
  • 21
    • 33751257780 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc
    • Lee SG, Su ZZ, Emdad L, Sarkar D and Fisher PB: Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA 103: 17390-17395, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17390-17395
    • Lee, S.G.1    Su, Z.Z.2    Emdad, L.3    Sarkar, D.4    Fisher, P.B.5
  • 22
    • 39149100913 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
    • Lee SG, Su ZZ, Emdad L, et al: Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27: 1114-1121, 2008.
    • (2008) Oncogene , vol.27 , pp. 1114-1121
    • Lee, S.G.1    Su, Z.Z.2    Emdad, L.3
  • 23
    • 84872044595 scopus 로고    scopus 로고
    • AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis
    • Ke ZF, Mao X, Zeng C, et al: AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis. Med Oncol 30: 383, 2013.
    • (2013) Med Oncol , vol.30 , pp. 383
    • Ke, Z.F.1    Mao, X.2    Zeng, C.3
  • 24
    • 70349094044 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1
    • Li J, Yang L, Song L, et al: Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 28: 3188-3196, 2009.
    • (2009) Oncogene , vol.28 , pp. 3188-3196
    • Li, J.1    Yang, L.2    Song, L.3
  • 25
    • 70350447686 scopus 로고    scopus 로고
    • Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer
    • Song L, Li W, Zhang H, et al: Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 219: 317-326, 2009.
    • (2009) J Pathol , vol.219 , pp. 317-326
    • Song, L.1    Li, W.2    Zhang, H.3
  • 26
    • 32944459561 scopus 로고    scopus 로고
    • Activation of the nuclear factor kappaB pathway by astrocyte elevatedgene-1: Implications for tumor progression and metastasis
    • Emdad L, Sarkar D, Su ZZ, et al: Activation of the nuclear factor kappaB pathway by astrocyte elevatedgene-1: implications for tumor progression and metastasis. Cancer Res 66: 1509-1516, 2006.
    • (2006) Cancer Res , vol.66 , pp. 1509-1516
    • Emdad, L.1    Sarkar, D.2    Su, Z.Z.3
  • 27
    • 84861470722 scopus 로고    scopus 로고
    • Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines
    • Gnosa S, Shen YM, Wang CJ, et al: Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. J Transl Med 10: 109, 2012.
    • (2012) J Transl Med , vol.10 , pp. 109
    • Gnosa, S.1    Shen, Y.M.2    Wang, C.J.3
  • 28
    • 84881475971 scopus 로고    scopus 로고
    • Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-κB pathway
    • Zhang J, Zhang Y, Liu S, et al: Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-κB pathway. Tumor Biol 34: 2433-2440, 2013.
    • (2013) Tumor Biol , vol.34 , pp. 2433-2440
    • Zhang, J.1    Zhang, Y.2    Liu, S.3
  • 29
    • 43149096465 scopus 로고    scopus 로고
    • LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells
    • Ash SC, Yang DQ and Britt DE: LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem Biophys Res Commun 371: 333-338, 2008.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 333-338
    • Ash, S.C.1    Yang, D.Q.2    Britt, D.E.3
  • 30
    • 40449089338 scopus 로고    scopus 로고
    • Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    • Sarkar D, Park ES, Emdad L, et al: Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68: 1478-1484, 2008.
    • (2008) Cancer Res , vol.68 , pp. 1478-1484
    • Sarkar, D.1    Park, E.S.2    Emdad, L.3
  • 31
    • 68249158094 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling
    • Khuda II, Koide N, Noman AS, et al: Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 128 (Suppl 1): e700-e706, 2009.
    • (2009) Immunology , vol.128 , Issue.SUPPL. 1
    • Khuda, I.I.1    Koide, N.2    Noman, A.S.3
  • 32
    • 83455221361 scopus 로고    scopus 로고
    • Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells
    • Zhao Y, Kong X, Li X, et al: Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells. PLoS One 6: e29363, 2011.
    • (2011) PLoS One , vol.6
    • Zhao, Y.1    Kong, X.2    Li, X.3
  • 33
    • 84881549559 scopus 로고    scopus 로고
    • AEG-1 participates in TGF-beta1-induced EMT through p38 MAPK activation
    • Wei J, Li Z, Chen W, et al: AEG-1 participates in TGF-beta1-induced EMT through p38 MAPK activation. Cell Biol Int 37: 1016-1021, 2013.
    • (2013) Cell Biol Int , vol.37 , pp. 1016-1021
    • Wei, J.1    Li, Z.2    Chen, W.3
  • 34
    • 84863086393 scopus 로고    scopus 로고
    • Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma
    • Ge X, Lv X, Feng L, et al: Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma. PLoS One 7: e39449, 2012.
    • (2012) PLoS One , vol.7
    • Ge, X.1    Lv, X.2    Feng, L.3
  • 35
    • 84876335845 scopus 로고    scopus 로고
    • AEG-1 overexpression is essential for maintenance of malignant state in human AML cells via up-regulation of Akt1 mediated by AURKA activation
    • Long M, Hao M, Dong K, et al: AEG-1 overexpression is essential for maintenance of malignant state in human AML cells via up-regulation of Akt1 mediated by AURKA activation. Cell Signal 25: 1438-1446, 2013.
    • (2013) Cell Signal , vol.25 , pp. 1438-1446
    • Long, M.1    Hao, M.2    Dong, K.3
  • 36
    • 82255161958 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression
    • Zhang X, Zhang N and Zhang MX: Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression. Chin Med J (Engl) 124: 3546-3550, 2011.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 3546-3550
    • Zhang, X.1    Zhang, N.2    Zhang, M.X.3
  • 37
    • 72249107698 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis
    • Emdad L, Lee SG, Su ZZ, et al: Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci USA 106: 21300-21305, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21300-21305
    • Emdad, L.1    Lee, S.G.2    Su, Z.Z.3
  • 38
    • 78751506521 scopus 로고    scopus 로고
    • Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma
    • Noch E, Bookland M and Khalili K: Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma. Cancer Biol Ther 11: 32-9, 2011.
    • (2011) Cancer Biol Ther , vol.11 , pp. 32-39
    • Noch, E.1    Bookland, M.2    Khalili, K.3
  • 39
    • 79251475257 scopus 로고    scopus 로고
    • Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer
    • Li C, Li R, Song H, et al: Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. J Surg Oncol 103: 184-192, 2011.
    • (2011) J Surg Oncol , vol.103 , pp. 184-192
    • Li, C.1    Li, R.2    Song, H.3
  • 40
    • 80455144517 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma
    • Chen D, Yoo BK, Santhekadur PK, et al: Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma. Clin Cancer Res 17: 6693-6701, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 6693-6701
    • Chen, D.1    Yoo, B.K.2    Santhekadur, P.K.3
  • 41
    • 84880602868 scopus 로고    scopus 로고
    • Overexpression of astrocyte-elevated gene-1 is associated with cervical carcinoma progression and angiogenesis
    • Long M, Dong K, Gao P, et al: Overexpression of astrocyte-elevated gene-1 is associated with cervical carcinoma progression and angiogenesis. Oncol Rep 30: 1414-1422, 2013.
    • (2013) Oncol Rep , vol.30 , pp. 1414-1422
    • Long, M.1    Dong, K.2    Gao, P.3
  • 42
    • 80051879660 scopus 로고    scopus 로고
    • AEG-1 overexpression: A novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers
    • Li C, Liu J, Lu R, et al: AEG-1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers. Int J Gynecol Cancer 21: 602-608, 2011.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 602-608
    • Li, C.1    Liu, J.2    Lu, R.3
  • 43
    • 84878019715 scopus 로고    scopus 로고
    • Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma
    • Liu Y, Su Z, Li G, et al: Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma. Int J Cancer 133: 671-679, 2013.
    • (2013) Int J Cancer , vol.133 , pp. 671-679
    • Liu, Y.1    Su, Z.2    Li, G.3
  • 44
    • 84856101071 scopus 로고    scopus 로고
    • Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue
    • (In Chinese)
    • Deng N and Feng Y: Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue. Zhong Nan Da Xue Xue Bao Yi Xue Ban 12: 1195-1198, 2011 (In Chinese).
    • (2011) Zhong Nan Da Xue Xue Bao Yi Xue Ban , vol.12 , pp. 1195-1198
    • Deng, N.1    Feng, Y.2
  • 45
    • 80052849589 scopus 로고    scopus 로고
    • Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis
    • Wang F, Ke ZF, Sun SJ, et al: Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. Cancer Biol Ther 12: 539-548, 2011.
    • (2011) Cancer Biol Ther , vol.12 , pp. 539-548
    • Wang, F.1    Ke, Z.F.2    Sun, S.J.3
  • 46
    • 69149099584 scopus 로고    scopus 로고
    • Identification of genes conferring resistance to 5-fluorouracil
    • Yoo BK, Gredler R, Vozhilla N, et al: Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci USA 106: 12938-12943, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12938-12943
    • Yoo, B.K.1    Gredler, R.2    Vozhilla, N.3
  • 47
    • 77951049689 scopus 로고    scopus 로고
    • Molecular mechanism of chemoresistance by astrocyte elevated gene-1
    • Yoo BK, Chen D, Su ZZ, et al: Molecular mechanism of chemoresistance by astrocyte elevated gene-1. Cancer Res 70: 3249-3258, 2010.
    • (2010) Cancer Res , vol.70 , pp. 3249-3258
    • Yoo, B.K.1    Chen, D.2    Su, Z.Z.3
  • 48
    • 62149086700 scopus 로고    scopus 로고
    • Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells
    • Liu H, Song X, Liu C, et al: Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. J Exp Clin Cancer Res 28: 19, 2009.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 19
    • Liu, H.1    Song, X.2    Liu, C.3
  • 49
    • 78650666886 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 induces protective autophagy
    • Bhutia SK, Kegelman TP, Das SK, et al: Astrocyte elevated gene-1 induces protective autophagy. Proc Natl Acad Sci USA 107: 22243-22248, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 22243-22248
    • Bhutia, S.K.1    Kegelman, T.P.2    Das, S.K.3
  • 50
    • 84880952481 scopus 로고    scopus 로고
    • Drug Resistance Mediated by AEG-1/MTDH/LYRIC
    • Meng X, Thiel KW and Leslie KK: Drug Resistance Mediated by AEG-1/MTDH/LYRIC. Adv Cancer Res 120: 135-157, 2013.
    • (2013) Adv Cancer Res , vol.120 , pp. 135-157
    • Meng, X.1    Thiel, K.W.2    Leslie, K.K.3
  • 51
    • 84863259339 scopus 로고    scopus 로고
    • Metadherin regulates radioresistance in cervical cancer cells
    • Zhao Y, Moran MS, Yang Q, et al: Metadherin regulates radioresistance in cervical cancer cells. Oncol Rep 27: 1520-1526, 2012.
    • (2012) Oncol Rep , vol.27 , pp. 1520-1526
    • Zhao, Y.1    Moran, M.S.2    Yang, Q.3
  • 52
    • 84880927965 scopus 로고    scopus 로고
    • AEG-1/MTDH/LYRIC: Signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis
    • Emdad L, Das SK, Dasgupta S, et al: AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis. Adv Cancer Res 120: 75-111, 2013.
    • (2013) Adv Cancer Res , vol.120 , pp. 75-111
    • Emdad, L.1    Das, S.K.2    Dasgupta, S.3
  • 53
    • 84868257532 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 promotes hepatocarcinogenesis: Novel insights from a mouse model
    • Srivastava J, Siddiq A, Emdad L, et al: Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology 56: 1782-1791, 2012.
    • (2012) Hepatology , vol.56 , pp. 1782-1791
    • Srivastava, J.1    Siddiq, A.2    Emdad, L.3
  • 54
    • 84860718788 scopus 로고    scopus 로고
    • Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma
    • Gong Z, Liu W, You N, et al: Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma. Oncol Rep 27: 2073-2079, 2012.
    • (2012) Oncol Rep , vol.27 , pp. 2073-2079
    • Gong, Z.1    Liu, W.2    You, N.3
  • 55
    • 82555173154 scopus 로고    scopus 로고
    • Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
    • Zhu K, Dai Z, Pan Q, et al: Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 17: 7294-7302, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 7294-7302
    • Zhu, K.1    Dai, Z.2    Pan, Q.3
  • 56
    • 79955096969 scopus 로고    scopus 로고
    • Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma
    • Yoo BK, Santhekadur PK, Gredler R, et al: Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology 53: 1538-1548, 2011.
    • (2011) Hepatology , vol.53 , pp. 1538-1548
    • Yoo, B.K.1    Santhekadur, P.K.2    Gredler, R.3
  • 57
    • 84875102356 scopus 로고    scopus 로고
    • Metadherin is a prognostic predictor of hepatocellular carcinoma after curative hepatectomy
    • Ahn S, Hyeon J and Park CK: Metadherin is a prognostic predictor of hepatocellular carcinoma after curative hepatectomy. Gut Liver 7: 206-212, 2013.
    • (2013) Gut Liver , vol.7 , pp. 206-212
    • Ahn, S.1    Hyeon, J.2    Park, C.K.3
  • 58
    • 84880939050 scopus 로고    scopus 로고
    • AEG-1/MTDH/LYRIC in Liver Cancer
    • Sarkar D: AEG-1/MTDH/LYRIC in Liver Cancer. Adv Cancer Res 120: 193-221, 2013.
    • (2013) Adv Cancer Res , vol.120 , pp. 193-221
    • Sarkar, D.1
  • 59
    • 84901366462 scopus 로고    scopus 로고
    • Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer
    • Tokunaga E, Nakashima Y, Yamashita N, et al: Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer. Breast Cancer 21: 341-349, 2012.
    • (2012) Breast Cancer , vol.21 , pp. 341-349
    • Tokunaga, E.1    Nakashima, Y.2    Yamashita, N.3
  • 60
    • 79956200605 scopus 로고    scopus 로고
    • Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition
    • Li X, Kong X, Huo Q, et al: Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci 102: 1151-1157, 2011.
    • (2011) Cancer Sci , vol.102 , pp. 1151-1157
    • Li, X.1    Kong, X.2    Huo, Q.3
  • 61
    • 79952375168 scopus 로고    scopus 로고
    • Identification of novel variants of metadherin in breast cancer
    • Liu X, Zhang N, Li X, et al: Identification of novel variants of metadherin in breast cancer. PLoS One 6: e17582, 2011.
    • (2011) PLoS One , vol.6
    • Liu, X.1    Zhang, N.2    Li, X.3
  • 62
    • 84880960195 scopus 로고    scopus 로고
    • Pleiotropic Roles of AEG-1/MTDH/LYRIC in Breast Cancer
    • Wan L and Kang Y: Pleiotropic Roles of AEG-1/MTDH/LYRIC in Breast Cancer. Adv Cancer Res 120: 113-134, 2013.
    • (2013) Adv Cancer Res , vol.120 , pp. 113-134
    • Wan, L.1    Kang, Y.2
  • 63
    • 84863034803 scopus 로고    scopus 로고
    • Inhibition of metadherin sensitizes breast cancer cells to AZD6244
    • Kong X, Moran MS, Zhao Y and Yang Q: Inhibition of metadherin sensitizes breast cancer cells to AZD6244. Cancer Biol Ther 13: 43-49, 2012.
    • (2012) Cancer Biol Ther , vol.13 , pp. 43-49
    • Kong, X.1    Moran, M.S.2    Zhao, Y.3    Yang, Q.4
  • 64
    • 84902474525 scopus 로고    scopus 로고
    • MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin
    • Jul 15, (Epub ahead of print)
    • Zhang N, Wang X, Huo Q, et al: MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene: Jul 15, 2013 (Epub ahead of print).
    • (2013) Oncogene
    • Zhang, N.1    Wang, X.2    Huo, Q.3
  • 65
    • 65649106197 scopus 로고    scopus 로고
    • LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals
    • Thirkettle HJ, Girling J, Warren AY, et al: LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res 15: 3003-3013, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 3003-3013
    • Thirkettle, H.J.1    Girling, J.2    Warren, A.Y.3
  • 66
    • 36849061266 scopus 로고    scopus 로고
    • Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity
    • Kikuno N, Shiina H, Urakami S, et al: Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 26: 7647-7655, 2007.
    • (2007) Oncogene , vol.26 , pp. 7647-7655
    • Kikuno, N.1    Shiina, H.2    Urakami, S.3
  • 67
    • 84871384210 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor alpha and astrocyte-elevated gene-1 mediates cryptotanshinone exerted antitumor activity in hypoxic PC-3 cells
    • Lee HJ, Jung DB, Sohn EJ, et al: Inhibition of hypoxia inducible factor alpha and astrocyte-elevated gene-1 mediates cryptotanshinone exerted antitumor activity in hypoxic PC-3 cells. Evid Based Complement Alternat Med 2012: 390957, 2012.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 390957
    • Lee, H.J.1    Jung, D.B.2    Sohn, E.J.3
  • 68
    • 80054024743 scopus 로고    scopus 로고
    • Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity
    • Lee SG, Kim K, Kegelman TP, et al: Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity. Cancer Res 71: 6514-6523, 2011.
    • (2011) Cancer Res , vol.71 , pp. 6514-6523
    • Lee, S.G.1    Kim, K.2    Kegelman, T.P.3
  • 69
    • 77951725566 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion
    • Liu L, Wu J, Ying Z, et al: Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res 70: 3750-3759, 2010.
    • (2010) Cancer Res , vol.70 , pp. 3750-3759
    • Liu, L.1    Wu, J.2    Ying, Z.3
  • 70
    • 73949102954 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1: A novel target for human glioma therapy
    • Emdad L, Sarkar D, Lee SG, et al: Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol Cancer Ther 9: 79-88, 2010.
    • (2010) Mol Cancer Ther , vol.9 , pp. 79-88
    • Emdad, L.1    Sarkar, D.2    Lee, S.G.3
  • 71
    • 65549113479 scopus 로고    scopus 로고
    • Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis
    • Yu C, Chen K, Zheng H, et al: Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 30: 894-901, 2009.
    • (2009) Carcinogenesis , vol.30 , pp. 894-901
    • Yu, C.1    Chen, K.2    Zheng, H.3
  • 72
    • 80755159111 scopus 로고    scopus 로고
    • Prognostic value of the 7th edition of the AJCC staging system as a clinical staging system in patients with hepatocellular carcinoma
    • Chun YH, Kim SU, Park JY, et al: Prognostic value of the 7th edition of the AJCC staging system as a clinical staging system in patients with hepatocellular carcinoma. Eur J Cancer 47: 2568-2575, 2011.
    • (2011) Eur J Cancer , vol.47 , pp. 2568-2575
    • Chun, Y.H.1    Kim, S.U.2    Park, J.Y.3
  • 73
    • 78650115024 scopus 로고    scopus 로고
    • Evaluation of the seventh American Joint Committee on Cancer/International Union Against Cancer Classification of gastric adenocarcinoma in comparison with the sixth classification
    • Ahn HS, Lee HJ, Hahn S, et al: Evaluation of the seventh American Joint Committee on Cancer/International Union Against Cancer Classification of gastric adenocarcinoma in comparison with the sixth classification. Cancer 116: 5592-5598, 2010.
    • (2010) Cancer , vol.116 , pp. 5592-5598
    • Ahn, H.S.1    Lee, H.J.2    Hahn, S.3
  • 74
    • 79960317935 scopus 로고    scopus 로고
    • Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer
    • Jian-bo X, Hui W, Yu-long H, et al: Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 28: 455-462, 2011.
    • (2011) Med Oncol , vol.28 , pp. 455-462
    • Jian-bo, X.1    Hui, W.2    Yu-long, H.3
  • 75
    • 84883882634 scopus 로고    scopus 로고
    • Effect of silencing AEG-1 with small interfering RNA on the proliferation and cell cycle of gastric carcinoma SGC-7901 cells
    • (In Chinese)
    • Zhang CF, Xia YH, Zheng QF, et al: Effect of silencing AEG-1 with small interfering RNA on the proliferation and cell cycle of gastric carcinoma SGC-7901 cells. Zhonghua Zhong Liu Za Zhi 35: 22-27, 2013 (In Chinese).
    • (2013) Zhonghua Zhong Liu Za Zhi , vol.35 , pp. 22-27
    • Zhang, C.F.1    Xia, Y.H.2    Zheng, Q.F.3
  • 76
    • 84874097138 scopus 로고    scopus 로고
    • Deregulation of MTDH gene expression in gastric cancer
    • Baygi ME and Nikpour P: Deregulation of MTDH gene expression in gastric cancer. Asian Pac J Cancer Prev 13: 2833-2836, 2012.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2833-2836
    • Baygi, M.E.1    Nikpour, P.2
  • 77
    • 79957591404 scopus 로고    scopus 로고
    • Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions
    • Blanco MA, Alečkovi M, Hua Y, et al: Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J Biol Chem 286: 19982-19992, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 19982-19992
    • Blanco, M.A.1    Alečkovi, M.2    Hua, Y.3
  • 78
    • 85027933218 scopus 로고    scopus 로고
    • Prognostic impact of Metadherin-SND1 interaction in colon cancer
    • Wang N, Du X, Zang L, et al: Prognostic impact of Metadherin-SND1 interaction in colon cancer. Mol Biol Rep 39: 10497-10504, 2012.
    • (2012) Mol Biol Rep , vol.39 , pp. 10497-10504
    • Wang, N.1    Du, X.2    Zang, L.3
  • 79
    • 84880325345 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 interacts with β-catenin and increases migration and invasion of colorectal carcinoma
    • Zhang F, Yang Q, Meng F, et al: Astrocyte elevated gene-1 interacts with β-catenin and increases migration and invasion of colorectal carcinoma. Mol Carcinog 52: 603-610, 2013.
    • (2013) Mol Carcinog , vol.52 , pp. 603-610
    • Zhang, F.1    Yang, Q.2    Meng, F.3
  • 80
    • 33748083048 scopus 로고    scopus 로고
    • Evidence-based gallbladder cancer staging: Changing cancer staging by analysis of data from the National Cancer Database
    • Fong Y, Wagman L, Gonen M, et al: Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database. Ann Surg 243: 767-774, 2006.
    • (2006) Ann Surg , vol.243 , pp. 767-774
    • Fong, Y.1    Wagman, L.2    Gonen, M.3
  • 81
    • 80053135079 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor
    • Sun W, Fan YZ, Xi H, et al: Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: an unfavorable and independent prognostic factor. Oncol Rep 26: 1133-1142, 2011.
    • (2011) Oncol Rep , vol.26 , pp. 1133-1142
    • Sun, W.1    Fan, Y.Z.2    Xi, H.3
  • 82
    • 84874091389 scopus 로고    scopus 로고
    • MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma
    • Liu DC and Yang ZL: MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. Diagn Cytopathol 41: 199-205, 2013.
    • (2013) Diagn Cytopathol , vol.41 , pp. 199-205
    • Liu, D.C.1    Yang, Z.L.2
  • 83
    • 77953624680 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue
    • Su P, Zhang Q and Yang Q: Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue. Diagn Pathol 5: 38, 2010.
    • (2010) Diagn Pathol , vol.5 , pp. 38
    • Su, P.1    Zhang, Q.2    Yang, Q.3
  • 84
    • 84862531654 scopus 로고    scopus 로고
    • Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression
    • Sun S, Ke Z, Wang F, et al: Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Hum Pathol 43: 1051-1060, 2012.
    • (2012) Hum Pathol , vol.43 , pp. 1051-1060
    • Sun, S.1    Ke, Z.2    Wang, F.3
  • 85
    • 79951858334 scopus 로고    scopus 로고
    • Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression
    • Chen W, Ke Z, Shi H, Yang S and Wang L: Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression. Neoplasma 57: 522-529, 2010.
    • (2010) Neoplasma , vol.57 , pp. 522-529
    • Chen, W.1    Ke, Z.2    Shi, H.3    Yang, S.4    Wang, L.5
  • 86
    • 84876960888 scopus 로고    scopus 로고
    • Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: A microarray study
    • Erdem H, Oktay M, Yildirim U, Uzunlar AK and Kayikci MA: Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study. Pol J Pathol 64: 28-32, 2013.
    • (2013) Pol J Pathol , vol.64 , pp. 28-32
    • Erdem, H.1    Oktay, M.2    Yildirim, U.3    Uzunlar, A.K.4    Kayikci, M.A.5
  • 87
    • 84871584591 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling
    • Liu B, Wu Y and Peng D: Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling. Oncol Lett 5: 505-510, 2013.
    • (2013) Oncol Lett , vol.5 , pp. 505-510
    • Liu, B.1    Wu, Y.2    Peng, D.3
  • 88
    • 84862817214 scopus 로고    scopus 로고
    • Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma
    • Li C, Li Y, Wang X, et al: Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma. Histopathology 60: 953-963, 2012.
    • (2012) Histopathology , vol.60 , pp. 953-963
    • Li, C.1    Li, Y.2    Wang, X.3
  • 89
    • 84871107583 scopus 로고    scopus 로고
    • The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility
    • Yuan C, Li X, Yan S, et al: The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility. PLoS One 7: e51561, 2012.
    • (2012) PLoS One , vol.7
    • Yuan, C.1    Li, X.2    Yan, S.3
  • 90
    • 84874044706 scopus 로고    scopus 로고
    • Establishment and characterization of MTDH knockdown by artificial MicroRNA interference-functions as a potential tumor suppressor in breast cancer
    • Wang S, Shu JZ, Cai Y, Bao Z and Liang QM: Establishment and characterization of MTDH knockdown by artificial MicroRNA interference-functions as a potential tumor suppressor in breast cancer. Asian Pac J Cancer Prev 13: 2813-2818, 2012.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2813-2818
    • Wang, S.1    Shu, J.Z.2    Cai, Y.3    Bao, Z.4    Liang, Q.M.5
  • 91
    • 84874735111 scopus 로고    scopus 로고
    • Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
    • Ward A, Balwierz A, Zhang JD, et al: Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene 32: 1173-1182, 2013.
    • (2013) Oncogene , vol.32 , pp. 1173-1182
    • Ward, A.1    Balwierz, A.2    Zhang, J.D.3
  • 92
    • 83555174922 scopus 로고    scopus 로고
    • Exposure to cadmium chloride influences astrocyte-elevated gene-1 (AEG-1) expression in MDA-MB231 human breast cancer cells
    • Luparello C, Longo A and Vetrano M: Exposure to cadmium chloride influences astrocyte-elevated gene-1 (AEG-1) expression in MDA-MB231 human breast cancer cells. Biochimie 94: 207-213, 2012.
    • (2012) Biochimie , vol.94 , pp. 207-213
    • Luparello, C.1    Longo, A.2    Vetrano, M.3
  • 93
    • 84864797328 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 regulates astrocyte responses to neural injury: Implications for reactive astrogliosis and neurodegeneration
    • Vartak-Sharma N and Ghorpade A: Astrocyte elevated gene-1 regulates astrocyte responses to neural injury: implications for reactive astrogliosis and neurodegeneration. J Neuroinflammation 9: 195, 2012.
    • (2012) J Neuroinflammation , vol.9 , pp. 195
    • Vartak-Sharma, N.1    Ghorpade, A.2
  • 94
    • 84875980153 scopus 로고    scopus 로고
    • The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer
    • Zhang N, Wang X, Huo Q, et al: The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer. J Biol Chem 288: 9396-9407, 2013.
    • (2013) J Biol Chem , vol.288 , pp. 9396-9407
    • Zhang, N.1    Wang, X.2    Huo, Q.3
  • 95
    • 84875862077 scopus 로고    scopus 로고
    • Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells
    • Liu K, Guo L, Miao L, et al: Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells. Anticancer Drugs 24: 494-503, 2013.
    • (2013) Anticancer Drugs , vol.24 , pp. 494-503
    • Liu, K.1    Guo, L.2    Miao, L.3
  • 96
    • 84875113959 scopus 로고    scopus 로고
    • MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma
    • Wu C, Jin B, Chen L, et al: MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma. Cell Signal 25: 1212-1221, 2013.
    • (2013) Cell Signal , vol.25 , pp. 1212-1221
    • Wu, C.1    Jin, B.2    Chen, L.3
  • 97
    • 79951850570 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology
    • Yoo BK, Emdad L, Lee SG, et al: Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther 130: 1-8, 2011.
    • (2011) Pharmacol Ther , vol.130 , pp. 1-8
    • Yoo, B.K.1    Emdad, L.2    Lee, S.G.3
  • 98
    • 72249101914 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1: Far more than just a gene regulated in astrocytes
    • Sarkar D, Emdad L, Lee SG, et al: Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes. Cancer Res 69: 8529-8535, 2009.
    • (2009) Cancer Res , vol.69 , pp. 8529-8535
    • Sarkar, D.1    Emdad, L.2    Lee, S.G.3
  • 99
    • 84861989333 scopus 로고    scopus 로고
    • Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors
    • Chen X, Dong K, Long M, et al: Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors. Oncol Lett 4: 319-323, 2012.
    • (2012) Oncol Lett , vol.4 , pp. 319-323
    • Chen, X.1    Dong, K.2    Long, M.3
  • 100
    • 79959712035 scopus 로고    scopus 로고
    • MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer
    • Qian BJ, Yan F, Li N, et al: MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer. Cancer Immunol Immunother 60: 883-893, 2011.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 883-893
    • Qian, B.J.1    Yan, F.2    Li, N.3

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