메뉴 건너뛰기




Volumn 15, Issue 4, 2015, Pages 299-311

Melatonin and male reproductive health: Relevance of darkness and antioxidant properties

Author keywords

Antioxidant activity; Male reproductive system; Melatonin; Sperm

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ALPHA TOCOPHEROL; ANDROGEN; CYCLOPHOSPHAMIDE; DIMPYLATE; GONADOTROPIN; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN 3 RECEPTOR; MELATONIN RECEPTOR; REACTIVE OXYGEN METABOLITE; TOXIC SUBSTANCE; UNCLASSIFIED DRUG; ANTIOXIDANT;

EID: 84930982919     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524015666150505155530     Document Type: Article
Times cited : (44)

References (180)
  • 1
    • 0029268538 scopus 로고
    • On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals
    • [1] Hardeland R, Balzer I, Poeggeler B, et al. On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals. J Pineal Res 1995; 18(2): 104-11.
    • (1995) J Pineal Res , vol.18 , Issue.2 , pp. 104-111
    • Hardeland, R.1    Balzer, I.2    Poeggeler, B.3
  • 3
    • 0035049581 scopus 로고    scopus 로고
    • Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat
    • [3] Stefulj J, Hortner M, Ghosh M, et al. Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat. J Pineal Res 2001; 30(4): 243-7.
    • (2001) J Pineal Res , vol.30 , Issue.4 , pp. 243-247
    • Stefulj, J.1    Hortner, M.2    Ghosh, M.3
  • 4
    • 0029104550 scopus 로고
    • Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry
    • [4] Dubbels R, Reiter R, Klenke E, et al. Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. J Pineal Res 1995; 18(1): 28-31.
    • (1995) J Pineal Res , vol.18 , Issue.1 , pp. 28-31
    • Dubbels, R.1    Reiter, R.2    Klenke, E.3
  • 5
    • 0031087698 scopus 로고    scopus 로고
    • Melatonin production in an aerobic photosynthetic bacterium: An evolutionarily early association with darkness
    • [5] Tilden AR, Becker MA, Amma LL, Arciniega J, McGaw AK. Melatonin production in an aerobic photosynthetic bacterium: an evolutionarily early association with darkness. J Pineal Res 1997; 22(2): 102-6.
    • (1997) J Pineal Res , vol.22 , Issue.2 , pp. 102-106
    • Tilden, A.R.1    Becker, M.A.2    Amma, L.L.3    Arciniega, J.4    McGaw, A.K.5
  • 7
    • 0031303156 scopus 로고    scopus 로고
    • Efficacy of melatonin treatment in jet lag, shift work, and blindness
    • [7] Arendt J, Skene DJ, Middleton B, Lockley SW, Deacon S. Efficacy of melatonin treatment in jet lag, shift work, and blindness. J Biol Rhythms 1997; 12(6): 604-17.
    • (1997) J Biol Rhythms , vol.12 , Issue.6 , pp. 604-617
    • Arendt, J.1    Skene, D.J.2    Middleton, B.3    Lockley, S.W.4    Deacon, S.5
  • 8
    • 84885189105 scopus 로고    scopus 로고
    • Melatonin induces apoptosis through a caspasedependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells
    • [8] Perdomo J, Cabrera J, Estevez F, Loro J, Reiter RJ, Quintana J. Melatonin induces apoptosis through a caspasedependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. J Pineal Res 2013; 55(2): 195-206.
    • (2013) J Pineal Res , vol.55 , Issue.2 , pp. 195-206
    • Perdomo, J.1    Cabrera, J.2    Estevez, F.3    Loro, J.4    Reiter, R.J.5    Quintana, J.6
  • 9
    • 0035350773 scopus 로고    scopus 로고
    • Melatonin enhances Th2 cell mediated immune responses: Lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists
    • [9] Raghavendra V, Singh V, Kulkarni SK, Agrewala JN. Melatonin enhances Th2 cell mediated immune responses: lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists. Mol Cell Biochem 2001; 221(1-2): 57-62.
    • (2001) Mol Cell Biochem , vol.221 , Issue.1-2 , pp. 57-62
    • Raghavendra, V.1    Singh, V.2    Kulkarni, S.K.3    Agrewala, J.N.4
  • 10
    • 0032150574 scopus 로고    scopus 로고
    • Melatonin and regulation of the cardiovascular system
    • [10] Scalbert E, Guardiola-Lemaitre B, Delagrange P. Melatonin and regulation of the cardiovascular system. Therapie 1998; 53(5): 459-65.
    • (1998) Therapie , vol.53 , Issue.5 , pp. 459-465
    • Scalbert, E.1    Guardiola-Lemaitre, B.2    Delagrange, P.3
  • 11
    • 33645100557 scopus 로고    scopus 로고
    • Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status
    • [11] Peschke E, Frese T, Chankiewitz E, et al. Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. J Pineal Res 2006; 40(2): 135-43.
    • (2006) J Pineal Res , vol.40 , Issue.2 , pp. 135-143
    • Peschke, E.1    Frese, T.2    Chankiewitz, E.3
  • 13
    • 0042412174 scopus 로고    scopus 로고
    • Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype
    • [13] Shiu SY, Law IC, Lau KW, Tam PC, Yip AW, Ng WT. Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype. J Pineal Res 2003; 35(3): 177-82.
    • (2003) J Pineal Res , vol.35 , Issue.3 , pp. 177-182
    • Shiu, S.Y.1    Law, I.C.2    Lau, K.W.3    Tam, P.C.4    Yip, A.W.5    Ng, W.T.6
  • 15
    • 33747586751 scopus 로고    scopus 로고
    • Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis
    • [15] Armagan A, Uz E, Yilmaz HR, Soyupek S, Oksay T, Ozcelik N. Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis. Asian J Androl 2006; 8(5): 595-600.
    • (2006) Asian J Androl , vol.8 , Issue.5 , pp. 595-600
    • Armagan, A.1    Uz, E.2    Yilmaz, H.R.3    Soyupek, S.4    Oksay, T.5    Ozcelik, N.6
  • 16
    • 0030857820 scopus 로고    scopus 로고
    • Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates
    • [16] Escames G, Guerrero JM, Reiter RJ, et al. Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates. Neurosci Lett 1997; 230(3): 147-50.
    • (1997) Neurosci Lett , vol.230 , Issue.3 , pp. 147-150
    • Escames, G.1    Guerrero, J.M.2    Reiter, R.J.3
  • 17
    • 77957192581 scopus 로고    scopus 로고
    • Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa
    • [17] Espino J, Bejarano I, Ortiz A, et al. Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa. Fertil Steril 2010; 94(5): 1915-7.
    • (2010) Fertil Steril , vol.94 , Issue.5 , pp. 1915-1917
    • Espino, J.1    Bejarano, I.2    Ortiz, A.3
  • 18
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • [18] Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 2011; 51(1): 1-16.
    • (2011) J Pineal Res , vol.51 , Issue.1 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 19
    • 84888865976 scopus 로고    scopus 로고
    • Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice
    • [19] Chabra A, Shokrzadeh M, Naghshvar F, Salehi F, Ahmadi A. Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice. Hum Exp Toxicol 2014; 33(2): 185-95.
    • (2014) Hum Exp Toxicol , vol.33 , Issue.2 , pp. 185-195
    • Chabra, A.1    Shokrzadeh, M.2    Naghshvar, F.3    Salehi, F.4    Ahmadi, A.5
  • 21
    • 34247235199 scopus 로고    scopus 로고
    • The mammalian pineal gland: Known facts, unknown facets
    • [21] Maronde E, Stehle JH. The mammalian pineal gland: known facts, unknown facets. Trends Endocrinol Metab 2007; 18(4): 142-9.
    • (2007) Trends Endocrinol Metab , vol.18 , Issue.4 , pp. 142-149
    • Maronde, E.1    Stehle, J.H.2
  • 22
    • 0033925920 scopus 로고    scopus 로고
    • Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo
    • [22] Reiter RJ, Tan D-X, Qi W, Manchester LC, Karbownik M, Calvo JR. Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo. Neurosignals 2000; 9(3-4): 160-71.
    • (2000) Neurosignals , vol.9 , Issue.3-4 , pp. 160-171
    • Reiter, R.J.1    Tan, D.-X.2    Qi, W.3    Manchester, L.C.4    Karbownik, M.5    Calvo, J.R.6
  • 23
    • 10444245917 scopus 로고    scopus 로고
    • Human pineal physiology and functional significance of melatonin
    • [23] Macchi MM, Bruce JN. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol 2004; 25(3-4): 177-95.
    • (2004) Front Neuroendocrinol , vol.25 , Issue.3-4 , pp. 177-195
    • Macchi, M.M.1    Bruce, J.N.2
  • 24
    • 33645402334 scopus 로고    scopus 로고
    • Melatonin receptors in humans: Biological role and clinical relevance
    • [24] Ekmekcioglu C. Melatonin receptors in humans: biological role and clinical relevance. Biomed Pharmacother 2006; 60(3): 97-108.
    • (2006) Biomed Pharmacother , vol.60 , Issue.3 , pp. 97-108
    • Ekmekcioglu, C.1
  • 25
    • 10744232166 scopus 로고    scopus 로고
    • The melatonin receptor subtype MT2 is present in the human cardiovascular system
    • [25] Ekmekcioglu C, Thalhammer T, Humpeler S, et al. The melatonin receptor subtype MT2 is present in the human cardiovascular system. J Pineal Res 2003; 35(1): 40-4.
    • (2003) J Pineal Res , vol.35 , Issue.1 , pp. 40-44
    • Ekmekcioglu, C.1    Thalhammer, T.2    Humpeler, S.3
  • 26
    • 0029565036 scopus 로고
    • Selective effect of methoxyindoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells
    • [26] Konakchieva R, Kyurkchiev S, Kehayov I, Taushanova P, Kanchev L. Selective effect of methoxyindoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells. J Neuroimmunol 1995; 63(2): 125-32.
    • (1995) J Neuroimmunol , vol.63 , Issue.2 , pp. 125-132
    • Konakchieva, R.1    Kyurkchiev, S.2    Kehayov, I.3    Taushanova, P.4    Kanchev, L.5
  • 27
    • 0034889532 scopus 로고    scopus 로고
    • Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion
    • [27] Sjoblom M, Jedstedt G, Flemstrom G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 2001; 108(4): 625-33.
    • (2001) J Clin Invest , vol.108 , Issue.4 , pp. 625-633
    • Sjoblom, M.1    Jedstedt, G.2    Flemstrom, G.3
  • 28
    • 0034812402 scopus 로고    scopus 로고
    • Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes
    • [28] Brydon L, Petit L, Delagrange P, Strosberg AD, Jockers R. Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes. Endocrinology 2001; 142(10): 4264-71.
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4264-4271
    • Brydon, L.1    Petit, L.2    Delagrange, P.3    Strosberg, A.D.4    Jockers, R.5
  • 29
    • 10744223972 scopus 로고    scopus 로고
    • Differential expression of high-affinity melatonin receptors (MT1) in normal and malignant human breast tissue
    • [29] Dillon DC, Easley SE, Asch BB, et al. Differential expression of high-affinity melatonin receptors (MT1) in normal and malignant human breast tissue. Am J Clin Pathol 2002; 118(3): 451-8.
    • (2002) Am J Clin Pathol , vol.118 , Issue.3 , pp. 451-458
    • Dillon, D.C.1    Easley, S.E.2    Asch, B.B.3
  • 30
    • 27644449587 scopus 로고    scopus 로고
    • Functional MT1 and MT2 melatonin receptors in mammals
    • [30] Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine 2005; 27(2): 101-10.
    • (2005) Endocrine , vol.27 , Issue.2 , pp. 101-110
    • Dubocovich, M.L.1    Markowska, M.2
  • 31
    • 0034613342 scopus 로고    scopus 로고
    • Identification of the melatonin-binding SiteMT 3 as the quinone reductase 2
    • [31] Nosjean O, Ferro M, Coge F, et al. Identification of the melatonin-binding SiteMT 3 as the quinone reductase 2. J Biol Chem 2000; 275(40): 31311-7.
    • (2000) J Biol Chem , vol.275 , Issue.40 , pp. 31311-31317
    • Nosjean, O.1    Ferro, M.2    Coge, F.3
  • 32
    • 51149089969 scopus 로고    scopus 로고
    • Homology modeling of MT1 and MT2 receptors
    • [32] Farce A, Chugunov AO, Loge C, et al. Homology modeling of MT1 and MT2 receptors. Eur J Med Chem 2008; 43(9): 1926.
    • (2008) Eur J Med Chem , vol.43 , Issue.9 , pp. 1926
    • Farce, A.1    Chugunov, A.O.2    Loge, C.3
  • 33
    • 33646679411 scopus 로고    scopus 로고
    • Are G protein-coupled receptor heterodimers of physiological relevance?--Focus on melatonin receptors
    • [33] Levoye A, Jockers R, Ayoub MA, Delagrange P, Savaskan E, Guillaume JL. Are G protein-coupled receptor heterodimers of physiological relevance?--Focus on melatonin receptors. Chronobiol Int 2006; 23(1-2): 419-26.
    • (2006) Chronobiol Int , vol.23 , Issue.1-2 , pp. 419-426
    • Levoye, A.1    Jockers, R.2    Ayoub, M.A.3    Delagrange, P.4    Savaskan, E.5    Guillaume, J.L.6
  • 34
    • 84877030258 scopus 로고    scopus 로고
    • Homology models of melatonin receptors: Challenges and recent advances
    • [34] Pala D, Lodola A, Bedini A, Spadoni G, Rivara S. Homology models of melatonin receptors: challenges and recent advances. Int J Mol Sci 2013; 14(4): 8093-121.
    • (2013) Int J Mol Sci , vol.14 , Issue.4 , pp. 8093-8121
    • Pala, D.1    Lodola, A.2    Bedini, A.3    Spadoni, G.4    Rivara, S.5
  • 35
    • 0031297742 scopus 로고    scopus 로고
    • Melatonin receptors: Molecular biology of a new family of G protein-coupled receptors
    • [35] Reppert SM. Melatonin receptors: molecular biology of a new family of G protein-coupled receptors. J Biol Rhythms 1997; 12(6): 528-31.
    • (1997) J Biol Rhythms , vol.12 , Issue.6 , pp. 528-531
    • Reppert, S.M.1
  • 36
    • 0032589076 scopus 로고    scopus 로고
    • Characterization of 2-[125I] iodomelatonin binding sites in Syrian hamster peripheral organs
    • [36] Paul P, Lahaye C, Delagrange P, Nicolas J-P, Canet E, Boutin JA. Characterization of 2-[125I] iodomelatonin binding sites in Syrian hamster peripheral organs. J Pharmacol Exp Ther 1999; 290(1): 334-40.
    • (1999) J Pharmacol Exp Ther , vol.290 , Issue.1 , pp. 334-340
    • Paul, P.1    Lahaye, C.2    Delagrange, P.3    Nicolas, J.-P.4    Canet, E.5    Boutin, J.A.6
  • 37
    • 0035221189 scopus 로고    scopus 로고
    • Nuclear melatonin receptors
    • [37] Smirnov A. Nuclear melatonin receptors. Biochemistry (Moscow) 2001; 66(1): 19-26.
    • (2001) Biochemistry (Moscow) , vol.66 , Issue.1 , pp. 19-26
    • Smirnov, A.1
  • 38
    • 0031847447 scopus 로고    scopus 로고
    • The potential role of the transcription factor RZR/ROR as a mediator of nuclear melatonin signaling
    • [38] Wiesenberg I, Missbach M, Carlberg C. The potential role of the transcription factor RZR/ROR as a mediator of nuclear melatonin signaling. Restor Neurol Neurosci 1998; 12(2-3): 143-50.
    • (1998) Restor Neurol Neurosci , vol.12 , Issue.2-3 , pp. 143-150
    • Wiesenberg, I.1    Missbach, M.2    Carlberg, C.3
  • 39
    • 0028670212 scopus 로고
    • ROR gamma: The third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle
    • [39] Hirose T, Smith RJ, Jetten AM. ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochem Biophys Res Commun 1994; 205(3): 1976-83.
    • (1994) Biochem Biophys Res Commun , vol.205 , Issue.3 , pp. 1976-1983
    • Hirose, T.1    Smith, R.J.2    Jetten, A.M.3
  • 41
    • 0037337314 scopus 로고    scopus 로고
    • Calreticulin-melatonin. An unexpected relationship
    • [41] Macias M, Escames G, Leon J, et al. Calreticulin-melatonin. An unexpected relationship. Eur J Biochem 2003; 270(5): 832-40.
    • (2003) Eur J Biochem , vol.270 , Issue.5 , pp. 832-840
    • Macias, M.1    Escames, G.2    Leon, J.3
  • 42
    • 0016502371 scopus 로고
    • Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus
    • [42] Cardinali DP, Freire F. Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus. Mol Cell Endocrinol 1975; 2(5): 317-30.
    • (1975) Mol Cell Endocrinol , vol.2 , Issue.5 , pp. 317-330
    • Cardinali, D.P.1    Freire, F.2
  • 43
    • 4344580575 scopus 로고    scopus 로고
    • Melatonin stimulates calmodulin phosphorylation by protein kinase C
    • [43] Soto-Vega E, Meza I, Ramirez-Rodriguez G, Benitez-King G. Melatonin stimulates calmodulin phosphorylation by protein kinase C. J Pineal Res 2004; 37(2): 98-106.
    • (2004) J Pineal Res , vol.37 , Issue.2 , pp. 98-106
    • Soto-Vega, E.1    Meza, I.2    Ramirez-Rodriguez, G.3    Benitez-King, G.4
  • 45
    • 0036219437 scopus 로고    scopus 로고
    • Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells
    • [45] Dai J, Inscho EW, Yuan L, Hill SM. Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells. J Pineal Res 2002; 32(2): 112-9.
    • (2002) J Pineal Res , vol.32 , Issue.2 , pp. 112-119
    • Dai, J.1    Inscho, E.W.2    Yuan, L.3    Hill, S.M.4
  • 46
    • 0027258154 scopus 로고
    • Melatonin, hydroxyl radical-mediated oxidative damage, and aging: A hypothesis
    • [46] Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC. Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. J Pineal Res 1993; 14(4): 151-68.
    • (1993) J Pineal Res , vol.14 , Issue.4 , pp. 151-168
    • Poeggeler, B.1    Reiter, R.J.2    Tan, D.X.3    Chen, L.D.4    Manchester, L.C.5
  • 47
    • 0030781520 scopus 로고    scopus 로고
    • How melatonin interacts with lipid bilayers: A study by fluorescence and ESR spectroscopies
    • [47] Costa EJ, Shida CS, Biaggi MH, Ito AS, Lamy-Freund MT. How melatonin interacts with lipid bilayers: a study by fluorescence and ESR spectroscopies. FEBS Lett 1997; 416(1): 103-6.
    • (1997) FEBS Lett , vol.416 , Issue.1 , pp. 103-106
    • Costa, E.J.1    Shida, C.S.2    Biaggi, M.H.3    Ito, A.S.4    Lamy-Freund, M.T.5
  • 48
    • 21144451785 scopus 로고    scopus 로고
    • Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: Investigations with both indoleamine 2, 3-dioxygenase and myeloperoxidase
    • [48] Ferry G, Ubeaud C, Lambert P, et al. Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2, 3-dioxygenase and myeloperoxidase. Biochem J 2005; 388(Pt 1): 205-15.
    • (2005) Biochem J , vol.388 , Issue.1 , pp. 205-215
    • Ferry, G.1    Ubeaud, C.2    Lambert, P.3
  • 49
    • 0028618440 scopus 로고
    • Melatonin--a highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole accessed in vitro
    • [49] Poeggeler B, Saarela S, Reiter RJ, et al. Melatonin--a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro. Ann N Y Acad Sci 1994; 738: 419-20.
    • (1994) Ann N Y Acad Sci , vol.738 , pp. 419-420
    • Poeggeler, B.1    Saarela, S.2    Reiter, R.J.3
  • 50
    • 0027763443 scopus 로고
    • Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence
    • [50] Menendez-Pelaez A, Poeggeler B, Reiter RJ, Barlow-Walden L, Pablos MI, Tan DX. Nuclear localization of melatonin in different mammalian tissues: immunocytochemical and radioimmunoassay evidence. J Cell Biochem 1993; 53(4): 373-82.
    • (1993) J Cell Biochem , vol.53 , Issue.4 , pp. 373-382
    • Menendez-Pelaez, A.1    Poeggeler, B.2    Reiter, R.J.3    Barlow-Walden, L.4    Pablos, M.I.5    Tan, D.X.6
  • 51
    • 0029398053 scopus 로고
    • Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry
    • [51] Scaiano JC. Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry. J Pineal Res 1995; 19(4): 189-95.
    • (1995) J Pineal Res , vol.19 , Issue.4 , pp. 189-195
    • Scaiano, J.C.1
  • 52
    • 0032005373 scopus 로고    scopus 로고
    • Pulse radiolysis studies of melatonin and chloromelatonin
    • [52] Roberts JE, Hu DN, Wishart JF. Pulse radiolysis studies of melatonin and chloromelatonin. J Photochem Photobiol B 1998; 42(2): 125-32.
    • (1998) J Photochem Photobiol B , vol.42 , Issue.2 , pp. 125-132
    • Roberts, J.E.1    Hu, D.N.2    Wishart, J.F.3
  • 53
    • 20944434321 scopus 로고    scopus 로고
    • Antioxidant capacity of the neurohormone melatonin
    • [53] Sofic E, Rimpapa Z, Kundurovic Z, et al. Antioxidant capacity of the neurohormone melatonin. J Neural Transm 2005; 112(3): 349-58.
    • (2005) J Neural Transm , vol.112 , Issue.3 , pp. 349-358
    • Sofic, E.1    Rimpapa, Z.2    Kundurovic, Z.3
  • 54
    • 0030755902 scopus 로고    scopus 로고
    • Reaction of melatonin with lipoperoxyl radicals in phospholipid bilayers
    • [54] Livrea MA, Tesoriere L, D'Arpa D, Morreale M. Reaction of melatonin with lipoperoxyl radicals in phospholipid bilayers. Free Radic Biol Med 1997; 23(5): 706-11.
    • (1997) Free Radic Biol Med , vol.23 , Issue.5 , pp. 706-711
    • Livrea, M.A.1    Tesoriere, L.2    D'arpa, D.3    Morreale, M.4
  • 55
    • 84883743553 scopus 로고    scopus 로고
    • Melatonin inhibits visfatininduced inducible nitric oxide synthase expression and nitric oxide production in macrophages
    • [55] Kang YS, Kang YG, Park HJ, et al. Melatonin inhibits visfatininduced inducible nitric oxide synthase expression and nitric oxide production in macrophages. J Pineal Res 2013; 55(3): 294-303.
    • (2013) J Pineal Res , vol.55 , Issue.3 , pp. 294-303
    • Kang, Y.S.1    Kang, Y.G.2    Park, H.J.3
  • 56
    • 84874949228 scopus 로고    scopus 로고
    • On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
    • [56] Galano A, Tan DX, Reiter RJ. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 2013; 54(3): 245-57.
    • (2013) J Pineal Res , vol.54 , Issue.3 , pp. 245-257
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 57
    • 0036254849 scopus 로고    scopus 로고
    • The identification of the UV degradants of melatonin and their ability to scavenge free radicals
    • [57] Maharaj DS, Anoopkumar-Dukie S, Glass BD, et al. The identification of the UV degradants of melatonin and their ability to scavenge free radicals. J Pineal Res 2002; 32(4): 257-61.
    • (2002) J Pineal Res , vol.32 , Issue.4 , pp. 257-261
    • Maharaj, D.S.1    Anoopkumar-Dukie, S.2    Glass, B.D.3
  • 58
    • 0034917581 scopus 로고    scopus 로고
    • The effects of acute melatonin and ethanol treatment on antioxidant enzyme activities in rat testes
    • [58] Oner-Iyidogan Y, Gurdol F, Oner P. The effects of acute melatonin and ethanol treatment on antioxidant enzyme activities in rat testes. Pharmacol Res 2001; 44(2): 89-93.
    • (2001) Pharmacol Res , vol.44 , Issue.2 , pp. 89-93
    • Oner-Iyidogan, Y.1    Gurdol, F.2    Oner, P.3
  • 59
    • 0029032902 scopus 로고
    • Melatonin stimulates brain glutathione peroxidase activity
    • [59] Barlow-Walden LR, Reiter RJ, Abe M, et al. Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 1995; 26(5): 497-502.
    • (1995) Neurochem Int , vol.26 , Issue.5 , pp. 497-502
    • Barlow-Walden, L.R.1    Reiter, R.J.2    Abe, M.3
  • 60
    • 0001327186 scopus 로고
    • Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum
    • [60] Pozo D, Reiter RJ, Calvo JR, Guerrero JM. Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 1994; 55(24): PL455-60.
    • (1994) Life Sci , vol.55 , Issue.24 , pp. 455-460
    • Pozo, D.1    Reiter, R.J.2    Calvo, J.R.3    Guerrero, J.M.4
  • 61
    • 0037404268 scopus 로고    scopus 로고
    • Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: A study of their individual and synergistic actions
    • [61] Lopez-Burillo S, Tan DX, Mayo JC, Sainz RM, Manchester LC, Reiter RJ. Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. J Pineal Res 2003; 34(4): 269-77.
    • (2003) J Pineal Res , vol.34 , Issue.4 , pp. 269-277
    • Lopez-Burillo, S.1    Tan, D.X.2    Mayo, J.C.3    Sainz, R.M.4    Manchester, L.C.5    Reiter, R.J.6
  • 63
    • 3242664824 scopus 로고    scopus 로고
    • Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes
    • [63] Jou MJ, Peng TI, Reiter RJ, Jou SB, Wu HY, Wen ST. Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. J Pineal Res 2004; 37(1): 55-70.
    • (2004) J Pineal Res , vol.37 , Issue.1 , pp. 55-70
    • Jou, M.J.1    Peng, T.I.2    Reiter, R.J.3    Jou, S.B.4    Wu, H.Y.5    Wen, S.T.6
  • 64
    • 33644920991 scopus 로고    scopus 로고
    • Melatonin as a cytoskeletal modulator: Implications for cell physiology and disease
    • [64] Benitez-King G. Melatonin as a cytoskeletal modulator: implications for cell physiology and disease. J Pineal Res 2006; 40(1): 1-9.
    • (2006) J Pineal Res , vol.40 , Issue.1 , pp. 1-9
    • Benitez-King, G.1
  • 65
    • 0344069780 scopus 로고    scopus 로고
    • Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats
    • [65] Jahnke G, Marr M, Myers C, Wilson R, Travlos G, Price C. Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol Sci 1999; 50(2): 271-9.
    • (1999) Toxicol Sci , vol.50 , Issue.2 , pp. 271-279
    • Jahnke, G.1    Marr, M.2    Myers, C.3    Wilson, R.4    Travlos, G.5    Price, C.6
  • 66
    • 0017704893 scopus 로고
    • The effects of oral melatonin on skin color and on the release of pituitary hormones
    • [66] Nordlund JJ, Lerner AB. The effects of oral melatonin on skin color and on the release of pituitary hormones. J Clin Endocrinol Metab 1977; 45(4): 768-74.
    • (1977) J Clin Endocrinol Metab , vol.45 , Issue.4 , pp. 768-774
    • Nordlund, J.J.1    Lerner, A.B.2
  • 67
    • 77955169457 scopus 로고    scopus 로고
    • Melatonin in traditional Mediterranean diets
    • [67] Iriti M, Varoni EM, Vitalini S. Melatonin in traditional Mediterranean diets. J Pineal Res 2010; 49(2): 101-5.
    • (2010) J Pineal Res , vol.49 , Issue.2 , pp. 101-105
    • Iriti, M.1    Varoni, E.M.2    Vitalini, S.3
  • 68
    • 0027725205 scopus 로고
    • Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization
    • [68] Menendez-Pelaez A, Reiter RJ. Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J Pineal Res 1993; 15(2): 59-69.
    • (1993) J Pineal Res , vol.15 , Issue.2 , pp. 59-69
    • Menendez-Pelaez, A.1    Reiter, R.J.2
  • 70
    • 0020579435 scopus 로고
    • Role of the pineal gland in ovine photoperiodism: Regulation of seasonal breeding and negative feedback effects of estradiol upon luteinizing hormone secretion
    • [70] Bittman EL, Karsch FJ, Hopkins JW. Role of the pineal gland in ovine photoperiodism: regulation of seasonal breeding and negative feedback effects of estradiol upon luteinizing hormone secretion. Endocrinology 1983; 113(1): 329-36.
    • (1983) Endocrinology , vol.113 , Issue.1 , pp. 329-336
    • Bittman, E.L.1    Karsch, F.J.2    Hopkins, J.W.3
  • 72
    • 33845427595 scopus 로고    scopus 로고
    • Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotrophin-releasing hormone
    • [72] Wu Y-H, Zhou J-N, Balesar R, et al. Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotrophin-releasing hormone. J Comp Neurol 2006; 499(6): 897-910.
    • (2006) J Comp Neurol , vol.499 , Issue.6 , pp. 897-910
    • Wu, Y.-H.1    Zhou, J.-N.2    Balesar, R.3
  • 74
    • 14244256096 scopus 로고    scopus 로고
    • Direct effect of melatonin on Syrian hamster testes: Melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system
    • [74] Frungieri MB, Mayerhofer A, Zitta K, Pignataro OP, Calandra RS, Gonzalez-Calvar SI. Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system. Endocrinology 2005; 146(3): 1541-52.
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1541-1552
    • Frungieri, M.B.1    Mayerhofer, A.2    Zitta, K.3    Pignataro, O.P.4    Calandra, R.S.5    Gonzalez-Calvar, S.I.6
  • 75
    • 0031921718 scopus 로고    scopus 로고
    • Melatonin receptors in benign prostate epithelial cells: Evidence for the involvement of cholera and pertussis toxins–sensitive G proteins in their signal transduction pathways
    • [75] Gilad E, Pick E, Matzkin H, Zisapel N. Melatonin receptors in benign prostate epithelial cells: Evidence for the involvement of cholera and pertussis toxins–sensitive G proteins in their signal transduction pathways. Prostate 1998; 35(1): 27-34.
    • (1998) Prostate , vol.35 , Issue.1 , pp. 27-34
    • Gilad, E.1    Pick, E.2    Matzkin, H.3    Zisapel, N.4
  • 76
    • 0019992388 scopus 로고
    • Serum immunoreactive melatonin in boys with delayed puberty
    • [76] Cohen HN, Hay ID, Annesley TM, et al. Serum immunoreactive melatonin in boys with delayed puberty. Clin Endocrinol (Oxf) 1982; 17(5): 517-21.
    • (1982) Clin Endocrinol (Oxf) , vol.17 , Issue.5 , pp. 517-521
    • Cohen, H.N.1    Hay, I.D.2    Annesley, T.M.3
  • 78
    • 0018578473 scopus 로고
    • Melatonin, the pineal gland and human puberty
    • [78] Silman R, Leone R, Hooper R, Preece M. Melatonin, the pineal gland and human puberty. Nature 1979; 282(5736): 301-3.
    • (1979) Nature , vol.282 , Issue.5736 , pp. 301-303
    • Silman, R.1    Leone, R.2    Hooper, R.3    Preece, M.4
  • 79
    • 23044447129 scopus 로고    scopus 로고
    • Altered melatonin secretion in hypogonadal men: Clinical evidence
    • [79] Kumanov P, Tomova A, Isidori A, Nordio M. Altered melatonin secretion in hypogonadal men: clinical evidence. Int J Androl 2005; 28(4): 234-40.
    • (2005) Int J Androl , vol.28 , Issue.4 , pp. 234-240
    • Kumanov, P.1    Tomova, A.2    Isidori, A.3    Nordio, M.4
  • 80
    • 0031741172 scopus 로고    scopus 로고
    • Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea
    • [80] Kadva A, Djahanbakhch O, Monson J, Di WL, Silman R. Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea. J Clin Endocrinol Metab 1998; 83(10): 3653-62.
    • (1998) J Clin Endocrinol Metab , vol.83 , Issue.10 , pp. 3653-3662
    • Kadva, A.1    Djahanbakhch, O.2    Monson, J.3    Di, W.L.4    Silman, R.5
  • 81
    • 0023937455 scopus 로고
    • Inhibitory actions of pineal indoles on steroidogenesis in isolated rat Leydig cells
    • [81] Ng TB, Lo LL. Inhibitory actions of pineal indoles on steroidogenesis in isolated rat Leydig cells. J Pineal Res 1988; 5(3): 229-43.
    • (1988) J Pineal Res , vol.5 , Issue.3 , pp. 229-243
    • Ng, T.B.1    Lo, L.L.2
  • 82
    • 0030872149 scopus 로고    scopus 로고
    • Melatonin receptors are present in adult rat Leydig cells and are coupled through a pertussis toxin-sensitive G-protein
    • [82] Valenti S, Giusti M, Guido R, Giordano G. Melatonin receptors are present in adult rat Leydig cells and are coupled through a pertussis toxin-sensitive G-protein. Eur J Endocrinol 1997; 136(6): 633-9.
    • (1997) Eur J Endocrinol , vol.136 , Issue.6 , pp. 633-639
    • Valenti, S.1    Giusti, M.2    Guido, R.3    Giordano, G.4
  • 83
    • 78049284296 scopus 로고    scopus 로고
    • Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development
    • [83] Izzo G, Francesco A, Ferrara D, et al. Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development. Zygote 2010; 18(03): 257-64.
    • (2010) Zygote , vol.18 , Issue.3 , pp. 257-264
    • Izzo, G.1    Francesco, A.2    Ferrara, D.3
  • 84
    • 0024948609 scopus 로고
    • Testicular function of sexually immature rats chronically treated with melatonin
    • [84] Olivares A, Valladares L, Bustos-Obregon E, Nunez S. Testicular function of sexually immature rats chronically treated with melatonin. Arch Biol Med Exp 1989; 22(4): 387.
    • (1989) Arch Biol Med Exp , vol.22 , Issue.4 , pp. 387
    • Olivares, A.1    Valladares, L.2    Bustos-Obregon, E.3    Nunez, S.4
  • 85
    • 0028879256 scopus 로고
    • In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3', 5'-monophosphate production
    • [85] Valenti S, Guido R, Giusti M, Giordano G. In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3', 5'-monophosphate production. Endocrinology 1995; 136(12): 5357-62.
    • (1995) Endocrinology , vol.136 , Issue.12 , pp. 5357-5362
    • Valenti, S.1    Guido, R.2    Giusti, M.3    Giordano, G.4
  • 86
    • 0020572624 scopus 로고
    • Effects of pinealectomy on reproduction in the Syrian hamster mutant anophthalmic white (Wh)
    • [86] Hagen SC, Asher JH, Jr. Effects of pinealectomy on reproduction in the Syrian hamster mutant anophthalmic white (Wh). Am J Anat 1983; 167(4): 523-38.
    • (1983) Am J Anat , vol.167 , Issue.4 , pp. 523-538
    • Hagen, S.C.1    Asher, J.H.2
  • 87
    • 0022243892 scopus 로고
    • The pineal gland: Anatomy, physiology, and clinical significance
    • [87] Erlich SS, Apuzzo ML. The pineal gland: anatomy, physiology, and clinical significance. J Neurosurg 1985; 63(3): 321-41.
    • (1985) J Neurosurg , vol.63 , Issue.3 , pp. 321-341
    • Erlich, S.S.1    Apuzzo, M.L.2
  • 88
    • 0033060527 scopus 로고    scopus 로고
    • Frequency coding of melatonin signals sufficient to induce testicular growth in photoregressed Siberian hamsters
    • [88] Prendergast BJ, Hugenberger JL. Frequency coding of melatonin signals sufficient to induce testicular growth in photoregressed Siberian hamsters. J Neuroendocrinol 1999; 11(4): 237-41.
    • (1999) J Neuroendocrinol , vol.11 , Issue.4 , pp. 237-241
    • Prendergast, B.J.1    Hugenberger, J.L.2
  • 89
    • 0024773904 scopus 로고
    • Effect of melatonin infusion duration and frequency on gonad, lipid, and body mass in pinealectomized male Siberian hamsters
    • [89] Elliott JA, Bartness TJ, Goldman BD. Effect of melatonin infusion duration and frequency on gonad, lipid, and body mass in pinealectomized male Siberian hamsters. J Biol Rhythms 1989; 4(4): 439-55.
    • (1989) J Biol Rhythms , vol.4 , Issue.4 , pp. 439-455
    • Elliott, J.A.1    Bartness, T.J.2    Goldman, B.D.3
  • 90
    • 0024956465 scopus 로고
    • Histological studies on the effects of pineal 5-methoxyindoles on the reproductive organs of the male golden hamster
    • [90] Ooi VE, Ng TB. Histological studies on the effects of pineal 5-methoxyindoles on the reproductive organs of the male golden hamster. J Pineal Res 1989; 7(4): 315-24.
    • (1989) J Pineal Res , vol.7 , Issue.4 , pp. 315-324
    • Ooi, V.E.1    Ng, T.B.2
  • 91
    • 0017660325 scopus 로고
    • Subcutaneous melatonin implants inhibit reproductive atrophy in male hamsters induced by daily melatonin injections
    • [91] Reiter RJ, Rudeen PK, Sackman JW, Vaughan MK, Johnson LY, Little JC. Subcutaneous melatonin implants inhibit reproductive atrophy in male hamsters induced by daily melatonin injections. Endocr Res Commun 1977; 4(1): 35-44.
    • (1977) Endocr Res Commun , vol.4 , Issue.1 , pp. 35-44
    • Reiter, R.J.1    Rudeen, P.K.2    Sackman, J.W.3    Vaughan, M.K.4    Johnson, L.Y.5    Little, J.C.6
  • 92
    • 0029585074 scopus 로고
    • Direct effects of the pineal hormone melatonin on testosterone synthesis of Leydig cells in Djungarian hamsters (Phodopus sungorus) in vitro
    • [92] Niedziela M, Lerchl A, Nieschlag E. Direct effects of the pineal hormone melatonin on testosterone synthesis of Leydig cells in Djungarian hamsters (Phodopus sungorus) in vitro. Neurosci Lett 1995; 201(3): 247-50.
    • (1995) Neurosci Lett , vol.201 , Issue.3 , pp. 247-250
    • Niedziela, M.1    Lerchl, A.2    Nieschlag, E.3
  • 93
    • 84861744100 scopus 로고    scopus 로고
    • New insights into melatonin/CRH signaling in hamster Leydig cells
    • [93] Rossi SP, Matzkin ME, Terradas C, et al. New insights into melatonin/CRH signaling in hamster Leydig cells. Gen Comp Endocrinol 2012; 178(1): 153-63.
    • (2012) Gen Comp Endocrinol , vol.178 , Issue.1 , pp. 153-163
    • Rossi, S.P.1    Matzkin, M.E.2    Terradas, C.3
  • 94
    • 14244256096 scopus 로고    scopus 로고
    • Direct effect of melatonin on Syrian hamster testes: Melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system
    • [94] Frungieri MB, Mayerhofer A, Zitta K, Pignataro OP, Calandra RS, Gonzalez-Calvar SI. Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system. Endocrinology 2005; 146(3): 1541-52.
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1541-1552
    • Frungieri, M.B.1    Mayerhofer, A.2    Zitta, K.3    Pignataro, O.P.4    Calandra, R.S.5    Gonzalez-Calvar, S.I.6
  • 95
    • 33646696915 scopus 로고    scopus 로고
    • Melatonin hormone profile in infertile males
    • [95] Awad H, Halawa F, Mostafa T, Atta H. Melatonin hormone profile in infertile males. Int J Androl 2006; 29(3): 409-13.
    • (2006) Int J Androl , vol.29 , Issue.3 , pp. 409-413
    • Awad, H.1    Halawa, F.2    Mostafa, T.3    Atta, H.4
  • 96
    • 84895806150 scopus 로고    scopus 로고
    • Persistence of fertility despite semen alterations in a pinealectomised patient treated with melatonin
    • [96] Kocher L, Lornage J, Claustrat B. Persistence of fertility despite semen alterations in a pinealectomised patient treated with melatonin. Neuro Endocrinol Lett 2013; 34(8): 763-6.
    • (2013) Neuro Endocrinol Lett , vol.34 , Issue.8 , pp. 763-766
    • Kocher, L.1    Lornage, J.2    Claustrat, B.3
  • 97
    • 0036233843 scopus 로고    scopus 로고
    • Seminal plasma melatonin and gonadal steroids concentrations in normal men
    • [97] Luboshitzky R, Shen-Orr Z, Herer P. Seminal plasma melatonin and gonadal steroids concentrations in normal men. Arch Androl 2002; 48(3): 225-32.
    • (2002) Arch Androl , vol.48 , Issue.3 , pp. 225-232
    • Luboshitzky, R.1    Shen-Orr, Z.2    Herer, P.3
  • 98
    • 0033939837 scopus 로고    scopus 로고
    • Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis
    • [98] Shiu SY, Li L, Siu SW, Xi SC, Fong SW, Pang SF. Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis. Biol Signals Recept 2000; 9(3-4): 172-87.
    • (2000) Biol Signals Recept , vol.9 , Issue.3-4 , pp. 172-187
    • Shiu, S.Y.1    Li, L.2    Siu, S.W.3    Xi, S.C.4    Fong, S.W.5    Pang, S.F.6
  • 99
    • 0036603478 scopus 로고    scopus 로고
    • Melatonin and prostate cancer cell proliferation: Interplay with castration, epidermal growth factor, and androgen sensitivity
    • [99] Siu SW, Lau KW, Tam PC, Shiu SY. Melatonin and prostate cancer cell proliferation: interplay with castration, epidermal growth factor, and androgen sensitivity. Prostate 2002; 52(2): 106-22.
    • (2002) Prostate , vol.52 , Issue.2 , pp. 106-122
    • Siu, S.W.1    Lau, K.W.2    Tam, P.C.3    Shiu, S.Y.4
  • 100
    • 0025242959 scopus 로고
    • Differences in the quality of semen in outdoor workers during summer and winter
    • [100] Levine RJ, Mathew RM, Chenault CB, et al. Differences in the quality of semen in outdoor workers during summer and winter. N Engl J Med 1990; 323(1): 12-6.
    • (1990) N Engl J Med , vol.323 , Issue.1 , pp. 12-16
    • Levine, R.J.1    Mathew, R.M.2    Chenault, C.B.3
  • 101
    • 0026670233 scopus 로고
    • Effects of indoleamines on sperm motility in vitro
    • [101] Irez TO, Senol H, Alagoz M, et al. Effects of indoleamines on sperm motility in vitro. Hum Reprod 1992; 7(7): 987-90.
    • (1992) Hum Reprod , vol.7 , Issue.7 , pp. 987-990
    • Irez, T.O.1    Senol, H.2    Alagoz, M.3
  • 102
    • 4644349894 scopus 로고    scopus 로고
    • Melatonin administration alters semen quality in normal men
    • author reply 6-7
    • [102] Lerchl A. Melatonin administration alters semen quality in normal men. J Androl 2004; 25(2): 185-6; author reply 6-7.
    • (2004) J Androl , vol.25 , Issue.2 , pp. 185-186
    • Lerchl, A.1
  • 104
    • 0030067520 scopus 로고    scopus 로고
    • Melatonin in the rat testis: Evidence for local synthesis
    • [104] Tijmes M, Pedraza R, Valladares L. Melatonin in the rat testis: evidence for local synthesis. Steroids 1996; 61(2): 65-8.
    • (1996) Steroids , vol.61 , Issue.2 , pp. 65-68
    • Tijmes, M.1    Pedraza, R.2    Valladares, L.3
  • 106
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • [106] Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009; 47(2): 109-26.
    • (2009) J Pineal Res , vol.47 , Issue.2 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 107
    • 79955783055 scopus 로고    scopus 로고
    • Melatonin and its metabolites as antinitrosating and anti-nitrating agents
    • [107] Hardeland R. Melatonin and its metabolites as antinitrosating and anti-nitrating agents. J Exp Integr Med 2011; 1(2): 67-81.
    • (2011) J Exp Integr Med , vol.1 , Issue.2 , pp. 67-81
    • Hardeland, R.1
  • 108
    • 0036798932 scopus 로고    scopus 로고
    • Gastrointestinal melatonin: Localization, function, and clinical relevance
    • [108] Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci 2002; 47(10): 2336-48.
    • (2002) Dig Dis Sci , vol.47 , Issue.10 , pp. 2336-2348
    • Bubenik, G.A.1
  • 109
    • 0141925910 scopus 로고    scopus 로고
    • Changes in male reproductive function after high altitude mountaineering
    • [109] Okumura A, Fuse H, Kawauchi Y, Mizuno I, Akashi T. Changes in male reproductive function after high altitude mountaineering. High Alt Med Biol 2003; 4(3): 349-53.
    • (2003) High Alt Med Biol , vol.4 , Issue.3 , pp. 349-353
    • Okumura, A.1    Fuse, H.2    Kawauchi, Y.3    Mizuno, I.4    Akashi, T.5
  • 110
    • 33745089406 scopus 로고    scopus 로고
    • Effect of acute hypobaric hypoxia on spermatogenesis and lactate concentration in testicular tissue of male albino rats
    • [110] Shevantaeva ON, Kosyuga YI. Effect of acute hypobaric hypoxia on spermatogenesis and lactate concentration in testicular tissue of male albino rats. Bull Exp Biol Med 2006; 141(1): 20-2.
    • (2006) Bull Exp Biol Med , vol.141 , Issue.1 , pp. 20-22
    • Shevantaeva, O.N.1    Kosyuga, Y.I.2
  • 111
    • 26944474771 scopus 로고    scopus 로고
    • Increase in testicular temperature and vascularization induced by hypobaric hypoxia in rats
    • [111] Farias JG, Bustos-Obregon E, Reyes JG. Increase in testicular temperature and vascularization induced by hypobaric hypoxia in rats. J Androl 2005; 26(6): 693-7.
    • (2005) J Androl , vol.26 , Issue.6 , pp. 693-697
    • Farias, J.G.1    Bustos-Obregon, E.2    Reyes, J.G.3
  • 112
    • 80052048218 scopus 로고    scopus 로고
    • Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin
    • [112] Vargas A, Bustos-Obregon E, Hartley R. Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. Biol Res 2011; 44(2): 161-7.
    • (2011) Biol Res , vol.44 , Issue.2 , pp. 161-167
    • Vargas, A.1    Bustos-Obregon, E.2    Hartley, R.3
  • 113
    • 77953546377 scopus 로고    scopus 로고
    • Rat spermatogenesis damage in intermittent hypobaric hypoxia and the protective role of melatonin. I Cauda epididymal spermatozoa
    • [113] Hartley R, Castro-Sanchez R, Ramos-Gonzalez B, Bustos-Obregon E. Rat spermatogenesis damage in intermittent hypobaric hypoxia and the protective role of melatonin. I Cauda epididymal spermatozoa. Int J Morphology 2009; 27(4): 1275-84.
    • (2009) Int J Morphology , vol.27 , Issue.4 , pp. 1275-1284
    • Hartley, R.1    Castro-Sanchez, R.2    Ramos-Gonzalez, B.3    Bustos-Obregon, E.4
  • 114
    • 77956715015 scopus 로고    scopus 로고
    • Rat spermatogenesis damage in intermittent hypobaric hypoxia and the protective role of melatonin. II: Testicular parameters
    • [114] Bustos-Obregon E, Castro-Sanchez R, Ramos B, Torres-Diaz L. Rat spermatogenesis damage in intermittent hypobaric hypoxia and the protective role of melatonin. II: testicular parameters. Int J Morphology 2010; 28(2): 537-47.
    • (2010) Int J Morphology , vol.28 , Issue.2 , pp. 537-547
    • Bustos-Obregon, E.1    Castro-Sanchez, R.2    Ramos, B.3    Torres-Diaz, L.4
  • 115
    • 0023002038 scopus 로고
    • The fate of the human testes following unilateral torsion of the spermatic cord
    • [115] Anderson JB, Williamson RC. The fate of the human testes following unilateral torsion of the spermatic cord. Br J Urol 1986; 58(6): 698-704.
    • (1986) Br J Urol , vol.58 , Issue.6 , pp. 698-704
    • Erson, J.B.1    Williamson, R.C.2
  • 116
    • 0017169788 scopus 로고
    • Torsion of the testis and allied conditions
    • [116] Williamson RC. Torsion of the testis and allied conditions. Br J Surg 1976; 63(6): 465-76.
    • (1976) Br J Surg , vol.63 , Issue.6 , pp. 465-476
    • Williamson, R.C.1
  • 117
    • 1642422730 scopus 로고    scopus 로고
    • Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia–reperfusion injury
    • [117] Filho D, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia–reperfusion injury. Mol Asp Med 2004; 25(1): 199-210.
    • (2004) Mol Asp Med , vol.25 , Issue.1 , pp. 199-210
    • Filho, D.1    Torres, M.A.2    Bordin, A.L.3    Crezcynski-Pasa, T.B.4    Boveris, A.5
  • 118
    • 78249262577 scopus 로고    scopus 로고
    • Protective effects of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats
    • [118] Kanter M. Protective effects of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats. Exp Mol Pathol 2010; 89(3): 314-20.
    • (2010) Exp Mol Pathol , vol.89 , Issue.3 , pp. 314-320
    • Kanter, M.1
  • 119
    • 84864082535 scopus 로고    scopus 로고
    • Effects of melatonin on testis histology, oxidative stress and spermatogenesis after experimental testis ischemia-reperfusion in rats
    • [119] Koksal M, Oguz E, Baba F, et al. Effects of melatonin on testis histology, oxidative stress and spermatogenesis after experimental testis ischemia-reperfusion in rats. Eur Rev Med Pharmacol Sci 2012; 16(5): 582-8.
    • (2012) Eur Rev Med Pharmacol Sci , vol.16 , Issue.5 , pp. 582-588
    • Koksal, M.1    Oguz, E.2    Baba, F.3
  • 120
    • 77949263077 scopus 로고    scopus 로고
    • Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats
    • [120] Kurcer Z, Hekimoglu A, Aral F, Baba F, Sahna E. Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats. Fertil Steril 2010; 93(5): 1545-9.
    • (2010) Fertil Steril , vol.93 , Issue.5 , pp. 1545-1549
    • Kurcer, Z.1    Hekimoglu, A.2    Aral, F.3    Baba, F.4    Sahna, E.5
  • 121
    • 84866731056 scopus 로고    scopus 로고
    • Comparison of melatonin and ozone in the prevention of reperfusion injury following unilateral testicular torsion in rats
    • [121] Ekici S, Dogan Ekici AI, Ozturk G, et al. Comparison of melatonin and ozone in the prevention of reperfusion injury following unilateral testicular torsion in rats. Urology 2012; 80(4): 899-906.
    • (2012) Urology , vol.80 , Issue.4 , pp. 899-906
    • Ekici, S.1    Dogan Ekici, A.I.2    Ozturk, G.3
  • 122
    • 52949145257 scopus 로고    scopus 로고
    • Effects of melatonin on spermatogenesis and testicular ischemiareperfusion injury after unilateral testicular torsion-detorsion
    • [122] Yurtcu M, Abasiyanik A, Avunduk MC, Muhtaroglu S. Effects of melatonin on spermatogenesis and testicular ischemiareperfusion injury after unilateral testicular torsion-detorsion. J Pediatr Surg 2008; 43(10): 1873-8.
    • (2008) J Pediatr Surg , vol.43 , Issue.10 , pp. 1873-1878
    • Yurtcu, M.1    Abasiyanik, A.2    Avunduk, M.C.3    Muhtaroglu, S.4
  • 123
    • 84858277611 scopus 로고    scopus 로고
    • The role of mitochondria in energy production for human sperm motility
    • [123] Piomboni P, Focarelli R, Stendardi A, Ferramosca A, Zara V. The role of mitochondria in energy production for human sperm motility. Int J Androl 2012; 35(2): 109-24.
    • (2012) Int J Androl , vol.35 , Issue.2 , pp. 109-124
    • Piomboni, P.1    Focarelli, R.2    Stendardi, A.3    Ferramosca, A.4    Zara, V.5
  • 124
    • 0037382663 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the pathophysiology of human reproduction
    • [124] Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 2003; 79(4): 829-43.
    • (2003) Fertil Steril , vol.79 , Issue.4 , pp. 829-843
    • Agarwal, A.1    Saleh, R.A.2    Bedaiwy, M.A.3
  • 125
    • 1642634918 scopus 로고    scopus 로고
    • Redox activity associated with the maturation and capacitation of mammalian spermatozoa
    • [125] Aitken RJ, Ryan AL, Baker MA, McLaughlin EA. Redox activity associated with the maturation and capacitation of mammalian spermatozoa. Free Radic Biol Med 2004; 36(8): 994-1010.
    • (2004) Free Radic Biol Med , vol.36 , Issue.8 , pp. 994-1010
    • Aitken, R.J.1    Ryan, A.L.2    Baker, M.A.3    McLaughlin, E.A.4
  • 126
    • 10044267946 scopus 로고    scopus 로고
    • Increased seminal reactive oxygen species levels in patients with varicoceles correlate with varicocele grade but not with testis size
    • [126] Allamaneni SS, Naughton CK, Sharma RK, Thomas AJ, Jr, Agarwal A. Increased seminal reactive oxygen species levels in patients with varicoceles correlate with varicocele grade but not with testis size. Fertil Steril 2004; 82(6): 1684-6.
    • (2004) Fertil Steril , vol.82 , Issue.6 , pp. 1684-1686
    • Allamaneni, S.S.1    Naughton, C.K.2    Sharma, R.K.3    Thomas, A.J.4    Agarwal, A.5
  • 127
    • 0031793041 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in human sperm arcosome reaction induced by A23187, lysophosphatidylcholine, and biological fluid ultrafiltrates
    • [127] de Lamirande E, Tsai C, Harakat A, Gagnon C. Involvement of reactive oxygen species in human sperm arcosome reaction induced by A23187, lysophosphatidylcholine, and biological fluid ultrafiltrates. J Androl 1998; 19(5): 585-94.
    • (1998) J Androl , vol.19 , Issue.5 , pp. 585-594
    • De Lamirande, E.1    Tsai, C.2    Harakat, A.3    Gagnon, C.4
  • 129
    • 56749185765 scopus 로고    scopus 로고
    • Melatonin-enhanced hyperactivation of hamster sperm
    • [129] Fujinoki M. Melatonin-enhanced hyperactivation of hamster sperm. Reproduction 2008; 136(5): 533-41.
    • (2008) Reproduction , vol.136 , Issue.5 , pp. 533-541
    • Fujinoki, M.1
  • 130
    • 0036456610 scopus 로고    scopus 로고
    • The effects of melatonin on sperm motility in vitro in Wistar rats
    • [130] Gwayi N, Bernard RT. The effects of melatonin on sperm motility in vitro in Wistar rats. Andrologia 2002; 34(6): 391-6.
    • (2002) Andrologia , vol.34 , Issue.6 , pp. 391-396
    • Gwayi, N.1    Bernard, R.T.2
  • 131
    • 77949725046 scopus 로고    scopus 로고
    • The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROS
    • [131] Du Plessis S, Hagenaar K, Lampiao F. The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROS. Andrologia 2010; 42(2): 112-6.
    • (2010) Andrologia , vol.42 , Issue.2 , pp. 112-116
    • Du Plessis, S.1    Hagenaar, K.2    Lampiao, F.3
  • 132
    • 79956339715 scopus 로고    scopus 로고
    • Melatonin protects human spermatozoa from apoptosis via melatonin receptor-and extracellular signal-regulated kinase-mediated pathways
    • [132] Espino J, Ortiz A, Bejarano I, et al. Melatonin protects human spermatozoa from apoptosis via melatonin receptor-and extracellular signal-regulated kinase-mediated pathways. Fertil Steril 2011; 95(7): 2290-6.
    • (2011) Fertil Steril , vol.95 , Issue.7 , pp. 2290-2296
    • Espino, J.1    Ortiz, A.2    Bejarano, I.3
  • 133
    • 79951617992 scopus 로고    scopus 로고
    • High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility
    • [133] Ortiz A, Espino J, Bejarano I, et al. High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility. J Pineal Res 2011; 50(2): 132-9.
    • (2011) J Pineal Res , vol.50 , Issue.2 , pp. 132-139
    • Ortiz, A.1    Espino, J.2    Bejarano, I.3
  • 134
    • 58149250070 scopus 로고    scopus 로고
    • Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats
    • [134] Huang F, Ning H, Xin QQ, et al. Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats. Toxicology 2009; 256(1-2): 75-82.
    • (2009) Toxicology , vol.256 , Issue.1-2 , pp. 75-82
    • Huang, F.1    Ning, H.2    Xin, Q.Q.3
  • 135
    • 79956339715 scopus 로고    scopus 로고
    • Melatonin protects human spermatozoa from apoptosis via melatonin receptor-and extracellular signal-regulated kinase-mediated pathways
    • [135] Espino J, Ortiz A, Bejarano I, et al. Melatonin protects human spermatozoa from apoptosis via melatonin receptor-and extracellular signal-regulated kinase-mediated pathways. Fertil Steril 2011; 95(7): 2290-6.
    • (2011) Fertil Steril , vol.95 , Issue.7 , pp. 2290-2296
    • Espino, J.1    Ortiz, A.2    Bejarano, I.3
  • 136
    • 80053332413 scopus 로고    scopus 로고
    • Melatonin protects human spermatozoa from apoptosis via melatonin receptor-and extracellular signal-regulated kinase-mediated pathways
    • [136] Konakchieva R, Todorov P. Melatonin protects human spermatozoa from apoptosis via melatonin receptor-and extracellular signal-regulated kinase-mediated pathways. Fertil Steril 2011; 96(4): e159.
    • (2011) Fertil Steril , vol.96 , Issue.4
    • Konakchieva, R.1    Todorov, P.2
  • 137
    • 40849096175 scopus 로고    scopus 로고
    • Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2
    • [137] Radogna F, Cristofanon S, Paternoster L, et al. Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2. J Pineal Res 2008; 44(3): 316-25.
    • (2008) J Pineal Res , vol.44 , Issue.3 , pp. 316-325
    • Radogna, F.1    Cristofanon, S.2    Paternoster, L.3
  • 138
    • 84855161991 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • [138] American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2012; 35 (Suppl 1): S64-71.
    • (2012) Diabetes Care , vol.35 , Issue.1 , pp. 64-71
  • 139
    • 84857654651 scopus 로고    scopus 로고
    • Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
    • [139] Bonnefond A, Clement N, Fawcett K, et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet 2012; 44(3): 297-301.
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 297-301
    • Bonnefond, A.1    Clement, N.2    Fawcett, K.3
  • 140
    • 58149175669 scopus 로고    scopus 로고
    • Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    • [140] Lyssenko V, Nagorny CL, Erdos MR, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 2009; 41(1): 82-8.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 82-88
    • Lyssenko, V.1    Nagorny, C.L.2    Erdos, M.R.3
  • 141
    • 22044442280 scopus 로고    scopus 로고
    • Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy
    • [141] Tutuncu NB, Batur MK, Yildirir A, et al. Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy. J Pineal Res 2005; 39(1): 43-9.
    • (2005) J Pineal Res , vol.39 , Issue.1 , pp. 43-49
    • Tutuncu, N.B.1    Batur, M.K.2    Yildirir, A.3
  • 142
    • 84875666002 scopus 로고    scopus 로고
    • Melatonin secretion and the incidence of type 2 diabetes
    • [142] McMullan CJ, Schernhammer ES, Rimm EB, Hu FB, Forman JP. Melatonin secretion and the incidence of type 2 diabetes. JAMA 2013; 309(13): 1388-96.
    • (2013) JAMA , vol.309 , Issue.13 , pp. 1388-1396
    • McMullan, C.J.1    Schernhammer, E.S.2    Rimm, E.B.3    Hu, F.B.4    Forman, J.P.5
  • 143
    • 4544347701 scopus 로고    scopus 로고
    • Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum
    • [143] Paskaloglu K, Sener G, Ayangolu-Dulger G. Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. Eur J Pharmacol 2004; 499(3): 345-54.
    • (2004) Eur J Pharmacol , vol.499 , Issue.3 , pp. 345-354
    • Paskaloglu, K.1    Sener, G.2    Ayangolu-Dulger, G.3
  • 144
    • 0037166018 scopus 로고    scopus 로고
    • Melatonin administration affects plasma total sialic acid and lipid peroxidation levels in streptozotocin induced diabetic rats
    • [144] Gorgun FM, Ozturk Z, Gumustas MK, Kokogu E. Melatonin administration affects plasma total sialic acid and lipid peroxidation levels in streptozotocin induced diabetic rats. J Toxicol Environ Health A 2002; 65(10): 695-700.
    • (2002) J Toxicol Environ Health A , vol.65 , Issue.10 , pp. 695-700
    • Gorgun, F.M.1    Ozturk, Z.2    Gumustas, M.K.3    Kokogu, E.4
  • 145
    • 0036255912 scopus 로고    scopus 로고
    • Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus
    • [145] Baydas G, Canatan H, Turkoglu A. Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. J Pineal Res 2002; 32(4): 225-30.
    • (2002) J Pineal Res , vol.32 , Issue.4 , pp. 225-230
    • Baydas, G.1    Canatan, H.2    Turkoglu, A.3
  • 146
    • 84930982869 scopus 로고    scopus 로고
    • Diabetes Mellitus and male reproductive function: Where we stand?
    • [146] Alves MG, Oliveira PF. Diabetes Mellitus and male reproductive function: where we stand? Int J Diab Vasc Res 2013; 1(1): 1-3.
    • (2013) Int J Diab Vasc Res , vol.1 , Issue.1 , pp. 1-3
    • Alves, M.G.1    Oliveira, P.F.2
  • 147
    • 34447538222 scopus 로고    scopus 로고
    • Insulin dependant diabetes mellitus: Implications for male reproductive function
    • [147] Agbaje I, Rogers D, McVicar C, et al. Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod 2007; 22(7): 1871-7.
    • (2007) Hum Reprod , vol.22 , Issue.7 , pp. 1871-1877
    • Agbaje, I.1    Rogers, D.2    McVicar, C.3
  • 148
    • 0016341482 scopus 로고
    • Impotence and diabetes: Histological studies of the autonomic nervous fibers of the corpora cavernosa in impotent diabetic males
    • [148] Faerman I, Glocer L, Fox D, Jadzinsky MN, Rapaport M. Impotence and diabetes: histological studies of the autonomic nervous fibers of the corpora cavernosa in impotent diabetic males. Diabetes 1974; 23(12): 971-6.
    • (1974) Diabetes , vol.23 , Issue.12 , pp. 971-976
    • Faerman, I.1    Glocer, L.2    Fox, D.3    Jadzinsky, M.N.4    Rapaport, M.5
  • 149
    • 0022196899 scopus 로고
    • Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men
    • [149] Cameron DF, Murray FT, Drylie DD. Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men. Anat Rec 1985; 213(1): 53-62.
    • (1985) Anat Rec , vol.213 , Issue.1 , pp. 53-62
    • Cameron, D.F.1    Murray, F.T.2    Drylie, D.D.3
  • 150
    • 0023227074 scopus 로고
    • The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat
    • [150] Seethalakshmi L, Menon M, Diamond D. The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat. J Urol 1987; 138(1): 190.
    • (1987) J Urol , vol.138 , Issue.1 , pp. 190
    • Seethalakshmi, L.1    Menon, M.2    Diamond, D.3
  • 152
    • 84885600016 scopus 로고    scopus 로고
    • High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters
    • [152] Rato L, Alves M, Dias T, et al. High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters. Andrology 2013; 1(3): 495-504.
    • (2013) Andrology , vol.1 , Issue.3 , pp. 495-504
    • Rato, L.1    Alves, M.2    Dias, T.3
  • 153
    • 84892411578 scopus 로고    scopus 로고
    • Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
    • [153] Rato L, Duarte AI, Tomas GD, et al. Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress. Biochim Biophys Acta 2013; 1837(3): 335-44.
    • (2013) Biochim Biophys Acta , vol.1837 , Issue.3 , pp. 335-344
    • Rato, L.1    Duarte, A.I.2    Tomas, G.D.3
  • 154
    • 43949145970 scopus 로고    scopus 로고
    • Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats
    • [154] Guneli E, Tugyan K, Ozturk H, Gumustekin M, Cilaker S, Uysal N. Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats. Eur Surg Res 2008; 40(4): 354-60.
    • (2008) Eur Surg Res , vol.40 , Issue.4 , pp. 354-360
    • Guneli, E.1    Tugyan, K.2    Ozturk, H.3    Gumustekin, M.4    Cilaker, S.5    Uysal, N.6
  • 155
    • 84858283791 scopus 로고    scopus 로고
    • Melatonin prevents testicular damage in hyperlipidaemic mice
    • [155] Zhang K, Lv Z, Jia X, Huang D. Melatonin prevents testicular damage in hyperlipidaemic mice. Andrologia 2012; 44(4): 230-6.
    • (2012) Andrologia , vol.44 , Issue.4 , pp. 230-236
    • Zhang, K.1    Lv, Z.2    Jia, X.3    Huang, D.4
  • 156
    • 33751073149 scopus 로고    scopus 로고
    • Endocrine disruption in male mosquitofish (Gambusia holbrooki) inhabiting wetlands in Western Australia
    • [156] Game C, Gagnon MM, Webb D, Lim R. Endocrine disruption in male mosquitofish (Gambusia holbrooki) inhabiting wetlands in Western Australia. Ecotoxicology 2006; 15(8): 665-72.
    • (2006) Ecotoxicology , vol.15 , Issue.8 , pp. 665-672
    • Game, C.1    Gagnon, M.M.2    Webb, D.3    Lim, R.4
  • 157
    • 0038780037 scopus 로고    scopus 로고
    • Lead and cadmium concentration in the seminal plasma of men in the general population: Correlation with sperm quality
    • [157] Pant N, Upadhyay G, Pandey S, Mathur N, Saxena DK, Srivastava SP. Lead and cadmium concentration in the seminal plasma of men in the general population: correlation with sperm quality. Reprod Toxicol 2003; 17(4): 447-50.
    • (2003) Reprod Toxicol , vol.17 , Issue.4 , pp. 447-450
    • Pant, N.1    Upadhyay, G.2    Pandey, S.3    Mathur, N.4    Saxena, D.K.5    Srivastava, S.P.6
  • 158
    • 0030721654 scopus 로고    scopus 로고
    • Cyclophosphamideinduced structural and biochemical changes in testis and epididymidis of rats
    • [158] Kaur F, Sangha GK, Bilaspuri GS. Cyclophosphamideinduced structural and biochemical changes in testis and epididymidis of rats. Indian J Exp Biol 1997; 35(7): 771-5.
    • (1997) Indian J Exp Biol , vol.35 , Issue.7 , pp. 771-775
    • Kaur, F.1    Sangha, G.K.2    Bilaspuri, G.S.3
  • 159
    • 0030752296 scopus 로고    scopus 로고
    • Melatonin in relation to cellular antioxidative defense mechanisms
    • [159] Reiter RJ, Carneiro RC, Oh CS. Melatonin in relation to cellular antioxidative defense mechanisms. Horm Metab Res 1997; 29(8): 363-72.
    • (1997) Horm Metab Res , vol.29 , Issue.8 , pp. 363-372
    • Reiter, R.J.1    Carneiro, R.C.2    Oh, C.S.3
  • 160
    • 80052827173 scopus 로고    scopus 로고
    • Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse
    • [160] Anjum S, Rahman S, Kaur M, et al. Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse. Food Chem Toxicol 2011; 49(11): 2849-54.
    • (2011) Food Chem Toxicol , vol.49 , Issue.11 , pp. 2849-2854
    • Anjum, S.1    Rahman, S.2    Kaur, M.3
  • 161
    • 81855211073 scopus 로고    scopus 로고
    • Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes
    • [161] Ji YL, Wang H, Zhao XF, et al. Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes. Toxicol Sci 2011; 124(2): 446-59.
    • (2011) Toxicol Sci , vol.124 , Issue.2 , pp. 446-459
    • Ji, Y.L.1    Wang, H.2    Zhao, X.F.3
  • 162
    • 83555173352 scopus 로고    scopus 로고
    • Melatonin alleviates cadmiuminduced cellular stress and germ cell apoptosis in testes
    • [162] Ji YL, Wang H, Meng C, et al. Melatonin alleviates cadmiuminduced cellular stress and germ cell apoptosis in testes. J Pineal Res 2012; 52(1): 71-9.
    • (2012) J Pineal Res , vol.52 , Issue.1 , pp. 71-79
    • Ji, Y.L.1    Wang, H.2    Meng, C.3
  • 163
    • 11144344883 scopus 로고    scopus 로고
    • Diazinon alters sperm chromatin structure in mice by phosphorylating nuclear protamines
    • [163] Pina-Guzman B, Solis-Heredia MJ, Quintanilla-Vega B. Diazinon alters sperm chromatin structure in mice by phosphorylating nuclear protamines. Toxicol Appl Pharmacol 2005; 202(2): 189-98.
    • (2005) Toxicol Appl Pharmacol , vol.202 , Issue.2 , pp. 189-198
    • Pina-Guzman, B.1    Solis-Heredia, M.J.2    Quintanilla-Vega, B.3
  • 164
    • 47249094440 scopus 로고    scopus 로고
    • Sperm chromatin alteration and DNA damage by methyl-parathion, chlorpyrifos and diazinon and their oxon metabolites in human spermatozoa
    • [164] Salazar-Arredondo E, de Jesus Solis-Heredia M, Rojas-Garcia E, Hernandez-Ochoa I, Quintanilla-Vega B. Sperm chromatin alteration and DNA damage by methyl-parathion, chlorpyrifos and diazinon and their oxon metabolites in human spermatozoa. Reprod Toxicol 2008; 25(4): 455-60.
    • (2008) Reprod Toxicol , vol.25 , Issue.4 , pp. 455-460
    • Salazar-Arredondo, E.1    Rojas-Garcia, E.2    Hernandez-Ochoa, I.3    Quintanilla-Vega, B.4
  • 165
    • 22244441123 scopus 로고    scopus 로고
    • Melatonin as protective agent for the cytotoxic effects of diazinon in the spermatogenesis in the earthworm Eisenia foetida
    • [165] Bustos-Obregon E, Gonzalez JR, Espinoza O. Melatonin as protective agent for the cytotoxic effects of diazinon in the spermatogenesis in the earthworm Eisenia foetida. Ital J Anat Embryol 2005; 110(2 Suppl 1): 159-65.
    • (2005) Ital J Anat Embryol , vol.110 , Issue.2-1 , pp. 159-165
    • Bustos-Obregon, E.1    Gonzalez, J.R.2    Espinoza, O.3
  • 166
    • 55049123691 scopus 로고    scopus 로고
    • Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA
    • [166] Sarabia L, Maurer I, Bustos-Obregon E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA. Ecotoxicol Environ Saf 2009; 72(2): 663-8.
    • (2009) Ecotoxicol Environ Saf , vol.72 , Issue.2 , pp. 663-668
    • Sarabia, L.1    Maurer, I.2    Bustos-Obregon, E.3
  • 167
    • 10344222920 scopus 로고    scopus 로고
    • Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane
    • [167] Kim Y, Jung K, Hwang T, et al. Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane. Scand J Work Environ Health 1996; 22(5): 387-91.
    • (1996) Scand J Work Environ Health , vol.22 , Issue.5 , pp. 387-391
    • Kim, Y.1    Jung, K.2    Hwang, T.3
  • 168
    • 0035396417 scopus 로고    scopus 로고
    • Involvement of Bcl-2 family genes and Fas signaling system in primary and secondary male germ cell apoptosis induced by 2-bromopropane in rat
    • [168] Yu X, Kubota H, Wang R, et al. Involvement of Bcl-2 family genes and Fas signaling system in primary and secondary male germ cell apoptosis induced by 2-bromopropane in rat. Toxicol Appl Pharmacol 2001; 174(1): 35-48.
    • (2001) Toxicol Appl Pharmacol , vol.174 , Issue.1 , pp. 35-48
    • Yu, X.1    Kubota, H.2    Wang, R.3
  • 169
    • 12144291434 scopus 로고    scopus 로고
    • NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane
    • [169] Boekelheide K, Darney SP, Daston GP, et al. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane. Reprod Toxicol 2004; 18(2): 189-217.
    • (2004) Reprod Toxicol , vol.18 , Issue.2 , pp. 189-217
    • Boekelheide, K.1    Darney, S.P.2    Daston, G.P.3
  • 170
    • 0031853540 scopus 로고    scopus 로고
    • Behaviour of spermatogonia following recovery from busulfan treatment in the rat
    • [170] Jiang FX. Behaviour of spermatogonia following recovery from busulfan treatment in the rat. Anat Embryol (Berl) 1998; 198(1): 53-61.
    • (1998) Anat Embryol (Berl) , vol.198 , Issue.1 , pp. 53-61
    • Jiang, F.X.1
  • 171
    • 77955044487 scopus 로고    scopus 로고
    • Effect of Melatonin on proliferative activity and apoptosis in spermatogenic cells in mouse under chemotherapy
    • [171] Ghasemi FM, Faghani M, Khajehjahromi S, Bahadori M, Nasiri EE, Hemadi M. Effect of Melatonin on proliferative activity and apoptosis in spermatogenic cells in mouse under chemotherapy. J Reprod Contracept 2010; 21(2): 79-94.
    • (2010) J Reprod Contracept , vol.21 , Issue.2 , pp. 79-94
    • Ghasemi, F.M.1    Faghani, M.2    Khajehjahromi, S.3    Bahadori, M.4    Nasiri, E.E.5    Hemadi, M.6
  • 172
    • 0037931787 scopus 로고    scopus 로고
    • Mechanisms of action of cyclophosphamide as a male-mediated developmental toxicant
    • [172] Robaire B, Hales BF. Mechanisms of action of cyclophosphamide as a male-mediated developmental toxicant. Adv Exp Med Biol 2003; 518: 169-80.
    • (2003) Adv Exp Med Biol , vol.518 , pp. 169-180
    • Robaire, B.1    Hales, B.F.2
  • 173
    • 0029120809 scopus 로고
    • Hormonal protection from cyclophosphamideinduced inactivation of rat stem spermatogonia
    • [173] Meistrich ML, Parchuri N, Wilson G, Kurdoglu B, Kangasniemi M. Hormonal protection from cyclophosphamideinduced inactivation of rat stem spermatogonia. J Androl 1995; 16(4): 334-41.
    • (1995) J Androl , vol.16 , Issue.4 , pp. 334-341
    • Meistrich, M.L.1    Parchuri, N.2    Wilson, G.3    Kurdoglu, B.4    Kangasniemi, M.5
  • 174
    • 0035990685 scopus 로고    scopus 로고
    • Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: A correlative study with testicular oxidative stress
    • [174] Ghosh D, Das UB, Ghosh S, Mallick M, Debnath J. Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: a correlative study with testicular oxidative stress. Drug Chem Toxicol 2002; 25(3): 281-92.
    • (2002) Drug Chem Toxicol , vol.25 , Issue.3 , pp. 281-292
    • Ghosh, D.1    Das, U.B.2    Ghosh, S.3    Mallick, M.4    Debnath, J.5
  • 175
    • 18344382145 scopus 로고    scopus 로고
    • Protective effects of Emblica officinalis Gaertn. In cyclophosphamide-treated mice
    • [175] Haque R, Bin-Hafeez B, Ahmad I, Parvez S, Pandey S, Raisuddin S. Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Hum Exp Toxicol 2001; 20(12): 643-50.
    • (2001) Hum Exp Toxicol , vol.20 , Issue.12 , pp. 643-650
    • Haque, R.1    Bin-Hafeez, B.2    Ahmad, I.3    Parvez, S.4    Pandey, S.5    Raisuddin, S.6
  • 176
    • 0035178919 scopus 로고    scopus 로고
    • Role for the pineal and melatonin in glucose homeostasis: Pinealectomy increases night-time glucose concentrations
    • [176] La Fleur SE, Kalsbeek A, Wortel J, van der Vliet J, Buijs RM. Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night-time glucose concentrations. J Neuroendocrinol 2001; 13(12): 1025-32.
    • (2001) J Neuroendocrinol , vol.13 , Issue.12 , pp. 1025-1032
    • La Fleur, S.E.1    Kalsbeek, A.2    Wortel, J.3    Van Der Vliet, J.4    Buijs, R.M.5
  • 179
    • 0026039740 scopus 로고
    • Inhibitory action of melatonin and structurally related compounds on testosterone production by mouse Leydig cells in vitro
    • [179] Persengiev S, Kehajova J. Inhibitory action of melatonin and structurally related compounds on testosterone production by mouse Leydig cells in vitro. Cell Biochem Funct 1991; 9(4): 281-6.
    • (1991) Cell Biochem Funct , vol.9 , Issue.4 , pp. 281-286
    • Persengiev, S.1    Kehajova, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.