Melatonin enhances Th2 cell mediated immune responses: Lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists

Molecular and Cellular Biochemistry

Volumn 221, Issue 1-2, 2001, Pages 57-62

  Raghavendra, Vasudeva ^b   Singh, Vinod ^a   Kulkarni, Shrinivas K ^b   Agrewala, Javed N ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Central peripheral benzodiazepine receptors; Endopioids; IFN ; IgG1; IgG2a; IL 4; Melatonin Th1 Th2 cells

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; CENTRAL NERVOUS SYSTEM AGENTS; CYTOKINE; FLUMAZENIL; IMMUNOGLOBULIN G; ISOQUINOLINE DERIVATIVE; MELATONIN; MU OPIATE RECEPTOR; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NALTREXONE; NARCOTIC ANTAGONIST; OVALBUMIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HYBRIDOMA; IMMUNOLOGY; MOUSE; TH2 CELL;

ANIMALS; CELL LINE; CENTRAL NERVOUS SYSTEM AGENTS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUMAZENIL; HYBRIDOMAS; IMMUNOGLOBULIN G; ISOQUINOLINES; MELATONIN; MICE; MICE, INBRED BALB C; NALTREXONE; NARCOTIC ANTAGONISTS; OVALBUMIN; PERIPHERAL NERVOUS SYSTEM AGENTS; RECEPTORS, GABA-A; RECEPTORS, OPIOID, MU; TH2 CELLS;

EID: 0035350773     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010968611716     Document Type: Article

References (39)

1. Liebmann PM, Wolfer A, Felsner P, Hofer D, Schauenstein K: Melatonin and the immune system. Int Arch Allergy Immunol 112: 203-211, 1997
2. Maestroni GJM, Conti A, Pierpaoli W: Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immuno-suppressive effect of corticosterone. J Neuroimmunol 13: 19-30, 1986
3. Maestroni GJM, Conti A, Pierpaoli W: Role of the pineal gland in immunity: II. Melatonin enhances the antibody response via an opiatergic mechanism. Clin Exp Immunol 68: 384-391, 1987
4. Maestroni GJM, Conti A, Pierpaoli W: Role of the pineal gland in immunity. III. Melatonin antagonizes the immuno suppressive effect of acute stress via an opiatergic mechanism. Immunology 63: 465-469, 1988
5. Caroleo MC, Frasca D, Nistico G, Doria G: Melatonin as an immunomodulatory in immunodeficient mice. J Immunopharmacol 23: 81-89, 1992
6. Steinhilber D, Brungs M, Werz O, Wiesenberg I, Danielsson C, Kahlen JP, Nayeri S, Schrader M, Carlberg C: The Nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes. J Biol Chem 270: 7037-7040, 1995
7. Garcia-Perganeda A, Guerrero JM, Rafii-El-Idrissi M, Romero MP, Pozo D, Calvo JR: Characterization of membrane melatonin receptor in mouse peritoneal macrophages: Inhibition of adenylyl cyclase by a pertusis toxin-sensitive G protein. J Neuroimmunol 95: 85-94, 1999
8. Garcia-Perganeda A, Pozo D, Guerrero JM, Calvo JR: Signal transduction for melatonin in human lymphocytes: Involvement of a pertusistoxin-sensitive G-protein. J Immunol 159: 3774-3781, 1997
9. Rafii-El-Idrissi M, Calvo JR, Harmouch A, Garcia-Mourino S, Guerrero JM: Specific binding of melatonin by purified cell nuclei from spleen and thymus of the rat. J Neuroimmunol 86: 190-197, 1998
10. + Th1 cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. J Neuroimmunol 28: 167-176, 1990
11. Tenn CC, Niles LP: Central type benzodiazepine receptors mediate the anti dopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: Involvement of GABAergic mechanism. J Pharmacol Exp Ther 274: 84-89, 1995
12. Golombek DA, Pavet P, Cardinali DP: Melatonin effects on behavior: Possible mediation by the central GABAergic system. Neurosci Biobehav Rev 20: 403-412, 1996
13. Raghavendra V, Kulkarni SK: Reversal of morphine tolerance and dependence by melatonin: Possible role of central and peripheral benzodiazepine receptors. Brain Res 834: 178-181, 1999
14. Lenfant M, Haumont J, Zavala F: In vivo immunomodulating activity of PK11195, a structurally unrelated ligand for 'peripheral' benzodiazepine binding site: I. Potentiation in mice of the humoral response to sheep red blood cells. Int J Immunopharmacol 8: 825-829, 1986
15. Zavala F, Taupin V, Descamps-Latscha B: In vivo treatment with benzodiazepines inhibits murine phagocyte oxidative metabolism and production of interleukin 1, tumor necrosis factor and interleukin 6. J Pharmacol Exp Ther 255: 442-450, 1990
16. Matsumoto T, Ogata M, Koga K, Shigematsu A: Effect of peripheral benzodiazepine receptor ligands on lipopolysaccharide-induced tumor necrosis factor activity in thioglycolate-treated mice. Antimicrob Agents Chemother 38: 812-816, 1994
17. Shaji AV, Kulkarni SK, Agrewala JN: Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells. Clin Exp Immunol 111: 181-185, 1998
18. Sugden D: Psychopharmacological effects of melatonin in mouse and rat. J Pharmacol Exp Ther 227: 587-591, 1995
19. Agrewala JN, Suvas S, Verma RK, Mishra GC: Differential effect of anti-B7-1 and anti-M150 antibodies in restricting the delivery of costimulatory signals from B cells and macrophages. J Immunol 160: 1067-1077, 1998
20. Raghavendra V, Agrewala JN, Kulkarni SK: Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice. Eur J Pharmacol 395: 15-21, 2000
21. + T lymphocytes. Immunol Today 9: 268-274, 1998
22. Janeway CA, Bottomly K: Signals and signs for lymphocyte response. Cell 76: 275-285, 1994
23. Jenkins MK: The ups and downs of T cell co-stimulation. Immunity 1: 443-449, 1994
24. Paul WE, Seder RA: Lymphocytes responses and cytokines. Cell 76: 241-251, 1994
25. + T lymphocytes specific for an epitope of the 16-kDa α-crystalline antigen of Mycobacterium tuberculosis. Eur J Immunol 29: 1753-1761, 1999
26. + (sIgD) B cells to secrete IgG1 and IgG3. J Exp Med 179: 757-762, 1994
27. Moore KW, O'Garra A, De Waal-Malefyt R, Vieira P, Mosmann TR: Interleukin-10. Ann Rev Immunol 11: 165-190, 1993
28. Flores LR, Wahl SM, Bayer BM: Mechanisms of morphine-induced immuno-suppression: Effect of acute morphine administration on lymphocyte trafficking. J Pharmacol Exp Ther 272: 1246-1251, 1995
29. Roy S, Chapin RB, Cain KJ, Charboneau RG, Ramakrishnan S, Barke RA: Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes. Cell Immunol 179: 1-9, 1997
30. Jonsdottir IH, Johansson C, Asea A, Hellstrand K, Thoren P, Hoffmann P: Chronic intracerebroventricular administration of beta-endorphin augments natural killer cell cytotoxicity in rats. Reg Pept 62: 113-118, 1996
31. Hellstrand K, Hermodasson S: Role of serotonin in the regulation of human natural killer cell cytotoxicity. J Immunol 139: 869-875, 1987
32. Woolf CJ, Allehorne A, Garabedian SB, Poole S: Cytokine, nerve growth factor and inflammatory hyperalgesia: The contribution of tumor necrosis factor alpha. Br J Pharmacol 121: 417-424, 1997
33. Kanaan SA, Garabedian BS, Haddad JJ, Abadelnoor AM, Atweh SF, Jabbur SJ, Saade NE: Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. Pharmacology 54: 285-297, 1997.
34. Lenfant M, Zavala F, Haumont J, Potier P: Presence d'un site de fixation de 'type peripherique' des benzodiazepines sur le macrophages; son roleeventuel dans l'immunomodulation. C R Acad Sci Ser III Sci Vie 300: 309-314, 1985
35. Martins E Jr, Fernandes LC, Bartol I, Cipolla-Neto J, Costa-Rosa LFBP: The effect of melatonin chronic treatment upon macrophage and lymphocyte metabolism and function in Walker-256 tumour-bearing rats. J Neuroimmunol 82: 81-89, 1998
36. Nava F, Calpai G, Facciola G, Cuzzocrea S, Giuliani G, De Sarro A, Caputi AP: Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharides in rat. Eur J Pharmacol 331: 267-274, 1997
37. Carmel I, Fares FA, Leschiner S, Scherubl H, Weisinger G, Gavish M: Peripheral type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line. Biochem Pharmacol 59: 831-842, 1999
38. Gavish M, Bachman I, Shoukrun R, Katz V, Veenman L, Weisinger G, Weizman A: Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev 51: 629-650, 1999
39. Karasek M, Pawlikowski M: Pineal gland, melatonin and cancer. Neuroendocrinol Lett 20: 139-144, 1999