Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice

Human and Experimental Toxicology

Volumn 33, Issue 2, 2014, Pages 185-195

  Chabra, A ^a   Shokrzadeh, M ^a,b   Naghshvar, F ^a   Salehi, F ^a   Ahmadi, A ^b  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

cyclophosphamide; Melatonin; oxidative stress; reproductive toxicity; testicular toxicity

Indexed keywords

ANTIOXIDANT; CATALASE; CYCLOPHOSPHAMIDE; GLUTATHIONE; INDOLEAMINE; MELATONIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; HISTOPATHOLOGY; LEUKOCYTE DIFFERENTIAL COUNT; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON; TESTIS INJURY; TISSUE HOMOGENATE;

CYCLOPHOSPHAMIDE; MELATONIN; OXIDATIVE STRESS; REPRODUCTIVE TOXICITY; TESTICULAR TOXICITY;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIOXIDANTS; CYCLOPHOSPHAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; INFERTILITY, MALE; LIPID PEROXIDATION; MALE; MELATONIN; MICE; MOLECULAR STRUCTURE; OXIDATIVE STRESS;

EID: 84888865976     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113489052     Document Type: Article

References (53)

1. Turner AJ. Therapeutic drug monitoring: edited by B Widdop. pp. 359. Churchill Livingstone, Edinburgh. 1985. £32. ISBN 0-443-02686-6. Biochem Educ. 1986 ; 14: 93
2. Marinello AJ, Bansal SK, Paul B, et al. Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450. Cancer Res. 1984 ; 44: 4615-4621 (Pubitemid 14008786)
3. Fraiser LH, Kanekal S, Kehrer JP. Cyclophosphamide toxicity. Characterising and avoiding the problem. Drugs. 1991 ; 42: 781-795 (Pubitemid 21920784)
4. Lee S, Schmitt CA. Chemotherapy response and resistance. Curr Opin Genet Dev. 2003 ; 13: 90-96 (Pubitemid 36143933)
5. Pendse S, Ginsburg E, Singh AK. Strategies for preservation of ovarian and testicular function after immunosuppression. Am J Kidney Dis. 2004 ; 43: 772-781 (Pubitemid 38529614)
6. Anderson D, Bishop JB, Garner RC, et al. Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutat Res. 1995 ; 330: 115-181
7. Kaur F, Sangha GK, Bilaspuri GS. Cyclophosphamide-induced structural and biochemical changes in testis and epididymidis of rats. Indian J Exp Biol. 1997 ; 35: 771-775 (Pubitemid 27516028)
8. Meistrich ML, Parchuri N, Wilson G, et al. Hormonal protection from cyclophosphamide-induced inactivation of rat stem spermatogonia. J Androl. 1995 ; 16: 334-341
9. Das UB, Mallick M, Debnath JM, et al. Protective effect of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorders in male rats. Asian J Androl. 2002 ; 4: 201-207
10. Ghosh D, Das UB, Ghosh S, et al. Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: a correlative study with testicular oxidative stress. Drug Chem Toxicol. 2002 ; 25: 281-292 (Pubitemid 34831279)
11. Haque R, Bin-Hafeez B, Ahmad I, et al. Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Hum Exp Toxicol. 2001 ; 20: 643-650
12. Altuntas I, Delibas N, Sutcu R. The effects of organophosphate insecticide methidathion on lipid peroxidation and anti-oxidant enzymes in rat erythrocytes: role of vitamins E and C. Hum Exp Toxicol. 2002 ; 21: 681-685 (Pubitemid 36124501)
13. Selvakumar E, Prahalathan C, Mythili Y, et al. Protective effect of dl-alpha-lipoic acid in cyclophosphamide induced oxidative injury in rat testis. Reprod Toxicol. 2004 ; 19: 163-167 (Pubitemid 40288195)
14. Selvakumar E, Prahalathan C, Sudharsan PT, et al. Protective effect of lipoic acid on cyclophosphamide-induced testicular toxicity. Clin Chim Acta. 2006 ; 367: 114-119
15. Zhang YM. Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells. Toxicol Sci. 2005 ; 88: 545-550 (Pubitemid 41672162)
16. Ghosh D, Das UB, Misro M. Protective role of alpha-tocopherol-succinate (provitamin-E) in cyclophosphamide induced testicular gametogenic and steroidogenic disorders: a correlative approach to oxidative stress. Free Radic Res. 2002 ; 36: 1209-1218 (Pubitemid 35230241)
17. Reiter RJ. Interactions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review. Braz J Med Biol Res. 1993 ; 26: 1141-1155
18. Reiter R, Tang L, Garcia JJ, et al. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 1997 ; 60: 2255-2271
19. Cagnoli CM, Atabay C, Kharlamova E, et al. Melatonin protects neurons from singlet oxygen-induced apoptosis. J Pineal Res. 1995 ; 18: 222-226
20. Marshall KA, Reiter RJ, Poeggeler B, et al. Evaluation of the antioxidant activity of melatonin in vitro. Free Radic Biol Med. 1996 ; 21: 307-315 (Pubitemid 26271720)
21. Pieri C, Marra M, Moroni F, et al. Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci. 1994 ; 55: PL271 - PL276
22. Oner-Iyidogan Y, Gurdol F, Oner P. The effects of acute melatonin and ethanol treatment on antioxidant enzyme activities in rat testes. Pharmacol Res. 2001 ; 44: 89-93 (Pubitemid 32695085)
23. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 ; 72: 248-254
24. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth Enzymol. 1990 ; 186: 407-421 (Pubitemid 20279982)
25. Shahidi F, Kamil J, Jeon Y-J, et al. Antioxidant role of chitosan in a cooked cod (Gadus Morhua) model system. J Food Lipid. 2002 ; 9: 57-64 (Pubitemid 34862183)
26. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972 ; 247: 3170-3175
27. Bonaventura J, Schroeder WA, Fang S. Human erythrocyte catalase: an improved method of isolation and a reevaluation of reported properties. Arch Biochem Biophys. 1972 ; 150: 606-617
28. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959 ; 82: 70-77
29. Batra N, Nehru B, Bansal MP. Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc status. Br J Nutr. 2004 ; 91: 387-391 (Pubitemid 38386902)
30. Fawcett DW Bloom and Fawcett: a textbook of histology. 12 th ed. New York, NY: Champan and Hall, 1994. New York, NY: Champan and Hall ; 1994 :
31. Manda K, Bhatia AL. Prophylactic action of melatonin against cyclophosphamide-induced oxidative stress in mice. Cell Biol Toxicol. 2003 ; 19: 367-372 (Pubitemid 38250043)
32. Gul M, Kutay FZ, Temocin S, et al. Cellular and clinical implications of glutathione. Indian J Exp Biol. 2000 ; 38: 625-634
33. Bartsch H, Nair J. Ultrasensitive and specific detection methods for exocylic DNA adducts: markers for lipid peroxidation and oxidative stress. Toxicol. 2000 ; 153: 105-114
34. Chandrasekara N, Shahidi F. Antioxidative potential of cashew phenolics in food and biological model systems as affected by roasting. Food Chem. 2011 ; 129: 1388-1396
35. Ilbey YO, Ozbek E, Simsek A, et al. Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats. Fertil Steril. 2009 ; 92: 1124-1132
36. Elangovan N, Chiou TJ, Tzeng WF, et al. Cyclophosphamide treatment causes impairment of sperm and its fertilizing ability in mice. Toxicol. 2006 ; 222: 60-70
37. Tripathi DN, Jena GB. Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells. Toxicology. 2008 ; 248: 96-103
38. Vaisheva F, Delbes G, Hales BF, et al. Effects of the chemotherapeutic agents for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), on the male rat reproductive system and progeny outcome. J Androl. 2007 ; 28: 578-587 (Pubitemid 47057041)
39. Williams K, Frayne J, McLaughlin EA, et al. Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein. Mol Hum Reprod. 1998 ; 4: 235-242 (Pubitemid 28172589)
40. Huang F, Ning H, Xin QQ, et al. Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats. Toxicol. 2009 ; 256: 75-82
41. Melchiorri D, Reiter RJ, Attia AM, et al. Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats. Life Sci. 1995 ; 56: 83-89 (Pubitemid 24380187)
42. Sewerynek E, Melchiorri D, Reiter RJ, et al. Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin. Eur J Pharmacol. 1995 ; 293: 327-334 (Pubitemid 3006672)
43. De La Lastra CA, Cabeza J, Motilva V, et al. Melatonin protects against gastric ischemia-reperfusion injury in rats. J Pineal Res. 1997 ; 23: 47-52 (Pubitemid 127731737)
44. Melchiorri D, Reiter RJ, Chen LD, et al. Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain. Eur J Pharmacol. 1996 ; 305: 239-242 (Pubitemid 26197612)
45. Melchiorri D, Reiter RJ, Sewerynek E, et al. Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB J. 1995 ; 9: 1205-1210
46. Princ FG, Juknat AA, Maxit AG, et al. Melatonin's antioxidant protection against delta-aminolevulinic acid-induced oxidative damage in rat cerebellum. J Pineal Res. 1997 ; 23: 40-46 (Pubitemid 127500268)
47. Melchiorri D, Reiter RJ, Sewerynek E, et al. Paraquat toxicity and oxidative damage. Reduction by melatonin. Biochem Pharmacol. 1996 ; 51: 1095-1099
48. Tan DX, Reiter RJ, Manchester LC, et al. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem. 2002 ; 2: 181-197
49. Gwayi N, Bernard RT. The effects of melatonin on sperm motility in vitro in Wistar rats. Andrologia. 2002 ; 34: 391-396 (Pubitemid 35463786)
50. Gavazza M, Catala A. Relative efficacies of alpha-tocopherol, N-acetyl-serotonin, and melatonin in reducing non-enzymatic lipid peroxidation of rat testicular microsomes and mitochondria. Mol Cell Biochem. 2009 ; 321: 37-43
51. Poli G, Cheeseman KH, Biasi F, et al. Promethazine inhibits the formation of aldehydic products of lipid peroxidation but not covalent binding resulting from the exposure of rat liver fractions to CCl4. Biochem J. 1989 ; 264: 527-532 (Pubitemid 20024524)
52. Ahmadi A, Hosseinimehr SJ, Naghshvar F, et al. Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Arch Pharm Res. 2008 ; 31: 794-797
53. Hosseinimehr SJ, Ahmadashrafi S, Naghshvar F, et al. Chemoprotective effects of Zataria multiflora against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Integr Cancer Ther. 2010 ; 9: 219-223