Melatonin in relation to cellular antioxidative defense mechanisms

Hormone and Metabolic Research

Volumn 29, Issue 8, 1997, Pages 363-372

  Reiter, R J ^a,b   Carneiro, Regina C ^a   Oh, C S ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Antioxidative Defense System; Free Radicals; Hydroxyl Radical; Lipid Peroxidation; Melatonin; Oxidative Stress; Peroxyl Radical

Indexed keywords

CARBON TETRACHLORIDE; CARCINOGEN; FREE RADICAL; HYDROXYL RADICAL; KAINIC ACID; LIPOPOLYSACCHARIDE; MELATONIN; PARAQUAT; POTASSIUM CYANIDE; SUPEROXIDE DISMUTASE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; CIRCADIAN RHYTHM; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; INTOXICATION; LIPID PEROXIDATION; NERVE INJURY; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW;

EID: 0030752296     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-979057     Document Type: Review

References (106)

1. Bartness, T. J., J. B. Powers, M. H. Hastings, E. L. Bittman, B. D. Goldman: The timed infusion paradigm of melatonin delivery: What has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses? J Pineal Res 15: 151-190 (1993)
2. Goldman, B. D., R. J. Nelson: Melatonin and seasonality in mammals. In: Yu HS, Reiter RJ (ed). Melatonin. CRC Press, Boca Raton (1993)
3. Reiter, R. J.: The melatonin rhythm: Both a clock and a calendar. Experientia 49: 654-664 (1993)
4. Armstrong, S.: Melatonin: The internal Zeitgeber of mammals? Pineal Res Rev 7: 158-202 (1989)
5. Redman J. S., K. T. Armstrong, N. Ng: Free-running activity rhythms in the rat: Entrainment by melatonin. Science 219: 1089-1091 (1983)
6. Maestroni, G. J. M.: The immunoneuroendocrine role of melatonin. J Pineal Res 14: 1-10 (1993)
7. Arendt, J., M. Aldhous, V. Marks: Alleviation of jet lag by melatonin: Preliminary results of controlled double blind trial. Brit Med J 292: 1170 (1986)
8. Dawson, D., N. Encel: Melatonin and sleep in humans. J Pineal Res 15 :1-12 (1993)
9. Reiter, R. J.: Melatonin: That ubiquitously acting pineal hormone. News Physiol Sci 6: 223-227 (1992)
10. Reppert, S. M., D. R. Weaver, T. Ebisawa: Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 13: 1177-1182 (1994)
11. Shin, S. Y. W., N. Ng, S. F. Pang: A molecular perspective of the genetic relationships of G-protein coupled melatonin receptor subtypes. J Pineal Res 20: 198-204 (1996)
12. Williams, L. M., L. T. Hannah, M. H. Hastings, E. S. Maywood: Melatonin receptors in the rat brain and pituitary. J Pineal Res 19: 173-177 (1995)
13. Acuña-Castroviejo, D., R. J. Reiter, A. Menendez-Pelaez, M. I. Pablos. A. Burgos: Characterization of high-affinity melatonin sending sites in purified cell nuclei of rat liver. J Pineal Res 16: 100-112 (1994)
14. Carlberg, C., I. Weisenberg: The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase: An unexpected relationship. J Pineal Res 18: 171-178 (1995)
15. Huerto-Delgadillo, L., F. Anton-Tay, G. Benitz-King: Effects of melatonin on microtubule assembly depends on hormone concentration: Role of melatonin as a calmodulin antagonist. J Pineal Res 17: 55-62 (1994)
16. Bettahi, I., D. Pozo, C. Osuna, R. J. Reiter, D. Acuña-Castroviejo, J. M. Guerrero: Melatonin reduces nitric oxide synthase activity in rat hypothalamus. J Pineal Res 20: 205-210 (1996)
17. Pozo, D., R. J. Reiter, J. R. Calvo, J. M. Guerrero: Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 55: PL 455-PL 460 (1994)
18. Reiter, R. J.: Antioxidant actions of melatonin. Adv Pharmacol 38: 103-117 (1997)
19. Reiter, R. J., D. Melchiorri, E. Sewerynek, B. Poeggeler, L. R. Barlow-Walden, J. I. Chuang, G. G. Ortiz, D. Acuña-Castroviejo: A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 18: 1-11 (1995)
20. Ianas, O., R. Olnescu, I. Badescu: Melatonin involvement in oxidative stress. Rom J Endocrinol 29: 147-153 (1991)
21. Reiter, R. J., D. X. Tan, B. Poeggeler, A. Menendez-Pelaez, L. D. Chen, S. Saarela: Melatonin as a free radical scavenger: Implications for aging and age-related diseases. Ann NY Acad Sci 719: 1-12 (1994)
22. Tan, D. X., L. D. Chen, B. Poeggeler, L. C. Manchester, R. J. Reiter: Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine J 1: 57-60 (1993)
23. Hardeland, R., I. Balzer, B. Poeggeler, B. Fuhrberg, H. Uria, G. Behrmann, R. Wolf, T. J. Meyer, R. J. Reiter: On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photoxidation, and scavenging of free radicals. J Pineal Res 18: 104-111 (1995)
24. Poeggeler, B., R. J. Reiter, D. X. Tan, L. D. Chen, L. C. Manchester: Melatonin, hydroxyl-mediated oxidative damage, and aging. J Pineal Res 14: 151-168 (1993)
25. Pieri, C., M. Marra, R. Monari, R. Recchioni, F. Marchselli: Melatonin: A peroxyl radical scavenger more potent than vitamin E. Life Sci 55: PL271-PL276 (1994)
26. Scaiano, J. C.: Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry. J Pineal Res 19: 189-195 (1995)
27. Marshall, K. A., R. J. Reiter, B. Poeggeler, O. I. Aruoma, B. Halliwell: Evaluation of the antioxidative activity of melatonin in vitro. Free Radic Biol Med 21: 307-315 (1996)
28. Reiter, R. J.: Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 9: 526-533 (1995)
29. Cagnoli, C. M., C. Atabay, E. Kharlamova, H. Manev: Melatonin protects neurons from singlet oxygen-induced apoptosis. J Pineal Res 18: 222-226 (1995)
30. Chan, T. Y., P. L. Tang: Characterization of the antioxidant effects of melatonin and related indoleamines in vitro. J Pineal Res 20: 187-191 (1996)
31. Poeggeler, B., R. J. Reiter, R. Hardeland, D. X. Tan, L. R. Barlow-Walden: Melatonin and structurally - related endogenous indoles act as potent electron donors and radical scavengers in vitro. Redox Rept 2: 179-184 (1996)
32. Poeggeler, B., I. Balzer, R. Hardeland, A. Lerchl: Pineal hormone melatonin oscillates in the dinoflagellate Gonyaulax polyedra. Naturwissenschaften 78: 268-269 (1991)
33. Poeggeler, B., R. Hardeland: Detection and quantitation of melatonin in a dinoflagellate, Gonyaulax polyedra: Solutions to the problem of methoxyindole destruction in non-vertebrate material. J Pineal Res 17: 1-10 (1995)
34. Manchester, L. C., B. Poeggeler, F. L. Alvarez, G. B. Ogden, R. J. Reiter: Melatonin immunoreactivity in the prokaryote Rhodopirillum rubrum: Implications for an ancient antioxidative system. Cell Molec Biol Res 41: 391-395 (1995)
35. Tilden, A., M. A. Becker, L. L. Amma, J. Arciniega, A. K. McGaw: Melatonin production in an aerobic photosynthetic bacterium: An evolutionarily early association with darkness. J Pineal Res 22: 102-106 (1997)
36. Tan, D. X., B. Poeggeler, R. J. Reiter, L. D. Chen, S. Chen, L. C. Manchester, L. R. Barlow-Walden: The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo. Cancer Lett 70: 65-71 (1993)
37. Tan, D. X., R. J. Reiter, L. D. Chen, B. Poeggeler, L. C. Manchester, L. R. Barlow-Walden: Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. Carcinogenesis 15: 615-618 (1994)
38. Jaeschke, H.: Mechanisms of oxidant stress-induced acute tissue injury. Proc Soc Exp Biol Med 209: 104-111 (1995)
39. Ready, M. V., K. Randerrath: Nuclease P1-mediated enhancement of sensitivity of 32 p-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7: 1543-1551 (1986)
40. Vijayalaxmi, R. J. Reiter, E. Sewerynek, B. Poeggeler, B. Z. Leal, M. Meltz: Marked reduction of radiation-induced micronuclei in human blood lymphocytes pretreated with melatonin. Radiat Res 143: 102-106 (1995)
41. Vijayalaxmi, R. J. Reiter, M. Meltz: Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat Res 346: 23-31 (1995)
42. Vijayalaxmi, R. J. Reiter, T. S. Herman, M. L. Meltz: Melatonin and radioprotection from genetic damage: In vivo/in vitro studies in human volunteers. Radiat Res 371: 221 -228 (1996)
43. Blinkenstaff, R. T., S. M. Brandstadter, S. Reddy, R. Witt: Potential radioprotective agents: Homologs of melatonin. J Pharm Sci 83: 216-218 (1994)
44. Sewerynek, E., M. Abe, R. J. Reiter, L. R. Barlow-Walden, L. D. Chen, T. J. McCabe, L. J. Roman, B. Diaz-Lopez: Melatonin administration prevents lipopolysaccharide-induced oxidative damage in phenobarbital-treated animals. J Cell Biochem 58: 436-444 (1995)
45. Sewerynek, E., D. Melchiorri, L. D. Chen, R. J. Reiter: Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation in vitro. Free Rad Biol Med 19: 903-909 (1995)
46. Sewerynek, E., D. Melchiorri, R. J. Reiter, G. G. Ortiz, A. Lewinski: Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin. Eur J Pharmacol 293: 327-334 (1995)
47. Sewerynek, E., G. G. Ortiz, R. J. Reiter, M. I. Pablos, D. Melchiorri, W. M. U. Daniels: Lipopolysaccharide-induced DNA damage is greatly reduced in rats treated with the pineal hormone melatonin. Molec Cell Endocrinol 117: 183-188 (1996)
48. Uz, T., P. Giusti, D. Frasneschini, A. Kharlamova, H. Manev: Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats. Neuroscience 73: 631-636 (1996)
49. Buttke, T. M., P. A. Sandstrom: Oxidative stress as a mediator of apoptosis. Immunol Today, 15: 7-10 (1994)
50. Schwartzman, R. A., J. C. Cidlowski: Apoptosis: The biochemistry and molecular biology of programmed cell death. Endocrine Rev 14: 133-151 (1993)
51. Sainz, R. M., J. C. Mayo, H. Uria, M. Kolter, I. Antolin, C. Rodriquez, A. Menendez-Pelaez: The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes. J Pineal Res 19: 178-188 (1995)
52. Provinciali, M., G. Di Stefano, D. Bulian, A. Tibaldi, N. Fabris: Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice. Mech Aging Dev 90: 1-19 (1996)
53. Pappolla, M. A., M. Sos, R. A. Beck, D. L. M. Hickson-Bick, R. J. Reiter, S. Efthimiopoulos, N. K. Robakis: Melatonin prevents death of neuroblastoma cells exposed to Alzheimer amyloid protein. J Neurosci 17: 1683-1690 (1997)
54. Porter, N. A., S. E. Caldwell, K. A. Mills: Mechanism's of free radical oxidation of unsaturated lipids. Lipids 30: 277-290 (1995)
55. Costa, E. J. X., R. Harzar Lopes, M. T. Lamy-Freund: Permeability of pure lipid bilayers to melatonin. J Pineal Res 19: 123-126 (1995)
56. Pierrefiche, G., G. Topall, I. Courbain, H. Henriet: Antioxidant activity of melatonin in mice. Res Commun Chem Pathol Pharmacol 80: 211-223 (1993)
57. Pierrifiche, G., H. Laborit: Oxygen radicals, melatonin, and aging. Exp Gerontol 30: 213-227 (1995)
58. Melchiorri, D., R. J. Reiter, A. M. Attia, M. Hara, A. Burgos, E. Sewerynek: Potent protective effects of melatonin on in vivo paraquat-induced oxidative damage in rats. Life Sci 56: 83-89 (1995)
59. Melchiorri, D., R. J. Reiter, E. Seweryrtek, M. Hara, L. D. Chen, G. Nistico: Paraquat toxicity and oxidative damage: Reduction by melatonin. Biochem Pharmacol 51: 1095-1099 (1996)
60. Melchiorri, D., R. J. Reiter, E. Sewerynek, L. D. Chen, G. Nistico: Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB J 9: 1205-1210 (1995)
61. Melchiorri, D., R. J. Reiter, L. D. Chen, E. Sewerynek, G. Nistico: Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain. Eur J Pharmacol 305: 239-242 (1996)
62. Giusti, P., M. Gusella, M. Lipartiti, D. Milani, W. Zhu, S. Vicini, H. Manev: Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity. Exp Neural 131: 39-46 (1995)
63. Giusti, P., M. Lipartiti, D. Franceschini, N. Schiavo, M. Florani, H. Manev: Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. FASEB J 10: 891-896 (1996)
64. Manev, H., T. Uz, A. Kharlamova, C. M. Cagnoli, D. Franceschini, P. Giusti: In vivo protection against kainate-induced apoptosis by the pineal hormone melatonin: Effect of exogenous melatonin and circadian rhythm. Restr Neurol Neurosci 9: 251-256 (1996)
65. Maestroni, G. J. M.: Melatonin as a therapeutic agent in experimental endotoxic shock. J Pineal Res 20: 84-89 (1996)
66. Pentney, P. T., G. A. Bubinek: Melatonin reduces the severity of dextran-induced colitis in mice. J Pineal Res 19: 31-39 (1995)
67. Sewerynek, E., R. J. Reiter, D. Melchiorri, G. G. Ortiz, A. Lewinski: Oxidative damage in the liver induced by ischemia-reperfusion: Protection by melatonin. Hepato-Gastroenterology 43: 898-905 (1996)
68. Sokol, R. J., B. M. Winkhofer-Roob, M. D. Devereaux, J. M. McKim Jr.: Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. Gastroenterology 109: 1249-1254 (1995)
69. Sokol, R. J., M. W. Deveraux, M. S. Straka, G. Evesson: Melatonin attenuates hydrophobic bile acid toxicity to isolated rat hepatocytes. Hepatology 24 (Suppl #4, Pt 2): 338 A (1996)
70. Chen, L. D., D. Melchiorri, E. Sewerynek, R. J. Reiter: Retinal lipid peroxidation in vitro is inhibited by melatonin. Neurosci Res Commun 17: 151-158 (1995)
71. Daniels, W. M. U., R. J. Reiter, D. Melchiorri, E. Sewerynek, M. I. Pablos, G. G. Ortiz: Melatonin counteracts lipid peroxidation induced by carbon tetrochloride but does not restore glucose-6-phosphatase activity. J Pineal Res 19: 1-6 (1995)
72. Hara, M., M. Abe, T. Susuki, R. J. Reiter: Tissues changes in glutathione metabolism and lipid peroxidation induced by swimming are partially prevented by melatonin. Pharmcol Toxicol 78: 308-312 (1996)
73. 2 induced lipid peroxidation in homogenates of different rat brain regions. J Pineal Res 19: 51-56 (1995)
74. Yamamoto, H. A., H. W. Tang: Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice. J Pineal Res 21: 108-113 (1996)
75. Harman, D.: Free radical theory of aging: Alzheimer's disease pathogenesis. Age 18: 97-119 (1995)
76. Harris, M. E., K. Hensley, D. A. Butterfield, R. A. Leedle, J. M. Carney: Direct evidence of oxidative injury produced by Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. Exp Neurol 131: 193-202 (1996)
77. Olanow, C. W.: Oxidation reactions in Parkinson's disease. Neurology 40 (Suppl 3): 32-37 (1990)
78. Miller, J. W., J. Selhub, J. A. Joseph: Oxidative damage caused by free radicals produced during catecholamine autoxidation: Protective effects of O-methylation and melatonin. Free Rad Biol Med 21: 241-249 (1996)
79. Adams, J. D., L. K. Klaidman, A. C. Leung: MPP + and MPDP + induced oxygen radical formation with mitochondrial enzymes. Free Radic Biol Med 15: 181-186 (1993)
80. Adams, J. D., I. N. Odunze: Oxygen free radicals and Parkinson's disease. Free Radic Biol Med 10: 161-169 (1991)
81. Bindoli, A., M. P. Rigobello, D. J. Deeble: Biochemical and toxicological properties of oxidative products of catecholamines. Free Radic Biol Med 13: 391-405 (1992)
82. Acuña-Castroviejo, D., A. Coto-Montes, M. G. Monti, G. G. Ortiz, R. J. Reiter: Melatonin is protective against MPTP-induced striatal and hippocampal lesions. Life Sci 60: PL23-PL29 (1996)
83. Tipton, K. F., T. P. Singer: Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem 61: 1191-1206 (1993)
84. Shida, C. S., A. M. L. Castrucci, M. T. Lamy-Freund: High melatonin solubility in aqueous medium. J Pineal Res 16: 198-201 (1994)
85. Menendez-Pelaez, A., B. Poeggeler, R. J. Reiter, L. R. Barlow-Walden, M. I. Pablos, D. X. Tan: Nuclear localization of melatonin in different mammalian tissues: Immunological and radioimmunoassay evidence. J Cell Biochem 53: 373-382 (1993)
86. Menendez-Pelaez, A., R. J. Reiter: The distribution of melatonin in mammalian tissues: The relative importance of nuclear verses cytosolic localization. J Pineal Res 15: 59-69 (1993)
87. Yu, H. S.: Melatonin in the eye: Functional implications. In: Yu HS, Reiter RJ (ed). Melatonin. CRC Press, Boca Raton (1993), 365-393.
88. Heather, G.: Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin. Ann NY Acad Sci 719: 146-158 (1994)
89. Manev, H., T. Uz, A. Kharlamov, J. Y. Joo: Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats. FASEB J 10: 1546-1551 (1996)
90. Reiter, R. J.: The aging pineal gland and its physiological consequences. Bio Essays 14: 169-175 (1992)
91. Reiter, R. J.: Melatonin in the context of the free radical theory of aging. Ann NY Acad Sci 786: 362-378 (1996)
92. Antolin, E., C. Rodriguez, R. M. Sainz, J. C. Mayo, H. Uria, M. L. Kalter, M. J. Rodriguez-Colinga, D. Tolivia, A. Menendez-Pelaez: Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes. FASEB J 10: 882-890 (1996)
93. Pablos, M. I., M. T. Agapito, R. Gutierrez, J. M. Redo, R. J. Reiter, L. R. Barlow-Walden, D. Acu-a-Castroviejo, A. Menendez-Pelaez: Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res 19: 111-115 (1995)
94. Bangha, E., P. Elsner, G. S. Kistler: Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose-response study. Arch Dermatol Res 288: 522-526 (1996)
95. Dorr, D., I. Fridovich: Free radicals in cutaneous biology. J Invest Dermatol 102: 671-675 (1994)
96. Morrey, K. M., J. A. McLauhlan, C. D. Sherkin, O. Barouche: Activation of human monocytes by the pineal hormone melatonin. J Immunol 153: 2671-2680 (1994)
97. Ben-Nathan, D., G. J. M. Maestroni, A. Conti: The protective effect of melatonin in viral and bacterial infections. In: Maestroni GJM, Conti A, Reiter RJ, (ed). Therapeutic Potential of Melatonin. Karger, Basel (1997), 71-80.
98. Ben-Nathan, D., G. J. M. Maestroni, S. Lustig, A. Conti: Protective effects of melatonin in mice infected with encephalitis virus. Arch Virol 140: 223-230 (1995)
99. Ellis, L. C.: Melatonin reduces mortality from Aleutian disease in mink (Mustela vison). J Pineal Res 21: 214-217 (1996)
100. Lin, J. Y., K. Chadee: Macrophage cytotoxicity against entomoeba histolytica tsophozoites is mediated by nitric oxide from L-arginine. J Immunol 141: 3999-4004 (1992)
101. Blask, D. E.: Melatonin in oncology. In: Yu Hs, Reiter RJ (ed). Melatonin. CRC Press, Boca Raton (1993), 447-476.
102. Bauerle, P. A., R. A. Rupec, H. L. Pahl: Reactive oxygen intermediates as second messengers of a general pathogen response. Pathol Biol 44: 29-35 (1996)
103. Thanos, D., T. Maniatis: NF-κB: A lesson in family values. Cell 80: 529-532 (1995)
104. Chuang, J. I., N. Mohan, M. L. Meltz, R. J. Reiter: Effect of melatonin on NF- κB DNA-binding activity in the rat spleen. Cell Biol Int 20: 687-692 (1996)
105. Janzen, E. G.: The fate of the free radical. Redox Rept 2: 153-159 (1996)
106. Knight, J. A.: Diseases related to oxygen-derived free radicals. Ann Clin Lab Sci 25: 111-121 (1995)