Melatonin receptors are present in adult rat Leydig cells and are coupled through a pertussis toxin-sensitive G-protein

European Journal of Endocrinology

Volumn 136, Issue 6, 1997, Pages 633-639

  Valenti, Sandra ^a,b   Giusti, Massimo ^a   Guido, Roberta ^a   Giordano, Giulio ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b DISEM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MELATONIN RECEPTOR;

ANDROGEN SYNTHESIS; ANIMAL CELL; ARTICLE; HORMONE RECEPTOR INTERACTION; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

EID: 0030872149     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1360633     Document Type: Article

References (28)

1. Arendt J. Melatonin. Clinical Endocrinology 1988 29 205-229.
2. Stankov B & Reiter RJ. Melatonin receptors: current status, facts and hypothesis. Life Sciences 1990 44 971-982.
3. Olivares AN, Valladares LE, Bustos-Obregon E & Nunez SM. Testicular function of sexually immature rats chronically treated with melatonin. Archivas de Biologica y Medicina Experimentales 1989 22 387-393.
4. Ng TB & Ooi VEC. Effect of pineal indoles on testicular histology of mice. Archives of Andrology 1990 25 137-145.
5. Ellis LC. Inhibition of rat testicular androgen synthesis in vitro by melatonin and serotonin. Endocrinology 1972 90 17-28.
6. Ng TB & Lo LL. Inhibitory actions of pineal indoles on steroidogenesis in isolated rat Leydig cells. Journal of Pineal Research 1988 5 229-243.
7. Valenti S, Guido R, Giusti M & Giordano G. In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3′,5′-monophosphate production. Endocrinology 1995 136 5357-5362.
8. Vera H, Tijmes M, Ronco AM & Valladares LE. Melatonin-binding sites in interstitial cells from immature rat testes. Biological Research 1993 26 337-340.
9. Rivkees SA, Carlson RL & Reppert SM. Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain. Proceedings of the National Academy of Sciences of the USA 1989 86 3882-3886.
10. Carlson LL, Weaver DR & Reppert SM. Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Endocrinology 1989 125 2670-2676.
11. 125I-labelled iodomelatonin-binding sites in the duck kidney. Journal of Endocrinology 1992 135 353-359.
12. Morgan PJ, Barrett P, Hazlerigg D, Milligan G, Lason W, MacLean A & Davidson G. Melatonin receptors couple through a colera toxin-sensitive mechanism to inhibit cyclic AMP in the ovine pituitary. Journal of Neuroendocrinology 1995 7 361-369.
13. 125I)-iodomelatonin binding sites in the human kidney and the effect of guanosine 5′-O-(3-thiotriphospate). Journal of Clinical Endocrinology and Metabolism 1995 80 1560-1565.
14. Yie SM, Niles LP & Younglai EV. Melatonin receptors on human granulosa cell membranes. Journal of Clinical Endocrinology und Metabolism 1995 80 1747-1749.
15. Milligan G. Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins. Biochemical Journal 1988 255 1-13.
16. Taylor CW. The role of G proteins in transmembrane signalling. Biochemical Journal 1990 272 1-13.
17. Conte D, Questino P, Fillo S, Nordio M, Isidori A & Romanelli F. Endothelin stimulates testosterone secretion by rat Leydig cells. Journal of Endocrinology 1993 136 R1-R4.
18. Lowry OH, Rosebrough NJ, Farr AR & Randall RJ. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951 193 265-275.
19. Persengiev S & Kehajova J. Inhibitory action of melatonin and structurally related compounds on testosterone production by mouse Leydig cells in vitro. Cell Biochemistry and Function 1991 9 281-286.
20. Niedziela M, Lerchl A & Nieschlag E. Direct effects of the pineal hormone melatonin on testosterone synthesis of Leydig cells in Djungarian hamsters (Phodopus sungorus) in vitro. Neuroscience Letters 1995 201 247-250.
21. 125-I)-iodomelatonin binding sites in the rat epididymis. Journal of Pineal Research 1994 17 195-201.
22. Williams LM & Hannah LT. High-affinity melatonin receptors are present on the epididymis of the immature rat. 77th Annual Meeting of the Endocrine Society, Washington DC. 1995 Abstract P3-404.
23. Eskola V, Rannikko A, Huhtaniemi I & Warren DW. Ontogeny of the inhibitory guanine nucleotide-binding regulatory protein in the rat testis: mRNA expression and modulation of LH and FSH action. Molecular and Cellular Endocrinology 1994 102 63-68.
24. Eskola V, Paukku T, Warren DW & Huhtaniemi I. A novel role for testiscular descent temperature-dependent induction of pertussis toxin-sensitive Gi protein function in postnatal rat Leydig cells. Endocrinology 1995 136 4659-4664.
25. 2+ not cAMP. American Journal of Physiology 1995 269 E85-E90.
26. Beckerandre M, Wiesenberg I, Schaerenwiemers N, Andre E, Missbach M, Saurat JH et al. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. Journal of Biological Chemistry 1994 269 28531-28534.
27. Reiter RJ. Functional pleiotropy of the neurohormone melatonin: antioxidant protection and neuroendocrine regulation. Frontiers in Neuroendocrinology 1995 16 383-415.
28. Pozo D, Reiter RJ, Calvo JP & Guerrero JM. Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sciences 1994 65 PL455-PL4603.