High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility

Journal of Pineal Research

Volumn 50, Issue 2, 2011, Pages 132-139

  Ortiz, A ^a   Espino, J ^b   Bejarano, I ^b   Lozano, G M ^a   Monllor, F ^a   Garcia J F ^a   Pariente, J A ^b   Rodriguez A B ^b  

^a Extremadura Centre for Human Assisted Reproduction   (Spain)

^b UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

male infertility; melatonin; shift work; sperm motility; sperm quality

Indexed keywords

6 HYDROXYMELATONIN O SULFATE; MELATONIN;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ASSESSMENT; COLORIMETRY; COMPUTER ASSISTED DIAGNOSIS; CONCENTRATION (PARAMETERS); DRUG EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IN VITRO STUDY; INCUBATION TIME; KINEMATICS; MALE; MALE INFERTILITY; PATIENT COUNSELING; SEMEN ANALYSIS; SPERM; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; SUPPLEMENTATION; VITAL STAIN;

ADULT; HUMANS; MALE; MELATONIN; MIDDLE AGED; SEMEN; SEMEN ANALYSIS; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; YOUNG ADULT;

EID: 79951617992     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2010.00822.x     Document Type: Article

References (38)

1. McLachlan R, De Krester D,. Male infertility: the case for continued research. Med J Aust 2001; 174: 116-117. (Pubitemid 32149354)
2. Shekarriz M, Thomas AJ Jr, Agarwal A,. Incidence and level of seminal reactive oxygen species in normal men. Urology 1995; 45: 103-107.
3. Agarwal A, Prabakaran S, Allamaneni S,. What an andrologist/urologist should know about free radicals and why. Urology 2006; 67: 2-8. (Pubitemid 43069245)
4. Tremellen K,. Oxidative stress and male infertility-a clinical perspective. Hum Reprod Update 2008; 14: 243-258. (Pubitemid 351566975)
5. Panke ES, Rollag MD, Reiter RJ,. Pineal melatonin concentrations in the Syrian hamster. Endocrinology 1979; 104: 194-197. (Pubitemid 9084612)
6. Reiter RJ,. Pineal control of a seasonal reproductive rhythm in male golden hamsters exposed to natural daylight and temperature. Endocrinology 1973; 92: 423-430.
7. Turek FW, Van Cauter E,. Rhythms in reproduction. In: The Physiology of Reproduction, 2nd edn, Knobil E, Neill JD, eds., Raven Press, New York, 1994; pp. 487-540.
8. Tan DX, Chen LD, Poeggeler B, et al. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993; 1: 57-60.
9. Hardeland R, Tan DX, Reiter RJ,. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009; 47: 109-126.
10. Espino J, Bejarano I, Redondo PC, et al. Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: evidence for the involvement of mitochondria and Bax activation. J Membrane Biol 2010; 233: 105-118.
11. Semercioz A, Onur R, Ogras S, et al. Effects of melatonin on testicular tissue nitric oxide level and antioxidant enzyme activities in experimentally induced left varicocele. Neuro Endocrinol Lett 2003; 24: 86-90. (Pubitemid 36559507)
12. Sönmez M, Yüce A, Türk G,. The protective effect of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats. Reprod Toxicol 2007; 23: 226-231. (Pubitemid 46215995)
13. Rao MW, Gangadharan B,. Antioxidant potential of melatonin against mercury induced intoxication in spermatozoa in vitro. Toxicol In Vitro 2008; 22: 935-942.
14. Espino J, Bejarano I, Ortiz A, et al. Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa. Fertil Steril 2010; 94: 1915-1917.
15. Sarabia L, Maurer I, Bustos-Obregon E,. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA. Ecotoxicol Environ Saf 2009; 72: 938-942.
16. Bornman MS, Oosthuizen JMC, Barnard HC, et al. Melatonin and sperm motility. Andrologia 1989; 21: 483-485. (Pubitemid 19258318)
17. Van Vuuren RJJ, Pitout MJ, Van Aswegen CH, et al. Putative melatonin receptor in human spermatozoa. Clin Biochem 1992; 25: 125-127.
18. Luboshitzky R, Shen-Orr Z, Nave R, et al. Melatonin administration alters semen quality in normal men. J Androl 2002; 23: 572-578. (Pubitemid 34655092)
19. Lerchl A,. Melatonin administration alters semen quality in normal men. J Androl 2004; 25: 185-186.
20. Fujinoki M,. Melatonin-enhanced hyperactivation of hamster sperm. Reproduction 2008; 136: 533-541.
21. Klante G, Brinschwitz T, Secci K, et al. Creatinine is an appropriate reference for urinary sulphatoxymelatonin of laboratory animals and humans. J Pineal Res 1997; 23: 191-197. (Pubitemid 127732131)
22. Oba S, Nakamura K, Sahashi Y, et al. Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration. J Pineal Res 2008; 45: 17-23. (Pubitemid 351986257)
23. Krause A, Krause W,. Seasonal variations in human seminal parameters. Eur J Obstet Gynecol Reprod Biol 2002; 101: 175-178. (Pubitemid 34163265)
24. W orld H ealth O rganization. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction, 4th edn. Cambridge University Press, Cambridge, 1999.
25. Luchetti F, Betti M, Canonico B, et al. ERK MAPK activation mediates the antiapoptotic signalling of melatonin in UVB-stressed U937 cells. Free Radic Biol Med 2009; 46: 339-351.
26. Casao A, Vega S, Palacín I, et al. Effects of melatonin implants during non-breeding season on sperm motility and reproductive parameters in Rasa aragonesa rams. Reprod Domest Anim 2010; 45: 425-432.
27. Ramadan TA, Taha TA, Samak MA, et al. Effectiveness of exposure to longday followed by melatonin treatment on semen characteristics of Damascus male goats during breeding and non-breeding seasons. Theriogenology 2009; 71: 458-468. (Pubitemid 50279870)
28. Du Plessis SS, Hagenaar K, Lampiao F,. The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROS. Andrologia 2010; 42: 112-116.
29. Casao A, Mendoza N, Pérez-Pé R, et al. Melatonin prevents capacitation and apoptotic-like changes of ram spermatozoa and increases fertility rate. J Pineal Res 2010; 48: 39-46.
30. Agarwal A, Ikemoto I, Loughlin KR,. Relationship of sperm parameters with levels of reactive oxygen species in semen specimens. J Urol 1994; 152: 107-110. (Pubitemid 24175713)
31. Meseguer M, Garrido N, Martinez-Conejero JA, et al. Role of cholesterol, calcium, and mitochondrial activity in the susceptibility for cryodamage after a cycle of freezing and thawing. Fertil Steril 2004; 81: 588-594. (Pubitemid 38376115)
32. Sikka SC,. Role of oxidative stress and antioxidants in andrology and assisted reproductive technology. J Androl 2004; 25: 5-18. (Pubitemid 38017778)
33. Tamura H, Takahasi A, Miwa I, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization. J Pineal Res 2008; 44: 280-287. (Pubitemid 351392942)
34. García JJ, Reiter RJ, Pié J, et al. Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress. J Bioenerg Biomembr 1999; 6: 609-616. (Pubitemid 30082903)
35. Martín M, Macias M, Escames G, et al. Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo. J Pineal Res 2000; 28: 242-248. (Pubitemid 30255377)
36. Leõn J, Acuña-Castroviejo D, Escames G, et al. Melatonin mitigates mitochondrial malfunction. J Pineal Res 2005; 38: 1-9. (Pubitemid 40139304)
37. Carretero M, Escames G, Lõpez LC, et al. Long-term melatonin administration protects brain mitochondria from aging. J Pineal Res 2009; 47: 192-200.
38. Paradies G, Petrosillo G, Paradies V, et al. Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. J Pineal Res 2010; 48: 297-310.