Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes

Toxicological Sciences

Volumn 124, Issue 2, 2011, Pages 446-459

  Ji, Yan Li ^a   Wang, Hua ^a   Zhao, Xian Feng ^a   Wang, Qun ^a   Zhang, Cheng ^a   Zhang, Ying ^a   Zhao, Mei ^a   Chen, Yuan Hua ^a   Meng, Xiu Hong ^a   Xu, De Xiang ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cadmium; Endoplasmic reticulum stress; Germ cell; Testis

Indexed keywords

BUTYRIC ACID DERIVATIVE; CADMIUM; CADMIUM CHLORIDE; CYTOCHROME C; FAS ANTIGEN; FAS LIGAND; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PHENYLBUTYRIC ACID; PROTEIN BAX; PROTEIN BCL W; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOSE RESPONSE; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; ENZYME RELEASE; EXPOSURE; GERM CELL; INTRACELLULAR SIGNALING; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPRODUCTIVE TOXICITY; TESTIS; TIME; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CADMIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED STRAINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPERMATOZOA; TESTIS; TIME FACTORS;

EID: 81855211073     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr232     Document Type: Article

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