Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1837, Issue 3, 2014, Pages 335-344

  Rato, Luís ^a,b   Duarte, Ana I ^b,c   Tomás, Gonçalo D ^a   Santos, Maria S ^b,d   Moreira, Paula I ^b,e   Socorro, Sílvia ^a   Cavaco, José E ^a   Alves, Marco G ^a   Oliveira, Pedro F ^a  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

High energy diet; Mitochondria; PGC 1 Sirt3 axis; Pre diabetes; Testicular bioenergetics

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE PHOSPHATE; GA BINDING PROTEIN; GLUCOSE; HYPOXANTHINE; INOSINE; LIPID; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 3; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL DIET; BIOENERGY; CONTROLLED STUDY; DNA CONTENT; ENERGY METABOLISM; GLUCOSE BLOOD LEVEL; IMPAIRED GLUCOSE TOLERANCE; LIPID OXIDATION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECTROPHOTOMETRY; TESTIS FUNCTION;

RATTUS;

HIGH-ENERGY DIET; MITOCHONDRIA; PGC-1Α/SIRT3 AXIS; PRE-DIABETES; TESTICULAR BIOENERGETICS;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; ENERGY METABOLISM; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; INSULIN; MALE; MITOCHONDRIA; NUCLEAR RESPIRATORY FACTOR 1; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PREDIABETIC STATE; RATS; RATS, WISTAR; SIRTUIN 3; TESTIS; TRANSCRIPTION FACTORS;

EID: 84892411578     PISSN: 00052728     EISSN: 18792650     Source Type: Journal    
DOI: 10.1016/j.bbabio.2013.12.008     Document Type: Article

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