Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids

Free Radical Biology and Medicine

Volumn 85, Issue , 2015, Pages 127-137

  Dai, Fang ^a   Liu, Guo Yun ^a   Li, Yan ^a   Yan, Wen Jing ^a   Wang, Qi ^a   Yang, Jie ^a   Lu, Dong Liang ^a   Ding, De Jun ^a   Lin, Dong ^a   Zhou, Bo ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; Curcumin; Electrophilicity; Prooxidant; Thioredoxin reductase

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CURCUMIN; DIARYLPENTANOID; DRUG ANALOG; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

APOPTOSIS; ARTICLE; CYTOTOXICITY; ELECTROPHILICITY; HUMAN; HUMAN CELL; LUNG CARCINOMA; METABOLIC STABILITY; MICHAEL ADDITION; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; DRUG SCREENING; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CURCUMIN; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PENTANOIC ACIDS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84930946260     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.04.017     Document Type: Article

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