Selective induction of tumor cell apoptosis by a novel P450-mediated reactive oxygen species (ROS) inducer methyl 3-(4-nitrophenyl) propiolate

Journal of Biological Chemistry

Volumn 288, Issue 13, 2013, Pages 8826-8837

  Sun, Xiaoxiao ^a   Ai, Midan ^a   Wang, Ying ^a   Shen, Shensi ^a   Gu, Yuan ^a   Jin, Yi ^a   Zhou, Zuyu ^a   Long, Yaqiu ^a   Yu, Qiang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER DRUG; ANTIOXIDANT CAPACITY; MULTIPLE CELLS; REACTIVE OXYGEN SPECIES; ROS GENERATIONS; SELECTIVE INDUCTION; SENSITIVITY STUDIES; TUMOR CELLS;

CELL CULTURE; DISEASES; OXYGEN; TUMORS;

CELL DEATH;

ANTINEOPLASTIC AGENT; CYTOCHROME P450; MENADIONE; METHYL 3 (4 NITROPHENYL)PROPIOLATE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; TUMOR CELL;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES C; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HEP G2 CELLS; HUMANS; JANUS KINASE 1; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MUTATION; NEOPLASMS; OXIDATION-REDUCTION; PHENYLPROPIONATES; PROPIONATES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84876007871     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.429316     Document Type: Article

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