Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1083-1092

  Yamakoshi, Hiroyuki ^a   Ohori, Hisatsugu ^a   Kudo, Chieko ^a   Sato, Atsuko ^a   Kanoh, Naoki ^a   Ishioka, Chikashi ^a   Shibata, Hiroyuki ^b   Iwabuchi, Yoshiharu ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b AKITA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Bis(arylmethylidene)acetones; C5 curcumin; Cancer chemotherapy; Curcumin; Cytotoxicity; Molecular probe

Indexed keywords

1 (2,3,4 TRIMETHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (2,4,5 TRIMETHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (3 HYDROXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (3 METHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (4 (2 HYDROXYETHOXY) 3,5 DIMETHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (4 HYDROXY 3,5 DIMETHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) PENTA 1,4 DIEN 3 ONE; 1 [3 (1 ETHOXYETHOXY)PHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)]PENTA 1,4 DIEN 3 ONE; 1 [3 (ADAMANTANE 1 CARBOXY)PHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)]PENTA 1,4 DIEN 3 ONE; 1 [3 (METHOXYMETHOXY)PHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)]PENTA 1,4 DIEN 3 ONE; 1 [3,5 DIMETHOXY 4 [(1 (4 (TETRAHYDRO 2H PYRAN 2 YLOXY)BENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY]PHENYL] 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 [4 ((1 (10 HYDROXYDECYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 3,5 DI METHOXYPHENYL] 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 [4 (1 ETHOXYETHOXY) 3,5 DIMETHOXYPHENYL] 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 [4 (2 AZIDOETHOXY) 3,5 DIMETHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 PHENYL 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1,5 BIS(2,3,4,6 TETRAMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1,5 BIS(3,4 DIMETHOXYPHENYL) 5 (PROPYLTHIO)PENT 1 EN 3 ONE; 1,5 BIS(3,4 DIMETHOXYPHENYL)PENT 1 EN 3 ONE; 1,5 BIS(4 (2 AZIDOETHOXY) 3,5 DIMETHOXYPHENYL)PENTA 1, 4 DIEN 3 ONE; 1,5 BIS(4 HYDROXY 3 METHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 10 [4 [(2,6 DIMETHOXY 4 3 OXO 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIENYL)PHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]DECYL 2 [(3,5,6 TRIMETHYL 1,7 DI OXO 1,7 DIHYDROPYRAZOLO[1,2 A]PYRAZOL 2 YL)METHYLTHIO]ETHANOATE; 1[(3,5 DIMETHOXY 4 (METHOXYMETHOXY)PHENYL) 5 (3,5 DIMETHOXY 4 (PROP 2 YNYLOXY)PHENYL)]PENTA 1,4 DIEN 3 ONE; 2 [(2,6 DIMETHOXY 4, 3 OXO 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIENYL)PHENOXY]ETHANOIC ACID; ACETONE; BIS(ARYLMETHYLIDENE)ACETONE; C 5 CURCUMINOID; CURCUMIN; METHYL 2 [(2,6 DIMETHOXY 4 3 OXO 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIENYL)PHENOXY]ETHANOATE; PLANT EXTRACT; TERTBUTYL 10 [4 [(2,6 DIMETHOXY 4,3 OXO 5 (3,4,5 TRIMETHOXYPHENYL)PENTA 1,4 DIENYL)PHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]DECYLCARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL STRAIN HCT116; CONTROLLED STUDY; CURCUMA DOMESTICA; CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MEDICINAL PLANT; MOLECULAR PROBE; RHIZOME; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CURCUMA; CURCUMIN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

CURCUMA LONGA;

EID: 75149160541     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.045     Document Type: Article

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