Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase

Free Radical Biology and Medicine

Volumn 69, Issue , 2014, Pages 15-25

  Duan, Dongzhu ^a   Zhang, Baoxin ^a   Yao, Juan ^a   Liu, Yaping ^a   Sun, Jinyu ^a   Ge, Chunpo ^a   Peng, Shoujiao ^a   Fang, Jianguo ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; Free radicals; Gambogic acid; Reactive oxygen species; Thioredoxin reductase

Indexed keywords

CASPASE 3; GAMBOGIC ACID; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE 1;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG SENSITIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REDUCTION;

APOPTOSIS; FREE RADICALS; GAMBOGIC ACID; REACTIVE OXYGEN SPECIES; THIOREDOXIN REDUCTASE;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOSOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MEDICINE, CHINESE TRADITIONAL; MOLECULAR TARGETED THERAPY; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; THIOREDOXIN REDUCTASE 1; XANTHONES;

EID: 84893502890     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.12.027     Document Type: Article

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