Anticancer effect of a curcumin derivative B63: ROS production and mitochondrial dysfunction

Current Cancer Drug Targets

Volumn 14, Issue 2, 2014, Pages 156-166

  Zheng, Adi ^a   Li, Hao ^a   Wang, Xun ^a   Feng, Zhihui ^a   Xu, Jie ^a   Cao, Ke ^a   Zhou, Bo ^b   Wu, Jing ^a   Liu, Jiankang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

Colon cancer cells; Curcumin; Curcumin derivative; ER stress; Mitochondrial dysfunction; ROS

Indexed keywords

1,5 BIS(2 METHOXYPHENYL)PENTA1,4 DIEN 3 ONE; CASPASE 3; CURCUMIN; CYTOCHROME C; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOAVAILABILITY; BIOLOGICAL ACTIVITY; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEQUENCE ANALYSIS; TUMOR GROWTH; TUMOR XENOGRAFT; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FEMALE; HCT116 CELL LINE; IC50; MEDICINAL PLANT; METABOLISM; MITOCHONDRION; NECROSIS; NUDE MOUSE; OXIDATIVE STRESS; PATHOLOGY; PHYTOTHERAPY; S PHASE CELL CYCLE CHECKPOINT; TIME; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; FEMALE; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; NECROSIS; OXIDATIVE STRESS; PHYTOTHERAPY; PLANTS, MEDICINAL; REACTIVE OXYGEN SPECIES; S PHASE CELL CYCLE CHECKPOINTS; TIME FACTORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84896345788     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/1568009613666131126115444     Document Type: Article

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