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Volumn 9, Issue 3, 2014, Pages 362-373

Diabetes and Retinal Vascular Dysfunction

Author keywords

Diabetes; Inflammation; Oxidative Stress; Retinal vasculature; Thrombospondins

Indexed keywords


EID: 84930945677     PISSN: 20082010     EISSN: 2008322X     Source Type: Journal    
DOI: 10.4103/2008-322X.143378     Document Type: Review
Times cited : (168)

References (135)
  • 1
    • 79957722029 scopus 로고    scopus 로고
    • The blood-retinal barrier: Structure and functional significance
    • Runkle EA, Antonetti DA. The blood-retinal barrier: Structure and functional significance. Methods Mol Biol 2011;686:133-148.
    • (2011) Methods Mol Biol , vol.686 , pp. 133-148
    • Runkle, E.A.1    Antonetti, D.A.2
  • 2
    • 55849146641 scopus 로고    scopus 로고
    • Blood-retinal barrier in hypoxic ischaemic conditions: Basic concepts, clinical features and management
    • Kaur C, Foulds WS, Ling EA. Blood-retinal barrier in hypoxic ischaemic conditions: Basic concepts, clinical features and management. Prog Retin Eye Res 2008;27:622-647.
    • (2008) Prog Retin Eye Res , vol.27 , pp. 622-647
    • Kaur, C.1    Foulds, W.S.2    Ling, E.A.3
  • 3
    • 68149137750 scopus 로고    scopus 로고
    • Inner blood-retinal barrier transporters: Role of retinal drug delivery
    • Hosoya K, Tachikawa M. Inner blood-retinal barrier transporters: Role of retinal drug delivery. Pharm Res 2009;26:2055-2065.
    • (2009) Pharm Res , vol.26 , pp. 2055-2065
    • Hosoya, K.1    Tachikawa, M.2
  • 4
    • 84876729820 scopus 로고    scopus 로고
    • Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions
    • Klaassen I, Van Noorden CJ, Schlingemann RO. Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. Prog Retin Eye Res 2013;34:19-48.
    • (2013) Prog Retin Eye Res , vol.34 , pp. 19-48
    • Klaassen, I.1    Van Noorden, C.J.2    Schlingemann, R.O.3
  • 6
    • 84870688100 scopus 로고    scopus 로고
    • By the numbers: New estimates from the IDF Diabetes Atlas Update for 2012
    • Guariguata L. By the numbers: new estimates from the IDF Diabetes Atlas Update for 2012. Diabetes Res Clin Pract. 2012;98:524-525.
    • (2012) Diabetes Res Clin Pract , vol.98 , pp. 524-525
    • Guariguata, L.1
  • 8
    • 1842425677 scopus 로고    scopus 로고
    • The prevalence of diabetic retinopathy among adult type 1 diabetic persons in the United States
    • Roy MS, Klein R, O'Colmain BJ, Klein BE, Moss SE, Kempen JH. The prevalence of diabetic retinopathy among adult type 1 diabetic persons in the United States. Arch Ophthalmol 2004;122:546-551.
    • (2004) Arch Ophthalmol , vol.122 , pp. 546-551
    • Roy, M.S.1    Klein, R.2    O'Colmain, B.J.3    Klein, B.E.4    Moss, S.E.5    Kempen, J.H.6
  • 13
  • 15
    • 23644432209 scopus 로고    scopus 로고
    • Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression
    • Yamagishi S, Takeuchi M, Matsui T, Nakamura K, Imaizumi T, Inoue H. Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression. FEBS Lett 2005;579:4265-4270.
    • (2005) FEBS Lett , vol.579 , pp. 4265-4270
    • Yamagishi, S.1    Takeuchi, M.2    Matsui, T.3    Nakamura, K.4    Imaizumi, T.5    Inoue, H.6
  • 16
    • 77749304040 scopus 로고    scopus 로고
    • Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy
    • Kim JH, Kim JH, Jun HO, Yu YS, Kim KW. Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy. Am J Pathol 2010;176:1517-1524.
    • (2010) Am J Pathol , vol.176 , pp. 1517-1524
    • Kim, J.H.1    Kim, J.H.2    Jun, H.O.3    Yu, Y.S.4    Kim, K.W.5
  • 17
    • 0141961133 scopus 로고    scopus 로고
    • Inhibition of advanced glycation end-products protects against retinal capillary basement membrane expansion during long-term diabetes
    • Gardiner TA, Anderson HR, Stitt AW. Inhibition of advanced glycation end-products protects against retinal capillary basement membrane expansion during long-term diabetes. J Pathol 2003;201:328-333.
    • (2003) J Pathol , vol.201 , pp. 328-333
    • Gardiner, T.A.1    Anderson, H.R.2    Stitt, A.W.3
  • 18
    • 19944367877 scopus 로고    scopus 로고
    • Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor
    • Stitt AW, Hughes SJ, Canning P, Lynch O, Cox O, Frizzell N, et al. Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor. Diabetologia 2004;47:1735-1746.
    • (2004) Diabetologia , vol.47 , pp. 1735-1746
    • Stitt, A.W.1    Hughes, S.J.2    Canning, P.3    Lynch, O.4    Cox, O.5    Frizzell, N.6
  • 19
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy
    • Kowluru RA, Chan PS. Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007;2007:43603.
    • (2007) Exp Diabetes Res , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 20
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405-412.
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 21
    • 77953200258 scopus 로고    scopus 로고
    • Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: Role of NADPH oxidase 4
    • Li J, Wang JJ, Yu Q, Chen K, Mahadev K, Zhang SX. Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: Role of NADPH oxidase 4. Diabetes 2010;59:1528-1538.
    • (2010) Diabetes , vol.59 , pp. 1528-1538
    • Li, J.1    Wang, J.J.2    Yu, Q.3    Chen, K.4    Mahadev, K.5    Zhang, S.X.6
  • 22
    • 64649091717 scopus 로고    scopus 로고
    • Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: Involvement of a mitochondria-reactive oxygen species pathway
    • Zheng Z, Chen H, Ke G, Fan Y, Zou H, Sun X, et al. Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway. Diabetes 2009;58:954-964.
    • (2009) Diabetes , vol.58 , pp. 954-964
    • Zheng, Z.1    Chen, H.2    Ke, G.3    Fan, Y.4    Zou, H.5    Sun, X.6
  • 24
    • 62649094525 scopus 로고    scopus 로고
    • Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation
    • Warboys CM, Toh HB, Fraser PA. Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation. Invest Ophthalmol Vis Sci 2009;50:1319-1328.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1319-1328
    • Warboys, C.M.1    Toh, H.B.2    Fraser, P.A.3
  • 25
    • 10744232432 scopus 로고    scopus 로고
    • Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C
    • Pricci F, Leto G, Amadio L, Iacobini C, Cordone S, Catalano S, et al. Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C. Free Radic Biol Med 2003;35:683-694.
    • (2003) Free Radic Biol Med , vol.35 , pp. 683-694
    • Pricci, F.1    Leto, G.2    Amadio, L.3    Iacobini, C.4    Cordone, S.5    Catalano, S.6
  • 26
    • 84555188488 scopus 로고    scopus 로고
    • Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin
    • Zheng Z, Chen H, Li J, Li T, Zheng B, Zheng Y, et al. Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. Diabetes 2012;61:217-228.
    • (2012) Diabetes , vol.61 , pp. 217-228
    • Zheng, Z.1    Chen, H.2    Li, J.3    Li, T.4    Zheng, B.5    Zheng, Y.6
  • 27
    • 84885357617 scopus 로고    scopus 로고
    • Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina
    • Du Y, Veenstra A, Palczewski K, Kern TS. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci USA 2013;110:16586-16591.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 16586-16591
    • Du, Y.1    Veenstra, A.2    Palczewski, K.3    Kern, T.S.4
  • 28
    • 79960190061 scopus 로고    scopus 로고
    • Inflammation in diabetic retinopathy
    • Tang J, Kern TS. Inflammation in diabetic retinopathy. Prog Retin Eye Res 2011;30:343-358.
    • (2011) Prog Retin Eye Res , vol.30 , pp. 343-358
    • Tang, J.1    Kern, T.S.2
  • 29
    • 34547674399 scopus 로고    scopus 로고
    • Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes
    • Zheng L, Du Y, Miller C, Gubitosi-Klug RA, Ball S, Berkowitz BA, et al. Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia 2007;50:1987-1996.
    • (2007) Diabetologia , vol.50 , pp. 1987-1996
    • Zheng, L.1    Du, Y.2    Miller, C.3    Gubitosi-Klug, R.A.4    Ball, S.5    Berkowitz, B.A.6
  • 30
    • 78649432851 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy
    • Mishra A, Newman EA. Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy. Glia 2010;58:1996-2004.
    • (2010) Glia , vol.58 , pp. 1996-2004
    • Mishra, A.1    Newman, E.A.2
  • 31
    • 84861842059 scopus 로고    scopus 로고
    • Aminoguanidine reverses the loss of functional hyperemia in a rat model of diabetic retinopathy
    • Mishra A, Newman EA. Aminoguanidine reverses the loss of functional hyperemia in a rat model of diabetic retinopathy. Front Neuroenergetics 2011;3:10.
    • (2011) Front Neuroenergetics , vol.3 , pp. 10
    • Mishra, A.1    Newman, E.A.2
  • 32
    • 79958859597 scopus 로고    scopus 로고
    • Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy
    • Perrone L, Devi TS, Hosoya KI, Terasaki T, Singh LP. Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy. Cell Death Dis 2010;1:e65.
    • (2010) Cell Death Dis , vol.1 , pp. e65
    • Perrone, L.1    Devi, T.S.2    Hosoya, K.I.3    Terasaki, T.4    Singh, L.P.5
  • 33
    • 15744404419 scopus 로고    scopus 로고
    • Subconjunctivally administered celecoxib-PLGA microparticles sustain retinal drug levels and alleviate diabetes-induced oxidative stress in a rat model
    • Ayalasomayajula SP, Kompella UB. Subconjunctivally administered celecoxib-PLGA microparticles sustain retinal drug levels and alleviate diabetes-induced oxidative stress in a rat model. Eur J Pharmacol 2005;511:191-198.
    • (2005) Eur J Pharmacol , vol.511 , pp. 191-198
    • Ayalasomayajula, S.P.1    Kompella, U.B.2
  • 34
    • 84871998547 scopus 로고    scopus 로고
    • Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienes
    • Talahalli R, Zarini S, Tang J, Li G, Murphy R, Kern TS, et al. Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienes. J Leukoc Biol 2013;93:135-143.
    • (2013) J Leukoc Biol , vol.93 , pp. 135-143
    • Talahalli, R.1    Zarini, S.2    Tang, J.3    Li, G.4    Murphy, R.5    Kern, T.S.6
  • 35
    • 17844392902 scopus 로고    scopus 로고
    • Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    • Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, et al. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 2005;54:1559-1565.
    • (2005) Diabetes , vol.54 , pp. 1559-1565
    • Krady, J.K.1    Basu, A.2    Allen, C.M.3    Xu, Y.4    LaNoue, K.F.5    Gardner, T.W.6
  • 36
    • 67349269219 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy
    • Li J, Wang JJ, Yu Q, Wang M, Zhang SX. Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Lett 2009;583:1521-1527.
    • (2009) FEBS Lett , vol.583 , pp. 1521-1527
    • Li, J.1    Wang, J.J.2    Yu, Q.3    Wang, M.4    Zhang, S.X.5
  • 37
    • 84881015701 scopus 로고    scopus 로고
    • Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor
    • Yang W, Yu X, Zhang Q, Lu Q, Wang J, Cui W, et al. Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor. Exp Eye Res 2013;115:96-105.
    • (2013) Exp Eye Res , vol.115 , pp. 96-105
    • Yang, W.1    Yu, X.2    Zhang, Q.3    Lu, Q.4    Wang, J.5    Cui, W.6
  • 38
    • 84884343947 scopus 로고    scopus 로고
    • Pathogenic role of diabetes-induced PPAR-A down-regulation in microvascular dysfunction
    • Hu Y, Chen Y, Ding L, He X, Takahashi Y, Gao Y, et al. Pathogenic role of diabetes-induced PPAR-a down-regulation in microvascular dysfunction. Proc Natl Acad Sci USA 2013;110:15401-15406.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 15401-15406
    • Hu, Y.1    Chen, Y.2    Ding, L.3    He, X.4    Takahashi, Y.5    Gao, Y.6
  • 39
    • 84894556832 scopus 로고    scopus 로고
    • Potential therapeutic effects of pigment epithelium-derived factor for treatment of diabetic retinopathy
    • Liu X, Chen HH, Zhang LW. Potential therapeutic effects of pigment epithelium-derived factor for treatment of diabetic retinopathy. Int J Ophthalmol 2013;6:221-227.
    • (2013) Int J Ophthalmol , vol.6 , pp. 221-227
    • Liu, X.1    Chen, H.H.2    Zhang, L.W.3
  • 40
    • 70350590905 scopus 로고    scopus 로고
    • Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy
    • Yoshida Y, Yamagishi S, Matsui T, Jinnouchi Y, Fukami K, Imaizumi T, et al. Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy. Diabetes Metab Res Rev 2009;25:678-686.
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 678-686
    • Yoshida, Y.1    Yamagishi, S.2    Matsui, T.3    Jinnouchi, Y.4    Fukami, K.5    Imaizumi, T.6
  • 41
    • 79960341497 scopus 로고    scopus 로고
    • Identification of a Novel Inhibitor of the Canonical Wnt Pathway
    • July 15, 2011
    • Park K, Lee K, Zhang B, Zhou T, He X, Gao G, et al. Identification of a Novel Inhibitor of the Canonical Wnt Pathway. Mol Cell Biol. 2011 July 15, 2011;31(14):3038-51.
    • (2011) Mol Cell Biol. , vol.31 , Issue.14 , pp. 3038-3051
    • Park, K.1    Lee, K.2    Zhang, B.3    Zhou, T.4    He, X.5    Gao, G.6
  • 42
    • 0034614570 scopus 로고    scopus 로고
    • Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia
    • Sheibani N, Sorenson CM, Cornelius LA, Frazier WA. Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia. Biochem Biophys Res Commun 2000;267:257-261.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 257-261
    • Sheibani, N.1    Sorenson, C.M.2    Cornelius, L.A.3    Frazier, W.A.4
  • 43
    • 65249120890 scopus 로고    scopus 로고
    • Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes
    • Wang S, Gottlieb JL, Sorenson CM, Sheibani N. Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes. Arch Ophthalmol 2009;127:507-513.
    • (2009) Arch Ophthalmol , vol.127 , pp. 507-513
    • Wang, S.1    Gottlieb, J.L.2    Sorenson, C.M.3    Sheibani, N.4
  • 44
    • 84904883034 scopus 로고    scopus 로고
    • Thrombospondin-1 deficiency exacerbates the pathogenesis of diabetic retinopathy
    • Sorenson CM, Wang S, Gendron R, Paradis H, Sheibani N. Thrombospondin-1 deficiency exacerbates the pathogenesis of diabetic retinopathy. J Diabetes Metab 2013;Suppl 12:005. doi:10. 4172/2155-6156. S12-005
    • (2013) J Diabetes Metab , pp. S12-S15
    • Sorenson, C.M.1    Wang, S.2    Gendron, R.3    Paradis, H.4    Sheibani, N.5
  • 46
    • 79953269159 scopus 로고    scopus 로고
    • The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy
    • Barber AJ, Gardner TW, Abcouwer SF. The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci 2011;52:1156-1163.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1156-1163
    • Barber, A.J.1    Gardner, T.W.2    Abcouwer, S.F.3
  • 47
    • 30344486638 scopus 로고    scopus 로고
    • Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    • El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol 2006;168:235-244.
    • (2006) Am J Pathol , vol.168 , pp. 235-244
    • El-Remessy, A.B.1    Al-Shabrawey, M.2    Khalifa, Y.3    Tsai, N.T.4    Caldwell, R.B.5    Liou, G.I.6
  • 49
    • 84862737626 scopus 로고    scopus 로고
    • The potential role of glutamate in the current diabetes epidemic
    • Davalli AM, Perego C, Folli FB. The potential role of glutamate in the current diabetes epidemic. Acta Diabetol 2012;49:167-183.
    • (2012) Acta Diabetol , vol.49 , pp. 167-183
    • Davalli, A.M.1    Perego, C.2    Folli, F.B.3
  • 51
    • 77955141846 scopus 로고    scopus 로고
    • O-GlcNAc signaling in the cardiovascular system
    • Ngoh GA, Facundo HT, Zafir A, Jones SP. O-GlcNAc signaling in the cardiovascular system. Circ Res 2010;107:171-185.
    • (2010) Circ Res , vol.107 , pp. 171-185
    • Ngoh, G.A.1    Facundo, H.T.2    Zafir, A.3    Jones, S.P.4
  • 52
    • 84878211324 scopus 로고    scopus 로고
    • Retinal O-linked N-acetylglucosamine protein modifications: Implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy
    • Gurel Z, Sieg KM, Shallow KD, Sorenson CM, Sheibani N. Retinal O-linked N-acetylglucosamine protein modifications: Implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy. Mol Vis 2013;19:1047-1059.
    • (2013) Mol Vis , vol.19 , pp. 1047-1059
    • Gurel, Z.1    Sieg, K.M.2    Shallow, K.D.3    Sorenson, C.M.4    Sheibani, N.5
  • 53
    • 84864389693 scopus 로고    scopus 로고
    • Acetylation of retinal histones in diabetes increases inflammatory proteins: Effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)
    • Kadiyala CS, Zheng L, Du Y, Yohannes E, Kao HY, Miyagi M, et al. Acetylation of retinal histones in diabetes increases inflammatory proteins: Effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC). J Biol Chem 2012;287:25869-25880.
    • (2012) J Biol Chem , vol.287 , pp. 25869-25880
    • Kadiyala, C.S.1    Zheng, L.2    Du, Y.3    Yohannes, E.4    Kao, H.Y.5    Miyagi, M.6
  • 54
    • 84866054623 scopus 로고    scopus 로고
    • Post-translational processing of synaptophysin in the rat retina is disrupted by diabetes
    • D'Cruz TS, Weibley BN, Kimball SR, Barber AJ. Post-translational processing of synaptophysin in the rat retina is disrupted by diabetes. PLoS One 2012;7:e44711.
    • (2012) PLoS One , vol.7 , pp. e44711
    • D'Cruz, T.S.1    Weibley, B.N.2    Kimball, S.R.3    Barber, A.J.4
  • 55
    • 84856517048 scopus 로고    scopus 로고
    • Resveratrol blocks diabetes-induced early vascular lesions and vascular endothelial growth factor induction in mouse retinas
    • Kim YH, Kim YS, Roh GS, Choi WS, Cho GJ. Resveratrol blocks diabetes-induced early vascular lesions and vascular endothelial growth factor induction in mouse retinas. Acta Ophthalmol 2012;90:e31-e37.
    • (2012) Acta Ophthalmol , vol.90 , pp. e31-e37
    • Kim, Y.H.1    Kim, Y.S.2    Roh, G.S.3    Choi, W.S.4    Cho, G.J.5
  • 56
    • 84861918691 scopus 로고    scopus 로고
    • Protein kinase cß phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo
    • Murakami T, Frey T, Lin C, Antonetti DA. Protein kinase cß phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo. Diabetes 2012;61:1573-1583.
    • (2012) Diabetes , vol.61 , pp. 1573-1583
    • Murakami, T.1    Frey, T.2    Lin, C.3    Antonetti, D.A.4
  • 57
    • 0029973474 scopus 로고    scopus 로고
    • Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
    • Mizutani M, Kern TS, Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest 1996;97:2883-2890.
    • (1996) J Clin Invest , vol.97 , pp. 2883-2890
    • Mizutani, M.1    Kern, T.S.2    Lorenzi, M.3
  • 59
    • 18544366585 scopus 로고    scopus 로고
    • Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    • Enge M, Bjarnegård M, Gerhardt H, Gustafsson E, Kalén M, Asker N, et al. Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J 2002;21:4307-4316.
    • (2002) EMBO J , vol.21 , pp. 4307-4316
    • Enge, M.1    Bjarnegård, M.2    Gerhardt, H.3    Gustafsson, E.4    Kalén, M.5    Asker, N.6
  • 60
    • 0024420402 scopus 로고
    • Pathogenesis of diabetic retinopathy
    • Engerman RL. Pathogenesis of diabetic retinopathy. Diabetes 1989;38:1203-1206.
    • (1989) Diabetes , vol.38 , pp. 1203-1206
    • Engerman, R.L.1
  • 61
    • 0032863021 scopus 로고    scopus 로고
    • Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition
    • Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC, et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA 1999;96:10836-10841.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10836-10841
    • Miyamoto, K.1    Khosrof, S.2    Bursell, S.E.3    Rohan, R.4    Murata, T.5    Clermont, A.C.6
  • 62
    • 3142754459 scopus 로고    scopus 로고
    • Increased expression of intercellular adhesion molecule-1, vascular cellular adhesion molecule-1 and leukocyte common antigen in diabetic rat retina
    • Bai N, Tang S, Ma J, Luo Y, Lin S. Increased expression of intercellular adhesion molecule-1, vascular cellular adhesion molecule-1 and leukocyte common antigen in diabetic rat retina. Yan Ke Xue Bao 2003;19:176-183.
    • (2003) Yan Ke Xue Bao , vol.19 , pp. 176-183
    • Bai, N.1    Tang, S.2    Ma, J.3    Luo, Y.4    Lin, S.5
  • 63
    • 84878218816 scopus 로고    scopus 로고
    • Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
    • Costa PZ, Soares R. Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox. Life Sci 2013;92:1037-1045.
    • (2013) Life Sci , vol.92 , pp. 1037-1045
    • Costa, P.Z.1    Soares, R.2
  • 64
    • 77953860649 scopus 로고    scopus 로고
    • The role of epigenetics in the pathology of diabetic complications
    • Villeneuve LM, Natarajan R. The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol 2010;299:F14-F25.
    • (2010) Am J Physiol Renal Physiol , vol.299 , pp. F14-F25
    • Villeneuve, L.M.1    Natarajan, R.2
  • 66
    • 77955498700 scopus 로고    scopus 로고
    • Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon
    • Zhong Q, Kowluru RA. Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J Cell Biochem 2010;110:1306-1313.
    • (2010) J Cell Biochem , vol.110 , pp. 1306-1313
    • Zhong, Q.1    Kowluru, R.A.2
  • 67
    • 84878774334 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy
    • Zhong Q, Kowluru RA. Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. Diabetes 2013;62:2559-2568.
    • (2013) Diabetes , vol.62 , pp. 2559-2568
    • Zhong, Q.1    Kowluru, R.A.2
  • 68
    • 84875412672 scopus 로고    scopus 로고
    • Review: Epigenetic mechanisms in ocular disease
    • He S, Li X, Chan N, Hinton DR. Review: Epigenetic mechanisms in ocular disease. Mol Vis 2013;19:665-674.
    • (2013) Mol Vis , vol.19 , pp. 665-674
    • He, S.1    Li, X.2    Chan, N.3    Hinton, D.R.4
  • 69
    • 79953225170 scopus 로고    scopus 로고
    • MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy
    • McArthur K, Feng B, Wu Y, Chen S, Chakrabarti S. MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy. Diabetes 2011;60:1314-1323.
    • (2011) Diabetes , vol.60 , pp. 1314-1323
    • McArthur, K.1    Feng, B.2    Wu, Y.3    Chen, S.4    Chakrabarti, S.5
  • 70
    • 84875469801 scopus 로고    scopus 로고
    • MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model
    • Murray AR, Chen Q, Takahashi Y, Zhou KK, Park K, Ma JX. MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. Invest Ophthalmol Vis Sci 2013;54:1689-1697.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 1689-1697
    • Murray, A.R.1    Chen, Q.2    Takahashi, Y.3    Zhou, K.K.4    Park, K.5    Ma, J.X.6
  • 71
    • 80052333875 scopus 로고    scopus 로고
    • MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats
    • Kovacs B, Lumayag S, Cowan C, Xu S. MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci 2011;52:4402-4409.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 4402-4409
    • Kovacs, B.1    Lumayag, S.2    Cowan, C.3    Xu, S.4
  • 72
    • 84884733452 scopus 로고    scopus 로고
    • MicroRNA-dependent cross-talk between VEGF and HIF1a in the diabetic retina
    • Ling S, Birnbaum Y, Nanhwan MK, Thomas B, Bajaj M, Ye Y. MicroRNA-dependent cross-talk between VEGF and HIF1a in the diabetic retina. Cell Signal 2013;25:2840-2847.
    • (2013) Cell Signal , vol.25 , pp. 2840-2847
    • Ling, S.1    Birnbaum, Y.2    Nanhwan, M.K.3    Thomas, B.4    Bajaj, M.5    Ye, Y.6
  • 74
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006;7:41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 76
    • 58149376973 scopus 로고    scopus 로고
    • Maintaining blood-brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation
    • Al Ahmad A, Gassmann M, Ogunshola OO. Maintaining blood-brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation. J Cell Physiol 2009;218:612-622.
    • (2009) J Cell Physiol , vol.218 , pp. 612-622
    • Al Ahmad, A.1    Gassmann, M.2    Ogunshola, O.O.3
  • 77
    • 1842632667 scopus 로고    scopus 로고
    • Endothelial cell-cell junctions: Happy together
    • Dejana E. Endothelial cell-cell junctions: Happy together. Nat Rev Mol Cell Biol 2004;5:261-270.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 261-270
    • Dejana, E.1
  • 78
    • 38549128935 scopus 로고    scopus 로고
    • VE-cadherin: The major endothelial adhesion molecule controlling cellular junctions and blood vessel formation
    • Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol 2008;28:223-232.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 223-232
    • Vestweber, D.1
  • 79
    • 48649101326 scopus 로고    scopus 로고
    • Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    • Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol 2008;10:923-934.
    • (2008) Nat Cell Biol , vol.10 , pp. 923-934
    • Taddei, A.1    Giampietro, C.2    Conti, A.3    Orsenigo, F.4    Breviario, F.5    Pirazzoli, V.6
  • 83
    • 84859854623 scopus 로고    scopus 로고
    • Vascular endothelial-cadherin and vascular stability
    • Dejana E, Giampietro C. Vascular endothelial-cadherin and vascular stability. Curr Opin Hematol 2012;19:218-223.
    • (2012) Curr Opin Hematol , vol.19 , pp. 218-223
    • Dejana, E.1    Giampietro, C.2
  • 84
    • 33744908040 scopus 로고    scopus 로고
    • Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
    • Nagasawa K, Chiba H, Fujita H, Kojima T, Saito T, Endo T, et al. Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. J Cell Physiol 2006;208:123-132.
    • (2006) J Cell Physiol , vol.208 , pp. 123-132
    • Nagasawa, K.1    Chiba, H.2    Fujita, H.3    Kojima, T.4    Saito, T.5    Endo, T.6
  • 85
    • 78049252302 scopus 로고    scopus 로고
    • Pericytes: Blood-brain barrier safeguards against neurodegeneration?
    • Quaegebeur A, Segura I, Carmeliet P. Pericytes: Blood-brain barrier safeguards against neurodegeneration? Neuron 2010;68:321-323.
    • (2010) Neuron , vol.68 , pp. 321-323
    • Quaegebeur, A.1    Segura, I.2    Carmeliet, P.3
  • 87
    • 75649090531 scopus 로고    scopus 로고
    • Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice
    • Bobbie MW, Roy S, Trudeau K, Munger SJ, Simon AM, Roy S. Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice. Invest Ophthalmol Vis Sci 2010;51:3758-3763.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 3758-3763
    • Bobbie, M.W.1    Roy, S.2    Trudeau, K.3    Munger, S.J.4    Simon, A.M.5    Roy, S.6
  • 88
    • 0027319870 scopus 로고
    • Pericyte physiology
    • Shepro D, Morel NM. Pericyte physiology. FASEB J 1993;7:1031-1038.
    • (1993) FASEB J , vol.7 , pp. 1031-1038
    • Shepro, D.1    Morel, N.M.2
  • 90
    • 0242456268 scopus 로고    scopus 로고
    • Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival
    • Darland DC, Massingham LJ, Smith SR, Piek E, Saint-Geniez M, D'Amore PA. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol 2003;264:275-288.
    • (2003) Dev Biol , vol.264 , pp. 275-288
    • Darland, D.C.1    Massingham, L.J.2    Smith, S.R.3    Piek, E.4    Saint-Geniez, M.5    D'Amore, P.A.6
  • 92
    • 64549113715 scopus 로고    scopus 로고
    • TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature
    • Walshe TE, Saint-Geniez M, Maharaj AS, Sekiyama E, Maldonado AE, D'Amore PA. TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. PLoS One 2009;4:e5149.
    • (2009) PLoS One , vol.4 , pp. e5149
    • Walshe, T.E.1    Saint-Geniez, M.2    Maharaj, A.S.3    Sekiyama, E.4    Maldonado, A.E.5    D'Amore, P.A.6
  • 93
    • 37349105431 scopus 로고    scopus 로고
    • Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy
    • Ejaz S, Chekarova I, Ejaz A, Sohail A, Lim CW. Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy. Diabetes Obes Metab 2008;10:53-56.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 53-56
    • Ejaz, S.1    Chekarova, I.2    Ejaz, A.3    Sohail, A.4    Lim, C.W.5
  • 94
    • 0023886270 scopus 로고
    • Retinal astrocytes are immigrants from the optic nerve
    • Watanabe T, Raff MC. Retinal astrocytes are immigrants from the optic nerve. Nature 1988;332:834-837.
    • (1988) Nature , vol.332 , pp. 834-837
    • Watanabe, T.1    Raff, M.C.2
  • 95
    • 0023192574 scopus 로고
    • Retinal astrocytes: Their restriction to vascularized parts of the mammalian retina
    • Schnitzer J. Retinal astrocytes: Their restriction to vascularized parts of the mammalian retina. Neurosci Lett 1987;78:29-34.
    • (1987) Neurosci Lett , vol.78 , pp. 29-34
    • Schnitzer, J.1
  • 96
    • 0026681569 scopus 로고
    • Degeneration of astrocytes in feline retinopathy of prematurity causes failure of the blood-retinal barrier
    • Chan-Ling T, Stone J. Degeneration of astrocytes in feline retinopathy of prematurity causes failure of the blood-retinal barrier. Invest Ophthalmol Vis Sci 1992;33:2148-2159.
    • (1992) Invest Ophthalmol Vis Sci , vol.33 , pp. 2148-2159
    • Chan-Ling, T.1    Stone, J.2
  • 97
    • 44849099528 scopus 로고    scopus 로고
    • Blood-neural barrier: Its diversity and coordinated cell-to-cell communication
    • Choi YK, Kim KW. Blood-neural barrier: Its diversity and coordinated cell-to-cell communication. BMB Rep 2008;41:345-352.
    • (2008) BMB Rep , vol.41 , pp. 345-352
    • Choi, Y.K.1    Kim, K.W.2
  • 99
    • 42449129214 scopus 로고    scopus 로고
    • AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein kinase Czeta
    • Choi YK, Kim KW. AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein kinase Czeta. FEBS J 2008;275:2338-2353.
    • (2008) FEBS J , vol.275 , pp. 2338-2353
    • Choi, Y.K.1    Kim, K.W.2
  • 100
    • 34248154744 scopus 로고    scopus 로고
    • Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy
    • Nishikiori N, Osanai M, Chiba H, Kojima T, Mitamura Y, Ohguro H, et al. Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy. Diabetes 2007;56:1333-1340.
    • (2007) Diabetes , vol.56 , pp. 1333-1340
    • Nishikiori, N.1    Osanai, M.2    Chiba, H.3    Kojima, T.4    Mitamura, Y.5    Ohguro, H.6
  • 101
    • 84455205524 scopus 로고    scopus 로고
    • The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    • Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, et al. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 2011;334:1727-1731.
    • (2011) Science , vol.334 , pp. 1727-1731
    • Alvarez, J.I.1    Dodelet-Devillers, A.2    Kebir, H.3    Ifergan, I.4    Fabre, P.J.5    Terouz, S.6
  • 102
    • 62849101195 scopus 로고    scopus 로고
    • Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vessels
    • Kim JH, Kim JH, Yu YS, Kim DH, Kim KW. Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vessels. J Neurosci Res 2009;87:653-659.
    • (2009) J Neurosci Res , vol.87 , pp. 653-659
    • Kim, J.H.1    Kim, J.H.2    Yu, Y.S.3    Kim, D.H.4    Kim, K.W.5
  • 103
  • 104
    • 33748194692 scopus 로고    scopus 로고
    • Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: The role of reactive oxygen species in diabetic retinopathy
    • Cui Y, Xu X, Bi H, Zhu Q, Wu J, Xia X, et al. Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: The role of reactive oxygen species in diabetic retinopathy. Exp Eye Res 2006;83:807-816.
    • (2006) Exp Eye Res , vol.83 , pp. 807-816
    • Cui, Y.1    Xu, X.2    Bi, H.3    Zhu, Q.4    Wu, J.5    Xia, X.6
  • 105
    • 77954617065 scopus 로고    scopus 로고
    • High glucose disrupts mitochondrial morphology in retinal endothelial cells: Implications for diabetic retinopathy
    • Trudeau K, Molina AJ, Guo W, Roy S. High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am J Pathol 2010;177:447-455.
    • (2010) Am J Pathol , vol.177 , pp. 447-455
    • Trudeau, K.1    Molina, A.J.2    Guo, W.3    Roy, S.4
  • 106
    • 78649887659 scopus 로고    scopus 로고
    • PP2A contributes to endothelial death in high glucose: Inhibition by benfotiamine
    • Du Y, Kowluru A, Kern TS. PP2A contributes to endothelial death in high glucose: Inhibition by benfotiamine. Am J Physiol Regul Integr Comp Physiol 2010;299:R1610-7.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299 , pp. R1610-R1617
    • Du, Y.1    Kowluru, A.2    Kern, T.S.3
  • 107
    • 64849101327 scopus 로고    scopus 로고
    • High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway
    • Leal EC, Aveleira CA, Castilho AF, Serra AM, Baptista FI, Hosoya K, et al. High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway. Exp Eye Res 2009;88:983-991.
    • (2009) Exp Eye Res , vol.88 , pp. 983-991
    • Leal, E.C.1    Aveleira, C.A.2    Castilho, A.F.3    Serra, A.M.4    Baptista, F.I.5    Hosoya, K.6
  • 108
    • 62649162866 scopus 로고    scopus 로고
    • High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells
    • Li AF, Roy S. High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells. Invest Ophthalmol Vis Sci 2009;50:1400-1407.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1400-1407
    • Li, A.F.1    Roy, S.2
  • 109
    • 30444461395 scopus 로고    scopus 로고
    • Effects of VEGFR-1, VEGFR-2, and IGF-IR hammerhead ribozymes on glucose-mediated tight junction expression in cultured human retinal endothelial cells
    • Spoerri PE, Afzal A, Li Calzi S, Shaw LC, Cai J, Pan H, et al. Effects of VEGFR-1, VEGFR-2, and IGF-IR hammerhead ribozymes on glucose-mediated tight junction expression in cultured human retinal endothelial cells. Mol Vis 2006;12:32-34.
    • (2006) Mol Vis , vol.12 , pp. 32-34
    • Spoerri, P.E.1    Afzal, A.2    Li Calzi, S.3    Shaw, L.C.4    Cai, J.5    Pan, H.6
  • 110
    • 84871293609 scopus 로고    scopus 로고
    • High-glucose-induced endothelial cell injury is inhibited by a Peptide derived from human apolipoprotein e
    • Bhattacharjee PS, Huq TS, Potter V, Young A, Davenport IR, Graves R, et al. High-glucose-induced endothelial cell injury is inhibited by a Peptide derived from human apolipoprotein E. PLoS One 2012;7:e52152.
    • (2012) PLoS One , vol.7 , pp. e52152
    • Bhattacharjee, P.S.1    Huq, T.S.2    Potter, V.3    Young, A.4    Davenport, I.R.5    Graves, R.6
  • 111
    • 84885031592 scopus 로고    scopus 로고
    • Effects of high glucose-induced CX43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells
    • Tien T, Barrette KF, Chronopoulos A, Roy S. Effects of high glucose-induced CX43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells. Invest Ophthalmol Vis Sci 2013;54:6518-6525.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 6518-6525
    • Tien, T.1    Barrette, K.F.2    Chronopoulos, A.3    Roy, S.4
  • 112
    • 57349165885 scopus 로고    scopus 로고
    • High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs
    • Huang Q, Sheibani N. High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs. Am J Physiol Cell Physiol 2008;295:C1647-C1657.
    • (2008) Am J Physiol Cell Physiol , vol.295 , pp. C1647-C1657
    • Huang, Q.1    Sheibani, N.2
  • 113
    • 84873082879 scopus 로고    scopus 로고
    • KH902 suppresses high glucose-induced migration and sprouting of human retinal endothelial cells by blocking VEGF and PIGF
    • Chen X, Li J, Li M, Zeng M, Li T, Xiao W, et al. KH902 suppresses high glucose-induced migration and sprouting of human retinal endothelial cells by blocking VEGF and PIGF. Diabetes Obes Metab 2013;15:224-233.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 224-233
    • Chen, X.1    Li, J.2    Li, M.3    Zeng, M.4    Li, T.5    Xiao, W.6
  • 114
    • 57349165885 scopus 로고    scopus 로고
    • High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs
    • Huang Q, Sheibani N. High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs. Am J Physiol Cell Physiol 2008;295:C1647-C1657.
    • (2008) Am J Physiol Cell Physiol , vol.295 , pp. C1647-C1657
    • Huang, Q.1    Sheibani, N.2
  • 115
    • 84863314391 scopus 로고    scopus 로고
    • Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation
    • Yuan L, Hu J, Luo Y, Liu Q, Li T, Parish CR, et al. Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation. Mol Vis 2012;18:1684-1695.
    • (2012) Mol Vis , vol.18 , pp. 1684-1695
    • Yuan, L.1    Hu, J.2    Luo, Y.3    Liu, Q.4    Li, T.5    Parish, C.R.6
  • 116
    • 0037646838 scopus 로고    scopus 로고
    • Isolation and characterization of murine retinal endothelial cells
    • Su X, Sorenson CM, Sheibani N. Isolation and characterization of murine retinal endothelial cells. Mol Vis 2003;9:171-178.
    • (2003) Mol Vis , vol.9 , pp. 171-178
    • Su, X.1    Sorenson, C.M.2    Sheibani, N.3
  • 117
    • 0036306098 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes
    • Romeo G, Liu WH, Asnaghi V, Kern TS, Lorenzi M. Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes 2002;51:2241-2248.
    • (2002) Diabetes , vol.51 , pp. 2241-2248
    • Romeo, G.1    Liu, W.H.2    Asnaghi, V.3    Kern, T.S.4    Lorenzi, M.5
  • 118
    • 48249083387 scopus 로고    scopus 로고
    • Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells
    • Takamura Y, Tomomatsu T, Kubo E, Tsuzuki S, Akagi Y. Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells. Invest Ophthalmol Vis Sci 2008;49:3216-3223.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 3216-3223
    • Takamura, Y.1    Tomomatsu, T.2    Kubo, E.3    Tsuzuki, S.4    Akagi, Y.5
  • 119
    • 70449108112 scopus 로고    scopus 로고
    • Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
    • Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, et al. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med 2009;15:1298-1306.
    • (2009) Nat Med , vol.15 , pp. 1298-1306
    • Geraldes, P.1    Hiraoka-Yamamoto, J.2    Matsumoto, M.3    Clermont, A.4    Leitges, M.5    Marette, A.6
  • 120
    • 84867507033 scopus 로고    scopus 로고
    • Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy
    • Fu D, Wu M, Zhang J, Du M, Yang S, Hammad SM, et al. Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy. Diabetologia 2012;55:3128-3140.
    • (2012) Diabetologia , vol.55 , pp. 3128-3140
    • Fu, D.1    Wu, M.2    Zhang, J.3    Du, M.4    Yang, S.5    Hammad, S.M.6
  • 121
    • 84874991065 scopus 로고    scopus 로고
    • Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy
    • Devi TS, Hosoya K, Terasaki T, Singh LP. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy. Exp Cell Res 2013;319:1001-1012.
    • (2013) Exp Cell Res , vol.319 , pp. 1001-1012
    • Devi, T.S.1    Hosoya, K.2    Terasaki, T.3    Singh, L.P.4
  • 122
    • 84867911383 scopus 로고    scopus 로고
    • Antibody-mediated retinal pericyte injury: Implications for diabetic retinopathy
    • Li Y, Smith D, Li Q, Sheibani N, Huang S, Kern T, et al. Antibody-mediated retinal pericyte injury: Implications for diabetic retinopathy. Invest Ophthalmol Vis Sci 2012;53:5520-5526.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 5520-5526
    • Li, Y.1    Smith, D.2    Li, Q.3    Sheibani, N.4    Huang, S.5    Kern, T.6
  • 123
    • 84855374179 scopus 로고    scopus 로고
    • High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes
    • Trudeau K, Molina AJ, Roy S. High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest Ophthalmol Vis Sci 2011;52:8657-8664.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 8657-8664
    • Trudeau, K.1    Molina, A.J.2    Roy, S.3
  • 124
    • 33747871836 scopus 로고    scopus 로고
    • Effects of mechanical stress and high glucose on pericyte proliferation, apoptosis and contractile phenotype
    • Beltramo E, Berrone E, Giunti S, Gruden G, Perin PC, Porta M. Effects of mechanical stress and high glucose on pericyte proliferation, apoptosis and contractile phenotype. Exp Eye Res 2006;83:989-994.
    • (2006) Exp Eye Res , vol.83 , pp. 989-994
    • Beltramo, E.1    Berrone, E.2    Giunti, S.3    Gruden, G.4    Perin, P.C.5    Porta, M.6
  • 125
    • 52749091381 scopus 로고    scopus 로고
    • Pericyte migration: A novel mechanism of pericyte loss in experimental diabetic retinopathy
    • Pfister F, Feng Y, vom Hagen F, Hoffmann S, Molema G, Hillebrands JL, et al. Pericyte migration: A novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes 2008;57:2495-2502.
    • (2008) Diabetes , vol.57 , pp. 2495-2502
    • Pfister, F.1    Feng, Y.2    Vom Hagen, F.3    Hoffmann, S.4    Molema, G.5    Hillebrands, J.L.6
  • 127
    • 84891749818 scopus 로고    scopus 로고
    • STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions
    • Shin ES, Huang Q, Gurel Z, Palenski TL, Zaitoun I, Sorenson CM, et al. STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions. Cell Death Dis 2014;5:e986.
    • (2014) Cell Death Dis , vol.5 , pp. e986
    • Shin, E.S.1    Huang, Q.2    Gurel, Z.3    Palenski, T.L.4    Zaitoun, I.5    Sorenson, C.M.6
  • 129
  • 131
    • 82955213965 scopus 로고    scopus 로고
    • Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss
    • Ly A, Yee P, Vessey KA, Phipps JA, Jobling AI, Fletcher EL. Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss. Invest Ophthalmol Vis Sci 2011;52:9316-9326.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 9316-9326
    • Ly, A.1    Yee, P.2    Vessey, K.A.3    Phipps, J.A.4    Jobling, A.I.5    Fletcher, E.L.6
  • 132
    • 84875722407 scopus 로고    scopus 로고
    • The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes
    • Lind KR, Ball KK, Cruz NF, Dienel GA. The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes. Neurochem Int 2013;62:784-795.
    • (2013) Neurochem Int , vol.62 , pp. 784-795
    • Lind, K.R.1    Ball, K.K.2    Cruz, N.F.3    Dienel, G.A.4
  • 133
    • 84890982027 scopus 로고    scopus 로고
    • NRF2 plays a protective role in diabetic retinopathy in mice
    • Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, et al. NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia 2014;57:204-213.
    • (2014) Diabetologia , vol.57 , pp. 204-213
    • Xu, Z.1    Wei, Y.2    Gong, J.3    Cho, H.4    Park, J.K.5    Sung, E.R.6
  • 134
    • 84875262617 scopus 로고    scopus 로고
    • High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications
    • Aghdam SY, Gurel Z, Ghaffarieh A, Sorenson CM, Sheibani N. High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications. Biochem Biophys Res Commun 2013;432:339-344.
    • (2013) Biochem Biophys Res Commun , vol.432 , pp. 339-344
    • Aghdam, S.Y.1    Gurel, Z.2    Ghaffarieh, A.3    Sorenson, C.M.4    Sheibani, N.5
  • 135
    • 84878211324 scopus 로고    scopus 로고
    • Retinal O-linked N-acetylglucosamine protein modifications: Implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy
    • Gurel Z, Sieg KM, Shallow KD, Sorenson CM, Sheibani N. Retinal O-linked N-acetylglucosamine protein modifications: Implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy. Mol Vis 2013;19:1047-1059.
    • (2013) Mol Vis , vol.19 , pp. 1047-1059
    • Gurel, Z.1    Sieg, K.M.2    Shallow, K.D.3    Sorenson, C.M.4    Sheibani, N.5


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