Inhibition of reactive oxygen species by lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: Role of NADPH oxidase 4

Diabetes

Volumn 59, Issue 6, 2010, Pages 1528-1538

  Li, Jingming ^a   Wang, Joshua J ^a   Yu, Qiang ^b   Chen, Kai ^c   Mahadev, Kalyankar ^d   Zhang, Sarah X ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DIPHENYLIODONIUM SALT; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MEVINOLIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; STAT3 PROTEIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD RETINA BARRIER; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DIABETIC RETINOPATHY; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE EXPRESSION; HYPOXIA; MALE; MEMBRANE DAMAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINA CELL; UPREGULATION;

ANIMALS; BLOOD-RETINAL BARRIER; CAPILLARIES; CATTLE; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; LOVASTATIN; MICE; NADPH OXIDASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RETINA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77953200258     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1057     Document Type: Article

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