Effects of mechanical stress and high glucose on pericyte proliferation, apoptosis and contractile phenotype

Experimental Eye Research

Volumn 83, Issue 4, 2006, Pages 989-994

  Beltramo, Elena ^a   Berrone, Elena ^a   Giunti, Sara ^a   Gruden, Gabriella ^a   Perin, Paolo Cavallo ^a   Porta, Massimo ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

apoptosis; cytoskeleton; diabetic retinopathy; high glucose; mechanical stress; pericytes; replication

Indexed keywords

ACTIN; DNA; GLUCOSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL CULTURE; CELL DIVISION; CELL PROLIFERATION; CELL STRUCTURE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COW; CYTOSKELETON; DIABETIC RETINOPATHY; DNA SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTATION; FIBER; HYPERGLYCEMIA; HYPERTENSION; IMMUNOFLUORESCENCE; MECHANICAL STRESS; NONHUMAN; PERICYTE; PHENOTYPE; PRIORITY JOURNAL;

ACTINS; ANIMALS; APOPTOSIS; CATTLE; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; CYTOSKELETON; GLUCOSE; PERICYTES; RETINAL VESSELS; STRESS, MECHANICAL;

EID: 33747871836     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2006.05.008     Document Type: Article

References (35)

1. Aiello L.P., Gardner T.W., King G.L., Blankenship G., Cavallerano J.D., Ferris III F.L., and Klein R. Diabetic retinopathy. (technical review). Diabetes Care 21 (1998) 143-156
2. Barnes A.J., Gilbert J., Taylor D., and Monbureau O. A new vacuum-operated stress-providing instrument that applies static or variable duration cycling tension or compression to cells in vitro. J. Cell Sci. 75 (1985) 35-42
3. Beltramo E., Berrone E., Buttiglieri S., and Porta M. Thiamine and benfotiamine prevent increased apoptosis in endothelial cells and pericytes cultured in high glucose. Diabetes Metab. Res. Rev. 20 (2004) 330-336
4. Brignardello E., Beltramo E., Molinatti P.A., Aragno M., Gatto V., Tamagno E., Danni O., Porta M., and Boccuzzi G. Dehydroepiandrosterone protects bovine retinal capillary pericytes against glucose toxicity. J. Endocrinol. 158 (1998) 21-26
5. Cortes P., Méndez M., Riser B.L., Guerin C.J., Rodriguez-Barbero A., Hassett C., and Yee J. F-actin distribution in glomerular cells: structural and functional implications. Kidney Int. 58 (2000) 2452-2461
6. Davies P.F., and Tripathi S.C. Mechanical stress mechanisms and the cell: an endothelial paradigm. (mini review). Circ. Res. 72 (1993) 239-245
7. Dosso A.A., Leuenberger P.M., and Rungger-Brandle E. Remodeling of retinal capillaries in the diabetic hypertensive rat. Investig. Ophthalmol. Vis. Sci. 40 (1999) 2405-2410
8. Durvasula R.V., Petermann A.T., Hiromura K., Blonski M., Pippin J., Mundel P., Pichler R., Griffin S., Couser W.G., and Shankland S.J. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int. 65 (2004) 30-39
9. Gillies M.C., and Su T. High glucose inhibits retinal capillary pericytes contractility in vitro. Investig. Ophthalmol. Vis. Sci. 34 (1993) 3396-3401
10. Gruden G., Zonca S., Hayward A., Thomas S., Maestrini S., Gnudi L., and Viberti G.C. Mechanical stretch-induced fibronectin and transforming growth factor-β1 production in human mesangial cells is p38 mitogen-activated protein kinase-dependent. Diabetes 49 (2000) 655-661
11. Hammes H.P., Lin J., Renner O., Shani M., Lundqvist A., Betsholtz C., Brownlee M., and Deutsch U. Pericytes and the pathogenesis of diabetic retinopathy. Diabetes 51 (2002) 3107-3112
12. Harris R.C., Haralson M.A., and Badr K.F. Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity. Lab. Investig. 66 (1992) 548-554
13. Hirschi K.K., and D'Amore P.A. Pericytes in the microvasculature. Cardiovasc. Res. 32 (1996) 687-698
14. Hughes S., and Chan-Ling T. Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo. Investig. Ophthalmol. Vis. Sci. 45 (2004) 2795-2806
15. i signalling and contraction in retinal microvascular pericytes. Mol. Vis. 10 (2004) 996-1004
16. Husse B., Sopart A., and Isenberg G. Cyclical mechanical stretch-induced apoptosis in myocytes from young rats but necrosis in myocytes from old rats. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H1521-H1527
17. Kippenberger S., Loitsch S., Guschel M., Muller J., Knies Y., Kaufmann R., and Bernd A. Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor. J. Biol. Chem. 280 (2005) 3060-3067
18. Klein R., Klein B.E.K., Moss S.E., and Cruickshanks K.J. The Wisconsin epidemiologic study of diabetic retinopathy. XVIII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes. Ophthalmology 105 (1998) 1801-1815
19. Klein R., and Klein B.E.K. Blood pressure control and diabetic retinopathy. Br. J. Ophthalmol. 86 (2002) 365-367
20. Liao X., Wang X., Gu Y., Chen Q., and Chen L.Y. Involvement of death receptor signaling in mechanical stretch-induced cardiomyocyte apoptosis. Life Sci. 77 (2005) 160-174
21. Liu X.M., Ensenat D., Wang H., Schafer A.I., and Durante W. Physiologic cyclic stretch inhibits apoptosis in vascular endothelium. FEBS Lett. 541 (2003) 52-56
22. Matthews D.R., Stratton I.M., Aldington S.J., Holman R.R., Kohner E.M., and UK Prospective Diabetes Study Group. Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69. Arch. Ophthalmol. 122 (2004) 1631-1640
23. McIntosh L.C., Muckersie L., and Forrester J.V. Retinal capillary endothelial cells prefer different substrates for growth and migration. Tissue Cell 20 (1988) 193-209
24. Nayak R.C., Berman A.B., George K.L., Eisenbarth G.S., and King K.L. A monoclonal antibody (3G5) - defined ganglioside antigen is expressed on the cell surface of microvascular pericytes. J. Exp. Med. 167 (1988) 1003-1015
25. Petermann A.T., Hiromura K., Blonski M., Pippin J., Monkawa T., Durvasula R., Couser W.G., and Shankland S.J. Mechanical stress reduces podocyte proliferation in vitro. Kidney Int. 61 (2002) 40-50
26. Podestà F., Romeo G., Liu W.H., Krajewski S., Reed J.C., Gerhardinger C., and Lorenzi M. Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro. Am. J. Pathol. 156 (2000) 1025-1032
27. Pomero F., Allione A., Beltramo E., Buttiglieri S., D'Alu F., Ponte E., Lacaria A., and Porta M. Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes. Diabetologia 46 (2003) 416-419
28. Rassam S.M., Patel V., and Kohner E.M. The effect of experimental hypertension on retinal vascular autoregulation in humans: a mechanism for the progression of diabetic retinopathy. Exp. Physiol. 80 (1995) 53-68
29. Shaw A., and Xu Q. Biomechanical stress-induced signaling in smooth muscle cells: an update. Curr. Vasc. Pharmacol. 1 (2003) 41-58
30. Sotoudeh M., Li Y.S., Yajima N., Tsou T.C., Wang Y., Usami S., Ratcliffe A., Chien S., and Shyy J.Y. Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. Am. J. Physiol. Heart Circ. Physiol. 282 (2002) H1709-H1716
31. Suzuma I., Suzuma K., Ueki K., Hata Y., Feener E.P., King G.L., and Aiello L.P. Stretch-induced retinal vascular growth factor expression is mediated by phosphatidylinositol 3-kinase and Protein Kinase C (PKC)-ζ but not stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J. Biol. Chem. 277 (2002) 1047-1057
32. Wan Nazaimoon W.M., Letchuman R., Noraini N., Ropilah A.R., Zainal M., Ismail I.S., Wan Mohamad W.B., Faridah I., Singaraveloo M., Sheriff I.H., and Khalid B.A. Systolic hypertension and duration of diabetes mellitus are important determinants of retinopathy and microalbuminuria in young diabetics. Diabetes Res. Clin. Pract. 46 (1999) 213-221
33. Wernig F., Mayr M., and Xu Q. Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by β1-integrin signaling pathways. Hypertension 41 (2003) 903-911
34. Wilkinson-Berka J.L., Babic S., de Gooyer T., Stitt A.W., Jaworski K., Ong L.G., Kelly D.G., and Gilbert R.E. Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy. Am. J. Pathol. 164 (2004) 1263-1273
35. Wong H.C., Boulton M., Marshall J., and Clark P. Growth of retinal capillary endothelial cells using pericyte conditioned medium. Invest. Opthalmol. Vis. Sci. 28 (1987) 1767-1775