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Volumn 110, Issue 38, 2013, Pages 15401-15406

Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRYPSIN;

EID: 84884343947     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307211110     Document Type: Article
Times cited : (113)

References (42)
  • 1
    • 33751533892 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXI. Peroxisome proliferator- activated receptors
    • Michalik L, et al. (2006) International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev 58(4):726-741.
    • (2006) Pharmacol Rev , vol.58 , Issue.4 , pp. 726-741
    • Michalik, L.1
  • 2
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J, Moller DE (2002) The mechanisms of action of PPARs. Annu Rev Med 53: 409-435.
    • (2002) Annu Rev Med , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 4
    • 33745309774 scopus 로고    scopus 로고
    • The role of the peroxisome proliferator-activated receptoralpha (PPAR-alpha) in the regulation of acute inflammation
    • Cuzzocrea S, et al. (2006) The role of the peroxisome proliferator-activated receptoralpha (PPAR-alpha) in the regulation of acute inflammation. J Leukoc Biol 79(5): 999-1010.
    • (2006) J Leukoc Biol , vol.79 , Issue.5 , pp. 999-1010
    • Cuzzocrea, S.1
  • 5
    • 3042630884 scopus 로고    scopus 로고
    • PPAR alpha, fibrates, lipid metabolism and inflammation
    • Duval C, Fruchart JC, Staels B (2004) PPAR alpha, fibrates, lipid metabolism and inflammation. Arch Mal Coeur Vaiss 97(6):665-672.
    • (2004) Arch Mal Coeur Vaiss , vol.97 , Issue.6 , pp. 665-672
    • Duval, C.1    Fruchart, J.C.2    Staels, B.3
  • 6
    • 33748041453 scopus 로고    scopus 로고
    • Efficacy of peroxisome proliferative activated receptor (PPAR)-alpha ligands, fenofibrate, on intimal hyperplasia and constrictive remodeling after coronary angioplasty in porcine models
    • Kasai T, Miyauchi K, Yokoyama T, Aihara K, Daida H (2006) Efficacy of peroxisome proliferative activated receptor (PPAR)-alpha ligands, fenofibrate, on intimal hyperplasia and constrictive remodeling after coronary angioplasty in porcine models. Atherosclerosis 188(2):274-280.
    • (2006) Atherosclerosis , vol.188 , Issue.2 , pp. 274-280
    • Kasai, T.1    Miyauchi, K.2    Yokoyama, T.3    Aihara, K.4    Daida, H.5
  • 7
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347(6294):645-650.
    • (1990) Nature , vol.347 , Issue.6294 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 8
    • 0026517010 scopus 로고
    • Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
    • Dreyer C, et al. (1992) Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68(5):879-887.
    • (1992) Cell , vol.68 , Issue.5 , pp. 879-887
    • Dreyer, C.1
  • 9
    • 0041831047 scopus 로고    scopus 로고
    • Analysis of the critical structural determinant(s) of speciesselective peroxisome proliferator-activated receptor alpha (PPAR alpha)-activation by phenylpropanoic acid-type PPAR alpha agonists
    • Miyachi H, Uchiki H (2003) Analysis of the critical structural determinant(s) of speciesselective peroxisome proliferator-activated receptor alpha (PPAR alpha)-activation by phenylpropanoic acid-type PPAR alpha agonists. Bioorg Med Chem Lett 13(19): 3145-3149.
    • (2003) Bioorg Med Chem Lett , vol.13 , Issue.19 , pp. 3145-3149
    • Miyachi, H.1    Uchiki, H.2
  • 10
    • 84862916369 scopus 로고    scopus 로고
    • PPAR-α agonist fenofibrate upregulates tetrahydrobiopterin level through increasing the expression of guanosine 5'-triphosphate cyclohydrolase-I in human umbilical vein endothelial cells
    • Liu J, et al. (2011) PPAR-α agonist fenofibrate upregulates tetrahydrobiopterin level through increasing the expression of guanosine 5'-triphosphate cyclohydrolase-I in human umbilical vein endothelial cells. PPAR Res 2011:523520.
    • (2011) PPAR Res , vol.2011 , pp. 523520
    • Liu, J.1
  • 11
    • 79955569162 scopus 로고    scopus 로고
    • Fenofibrate, a PPARalpha agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy
    • Castillero E, et al. (2011) Fenofibrate, a PPARalpha agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy. Am J Physiol Endocrinol Metab 300(5):E790-E799.
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , Issue.5
    • Castillero, E.1
  • 12
    • 0030930204 scopus 로고    scopus 로고
    • Blood glucose control and microvascular and macrovascular complications in diabetes
    • Hanssen KF (1997) Blood glucose control and microvascular and macrovascular complications in diabetes. Diabetes 46(Suppl 2):S101-S103.
    • (1997) Diabetes , vol.46 , Issue.SUPPL. 2
    • Hanssen, K.F.1
  • 13
    • 12344293480 scopus 로고    scopus 로고
    • Prevention of microvascular and macrovascular complications in diabetes mellitus
    • 428, 430 passim
    • Maji D (2004) Prevention of microvascular and macrovascular complications in diabetes mellitus. J Indian Med Assoc 102(8):426-, 428, 430 passim.
    • (2004) J Indian Med Assoc , vol.102 , Issue.8 , pp. 426
    • Maji, D.1
  • 14
    • 77955057772 scopus 로고    scopus 로고
    • PPARalpha: An emerging therapeutic target in diabetic microvascular damage
    • Hiukka A, Maranghi M, Matikainen N, Taskinen MR (2010) PPARalpha: An emerging therapeutic target in diabetic microvascular damage. Nat Rev Endocrinol 6(8): 454-463.
    • (2010) Nat Rev Endocrinol , vol.6 , Issue.8 , pp. 454-463
    • Hiukka, A.1    Maranghi, M.2    Matikainen, N.3    Taskinen, M.R.4
  • 15
    • 84856255697 scopus 로고    scopus 로고
    • Pharmacologic prevention of microvascular and macrovascular complications in diabetes mellitus: Implications of the results of recent clinical trials in type 2 diabetes
    • Tandon N, Ali MK, Narayan KM (2012) Pharmacologic prevention of microvascular and macrovascular complications in diabetes mellitus: Implications of the results of recent clinical trials in type 2 diabetes. Am J Cardiovasc Drugs 12(1):7-22.
    • (2012) Am J Cardiovasc Drugs , vol.12 , Issue.1 , pp. 7-22
    • Tandon, N.1    Ali, M.K.2    Narayan, K.M.3
  • 16
    • 36049001784 scopus 로고    scopus 로고
    • Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial
    • FIELD study investigators
    • Keech AC, et al.; FIELD study investigators (2007) Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial. Lancet 370(9600):1687-1697.
    • (2007) Lancet , vol.370 , Issue.9600 , pp. 1687-1697
    • Keech, A.C.1
  • 17
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • ACCORD Study Group
    • Ginsberg HN, et al.; ACCORD Study Group (2010) Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 362(17):1563-1574.
    • (2010) N Engl J Med , vol.362 , Issue.17 , pp. 1563-1574
    • Ginsberg, H.N.1
  • 18
    • 33745313224 scopus 로고    scopus 로고
    • Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha
    • Park CW, et al. (2006) Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha. Diabetes 55(4):885-893.
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 885-893
    • Park, C.W.1
  • 19
    • 84872016068 scopus 로고    scopus 로고
    • Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models
    • Chen Y, et al. (2013) Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models. Diabetes 62(1):261-272.
    • (2013) Diabetes , vol.62 , Issue.1 , pp. 261-272
    • Chen, Y.1
  • 20
    • 18444371741 scopus 로고    scopus 로고
    • PPAR activators inhibit endothelial cell migration by targeting Akt
    • Goetze S, et al. (2002) PPAR activators inhibit endothelial cell migration by targeting Akt. Biochem Biophys Res Commun 293(5):1431-1437.
    • (2002) Biochem Biophys Res Commun , vol.293 , Issue.5 , pp. 1431-1437
    • Goetze, S.1
  • 21
    • 36949008788 scopus 로고    scopus 로고
    • PPAR signaling in placental development and function
    • Barak Y, Sadovsky Y, Shalom-Barak T (2008) PPAR signaling in placental development and function. PPAR Res 2008:142082.
    • (2008) PPAR Res , vol.2008 , pp. 142082
    • Barak, Y.1    Sadovsky, Y.2    Shalom-Barak, T.3
  • 22
    • 0034132524 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor(PPAR)-structure, function, tissue distribution, gene expression
    • Takeyama K, Kodera Y, Suzawa M, Kato S (2000) [Peroxisome proliferator-activated receptor(PPAR)-structure, function, tissue distribution, gene expression]. Nihon Rinsho 58(2):357-363.
    • (2000) Nihon Rinsho , vol.58 , Issue.2 , pp. 357-363
    • Takeyama, K.1    Kodera, Y.2    Suzawa, M.3    Kato, S.4
  • 23
    • 0032109988 scopus 로고    scopus 로고
    • Lipid metabolism related nuclear receptor-The structure, function, expression and classification of peroxisome proliferation-activated receptor (PPAR)
    • Kawada T (1998) [Lipid metabolism related nuclear receptor-the structure, function, expression and classification of peroxisome proliferation-activated receptor (PPAR)]. Nihon Rinsho 56(7):1722-1728.
    • (1998) Nihon Rinsho , vol.56 , Issue.7 , pp. 1722-1728
    • Kawada, T.1
  • 24
    • 46749157847 scopus 로고    scopus 로고
    • Tissue-specific expression of PPAR mRNAs in diabetic rats and divergent effects of cilostazol
    • Wang F, et al. (2008) Tissue-specific expression of PPAR mRNAs in diabetic rats and divergent effects of cilostazol. Can J Physiol Pharmacol 86(7):465-471.
    • (2008) Can J Physiol Pharmacol , vol.86 , Issue.7 , pp. 465-471
    • Wang, F.1
  • 25
    • 3042634455 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo-A study using the novel PPARalpha/gamma agonist tesaglitazar
    • Hegarty BD, Furler SM, Oakes ND, Kraegen EW, Cooney GJ (2004) Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo-a study using the novel PPARalpha/gamma agonist tesaglitazar. Endocrinology 145(7):3158-3164.
    • (2004) Endocrinology , vol.145 , Issue.7 , pp. 3158-3164
    • Hegarty, B.D.1    Furler, S.M.2    Oakes, N.D.3    Kraegen, E.W.4    Cooney, G.J.5
  • 26
    • 84863992695 scopus 로고    scopus 로고
    • PPAR gamma activation protects the brain against microvascular dysfunction in sepsis
    • Araújo CV, et al. (2012) PPAR gamma activation protects the brain against microvascular dysfunction in sepsis. Microvasc Res 84(2):218-221.
    • (2012) Microvasc Res , vol.84 , Issue.2 , pp. 218-221
    • Araújo, C.V.1
  • 27
    • 80052319523 scopus 로고    scopus 로고
    • Omega-3 fatty acids attenuate constitutive and insulininduced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells
    • Madonna R, et al. (2011) Omega-3 fatty acids attenuate constitutive and insulininduced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells. Thromb Haemost 106(3):500-510.
    • (2011) Thromb Haemost , vol.106 , Issue.3 , pp. 500-510
    • Madonna, R.1
  • 28
    • 47349117843 scopus 로고    scopus 로고
    • Selective activation of peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism
    • Biscetti F, et al. (2008) Selective activation of peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism. Diabetes 57(5):1394-1404.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1394-1404
    • Biscetti, F.1
  • 29
    • 0035146287 scopus 로고    scopus 로고
    • Control of vascular cell proliferation and migration by PPAR-gamma: A new approach to the macrovascular complications of diabetes
    • Hsueh WA, Jackson S, Law RE (2001) Control of vascular cell proliferation and migration by PPAR-gamma: A new approach to the macrovascular complications of diabetes. Diabetes Care 24(2):392-397.
    • (2001) Diabetes Care , vol.24 , Issue.2 , pp. 392-397
    • Hsueh, W.A.1    Jackson, S.2    Law, R.E.3
  • 30
    • 0035877163 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia
    • Narravula S, Colgan SP (2001) Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. J Immunol 166(12):7543-7548.
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7543-7548
    • Narravula, S.1    Colgan, S.P.2
  • 31
    • 84875044542 scopus 로고    scopus 로고
    • Complement-mediated chronic inflammation is associated with diabetic microvascular complication
    • Fujita T, et al. (2013) Complement-mediated chronic inflammation is associated with diabetic microvascular complication. Diabetes Metab Res Rev 29(3):220-226.
    • (2013) Diabetes Metab Res Rev , vol.29 , Issue.3 , pp. 220-226
    • Fujita, T.1
  • 32
    • 79960190061 scopus 로고    scopus 로고
    • Inflammation in diabetic retinopathy
    • Tang J, Kern TS (2011) Inflammation in diabetic retinopathy. Prog Retin Eye Res 30(5): 343-358.
    • (2011) Prog Retin Eye Res , vol.30 , Issue.5 , pp. 343-358
    • Tang, J.1    Kern, T.S.2
  • 33
    • 53449084910 scopus 로고    scopus 로고
    • Control of chemokine gradients by the retinal pigment epithelium
    • Shi G, et al. (2008) Control of chemokine gradients by the retinal pigment epithelium. Invest Ophthalmol Vis Sci 49(10):4620-4630.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.10 , pp. 4620-4630
    • Shi, G.1
  • 34
    • 3242770428 scopus 로고    scopus 로고
    • Angiogenesis-related factors derived from retinal glial (Müller) cells in hypoxia
    • Eichler W, Yafai Y, Wiedemann P, Reichenbach A (2004) Angiogenesis-related factors derived from retinal glial (Müller) cells in hypoxia. Neuroreport 15(10):1633-1637.
    • (2004) Neuroreport , vol.15 , Issue.10 , pp. 1633-1637
    • Eichler, W.1    Yafai, Y.2    Wiedemann, P.3    Reichenbach, A.4
  • 35
    • 0035219629 scopus 로고    scopus 로고
    • Retinal pigment epitheliumimmune system interactions: Cytokine production and cytokine-induced changes
    • Holtkamp GM, Kijlstra A, Peek R, de Vos AF (2001) Retinal pigment epitheliumimmune system interactions: Cytokine production and cytokine-induced changes. Prog Retin Eye Res 20(1):29-48.
    • (2001) Prog Retin Eye Res , vol.20 , Issue.1 , pp. 29-48
    • Holtkamp, G.M.1    Kijlstra, A.2    Peek, R.3    De Vos, A.F.4
  • 36
    • 41149095864 scopus 로고    scopus 로고
    • PPARalpha activators upregulate eNOS activity and inhibit cytokine-induced NF-kappaB activation through AMP-activated protein kinase activation
    • Okayasu T, Tomizawa A, Suzuki K, Manaka K, Hattori Y (2008) PPARalpha activators upregulate eNOS activity and inhibit cytokine-induced NF-kappaB activation through AMP-activated protein kinase activation. Life Sci 82(15-16):884-891.
    • (2008) Life Sci , vol.82 , Issue.15-16 , pp. 884-891
    • Okayasu, T.1    Tomizawa, A.2    Suzuki, K.3    Manaka, K.4    Hattori, Y.5
  • 37
    • 0032439396 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) alpha activation and its consequences in humans
    • Hertz R, Bar-Tana J (1998) Peroxisome proliferator-activated receptor (PPAR) alpha activation and its consequences in humans. Toxicol Lett 102-103:85-90.
    • (1998) Toxicol Lett , vol.102-103 , pp. 85-90
    • Hertz, R.1    Bar-Tana, J.2
  • 38
    • 0038702371 scopus 로고    scopus 로고
    • Fenofibrate inhibits angiogenesis in vitro and in vivo
    • Varet J, et al. (2003) Fenofibrate inhibits angiogenesis in vitro and in vivo. Cell Mol Life Sci 60(4):810-819.
    • (2003) Cell Mol Life Sci , vol.60 , Issue.4 , pp. 810-819
    • Varet, J.1
  • 39
    • 73549107654 scopus 로고    scopus 로고
    • Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models
    • Chen Y, et al. (2009) Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol 175(6):2676-2685.
    • (2009) Am J Pathol , vol.175 , Issue.6 , pp. 2676-2685
    • Chen, Y.1
  • 40
    • 84874514724 scopus 로고    scopus 로고
    • Pathogenic role of the Wnt signaling pathway activation in laserinduced choroidal neovascularization
    • Hu Y, et al. (2013) Pathogenic role of the Wnt signaling pathway activation in laserinduced choroidal neovascularization. Invest Ophthalmol Vis Sci 54(1):141-154.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , Issue.1 , pp. 141-154
    • Hu, Y.1
  • 41
    • 0021710801 scopus 로고
    • Comparison of retinal and cerebral vasculature in trypsin digest preparations
    • Cogan DG, Kuwabara T (1984) Comparison of retinal and cerebral vasculature in trypsin digest preparations. Br J Ophthalmol 68(1):10-12.
    • (1984) Br J Ophthalmol , vol.68 , Issue.1 , pp. 10-12
    • Cogan, D.G.1    Kuwabara, T.2
  • 42
    • 0028830667 scopus 로고
    • Retinal trypsin digest study of cystoid macular edema associated with peripheral choroidal melanoma
    • Michael JC, De Venecia G (1995) Retinal trypsin digest study of cystoid macular edema associated with peripheral choroidal melanoma. Am J Ophthalmol 119(2):152-156.
    • (1995) Am J Ophthalmol , vol.119 , Issue.2 , pp. 152-156
    • Michael, J.C.1    De Venecia, G.2


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