메뉴 건너뛰기




Volumn 61, Issue 6, 2012, Pages 1573-1583

Protein kinase Cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor - Induced permeability in vivo

Author keywords

[No Author keywords available]

Indexed keywords

OCCLUDIN; PROTEASOME; PROTEIN KINASE C BETA; VASCULOTROPIN;

EID: 84861918691     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1367     Document Type: Article
Times cited : (133)

References (45)
  • 2
    • 1942502810 scopus 로고    scopus 로고
    • Regulation of tight junctions and loss of barrier function in pathophysiology
    • DOI 10.1016/j.biocel.2003.08.007, PII S1357272503002978
    • Harhaj NS, Antonetti DA. Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol 2004;36:1206-1237 (Pubitemid 38519069)
    • (2004) International Journal of Biochemistry and Cell Biology , vol.36 , Issue.7 , pp. 1206-1237
    • Harhaj, N.S.1    Antonetti, D.A.2
  • 5
    • 77952779304 scopus 로고    scopus 로고
    • Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    • Elman MJ, Aiello LP, Beck RW, et al. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 2010;117:1064-1077
    • (2010) Ophthalmology , vol.117 , pp. 1064-1077
    • Elman, M.J.1    Aiello, L.P.2    Beck, R.W.3
  • 7
    • 58249089758 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema
    • PKC-DRS2 Study Group
    • Davis MD, Sheetz MJ, Aiello LP, et al.; PKC-DRS2 Study Group. Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema. Invest Ophthalmol Vis Sci 2009;50:1-4
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1-4
    • Davis, M.D.1    Sheetz, M.J.2    Aiello, L.P.3
  • 8
    • 33751520614 scopus 로고    scopus 로고
    • Effect of rubox-istaurin on visual loss in patients with diabetic retinopathy
    • PKC-DRS2 Group
    • Aiello LP, Davis MD, Girach A, et al.; PKC-DRS2 Group. Effect of rubox-istaurin on visual loss in patients with diabetic retinopathy. Ophthalmology 2006;113:2221-2230
    • (2006) Ophthalmology , vol.113 , pp. 2221-2230
    • Aiello, L.P.1    Davis, M.D.2    Girach, A.3
  • 9
    • 80055100383 scopus 로고    scopus 로고
    • Oral protein kinase c beta inhibition using ruboxistaurin: Efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the Protein Kinase C beta Inhibitor-Diabetic Retinopathy Study and the Protein kinase C beta Inhibitor-Diabetic Retinopathy Study 2
    • Aiello LP, Vignati L, Sheetz MJ, et al. Oral protein kinase c beta inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the Protein Kinase C beta Inhibitor-Diabetic Retinopathy Study and the Protein kinase C beta Inhibitor-Diabetic Retinopathy Study 2. Retina 2011;31:2084-2094
    • (2011) Retina , vol.31 , pp. 2084-2094
    • Aiello, L.P.1    Vignati, L.2    Sheetz, M.J.3
  • 13
    • 79951681656 scopus 로고    scopus 로고
    • New aspects of the molecular constituents of tissue barriers
    • Bauer HC, Traweger A, Zweimueller-Mayer J, et al. New aspects of the molecular constituents of tissue barriers. J Neural Transm 2011;118:7-21
    • (2011) J Neural Transm , vol.118 , pp. 7-21
    • Bauer, H.C.1    Traweger, A.2    Zweimueller-Mayer, J.3
  • 15
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • Saitou M, Furuse M, Sasaki H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 2000;11:4131-4142
    • (2000) Mol Biol Cell , vol.11 , pp. 4131-4142
    • Saitou, M.1    Furuse, M.2    Sasaki, H.3
  • 16
    • 79959736965 scopus 로고    scopus 로고
    • PKCzeta phosphorylates occludin and promotes assembly of epithelial tight junctions
    • Jain S, Suzuki T, Seth A, et al. PKCzeta phosphorylates occludin and promotes assembly of epithelial tight junctions. Biochem J 2011;437:289-299
    • (2011) Biochem J , vol.437 , pp. 289-299
    • Jain, S.1    Suzuki, T.2    Seth, A.3
  • 17
    • 58549096092 scopus 로고    scopus 로고
    • PKC eta regulates occludin phosphorylation and epithelial tight junction integrity
    • Suzuki T, Elias BC, Seth A, et al. PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Proc Natl Acad Sci USA 2009;106:61-66
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 61-66
    • Suzuki, T.1    Elias, B.C.2    Seth, A.3
  • 18
    • 59449086585 scopus 로고    scopus 로고
    • Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions
    • Elias BC, Suzuki T, Seth A, et al. Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem 2009;284:1559-1569
    • (2009) J Biol Chem , vol.284 , pp. 1559-1569
    • Elias, B.C.1    Suzuki, T.2    Seth, A.3
  • 19
    • 79956202699 scopus 로고    scopus 로고
    • Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
    • Raleigh DR, Boe DM, Yu D, et al. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol 2011;193:565-582
    • (2011) J Cell Biol , vol.193 , pp. 565-582
    • Raleigh, D.R.1    Boe, D.M.2    Yu, D.3
  • 21
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    • Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999;274:23463-23467
    • (1999) J Biol Chem , vol.274 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3    Wolpert, E.B.4    Gardner, T.W.5
  • 22
    • 0033771018 scopus 로고    scopus 로고
    • Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes
    • The Penn State Retina Research Group
    • Barber AJ, Antonetti DA, Gardner TW; The Penn State Retina Research Group. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. Invest Ophthalmol Vis Sci 2000;41:3561-3568
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3561-3568
    • Barber, A.J.1    Antonetti, D.A.2    Gardner, T.W.3
  • 23
    • 61849157754 scopus 로고    scopus 로고
    • Identification and analysis of occludin phosphosites: A combined mass spectrometry and bioinformatics approach
    • Sundstrom JM, Tash BR, Murakami T, et al. Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach. J Proteome Res 2009;8:808-817
    • (2009) J Proteome Res , vol.8 , pp. 808-817
    • Sundstrom, J.M.1    Tash, B.R.2    Murakami, T.3
  • 24
    • 0038362292 scopus 로고    scopus 로고
    • When ubiquitin meets ubiquitin receptors: A signalling connection
    • DOI 10.1038/nrm1124
    • Di Fiore PP, Polo S, Hofmann K. When ubiquitin meets ubiquitin receptors: a signalling connection. Nat Rev Mol Cell Biol 2003;4:491-497 (Pubitemid 36648594)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.6 , pp. 491-497
    • Di, F.P.P.1    Polo, S.2    Hofmann, K.3
  • 25
    • 68949129005 scopus 로고    scopus 로고
    • Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
    • Murakami T, Felinski EA, Antonetti DA. Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem 2009;284:21036-21046
    • (2009) J Biol Chem , vol.284 , pp. 21036-21046
    • Murakami, T.1    Felinski, E.A.2    Antonetti, D.A.3
  • 26
    • 0038165451 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells
    • DOI 10.1074/jbc.M301410200
    • Duval M, Bédard-Goulet S, Delisle C, Gratton JP. Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cblmediated ubiquitination. Consequences on nitric oxide production from endothelial cells. J Biol Chem 2003;278:20091-20097 (Pubitemid 36799203)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.22 , pp. 20091-20097
    • Duval, M.1    Bedard-Goulet, S.2    Delisle, C.3    Gratton, J.-P.4
  • 28
    • 47249095733 scopus 로고    scopus 로고
    • Occludin independently regulates permeability under hydrostatic pressure and cell division in retinal pigment epithelial cells
    • Phillips BE, Cancel L, Tarbell JM, Antonetti DA. Occludin independently regulates permeability under hydrostatic pressure and cell division in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2008;49:2568-2576
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 2568-2576
    • Phillips, B.E.1    Cancel, L.2    Tarbell, J.M.3    Antonetti, D.A.4
  • 29
    • 0029782604 scopus 로고    scopus 로고
    • A carboxy-terminal deletion mutant of protein kinase CbetaII inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells
    • DOI 10.1210/me.10.10.1273
    • Chalfant CE, Ohno S, Konno Y, et al. A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells. Mol Endocrinol 1996;10:1273-1281 (Pubitemid 26330959)
    • (1996) Molecular Endocrinology , vol.10 , Issue.10 , pp. 1273-1281
    • Chalfant, C.E.1    Ohno, S.2    Konno, Y.3    Fisher, A.A.4    Bisnauth, L.D.5    Watson, J.E.6    Cooper, D.R.7
  • 30
    • 0642280833 scopus 로고    scopus 로고
    • Isolation and characterization of retinal endothelial cells
    • Nag S, Ed. Totowa, New Jersey, Humana Press
    • Antonetti DA, Wolpert EB. Isolation and characterization of retinal endothelial cells. In The Blood-Brain Barrier: Biology and Research Protocols. Nag S, Ed. Totowa, New Jersey, Humana Press, 2003, p. 365-374
    • (2003) The Blood-Brain Barrier: Biology and Research Protocols , pp. 365-374
    • Antonetti, D.A.1    Wolpert, E.B.2
  • 32
    • 0028121374 scopus 로고
    • Regulation of vascular endothelial barrier function
    • Lum H, Malik AB. Regulation of vascular endothelial barrier function. Am J Physiol 1994;267:L223-L241
    • (1994) Am J Physiol , vol.267
    • Lum, H.1    Malik, A.B.2
  • 33
    • 34748876124 scopus 로고    scopus 로고
    • A phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network
    • Scott IU, Edwards AR, Beck RW, et al.; Diabetic Retinopathy Clinical Research Network. A phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema. Ophthalmology 2007;114:1860-1867
    • (2007) Ophthalmology , vol.114 , pp. 1860-1867
    • Scott, I.U.1    Edwards, A.R.2    Beck, R.W.3
  • 34
    • 55949109631 scopus 로고    scopus 로고
    • Structural basis of protein kinase C isoform function
    • Steinberg SF. Structural basis of protein kinase C isoform function. Physiol Rev 2008;88:1341-1378
    • (2008) Physiol Rev , vol.88 , pp. 1341-1378
    • Steinberg, S.F.1
  • 36
    • 5044225158 scopus 로고    scopus 로고
    • Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase itch
    • DOI 10.1126/science.1099414
    • Gao M, Labuda T, Xia Y, et al. Jun turnover is controlled through JNKdependent phosphorylation of the E3 ligase Itch. Science 2004;306:271-275 (Pubitemid 39336871)
    • (2004) Science , vol.306 , Issue.5694 , pp. 271-275
    • Gao, M.1    Labuda, T.2    Xia, Y.3    Gallagher, E.4    Fang, D.5    Liu, Y.-C.6    Karin, M.7
  • 37
    • 77950585581 scopus 로고    scopus 로고
    • Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    • Marchiando AM, Shen L, Graham WV, et al. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol 2010;189:111-126
    • (2010) J Cell Biol , vol.189 , pp. 111-126
    • Marchiando, A.M.1    Shen, L.2    Graham, W.V.3
  • 38
    • 0024309730 scopus 로고
    • Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins
    • DOI 10.1084/jem.169.6.1977
    • Brett J, Gerlach H, Nawroth P, Steinberg S, Godman G, Stern D. Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. J Exp Med 1989; 169:1977-1991 (Pubitemid 19162960)
    • (1989) Journal of Experimental Medicine , vol.169 , Issue.6 , pp. 1977-1991
    • Brett, J.1    Gerlach, H.2    Nawroth, P.3    Steinberg, S.4    Godman, G.5    Stern, D.6
  • 39
    • 66849083904 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells
    • Takahashi S, Iwamoto N, Sasaki H, et al. The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells. J Cell Sci 2009;122:985-994
    • (2009) J Cell Sci , vol.122 , pp. 985-994
    • Takahashi, S.1    Iwamoto, N.2    Sasaki, H.3
  • 40
    • 63849263175 scopus 로고    scopus 로고
    • Rab family small G proteins in regulation of epithelial apical junctions
    • Nishimura N, Sasaki T. Rab family small G proteins in regulation of epithelial apical junctions. Front Biosci 2009;14:2115-2129
    • (2009) Front Biosci , vol.14 , pp. 2115-2129
    • Nishimura, N.1    Sasaki, T.2
  • 41
    • 19944433375 scopus 로고    scopus 로고
    • Rab13 mediates the continuous endocytic recycling of occludin to the cell surface
    • Morimoto S, Nishimura N, Terai T, et al. Rab13 mediates the continuous endocytic recycling of occludin to the cell surface. J Biol Chem 2005;280:2220-2228
    • (2005) J Biol Chem , vol.280 , pp. 2220-2228
    • Morimoto, S.1    Nishimura, N.2    Terai, T.3
  • 42
    • 33344474964 scopus 로고    scopus 로고
    • Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    • DOI 10.1016/j.yexcr.2005.11.012, PII S0014482705005215
    • Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 2006;312:549-560 (Pubitemid 43290332)
    • (2006) Experimental Cell Research , vol.312 , Issue.5 , pp. 549-560
    • Shibuya, M.1    Claesson-Welsh, L.2
  • 44
    • 70449442873 scopus 로고    scopus 로고
    • Redox-sensitivity of the dimerization of occludin
    • Walter JK, Castro V, Voss M, et al. Redox-sensitivity of the dimerization of occludin. Cell Mol Life Sci 2009;66:3655-3662
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3655-3662
    • Walter, J.K.1    Castro, V.2    Voss, M.3
  • 45
    • 67249083033 scopus 로고    scopus 로고
    • The oligomerization of the coiled coildomain of occludin is redox sensitive
    • Walter JK, Rueckert C, Voss M, et al. The oligomerization of the coiled coildomain of occludin is redox sensitive. Ann N Y Acad Sci 2009;1165:19-27
    • (2009) Ann N Y Acad Sci , vol.1165 , pp. 19-27
    • Walter, J.K.1    Rueckert, C.2    Voss, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.