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Volumn 54, Issue 10, 2013, Pages 6518-6525

Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells

Author keywords

Connexins; Gap junctions; Tight junctions

Indexed keywords

CONNEXIN 43; GLUCOSE; OCCLUDIN; PROTEIN ZO1; SMALL INTERFERING RNA;

EID: 84885031592     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-11763     Document Type: Article
Times cited : (78)

References (46)
  • 1
    • 0031737671 scopus 로고    scopus 로고
    • Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells
    • Penn State Retina Research Group
    • Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes. 1998;47:1953-1959.
    • (1998) Diabetes. , vol.47 , pp. 1953-1959
    • Antonetti, D.A.1    Barber, A.J.2    Khin, S.3    Lieth, E.4    Tarbell, J.M.5    Gardner, T.W.6
  • 2
    • 0028834838 scopus 로고
    • Histamine, ZO-1 and increased blood-retinal barrier permeability in diabetic retinopathy
    • Gardner TW. Histamine, ZO-1 and increased blood-retinal barrier permeability in diabetic retinopathy. Trans Am Ophthalmol Soc. 1995;93:583-621.
    • (1995) Trans Am Ophthalmol Soc. , vol.93 , pp. 583-621
    • Gardner, T.W.1
  • 3
    • 77749304040 scopus 로고    scopus 로고
    • Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy
    • Kim JH, Jun HO, Yu YS, Kim KW. Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy. Am J Pathol. 2010;176:1517-1524.
    • (2010) Am J Pathol. , vol.176 , pp. 1517-1524
    • Kim, J.H.1    Jun, H.O.2    Yu, Y.S.3    Kim, K.W.4
  • 4
    • 33745309083 scopus 로고    scopus 로고
    • ZO-1 expression and phosphorylation in diabetic nephropathy
    • Rincon-Choles H, Vasylyeva TL, Pergola PE, et al. ZO-1 expression and phosphorylation in diabetic nephropathy. Diabetes. 2006;55:894-900.
    • (2006) Diabetes. , vol.55 , pp. 894-900
    • Rincon-Choles, H.1    Vasylyeva, T.L.2    Pergola, P.E.3
  • 5
    • 84860197211 scopus 로고    scopus 로고
    • Diabetic macular edema
    • Lang GE. Diabetic macular edema. Ophthalmologica. 2012;227(suppl 1):21-29.
    • (2012) Ophthalmologica. , vol.227 , Issue.SUPPL. 1 , pp. 21-29
    • Lang, G.E.1
  • 6
    • 84863469630 scopus 로고    scopus 로고
    • Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability
    • Parthasarathi K. Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability. Am J Physiol Lung Cell Mol Physiol. 2012;303:L33-L42.
    • (2012) Am J Physiol Lung Cell Mol Physiol. , vol.303
    • Parthasarathi, K.1
  • 7
    • 33744908040 scopus 로고    scopus 로고
    • Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
    • Nagasawa K, Chiba H, Fujita H, et al. Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. J Cell Physiol. 2006;208:123-132.
    • (2006) J Cell Physiol. , vol.208 , pp. 123-132
    • Nagasawa, K.1    Chiba, H.2    Fujita, H.3
  • 8
    • 78149242584 scopus 로고    scopus 로고
    • Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly
    • Li MW, Mruk DD, Lee WM, et al. Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly. Proc Natl Acad Sci U S A. 2010;107:17998-18003.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , pp. 17998-18003
    • Li, M.W.1    Mruk, D.D.2    Lee, W.M.3
  • 9
    • 75649090531 scopus 로고    scopus 로고
    • Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice
    • Bobbie MW, Roy S, Trudeau K, Munger SJ, Simon AM, Roy S. Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice. Invest Ophthalmol Vis Sci. 2010;51:3758-3763.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 3758-3763
    • Bobbie, M.W.1    Roy, S.2    Trudeau, K.3    Munger, S.J.4    Simon, A.M.5    Roy, S.6
  • 10
    • 0036319123 scopus 로고    scopus 로고
    • Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells
    • Sato T, Haimovici R, Kao R, Li AF, Roy S. Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells. Diabetes. 2002;51:1565-1571.
    • (2002) Diabetes. , vol.51 , pp. 1565-1571
    • Sato, T.1    Haimovici, R.2    Kao, R.3    Li, A.F.4    Roy, S.5
  • 11
    • 0345714595 scopus 로고    scopus 로고
    • High glucose alters connexin 43 expression and gap junction intercellular communication activity in retinal pericytes
    • Li AF, Sato T, Haimovici R, Okamoto T, Roy S. High glucose alters connexin 43 expression and gap junction intercellular communication activity in retinal pericytes. Invest Ophthalmol Vis Sci. 2003;44:5376-5382.
    • (2003) Invest Ophthalmol Vis Sci. , vol.44 , pp. 5376-5382
    • Li, A.F.1    Sato, T.2    Haimovici, R.3    Okamoto, T.4    Roy, S.5
  • 12
    • 62649162866 scopus 로고    scopus 로고
    • High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells
    • Li AF, Roy S. High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells. Invest Ophthalmol Vis Sci. 2009;50:1400-1407.
    • (2009) Invest Ophthalmol Vis Sci. , vol.50 , pp. 1400-1407
    • Li, A.F.1    Roy, S.2
  • 14
    • 21044440344 scopus 로고    scopus 로고
    • Quantitative analysis of ZO-1 colocalization with Cx43 gap junction plaques in cultures of rat neonatal cardiomyocytes
    • Zhu C, Barker RJ, Hunter AW, Zhang Y, Jourdan J, Gourdie RJ. Quantitative analysis of ZO-1 colocalization with Cx43 gap junction plaques in cultures of rat neonatal cardiomyocytes. Microsc Microanal. 2005;11:244-248.
    • (2005) Microsc Microanal. , vol.11 , pp. 244-248
    • Zhu, C.1    Barker, R.J.2    Hunter, A.W.3    Zhang, Y.4    Jourdan, J.5    Gourdie, R.J.6
  • 15
  • 16
    • 0037155043 scopus 로고    scopus 로고
    • Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions
    • Barker RJ, Price RL, Gourdie RG. Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions. Circ Res. 2002;90:317-324.
    • (2002) Circ Res. , vol.90 , pp. 317-324
    • Barker, R.J.1    Price, R.L.2    Gourdie, R.G.3
  • 17
    • 39749165131 scopus 로고    scopus 로고
    • Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1
    • Bruce AF, Rothery S, Dupont E, Severs NJ. Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1. Cardiovasc Res. 2008;77:757-765.
    • (2008) Cardiovasc Res. , vol.77 , pp. 757-765
    • Bruce, A.F.1    Rothery, S.2    Dupont, E.3    Severs, N.J.4
  • 18
    • 79959542990 scopus 로고    scopus 로고
    • Detailed regulatory mechanism of the interaction between ZO-1 PDZ2 and connexin43 revealed by MD simulations
    • Xiao F, Weng J, Fan K, Wang W. Detailed regulatory mechanism of the interaction between ZO-1 PDZ2 and connexin43 revealed by MD simulations. PLoS One. 2011;6:e21527.
    • (2011) PLoS One. , vol.6
    • Xiao, F.1    Weng, J.2    Fan, K.3    Wang, W.4
  • 19
    • 21044444186 scopus 로고    scopus 로고
    • ZO-1 alters the plasma membrane localization and function of Cx43 in osteoblastic cells
    • Laing JG, Chou BC, Steinberg TH. ZO-1 alters the plasma membrane localization and function of Cx43 in osteoblastic cells. J Cell Sci. 2005;118:2167-2176.
    • (2005) J Cell Sci. , vol.118 , pp. 2167-2176
    • Laing, J.G.1    Chou, B.C.2    Steinberg, T.H.3
  • 20
    • 79251572022 scopus 로고    scopus 로고
    • Connexonmediated cell adhesion drives microtissue self-assembly
    • Bao B, Jiang J, Yanase T, Nishi Y, Morgan JR. Connexonmediated cell adhesion drives microtissue self-assembly. FASEB J. 2011;25:255-264.
    • (2011) FASEB J. , vol.25 , pp. 255-264
    • Bao, B.1    Jiang, J.2    Yanase, T.3    Nishi, Y.4    Morgan, J.R.5
  • 21
    • 60149097598 scopus 로고    scopus 로고
    • Adhesive properties of connexin hemichannels
    • Cotrina ML, Lin JH, Nedergaard M. Adhesive properties of connexin hemichannels. Glia. 2008;56:1791-1798.
    • (2008) Glia. , vol.56 , pp. 1791-1798
    • Cotrina, M.L.1    Lin, J.H.2    Nedergaard, M.3
  • 22
    • 84860419981 scopus 로고    scopus 로고
    • Two-dimensional kinetics of inter-connexin interactions from single-molecule force spectroscopy
    • Rico F, Oshima A, Hinterdorfer P, Fujiyoshi Y, Scheuring S. Two-dimensional kinetics of inter-connexin interactions from single-molecule force spectroscopy. J Mol Biol. 2011;412:72-79.
    • (2011) J Mol Biol. , vol.412 , pp. 72-79
    • Rico, F.1    Oshima, A.2    Hinterdorfer, P.3    Fujiyoshi, Y.4    Scheuring, S.5
  • 23
    • 79960731769 scopus 로고    scopus 로고
    • High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: Implications for diabetic retinopathy
    • Chronopoulos A, Trudeau K, Roy S, Huang H, Vinores SA. High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: implications for diabetic retinopathy. Curr Eye Res. 2011;36:747-753.
    • (2011) Curr Eye Res. , vol.36 , pp. 747-753
    • Chronopoulos, A.1    Trudeau, K.2    Roy, S.3    Huang, H.4    Vinores, S.A.5
  • 24
    • 0028962337 scopus 로고
    • Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells
    • O'Donnell ME, Brandt JD, Curry FR. Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells. Am J Physiol. 1995;268;C1067-C1074.
    • (1995) Am J Physiol. , vol.268
    • O'Donnell, M.E.1    Brandt, J.D.2    Curry, F.R.3
  • 26
    • 16544382115 scopus 로고    scopus 로고
    • Fibronectin overexpression inhibits trabecular meshwork cell monolayer permeability
    • Li AF, Tane N, Roy S. Fibronectin overexpression inhibits trabecular meshwork cell monolayer permeability. Mol Vis. 2004;10:750-757.
    • (2004) Mol Vis. , vol.10 , pp. 750-757
    • Li, A.F.1    Tane, N.2    Roy, S.3
  • 27
    • 0023108105 scopus 로고
    • Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication
    • El-Fouly MH, Trosko JE, Chang CC. Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication. Exp Cell Res. 1987;168:422-430.
    • (1987) Exp Cell Res. , vol.168 , pp. 422-430
    • El-Fouly, M.H.1    Trosko, J.E.2    Chang, C.C.3
  • 28
    • 0033624011 scopus 로고    scopus 로고
    • Cooperation of bcl-2 and myc in the neoplastic transformation of normal rat liver epithelial cells is related to the down-regulation of gap junction-mediated intercellular communication
    • DeoCampo ND, Wilson MR, Trosko JE. Cooperation of bcl-2 and myc in the neoplastic transformation of normal rat liver epithelial cells is related to the down-regulation of gap junction-mediated intercellular communication. Carcinogenesis. 2000;21:1501-1506.
    • (2000) Carcinogenesis. , vol.21 , pp. 1501-1506
    • DeoCampo, N.D.1    Wilson, M.R.2    Trosko, J.E.3
  • 29
    • 0029618669 scopus 로고
    • Synthesis and assembly of human beta 1 gap junctions in BHK cells by DNA transfection with the human beta 1 cDNA
    • Kumar NM, Friend DS, Gilula NB. Synthesis and assembly of human beta 1 gap junctions in BHK cells by DNA transfection with the human beta 1 cDNA. J Cell Sci. 1995;108:3725-3734.
    • (1995) J Cell Sci. , vol.108 , pp. 3725-3734
    • Kumar, N.M.1    Friend, D.S.2    Gilula, N.B.3
  • 30
    • 78650073594 scopus 로고    scopus 로고
    • High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: Mechanism for compromised extracellular matrix barrier function
    • Chronopoulos A, Tang A, Beglova E, Trackman PC, Roy S. High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function. Diabetes. 2010;59:3159-3166.
    • (2010) Diabetes. , vol.59 , pp. 3159-3166
    • Chronopoulos, A.1    Tang, A.2    Beglova, E.3    Trackman, P.C.4    Roy, S.5
  • 31
    • 34249813392 scopus 로고    scopus 로고
    • Junction interaction in the seminiferous epithelium: Regulatory roles of connexin-based gap junction
    • Lee NP, Yeung WS, Luk JM. Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction. Front Biosci. 2007;12:1552-1562.
    • (2007) Front Biosci. , vol.12 , pp. 1552-1562
    • Lee, N.P.1    Yeung, W.S.2    Luk, J.M.3
  • 32
    • 67650239304 scopus 로고    scopus 로고
    • Disruption of gap junctional intercellular communication by antibiotic gentamicin is associated with aberrant localization of occludin, N-cadherin, connexin 43, and vimentin in SerW3 Sertoli cells in vitro
    • Bekheet SH, Stahlmann R. Disruption of gap junctional intercellular communication by antibiotic gentamicin is associated with aberrant localization of occludin, N-cadherin, connexin 43, and vimentin in SerW3 Sertoli cells in vitro. Environ Toxicol Pharmacol. 2009;28:155-160.
    • (2009) Environ Toxicol Pharmacol. , vol.28 , pp. 155-160
    • Bekheet, S.H.1    Stahlmann, R.2
  • 33
    • 77956396619 scopus 로고    scopus 로고
    • Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility
    • Carette D, Weider K, Gilleron J, et al. Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility. Dev Biol. 2010;346:54-67.
    • (2010) Dev Biol. , vol.346 , pp. 54-67
    • Carette, D.1    Weider, K.2    Gilleron, J.3
  • 34
    • 33750289407 scopus 로고    scopus 로고
    • Connexin 26 expression prevents down-regulation of barrier and fence functions of tight junctions by Na{thorn}/K{thorn}-ATPase inhibitor ouabain in human airway epithelial cell line Calu-3
    • Go M, Kojima T, Takano K, et al. Connexin 26 expression prevents down-regulation of barrier and fence functions of tight junctions by Na{thorn}/K{thorn}-ATPase inhibitor ouabain in human airway epithelial cell line Calu-3. Exp Cell Res. 2006;312:3847-3856.
    • (2006) Exp Cell Res. , vol.312 , pp. 3847-3856
    • Go, M.1    Kojima, T.2    Takano, K.3
  • 35
    • 4644269182 scopus 로고    scopus 로고
    • Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43
    • Maass K, Ghanem A, Kim JS, et al. Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43. Mol Biol Cell. 2004;15:4597-4608.
    • (2004) Mol Biol Cell. , vol.15 , pp. 4597-4608
    • Maass, K.1    Ghanem, A.2    Kim, J.S.3
  • 36
    • 11144230049 scopus 로고    scopus 로고
    • Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1
    • Sorgen PL, Duffy HS, Sahoo P, Coombs W, Delmar M, Spray DC. Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J Biol Chem. 2004;279:54695-54701.
    • (2004) J Biol Chem. , vol.279 , pp. 54695-54701
    • Sorgen, P.L.1    Duffy, H.S.2    Sahoo, P.3    Coombs, W.4    Delmar, M.5    Spray, D.C.6
  • 38
    • 0346496133 scopus 로고    scopus 로고
    • Fusion of GFP to the carboxyl terminus of connexin43 increases gap junction size in HeLa cells
    • Hunter AW, Jourdan J, Gourdie RG. Fusion of GFP to the carboxyl terminus of connexin43 increases gap junction size in HeLa cells. Cell Commun Adhes. 2003;10:211-214.
    • (2003) Cell Commun Adhes. , vol.10 , pp. 211-214
    • Hunter, A.W.1    Jourdan, J.2    Gourdie, R.G.3
  • 39
    • 0034646317 scopus 로고    scopus 로고
    • Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cells
    • Bukauskas FF, Jordan K, Bukauskiene A, et al. Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cells. Proc Natl Acad Sci U S A. 2000;97:2556-2561.
    • (2000) Proc Natl Acad Sci U S A. , vol.97 , pp. 2556-2561
    • Bukauskas, F.F.1    Jordan, K.2    Bukauskiene, A.3
  • 40
    • 28644434657 scopus 로고    scopus 로고
    • Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion
    • Hunter AW, Barker RJ, Zhu C, Gourdie RG. Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell. 2005;16:5686-5698.
    • (2005) Mol Biol Cell. , vol.16 , pp. 5686-5698
    • Hunter, A.W.1    Barker, R.J.2    Zhu, C.3    Gourdie, R.G.4
  • 41
    • 36349013698 scopus 로고    scopus 로고
    • Connexins induce and maintain tight junctions in epithelial cells
    • Kojima T, Murata M, Go M, Spray DC, Sawada N. Connexins induce and maintain tight junctions in epithelial cells. J Membr Biol. 2007;217:13-19.
    • (2007) J Membr Biol. , vol.217 , pp. 13-19
    • Kojima, T.1    Murata, M.2    Go, M.3    Spray, D.C.4    Sawada, N.5
  • 42
    • 12944319328 scopus 로고    scopus 로고
    • Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: CDNA microarray analysis
    • Murata M, Kojima T, Yamamoto T, et al. Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. Cell Tissue Res. 2005;319:341-347.
    • (2005) Cell Tissue Res. , vol.319 , pp. 341-347
    • Murata, M.1    Kojima, T.2    Yamamoto, T.3
  • 43
    • 0036343899 scopus 로고    scopus 로고
    • Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line
    • Kojima T, Spray DC, Kokai Y, Chiba H, Mochizuki Y, Sawada N. Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line. Exp Cell Res. 2002;276:40-51.
    • (2002) Exp Cell Res. , vol.276 , pp. 40-51
    • Kojima, T.1    Spray, D.C.2    Kokai, Y.3    Chiba, H.4    Mochizuki, Y.5    Sawada, N.6
  • 45
    • 0034975483 scopus 로고    scopus 로고
    • Altered connexin expression in human congestive heart failure
    • Dupont E, Matsushita T, Kaba RA, et al. Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol. 2001;33:359-371.
    • (2001) J Mol Cell Cardiol. , vol.33 , pp. 359-371
    • Dupont, E.1    Matsushita, T.2    Kaba, R.A.3
  • 46
    • 33644979261 scopus 로고    scopus 로고
    • Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells
    • Lai A, Le DN, Paznekas WA, Gifford WD, Jabs EW, Charles AC. Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J Cell Sci. 2006;119:532-541.
    • (2006) J Cell Sci. , vol.119 , pp. 532-541
    • Lai, A.1    Le, D.N.2    Paznekas, W.A.3    Gifford, W.D.4    Jabs, E.W.5    Charles, A.C.6


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